{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T17:07:17Z","timestamp":1792602437518,"version":"4.5.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,2]],"date-time":"2019-01-02T00:00:00Z","timestamp":1546387200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004017","name":"Japanese Association of Dialysis Physicians","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004017","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007716","name":"Banyu Life Science Foundation International","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007716","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015649","name":"Yukiko Ishibashi Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015649","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001697","name":"Keio University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001697","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["201813428"],"award-info":[{"award-number":["201813428"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.celrep.2019.01.005","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T23:57:38Z","timestamp":1548806258000},"page":"1318-1332.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"title":["Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes"],"prefix":"10.1016","volume":"26","author":[{"given":"Akihito","family":"Hishikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaya","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Yokoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhiko","family":"Azegami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norifumi","family":"Yoshimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kanda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Sakamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2019.01.005_bib1","doi-asserted-by":"crossref","first-page":"6137","DOI":"10.1093\/nar\/gkm656","article-title":"Tip60 functions as a potential corepressor of KLF4 in regulation of HDC promoter activity","volume":"35","author":"Ai","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2019.01.005_bib2","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/nm.2135","article-title":"Methylation determines fibroblast activation and fibrogenesis in the kidney","volume":"16","author":"Bechtel","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2019.01.005_bib3","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/ncb1599","article-title":"Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair","volume":"9","author":"Berkovich","year":"2007","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2019.01.005_bib4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10689-013-9676-1","article-title":"Diversity of the clinical presentation of the MMR gene biallelic mutations","volume":"13","author":"Bougeard","year":"2014","journal-title":"Fam. Cancer"},{"key":"10.1016\/j.celrep.2019.01.005_bib5","doi-asserted-by":"crossref","first-page":"F784","DOI":"10.1152\/ajprenal.00210.2011","article-title":"Systemic administration of naked plasmid encoding HGF attenuates puromycin aminonucleoside-induced damage of murine glomerular podocytes","volume":"301","author":"Bu","year":"2011","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.celrep.2019.01.005_bib6","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.ceb.2012.07.005","article-title":"DNA damage, chromatin, and transcription: the trinity of aging","volume":"24","author":"Burgess","year":"2012","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.celrep.2019.01.005_bib7","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/nrm2944","article-title":"Progeria syndromes and ageing: what is the connection?","volume":"11","author":"Burtner","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2019.01.005_bib8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1139\/O10-113","article-title":"Heterochromatin and the DNA damage response: the need to relax","volume":"89","author":"Cann","year":"2011","journal-title":"Biochem. Cell Biol."},{"key":"10.1016\/j.celrep.2019.01.005_bib9","doi-asserted-by":"crossref","first-page":"e1057","DOI":"10.1371\/journal.pone.0001057","article-title":"gammaH2AX foci form preferentially in euchromatin after ionising-radiation","volume":"2","author":"Cowell","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2019.01.005_bib10","doi-asserted-by":"crossref","first-page":"e110","DOI":"10.1371\/journal.pgen.0030110","article-title":"DNA damage, homology-directed repair, and DNA methylation","volume":"3","author":"Cuozzo","year":"2007","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2019.01.005_bib11","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1681\/ASN.2009010019","article-title":"Wnt\/beta-catenin signaling promotes podocyte dysfunction and albuminuria","volume":"20","author":"Dai","year":"2009","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2019.01.005_bib12","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1038\/ki.2010.40","article-title":"Hepatocyte growth factor signaling ameliorates podocyte injury and proteinuria","volume":"77","author":"Dai","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.celrep.2019.01.005_bib13","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1038\/ki.2010.22","article-title":"Combined vitamin D analog and AT1 receptor antagonist synergistically block the development of kidney disease in a model of type 2 diabetes","volume":"77","author":"Deb","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.celrep.2019.01.005_bib14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1258\/la.2010.010090","article-title":"Single dose streptozotocin-induced diabetes: considerations for study design in islet transplantation models","volume":"45","author":"Deeds","year":"2011","journal-title":"Lab. Anim."