{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:00:43Z","timestamp":1791806443778,"version":"4.3.4"},"reference-count":82,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T00:00:00Z","timestamp":1548201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS083767"],"award-info":[{"award-number":["R01 NS083767"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS087913"],"award-info":[{"award-number":["R01 NS087913"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["18-29-01027"],"award-info":[{"award-number":["18-29-01027"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["17-29-06056"],"award-info":[{"award-number":["17-29-06056"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R21 CA175875"],"award-info":[{"award-number":["R21 CA175875"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P01 CA163205"],"award-info":[{"award-number":["P01 CA163205"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.celrep.2019.01.076","type":"journal-article","created":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T10:44:42Z","timestamp":1549968282000},"page":"1893-1905.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":213,"title":["Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation"],"prefix":"10.1016","volume":"26","author":[{"given":"Mutsuko","family":"Minata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Audia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songjian","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Bernstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marat S.","family":"Pavlyukov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvid","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hak","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Jae","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeri","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harim","family":"Koo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirti","family":"Snigdha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indrayani","family":"Waghmare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Mohyeldin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Gallego-Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongquan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah","family":"Mukheef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minerva","family":"Contreras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel F.","family":"Reyes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Vaillant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik P.","family":"Sulman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Yuan","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Markert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bakhos A.","family":"Tannous","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinghua","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhuri","family":"Kango-Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. James","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do-Hyun","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ichiro","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna P.","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2019.01.076_bib1","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1586\/era.13.44","article-title":"Enhancing radiation therapy for patients with glioblastoma","volume":"13","author":"Alexander","year":"2013","journal-title":"Expert Rev. Anticancer Ther."},{"key":"10.1016\/j.celrep.2019.01.076_bib2","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/nature05236","article-title":"Glioma stem cells promote radioresistance by preferential activation of the DNA damage response","volume":"444","author":"Bao","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.01.076_bib3","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1038\/sj.emboj.7600247","article-title":"Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation","volume":"23","author":"Bhat","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2019.01.076_bib4","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1101\/gad.176800.111","article-title":"The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma","volume":"25","author":"Bhat","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2019.01.076_bib5","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ccr.2013.08.001","article-title":"Mesenchymal differentiation mediated by NF-\u03baB promotes radiation resistance in glioblastoma","volume":"24","author":"Bhat","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2019.01.076_bib6","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1007\/s00018-011-0683-9","article-title":"ATM protein kinase: the linchpin of cellular defenses to stress","volume":"68","author":"Bhatti","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.celrep.2019.01.076_bib7","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/jcb.23349","article-title":"CD109-mediated degradation of TGF-\u03b2 receptors and inhibition of TGF-\u03b2 responses involve regulation of SMAD7 and Smurf2 localization and function","volume":"113","author":"Bizet","year":"2012","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.celrep.2019.01.076_bib8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000321554","article-title":"Analysis of thioester-containing proteins during the innate immune response of Drosophila melanogaster","volume":"3","author":"Bou Aoun","year":"2011","journal-title":"J.\u00a0Innate Immun."},{"key":"10.1016\/j.celrep.2019.01.076_bib9","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nnano.2011.164","article-title":"Nanochannel electroporation delivers precise amounts of biomolecules into living cells","volume":"6","author":"Boukany","year":"2011","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.celrep.2019.01.076_bib10","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.stem.2015.08.014","article-title":"Therapeutic Implications of Cellular Heterogeneity and Plasticity in Breast Cancer","volume":"17","author":"Brooks","year":"2015","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2019.01.076_bib11","doi-asserted-by":"crossref","first-page":"W74","DOI":"10.1093\/nar\/gkr355","article-title":"ConTra v2: a tool to identify transcription factor binding sites across species, update 2011","volume":"39","author":"Broos","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2019.01.076_bib12","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1001\/jamaoncol.2016.1373","article-title":"Association of the Extent of Resection With Survival in Glioblastoma: A Systematic Review and Meta-analysis","volume":"2","author":"Brown","year":"2016","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.celrep.2019.01.076_bib13","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/nature08712","article-title":"The