{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:48:26Z","timestamp":1792698506104,"version":"4.5.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,17]],"date-time":"2019-01-17T00:00:00Z","timestamp":1547683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.celrep.2019.01.056","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T11:07:43Z","timestamp":1549364863000},"page":"1419-1431.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":139,"title":["Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice"],"prefix":"10.1016","volume":"26","author":[{"given":"Mingmin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Geng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuqin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bailong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2019.01.056_bib1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.neuron.2013.07.051","article-title":"The sensory neurons of touch","volume":"79","author":"Abraira","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2019.01.056_bib2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.neuron.2016.11.027","article-title":"Touch Receptor-Derived Sensory Information Alleviates Acute Pain Signaling and Fine-Tunes Nociceptive Reflex Coordination","volume":"93","author":"Arcourt","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2019.01.056_bib3","doi-asserted-by":"crossref","first-page":"9075","DOI":"10.1073\/pnas.0901507106","article-title":"Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli","volume":"106","author":"Cavanaugh","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.01.056_bib4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.celrep.2019.01.056_bib5","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1056\/NEJMoa1602812","article-title":"The Role of PIEZO2 in Human Mechanosensation","volume":"375","author":"Chesler","year":"2016","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2019.01.056_bib6","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1126\/science.1193270","article-title":"Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels","volume":"330","author":"Coste","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.01.056_bib7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature10812","article-title":"Piezo proteins are pore-forming subunits of mechanically activated channels","volume":"483","author":"Coste","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.01.056_bib8","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1073\/pnas.1221400110","article-title":"Gain-of-function mutations in the mechanically activated ion channel PIEZO2 cause a subtype of Distal Arthrogryposis","volume":"110","author":"Coste","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.01.056_bib9","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1073\/pnas.1014411108","article-title":"Proper formation of whisker barrelettes requires periphery-derived Smad4-dependent TGF-beta signaling","volume":"108","author":"da Silva","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.01.056_bib10","doi-asserted-by":"crossref","first-page":"RC228","DOI":"10.1523\/JNEUROSCI.22-12-j0001.2002","article-title":"Distinct mechanosensitive properties of capsaicin-sensitive and -insensitive sensory neurons","volume":"22","author":"Drew","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2019.01.056_bib11","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.cell.2014.11.003","article-title":"Identification of spinal circuits transmitting and gating mechanical pain","volume":"159","author":"Duan","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.01.056_bib12","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.celrep.2012.07.014","article-title":"Inflammatory signals enhance piezo2-mediated mechanosensitive currents","volume":"2","author":"Dubin","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2019.01.056_bib13","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1126\/science.aar5703","article-title":"Piezo2 channel-Merkel cell signaling modulates the conversion of touch to itch","volume":"360","author":"Feng","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.01.056_bib14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/nature15247","article-title":"Architecture of the mammalian mechanosensitive Piezo1 channel","volume":"527","author":"Ge","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.01.056_bib15","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1113\/jphysiol.2006.117648","article-title":"Mechanosensitive currents in the neurites of cultured mouse sensory neurones","volume":"577","author":"Hu","year":"2006","journal-title":"J.\u00a0Physiol."},{"issue":"49","key":"10.1016\/j.celrep.2019.01.056_bib16","first-page":"2376","article-title":"Assessment of motor balance and coordination in mice using the balance beam","author":"Luong","year":"2011","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.celrep.2019.01.056_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0304-3940(99)00665-5","article-title":"Mechanical transduction by rat dorsal root ganglion neurons in\u00a0vitro","volume":"273","author":"McCarter","year":"1999","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.celrep.2019.01.056_bib18","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.neuron.2013.01.030","article-title":"Peptidergic CGRP\u03b1 primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold","volume":"78","author":"McCoy","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2019.01.056_bib19","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1126\/science.150.3699.971","article-title":"Pain mechanisms: a new theory","volume":"150","author":"Melzack","year":"1965","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.01.056_bib20","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1126\/scitranslmed.aat9897","article-title":"The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice","volume":"10","author":"Murthy","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2019.01.056_bib21","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/nature20793","article-title":"Piezo2 senses airway stretch and mediates lung inflation-induced apnoea","volume":"541","author":"Nonomura","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.01.056_bib22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nature13980","article-title":"Piezo2 is the major transducer of mechanical forces for touch sensation in mice","volume":"516","author":"Ranade","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.01.056_bib23","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.neuron.2015.08.032","article-title":"Mechanically Activated Ion Channels","volume":"87","author":"Ranade","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2019.01.056_bib24","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1016\/j.celrep.2017.11.035","article-title":"Cell-Type-Specific Splicing of Piezo2 Regulates Mechanotransduction","volume":"21","author":"Szczot","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2019.01.056_bib25","doi-asserted-by":"crossref","first-page":"eaat9892","DOI":"10.1126\/scitranslmed.aat9892","article-title":"PIEZO2 mediates injury-induced tactile pain in mice and humans","volume":"10","author":"Szczot","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2019.01.056_bib26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.3881","article-title":"Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing","volume":"18","author":"Usoskin","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2019.01.056_bib27","doi-asserted-by":"crossref","first-page":"e12177","DOI":"10.1371\/journal.pone.0012177","article-title":"TRPA1 mediates mechanical currents in the plasma membrane of mouse sensory neurons","volume":"5","author":"Vilceanu","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2019.01.056_bib28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/brain\/101.1.1","article-title":"The gate control theory of pain mechanisms. A re-examination and re-statement","volume":"101","author":"Wall","year":"1978","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2019.01.056_bib29","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/nature13251","article-title":"Piezo2 is required for Merkel-cell mechanotransduction","volume":"509","author":"Woo","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.01.056_bib30","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1038\/nn.4162","article-title":"Piezo2 is the principal mechanotransduction channel for proprioception","volume":"18","author":"Woo","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2019.01.056_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1523\/ENEURO.0069-16.2017","article-title":"Sensory neuron-specific deletion of TRPA1 results in mechanical cutaneous sensory deficits","volume":"4","author":"Zappia","year":"2017","journal-title":"eNeuro"},{"key":"10.1016\/j.celrep.2019.01.056_bib32","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/j.neuron.2016.01.046","article-title":"Ion permeation and mechanotransduction mechanisms of mechanosensitive piezo channels","volume":"89","author":"Zhao","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2019.01.056_bib33","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/nature25743","article-title":"Structure and mechanogating mechanism of the Piezo1 channel","volume":"554","author":"Zhao","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.01.056_bib34","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1744-8069-7-66","article-title":"Generation and characterization of an Advillin-Cre driver mouse line","volume":"7","author":"Zurborg","year":"2011","journal-title":"Mol. Pain"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719300853?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719300853?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:33:26Z","timestamp":1761906806000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124719300853"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S2211124719300853"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2019.01.056","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2019.01.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s).","name":"copyright","label":"Copyright"}]}}