{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T06:06:18Z","timestamp":1792821978429,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T00:00:00Z","timestamp":1543449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771670"],"award-info":[{"award-number":["81771670"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31570881"],"award-info":[{"award-number":["31570881"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701542"],"award-info":[{"award-number":["81701542"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81825018"],"award-info":[{"award-number":["81825018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773121"],"award-info":[{"award-number":["81773121"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Jiangsu Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["BK20150992"],"award-info":[{"award-number":["BK20150992"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1016\/j.celrep.2018.11.096","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T10:40:28Z","timestamp":1545129628000},"page":"3393-3404.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Methyltransferase Nsd2 Ensures Germinal Center Selection by Promoting Adhesive Interactions between B Cells and Follicular Dendritic Cells"],"prefix":"10.1016","volume":"25","author":[{"given":"Jingjing","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuye","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bichun","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehui","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenming","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulan","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0679-9768","authenticated-orcid":false,"given":"Xiaoming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2018.11.096_bib1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.smim.2007.12.001","article-title":"Follicular dendritic cell networks of primary follicles and germinal centers: phenotype and function","volume":"20","author":"Allen","year":"2008","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.celrep.2018.11.096_bib2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.immuni.2007.07.009","article-title":"Germinal-center organization and cellular dynamics","volume":"27","author":"Allen","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2018.11.096_bib3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.coi.2016.12.004","article-title":"Germinal centers: programmed for affinity maturation and antibody diversification","volume":"45","author":"Bannard","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.celrep.2018.11.096_bib4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1600-065X.2007.00540.x","article-title":"The role of integrins and coreceptors in refining thresholds for B-cell responses","volume":"218","author":"Batista","year":"2007","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2018.11.096_bib5","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/s41467-017-01029-x","article-title":"EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop","volume":"8","author":"B\u00e9guelin","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2018.11.096_bib6","doi-asserted-by":"crossref","first-page":"e1000080","DOI":"10.1371\/journal.pbio.1000080","article-title":"Impaired antibody response causes persistence of prototypic T\u00a0cell-contained virus","volume":"7","author":"Bergthaler","year":"2009","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2018.11.096_bib7","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nmeth.3364","article-title":"MiXCR: software for comprehensive adaptive immunity profiling","volume":"12","author":"Bolotin","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2018.11.096_bib8","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.1172\/JCI70626","article-title":"Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis","volume":"123","author":"Caganova","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2018.11.096_bib9","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1016\/j.celrep.2017.04.069","article-title":"Wolf-Hirschhorn syndrome candidate 1 is necessary for correct hematopoietic and B cell development","volume":"19","author":"Campos-Sanchez","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2018.11.096_bib10","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/sj.emboj.7600944","article-title":"B-cell activation by membrane-bound antigens is facilitated by the interaction of VLA-4 with VCAM-1","volume":"25","author":"Carrasco","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2018.11.096_bib11","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S1074-7613(04)00105-0","article-title":"LFA-1\/ICAM-1 interaction lowers the threshold of B cell activation by facilitating B cell adhesion and synapse formation","volume":"20","author":"Carrasco","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2018.11.096_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1600-065X.2012.01118.x","article-title":"Affinity-based selection and the germinal center response","volume":"247","author":"Chan","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2018.11.096_bib13","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.4049\/jimmunol.1700159","article-title":"Lis1 regulates germinal center B cell antigen acquisition and affinity maturation","volume":"198","author":"Chen","year":"2017","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2018.11.096_bib14","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1084\/jem.20171815","article-title":"Uhrf1 regulates germinal center B cell expansion and affinity maturation to control viral infection","volume":"215","author":"Chen","year":"2018","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2018.11.096_bib15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/ni.3642","article-title":"Themis2 lowers the threshold for B cell activation during positive selection","volume":"18","author":"Cheng","year":"2017","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2018.11.096_bib16","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.immuni.2016.07.023","article-title":"The transcription factor AP4 mediates resolution of chronic viral infection through amplification of germinal center B cell responses","volume":"45","author":"Chou","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2018.11.096_bib17","doi-asserted-by":"crossref","first-page":"3860","DOI":"10.4049\/jimmunol.1401660","article-title":"SAP-regulated