transcriptional network for mesenchymal transformation of brain tumours","volume":"463","author":"Carro","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.01.076_bib14","doi-asserted-by":"crossref","first-page":"3147","DOI":"10.1039\/C5LC00553A","article-title":"Dielectrophoresis-assisted\u00a03D nanoelectroporation for non-viral cell transfection in adoptive immunotherapy","volume":"15","author":"Chang","year":"2015","journal-title":"Lab Chip"},{"key":"10.1016\/j.celrep.2019.01.076_bib15","doi-asserted-by":"crossref","first-page":"7219","DOI":"10.1158\/0008-5472.CAN-15-2860","article-title":"FOXD1-ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells","volume":"76","author":"Cheng","year":"2016","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2019.01.076_bib16","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nm.4285","article-title":"Molecular definition of a metastatic lung cancer state reveals a targetable CD109-Janus kinase-Stat axis","volume":"23","author":"Chuang","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2019.01.076_bib17","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00401-007-0293-7","article-title":"Diffuse glioma growth: a guerilla war","volume":"114","author":"Claes","year":"2007","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2019.01.076_bib18","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nm.2304","article-title":"The cancer stem cell: premises, promises and challenges","volume":"17","author":"Clevers","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2019.01.076_bib19","doi-asserted-by":"crossref","first-page":"10773","DOI":"10.1523\/JNEUROSCI.3207-05.2005","article-title":"PBK\/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase","volume":"25","author":"Dougherty","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2019.01.076_bib20","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10137","article-title":"Role of YAP\/TAZ in mechanotransduction","volume":"474","author":"Dupont","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.01.076_bib21","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ceb.2017.10.006","article-title":"Upstairs, downstairs: spatial regulation of Hippo signalling","volume":"51","author":"Fulford","year":"2018","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.celrep.2019.01.076_bib22","doi-asserted-by":"crossref","first-page":"20303","DOI":"10.1074\/jbc.M300198200","article-title":"Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes","volume":"278","author":"Furuta","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2019.01.076_bib23","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1039\/c2lc40726d","article-title":"Microfabricated mimics of in\u00a0vivo structural cues for the study of guided tumor cell migration","volume":"12","author":"Gallego-Perez","year":"2012","journal-title":"Lab Chip"},{"key":"10.1016\/j.celrep.2019.01.076_bib24","doi-asserted-by":"crossref","first-page":"E14","DOI":"10.3171\/2015.12.FOCUS15572","article-title":"Contribution of combined intraoperative electrophysiological investigation with 3-T\u00a0intraoperative MRI for awake cerebral glioma surgery: comprehensive review of the clinical implications and radiological outcomes","volume":"40","author":"Ghinda","year":"2016","journal-title":"Neurosurg. Focus"},{"key":"10.1016\/j.celrep.2019.01.076_bib25","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1002\/stem.1322","article-title":"Tumor-specific activation of the C-JUN\/MELK pathway regulates glioma stem cell growth in a p53-dependent manner","volume":"31","author":"Gu","year":"2013","journal-title":"Stem Cells"},{"key":"10.1016\/j.celrep.2019.01.076_bib26","doi-asserted-by":"crossref","first-page":"5248","DOI":"10.1073\/pnas.1321014111","article-title":"In\u00a0vivo radiation response of proneural glioma characterized by protective p53 transcriptional program and proneural-mesenchymal shift","volume":"111","author":"Halliday","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.01.076_bib27","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.ccr.2006.11.008","article-title":"Radiation resistance and stem-like cells in brain tumors","volume":"10","author":"Hambardzumyan","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2019.01.076_bib28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1006\/cimm.1994.1181","article-title":"Cellular expression of a GPI-linked T\u00a0cell activation protein","volume":"156","author":"Haregewoin","year":"1994","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.celrep.2019.01.076_bib29","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1038\/sj.onc.1207418","article-title":"Expression of CD109 in human cancer","volume":"23","author":"Hashimoto","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2019.01.076_bib30","first-page":"1957","article-title":"p53 effects both the duration of G2\/M arrest and the fate of temozolomide-treated human glioblastoma cells","volume":"61","author":"Hirose","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2019.01.076_bib31","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0092-8674(03)00895-X","article-title":"Sequential modification of NEMO\/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress","volume":"115","author":"Huang","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.01.076_bib32","doi-asserted-by":"crossref","first-page":"e24217","DOI":"10.1371\/journal.pone.0024217","article-title":"CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway","volume":"6","author":"Jijiwa","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2019.01.076_bib33","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1038\/nm.4415","article-title":"Targeting glioma stem cells through combined BMI1 and EZH2 inhibition","volume":"23","author":"Jin","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2019.01.076_bib34","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1002\/dvdy.21996","article-title":"Regulation of organ size: insights from the Drosophila Hippo signaling pathway","volume":"238","author":"Kango-Singh","year":"2009","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.celrep.2019.01.076_bib35","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S1097-2765(01)80006-X","article-title":"PTP-ER, a novel tyrosine phosphatase, functions downstream of Ras1 to downregulate MAP kinase during Drosophila eye development","volume":"3","author":"Karim","year":"1999","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2019.01.076_bib36","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ccell.2015.07.013","article-title":"Spatiotemporal Evolution of the Primary Glioblastoma Genome","volume":"28","author":"Kim","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2019.01.076_bib37","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.ccell.2016.01.005","article-title":"Serine\/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-\u03baB-dependent Manner","volume":"29","author":"Kim","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2019.01.076_bib38","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1093\/neuonc\/nor133","article-title":"Correlation of the extent of tumor volume resection and patient survival in surgery of glioblastoma multiforme with high-field intraoperative MRI guidance","volume":"13","author":"Kuhnt","year":"2011","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.celrep.2019.01.076_bib39","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3171\/jns.2001.95.2.0190","article-title":"A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival","volume":"95","author":"Lacroix","year":"2001","journal-title":"J.