},{"key":"10.1016\/j.celrep.2019.01.005_bib15","doi-asserted-by":"crossref","first-page":"ra80","DOI":"10.1126\/scisignal.2001462","article-title":"DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination","volume":"3","author":"Du","year":"2010","journal-title":"Sci. Signal."},{"key":"10.1016\/j.celrep.2019.01.005_bib16","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nn.2514","article-title":"Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons","volume":"13","author":"Feng","year":"2010","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2019.01.005_bib17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/978-1-61779-998-3_9","article-title":"Analysis of DNA damage and repair in nuclear and mitochondrial DNA of animal cells using quantitative PCR","volume":"920","author":"Furda","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2019.01.005_bib18","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1242\/dev.063594","article-title":"The GUDMAP database\u2014an online resource for genitourinary research","volume":"138","author":"Harding","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.celrep.2019.01.005_bib19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/ki.2010.81","article-title":"Regression of glomerulosclerosis in response to transient treatment with angiotensin II blockers is attenuated by blockade of matrix metalloproteinase-2","volume":"78","author":"Hayashi","year":"2010","journal-title":"Kidney Int."},{"key":"10.1016\/j.celrep.2019.01.005_bib20","doi-asserted-by":"crossref","first-page":"2523","DOI":"10.1172\/JCI69557","article-title":"KLF4-dependent epigenetic remodeling modulates podocyte phenotypes and attenuates proteinuria","volume":"124","author":"Hayashi","year":"2014","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2019.01.005_bib21","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/ki.2015.178","article-title":"Renin-angiotensin\u00a0blockade resets podocyte epigenome through Kruppel-like Factor\u00a04 and attenuates proteinuria","volume":"88","author":"Hayashi","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.celrep.2019.01.005_bib22","doi-asserted-by":"crossref","first-page":"3604","DOI":"10.1038\/onc.2013.324","article-title":"RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis","volume":"33","author":"Huang","year":"2014","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2019.01.005_bib23","doi-asserted-by":"crossref","first-page":"7028","DOI":"10.1128\/MCB.00579-07","article-title":"DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics","volume":"27","author":"Ikura","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2019.01.005_bib24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1161\/HYPERTENSIONAHA.108.122721","article-title":"\u201cPulse\u201d treatment with high-dose angiotensin blocker reverses renal arteriolar hypertrophy and regresses hypertension","volume":"53","author":"Ishiguro","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.celrep.2019.01.005_bib25","doi-asserted-by":"crossref","first-page":"15741","DOI":"10.1074\/jbc.M513172200","article-title":"The FATC domains of PIKK proteins are functionally equivalent and participate in the Tip60-dependent activation of DNA-PKcs and ATM","volume":"281","author":"Jiang","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2019.01.005_bib26","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/ndt\/gfn598","article-title":"Insulin attenuates apoptosis induced by high glucose via the PI3-kinase\/Akt pathway in rat peritoneal mesothelial cells","volume":"24","author":"Kaifu","year":"2009","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.celrep.2019.01.005_bib27","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1083\/jcb.200612031","article-title":"Heterochromatin is refractory to gamma-H2AX modification in yeast and mammals","volume":"178","author":"Kim","year":"2007","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2019.01.005_bib28","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1126\/science.1102587","article-title":"What can progeroid syndromes tell us about human aging?","volume":"305","author":"Kipling","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.01.005_bib29","doi-asserted-by":"crossref","first-page":"R108","DOI":"10.1186\/gb-2013-14-10-r108","article-title":"Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development","volume":"14","author":"Ko","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2019.01.005_bib30","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/ki.2008.499","article-title":"Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons","volume":"75","author":"Kuwabara","year":"2009","journal-title":"Kidney Int."