T Cell-APC adhesion and ligation-dependent and -independent Ly108-CD3\u03b6 interactions","volume":"193","author":"Chu","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2018.11.096_bib18","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1126\/science.1697696","article-title":"Adhesion of human B cells to germinal centers in\u00a0vitro involves VLA-4 and INCAM-110","volume":"249","author":"Freedman","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.11.096_bib19","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nature13300","article-title":"Clonal selection in the germinal centre by regulated proliferation and hypermutation","volume":"509","author":"Gitlin","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.11.096_bib20","doi-asserted-by":"crossref","first-page":"e2001750","DOI":"10.1371\/journal.pbio.2001750","article-title":"Rictor positively regulates B cell receptor signaling by modulating actin reorganization via ezrin","volume":"15","author":"Huang","year":"2017","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2018.11.096_bib21","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1158\/1078-0432.CCR-10-1302","article-title":"The histone methyltransferase and putative oncoprotein MMSET is overexpressed in a large variety of human tumors","volume":"17","author":"Hudlebusch","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2018.11.096_bib22","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1182\/blood-2004-09-3704","article-title":"Overexpression of transcripts originating from the MMSET locus characterizes all t(4;14)(p16;q32)-positive multiple myeloma patients","volume":"105","author":"Keats","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2018.11.096_bib23","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1126\/science.1213368","article-title":"B cell receptor signal transduction in the GC is short-circuited by high phosphatase activity","volume":"336","author":"Khalil","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.11.096_bib24","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.4049\/jimmunol.148.8.2331","article-title":"Follicular dendritic cell-dependent adhesion and proliferation of B cells in\u00a0vitro","volume":"148","author":"Kosco","year":"1992","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2018.11.096_bib25","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.11.096_bib26","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.molcel.2011.08.042","article-title":"NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming","volume":"44","author":"Kuo","year":"2011","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2018.11.096_bib27","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1002\/jnr.21997","article-title":"Regulation of dendrite growth by the Cdc42 activator Zizimin1\/Dock9 in hippocampal neurons","volume":"87","author":"Kuramoto","year":"2009","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.celrep.2018.11.096_bib28","doi-asserted-by":"crossref","first-page":"11560","DOI":"10.1073\/pnas.1102571108","article-title":"Activation-induced cytidine deaminase mediates central tolerance in B cells","volume":"108","author":"Kuraoka","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2018.11.096_bib29","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.immuni.2016.02.010","article-title":"Complex antigens drive permissive clonal selection in germinal centers","volume":"44","author":"Kuraoka","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2018.11.096_bib30","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.immuni.2008.04.014","article-title":"Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell development","volume":"28","author":"Kwon","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2018.11.096_bib31","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/gb-2009-10-3-r25","article-title":"Ultrafast and memory-efficient alignment of short DNA sequences to the human genome","volume":"10","author":"Langmead","year":"2009","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2018.11.096_bib32","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1172\/JCI91144","article-title":"AKT-mediated stabilization of histone methyltransferase WHSC1 promotes prostate cancer metastasis","volume":"127","author":"Li","year":"2017","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2018.11.096_bib33","doi-asserted-by":"crossref","first-page":"eaai9264","DOI":"10.1126\/science.aai9264","article-title":"Ephrin B1-mediated repulsion and signaling control germinal center T\u00a0cell territoriality and function","volume":"356","author":"Lu","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2018.11.096_bib34","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.immuni.2018.01.008","article-title":"B cell receptor and CD40 signaling are rewired for synergistic induction of the c-Myc transcription factor in germinal center B cells","volume":"48","author":"Luo","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2018.11.096_bib35","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jviromet.2007.08.025","article-title":"Quantitative PCR technique for detecting lymphocytic choriomeningitis virus in\u00a0vivo","volume":"147","author":"McCausland","year":"2008","journal-title":"J.\u00a0Virol. Methods"},{"key":"10.1016\/j.celrep.2018.11.096_bib36","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/ncb835","article-title":"Zizimin1, a novel Cdc42 activator, reveals a new GEF domain for Rho proteins","volume":"4","author":"Meller","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2018.11.096_bib37","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.immuni.2016.09.001","article-title":"Germinal center B cell dynamics","volume":"45","author":"Mesin","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2018.11.096_bib38","doi-asserted-by":"crossref","first-page":"E10560","DOI":"10.1073\/pnas.1701366114","article-title":"Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination","volume":"114","author":"Nguyen","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2018.11.096_bib39","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nature08086","article-title":"A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome","volume":"460","author":"Nimura","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2018.11.096_bib40","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1038\/ni.3458","article-title":"Germinal