\u00a0Neurosurg."},{"key":"10.1016\/j.celrep.2019.01.076_bib40","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1101\/gad.261982.115","article-title":"Cancer stem cells in glioblastoma","volume":"29","author":"Lathia","year":"2015","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2019.01.076_bib41","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1158\/0008-5472.CAN-14-3331","article-title":"STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma","volume":"75","author":"Lau","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2019.01.076_bib42","doi-asserted-by":"crossref","first-page":"141","DOI":"10.2144\/000113999","article-title":"LASAGNA-Search: an integrated web tool for transcription factor binding site search and visualization","volume":"54","author":"Lee","year":"2013","journal-title":"Biotechniques"},{"key":"10.1016\/j.celrep.2019.01.076_bib43","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1093\/bioinformatics\/btu115","article-title":"LASAGNA-Search 2.0: integrated transcription factor binding site search and visualization in a browser","volume":"30","author":"Lee","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2019.01.076_bib44","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1101\/gad.1903310","article-title":"The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation","volume":"24","author":"Lian","year":"2010","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2019.01.076_bib45","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1002\/stem.1193","article-title":"ALDH1A isozymes are markers of human melanoma stem cells and potential therapeutic targets","volume":"30","author":"Luo","year":"2012","journal-title":"Stem Cells"},{"key":"10.1016\/j.celrep.2019.01.076_bib46","doi-asserted-by":"crossref","first-page":"e114713","DOI":"10.1371\/journal.pone.0114713","article-title":"A subpopulation of circulating endothelial cells express CD109 and is enriched in the blood of cancer patients","volume":"9","author":"Mancuso","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2019.01.076_bib47","doi-asserted-by":"crossref","first-page":"10069","DOI":"10.1073\/pnas.0703900104","article-title":"Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers","volume":"104","author":"Mani","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.01.076_bib48","doi-asserted-by":"crossref","first-page":"8644","DOI":"10.1073\/pnas.1221478110","article-title":"Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3","volume":"110","author":"Mao","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.01.076_bib49","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/stem.563","article-title":"Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis","volume":"29","author":"Marcato","year":"2011","journal-title":"Stem Cells"},{"key":"10.1016\/j.celrep.2019.01.076_bib50","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/nature12624","article-title":"Tumour heterogeneity and cancer cell plasticity","volume":"501","author":"Meacham","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.01.076_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/gad.274027.115","article-title":"Mechanisms of Hippo pathway regulation","volume":"30","author":"Meng","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2019.01.076_bib52","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1158\/1078-0432.CCR-11-1795","article-title":"Telomestatin impairs glioma stem cell survival and growth through the disruption of telomeric G-quadruplex and inhibition of the proto-oncogene, c-Myb","volume":"18","author":"Miyazaki","year":"2012","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2019.01.076_bib53","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/j.celrep.2017.10.083","article-title":"GPR56\/ADGRG1 Inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma","volume":"21","author":"Moreno","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2019.01.076_bib54","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/jnr.21471","article-title":"Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells","volume":"86","author":"Nakano","year":"2008","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.celrep.2019.01.076_bib55","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1093\/neuonc\/nor023","article-title":"Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway","volume":"13","author":"Nakano","year":"2011","journal-title":"Neuro Oncol."},{"issue":"Suppl_5","key":"10.1016\/j.celrep.2019.01.076_bib56","doi-asserted-by":"crossref","first-page":"v1","DOI":"10.1093\/neuonc\/nox158","article-title":"CBTRUS Statistical Report: primary brain and other central nervous system tumors diagnosed in the United States in 2010-2014","volume":"19","author":"Ostrom","year":"2017","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.celrep.2019.01.076_bib57","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.ccr.2014.06.005","article-title":"Most human non-GCIMP glioblastoma subtypes evolve from a common proneural-like precursor glioma","volume":"26","author":"Ozawa","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2019.01.076_bib58","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1126\/science.1254257","article-title":"Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma","volume":"344","author":"Patel","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.01.076_bib59","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nrm2729","article-title":"Random versus directionally persistent cell migration","volume":"10","author":"Petrie","year":"2009","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2019.01.076_bib60","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1152\/physrev.00005.2014","article-title":"The biology of YAP\/TAZ: hippo signaling and beyond","volume":"94","author":"Piccolo","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.celrep.2019.01.076_bib61","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1002\/glia.21148","article-title":"Drosophila