},{"key":"10.1016\/j.celrep.2019.01.005_bib31","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1093\/emboj\/21.7.1704","article-title":"Tip60 is targeted to proteasome-mediated degradation by Mdm2 and accumulates after UV irradiation","volume":"21","author":"Legube","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2019.01.005_bib32","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev.biochem.052308.093131","article-title":"The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway","volume":"79","author":"Lieber","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.celrep.2019.01.005_bib33","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1681\/ASN.2008121226","article-title":"New insights into epithelial-mesenchymal transition in kidney fibrosis","volume":"21","author":"Liu","year":"2010","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2019.01.005_bib34","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/sj.gt.3300947","article-title":"Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA","volume":"6","author":"Liu","year":"1999","journal-title":"Gene Ther."},{"key":"10.1016\/j.celrep.2019.01.005_bib35","doi-asserted-by":"crossref","first-page":"F1533","DOI":"10.1152\/ajprenal.00656.2012","article-title":"Nitro-oleic acid protects against adriamycin-induced nephropathy in mice","volume":"305","author":"Liu","year":"2013","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.celrep.2019.01.005_bib36","doi-asserted-by":"crossref","first-page":"400","DOI":"10.2353\/jmoldx.2009.080126","article-title":"MethySYBR, a novel quantitative PCR assay for the dual analysis of DNA methylation and CpG methylation density","volume":"11","author":"Lo","year":"2009","journal-title":"J.\u00a0Mol. Diagn."},{"key":"10.1016\/j.celrep.2019.01.005_bib37","doi-asserted-by":"crossref","first-page":"e23864","DOI":"10.1371\/journal.pone.0023864","article-title":"Asthmatics exhibit altered oxylipin profiles compared to healthy individuals after subway air exposure","volume":"6","author":"Lundstr\u00f6m","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2019.01.005_bib38","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1681\/ASN.2014070665","article-title":"Diabetes induces aberrant DNA methylation in the proximal tubules of the kidney","volume":"26","author":"Marumo","year":"2015","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2019.01.005_bib39","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1111\/acel.12071","article-title":"DNA damage in normally and prematurely aged mice","volume":"12","author":"Maslov","year":"2013","journal-title":"Aging Cell"},{"key":"10.1016\/j.celrep.2019.01.005_bib40","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1681\/ASN.2007101078","article-title":"GUDMAP: the genitourinary developmental molecular anatomy project","volume":"19","author":"McMahon","year":"2008","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2019.01.005_bib41","doi-asserted-by":"crossref","first-page":"18218","DOI":"10.1074\/jbc.M802332200","article-title":"Tip60 is regulated by circadian transcription factor clock and is involved in cisplatin resistance","volume":"283","author":"Miyamoto","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2019.01.005_bib42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/gene.10164","article-title":"Podocyte-specific expression of cre recombinase in transgenic mice","volume":"35","author":"Moeller","year":"2003","journal-title":"Genesis"},{"key":"10.1016\/j.celrep.2019.01.005_bib43","doi-asserted-by":"crossref","first-page":"3884","DOI":"10.1093\/ndt\/gfq323","article-title":"A\u00a0novel method for isolating podocytes using magnetic activated cell sorting","volume":"25","author":"Murakami","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.celrep.2019.01.005_bib44","doi-asserted-by":"crossref","first-page":"e1000155","DOI":"10.1371\/journal.pgen.1000155","article-title":"Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island","volume":"4","author":"O\u2019Hagan","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2019.01.005_bib45","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1093\/ndt\/gfw463","article-title":"O-linked \u03b2-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes","volume":"32","author":"Ono","year":"2017","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.celrep.2019.01.005_bib46","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s00412-010-0305-6","article-title":"Double-strand breaks and the concept of short- and long-term epigenetic memory","volume":"120","author":"Orlowski","year":"2011","journal-title":"Chromosoma"},{"key":"10.1016\/j.celrep.2019.01.005_bib47","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.bcp.2006.12.032","article-title":"Histone deacetylase inhibitor Trichostatin A induces global and gene-specific DNA demethylation in human cancer cell lines","volume":"73","author":"Ou","year":"2007","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.celrep.2019.01.005_bib48","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/ki.2015.148","article-title":"Recent developments in epigenetics of acute and chronic kidney diseases","volume":"88","author":"Reddy","year":"2015","journal-title":"Kidney Int."