center B cells recognize antigen through a specialized immune synapse architecture","volume":"17","author":"Nowosad","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2018.11.096_bib41","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/nm.3943","article-title":"The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development","volume":"21","author":"Ortega-Molina","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2018.11.096_bib42","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.immuni.2007.02.011","article-title":"The humoral immune response is initiated in lymph nodes by B cells that acquire soluble antigen directly in the follicles","volume":"26","author":"Pape","year":"2007","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2018.11.096_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms16067","article-title":"CTCF orchestrates the germinal centre transcriptional program and prevents premature plasma cell differentiation","volume":"8","author":"P\u00e9rez-Garc\u00eda","year":"2017","journal-title":"Nat. Commun"},{"key":"10.1016\/j.celrep.2018.11.096_bib44","doi-asserted-by":"crossref","first-page":"e29141","DOI":"10.1371\/journal.pone.0029141","article-title":"Activation-induced cytidine deaminase expression in CD4+ T\u00a0cells is associated with a unique IL-10-producing subset that increases with age","volume":"6","author":"Qin","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2018.11.096_bib45","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1038\/ni.1820","article-title":"Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production","volume":"10","author":"Randall","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2018.11.096_bib46","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1128\/MCB.01483-08","article-title":"Regulation of cell-cell adhesion by Abi\/Diaphanous complexes","volume":"29","author":"Ryu","year":"2009","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2018.11.096_bib47","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1111\/j.1600-065X.2012.01124.x","article-title":"Germinal center selection and the development of memory B and plasma cells","volume":"247","author":"Shlomchik","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2018.11.096_bib48","doi-asserted-by":"crossref","first-page":"a018267","DOI":"10.1101\/cshperspect.a018267","article-title":"The actin cytoskeleton and actin-based motility","volume":"10","author":"Svitkina","year":"2018","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.celrep.2018.11.096_bib49","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/978-1-4615-2930-9_77","article-title":"Follicular dendritic cells in germinal center reactions","volume":"329","author":"Tew","year":"1993","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.celrep.2018.11.096_bib50","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1600-065X.1997.tb00957.x","article-title":"Follicular dendritic cells and presentation of antigen and costimulatory signals to B cells","volume":"156","author":"Tew","year":"1997","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2018.11.096_bib51","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/nri.2017.67","article-title":"Cytoskeletal control of B cell responses to antigens","volume":"17","author":"Tolar","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2018.11.096_bib52","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1038\/nprot.2016.093","article-title":"High-quality full-length immunoglobulin profiling with unique molecular barcoding","volume":"11","author":"Turchaninova","year":"2016","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2018.11.096_bib53","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.4049\/jimmunol.1601415","article-title":"Dysregulation of B cell repertoire formation in myasthenia gravis patients revealed through deep sequencing","volume":"198","author":"Vander Heiden","year":"2017","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2018.11.096_bib54","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.cell.2010.10.032","article-title":"Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter","volume":"143","author":"Victora","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2018.11.096_bib55","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nrm3274","article-title":"Understanding the language of Lys36 methylation at histone H3","volume":"13","author":"Wagner","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2018.11.096_bib56","doi-asserted-by":"crossref","first-page":"4601","DOI":"10.4049\/jimmunol.1400090","article-title":"Integrin-mediated interactions between B cells and follicular dendritic cells influence germinal center B cell fitness","volume":"192","author":"Wang","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2018.11.096_bib57","doi-asserted-by":"crossref","first-page":"e134","DOI":"10.1093\/nar\/gks457","article-title":"Quantifying selection in high-throughput Immunoglobulin sequencing data sets","volume":"40","author":"Yaari","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2018.11.096_bib58","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1038\/nm.3940","article-title":"Disruption of KMT2D perturbs germinal center B cell development and promotes lymphomagenesis","volume":"21","author":"Zhang","year":"2015","journal-title":"Nat. Med."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718318874?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124718318874?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:29:32Z","timestamp":1761906572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124718318874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12]]},"references-count":58,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["S2211124718318874"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2018.11.096","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2018,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Methyltransferase Nsd2 Ensures Germinal Center Selection by Promoting Adhesive Interactions between B Cells and Follicular Dendritic Cells","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2018.11.096","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 The Author(s).","name":"copyright","label":"Copyright"}]}}