melanogaster as a model system for human brain cancers","volume":"59","author":"Read","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2019.01.076_bib62","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1016\/j.celrep.2016.11.056","article-title":"Clonal Variation in Drug and Radiation Response among Glioma-Initiating Cells Is Linked to Proneural-Mesenchymal Transition","volume":"17","author":"Segerman","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2019.01.076_bib63","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1093\/neuonc\/now096","article-title":"Stem cell-based therapies for tumors in the brain: are we there yet?","volume":"18","author":"Shah","year":"2016","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.celrep.2019.01.076_bib64","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/path.4981","article-title":"Significance of perivascular tumour cells defined by CD109 expression in progression of glioma","volume":"243","author":"Shiraki","year":"2017","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.celrep.2019.01.076_bib65","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1227\/01.neu.0000317304.31579.17","article-title":"Extent of resection and survival in glioblastoma multiforme: identification of and adjustment for bias","volume":"62","author":"Stummer","year":"2008","journal-title":"Neurosurgery"},{"key":"10.1016\/j.celrep.2019.01.076_bib66","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1200\/JCO.2007.11.8554","article-title":"Chemoradiotherapy in malignant glioma: standard of care and future directions","volume":"25","author":"Stupp","year":"2007","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.celrep.2019.01.076_bib67","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1182\/blood.V77.1.84.84","article-title":"Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets","volume":"77","author":"Sutherland","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2019.01.076_bib68","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature14228","article-title":"A gp130-Src-YAP module links inflammation to epithelial regeneration","volume":"519","author":"Taniguchi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.01.076_bib69","doi-asserted-by":"crossref","first-page":"12083","DOI":"10.1007\/s13277-014-2509-5","article-title":"CD109 is a potential target for triple-negative breast cancer","volume":"35","author":"Tao","year":"2014","journal-title":"Tumour Biol."},{"key":"10.1016\/j.celrep.2019.01.076_bib70","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1038\/nprot.2011.409","article-title":"Transcription factor binding predictions using TRAP for the analysis of ChIP-seq data and regulatory SNPs","volume":"6","author":"Thomas-Chollier","year":"2011","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2019.01.076_bib71","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1158\/1541-7786.MCR-06-0005","article-title":"Primary glioblastomas express mesenchymal stem-like properties","volume":"4","author":"Tso","year":"2006","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.celrep.2019.01.076_bib72","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1038\/ncb1748","article-title":"TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal","volume":"10","author":"Varelas","year":"2008","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2019.01.076_bib73","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ccr.2009.12.020","article-title":"Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1","volume":"17","author":"Verhaak","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2019.01.076_bib74","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/wrr.12023","article-title":"Transgenic mice overexpressing CD109 in the epidermis display decreased inflammation and granulation tissue and improved collagen architecture during wound healing","volume":"21","author":"Vorstenbosch","year":"2013","journal-title":"Wound Repair Regen."},{"key":"10.1016\/j.celrep.2019.01.076_bib75","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.5966\/sctm.2014-0086","article-title":"Intercellular cooperation and competition in brain cancers: lessons from Drosophila and human studies","volume":"3","author":"Waghmare","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.celrep.2019.01.076_bib76","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/ng.3590","article-title":"Clonal evolution of glioblastoma under therapy","volume":"48","author":"Wang","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2019.01.076_bib77","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.ccell.2017.06.003","article-title":"Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment","volume":"32","author":"Wang","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2019.01.076_bib78","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1126\/science.1121513","article-title":"Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli","volume":"311","author":"Wu","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.01.076_bib79","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.coph.2016.05.002","article-title":"YAP\/TAZ as therapeutic targets in cancer","volume":"29","author":"Zanconato","year":"2016","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.celrep.2019.01.076_bib80","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1440-1827.2005.01807.x","article-title":"CD109 expression in squamous cell carcinoma of the uterine cervix","volume":"55","author":"Zhang","year":"2005","journal-title":"Pathol. Int."},{"key":"10.1016\/j.celrep.2019.01.076_bib81","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.bbrc.2015.02.093","article-title":"CD109 attenuates TGF-\u03b21 signaling and enhances EGF signaling in SK-MG-1 human glioblastoma cells","volume":"459","author":"Zhang","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2019.01.076_bib82","first-page":"1500111","article-title":"Nanochannel Electroporation as a Platform for Living Cell Interrogation in Acute Myeloid Leukemia","volume":"2","author":"Zhao","year":"2015","journal-title":"Adv. Sci. (Weinh.)"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719301056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719301056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:35:02Z","timestamp":1761906902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124719301056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":82,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S2211124719301056"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2019.01.076","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2019.01.076","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors.","name":"copyright","label":"Copyright"}]}}