},{"key":"10.1016\/j.celrep.2019.01.005_bib49","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1681\/ASN.V133630","article-title":"A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression","volume":"13","author":"Saleem","year":"2002","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2019.01.005_bib50","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2164-14-559","article-title":"Transcriptional profiling reveals progeroid Ercc1(-\/\u0394) mice as a model system for glomerular aging","volume":"14","author":"Schermer","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.celrep.2019.01.005_bib51","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1097\/MNH.0000000000000311","article-title":"Can podocytes be regenerated in adults?","volume":"26","author":"Shankland","year":"2017","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.celrep.2019.01.005_bib52","doi-asserted-by":"crossref","first-page":"F1138","DOI":"10.1152\/ajprenal.00315.2002","article-title":"Diabetic kidney disease in the db\/db mouse","volume":"284","author":"Sharma","year":"2003","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.celrep.2019.01.005_bib53","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1681\/ASN.2013070723","article-title":"Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis","volume":"25","author":"Tampe","year":"2014","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2019.01.005_bib54","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/s41419-018-0362-y","article-title":"Sei-1 promotes double minute chromosomes formation through activation of the PI3K\/Akt\/BRCA1-Abraxas pathway and induces double-strand breaks in NIH-3T3 fibroblasts","volume":"9","author":"Tian","year":"2018","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2019.01.005_bib55","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cmet.2013.11.007","article-title":"Type 2 diabetes and congenital hyperinsulinism cause DNA double-strand breaks and p53 activity in \u03b2 cells","volume":"19","author":"Tornovsky-Babeay","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2019.01.005_bib56","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1146\/annurev-physiol-030212-183715","article-title":"Genome instability and aging","volume":"75","author":"Vijg","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.celrep.2019.01.005_bib57","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1681\/ASN.2013050452","article-title":"Unraveling the role of podocyte turnover in glomerular aging and injury","volume":"25","author":"Wanner","year":"2014","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2019.01.005_bib58","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/S0140-6736(16)32064-5","article-title":"Chronic Kidney Disease","volume":"389","author":"Webster","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2019.01.005_bib59","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ng.3287","article-title":"A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer","volume":"47","author":"Weren","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2019.01.005_bib60","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/nsmb1286","article-title":"MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control","volume":"14","author":"Wu","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2019.01.005_bib61","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/j.celrep.2014.04.021","article-title":"Dynamic interactions between TIP60 and p300 regulate FOXP3 function through a structural switch defined by a\u00a0single lysine on TIP60","volume":"7","author":"Xiao","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2019.01.005_bib62","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1006\/abio.1993.1458","article-title":"A novel ES cell line, TT2, with high germline-differentiating potency","volume":"214","author":"Yagi","year":"1993","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.celrep.2019.01.005_bib63","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.lfs.2018.04.044","article-title":"Effect of TET2 on the pathogenesis of diabetic nephropathy through activation of transforming growth factor \u03b21 expression via DNA demethylation","volume":"207","author":"Yang","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.celrep.2019.01.005_bib64","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1093\/ndt\/gfq029","article-title":"Podocyte-specific expression of tamoxifen-inducible Cre recombinase in mice","volume":"25","author":"Yokoi","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.celrep.2019.01.005_bib65","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.kint.2017.01.010","article-title":"DNA methyltransferase 1 may be a therapy target for\u00a0attenuating diabetic nephropathy and podocyte injury","volume":"92","author":"Zhang","year":"2017","journal-title":"Kidney Int."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719300051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719300051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:33:54Z","timestamp":1761906834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124719300051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":65,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S2211124719300051"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2019.01.005","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decreased KAT5 Expression Impairs DNA Repair and Induces Altered DNA Methylation in Kidney Podocytes","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2019.01.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s).","name":"copyright","label":"Copyright"}]}}