{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:41:46Z","timestamp":1789155706752,"version":"build-2803163510"},"reference-count":24,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006441","name":"Center for Outcomes Research and Evaluation, Yale School of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006441","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U19AI109965"],"award-info":[{"award-number":["U19AI109965"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI029564"],"award-info":[{"award-number":["R01AI029564"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U42OD010924"],"award-info":[{"award-number":["U42OD010924"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL007149"],"award-info":[{"award-number":["T32HL007149"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI138337"],"award-info":[{"award-number":["R01AI138337"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL130404"],"award-info":[{"award-number":["R01HL130404"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI143894"],"award-info":[{"award-number":["R01AI143894"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI117575"],"award-info":[{"award-number":["R21AI117575"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56AI110682"],"award-info":[{"award-number":["R56AI110682"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["5P30CA016086-41"],"award-info":[{"award-number":["5P30CA016086-41"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008615","name":"Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008615","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006808","name":"University of North Carolina","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006808","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1016\/j.celrep.2019.04.004","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T11:39:05Z","timestamp":1556624345000},"page":"1387-1396.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Identification of a Locus in Mice that Regulates the Collateral Damage and Lethality of Virus Infection"],"prefix":"10.1016","volume":"27","author":[{"given":"Ichiro","family":"Misumi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin D.","family":"Cook","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makayla M.","family":"Lund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah C.","family":"Vick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Uchimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Bergmeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Mieczkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Pardo-Manuel de Villena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny P.Y.","family":"Ting","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason K.","family":"Whitmire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2019.04.004_bib1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nprot.2014.005","article-title":"Intravascular staining for discrimination of vascular and tissue leukocytes","volume":"9","author":"Anderson","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2019.04.004_bib2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.3389\/fimmu.2014.00649","article-title":"Platelets and infection\u2014an emerging role of platelets in viral infection","volume":"5","author":"Assinger","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2019.04.004_bib3","doi-asserted-by":"crossref","first-page":"8925","DOI":"10.1073\/pnas.1408148111","article-title":"Type I interferon is a therapeutic target for virus-induced lethal vascular damage","volume":"111","author":"Baccala","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.celrep.2019.04.004_bib4","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1084\/jem.185.3.517","article-title":"Virus-induced transient bone marrow aplasia: major role of interferon-alpha\/beta during acute infection with the noncytopathic lymphocytic choriomeningitis virus","volume":"185","author":"Binder","year":"1997","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2019.04.004_bib5","doi-asserted-by":"crossref","first-page":"e1006498","DOI":"10.1371\/journal.ppat.1006498","article-title":"Host genetics play a critical role in controlling CD8 T\u00a0cell function and lethal immunopathology during chronic viral infection","volume":"13","author":"Christiaansen","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2019.04.004_bib6","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1084\/jem.20130904","article-title":"CRTAM controls residency of gut CD4+CD8+ T\u00a0cells in the steady state and maintenance of gut CD4+ Th17 during parasitic infection","volume":"211","author":"Cortez","year":"2014","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2019.04.004_bib7","doi-asserted-by":"crossref","first-page":"2485","DOI":"10.1084\/jem.20121015","article-title":"Programmed death 1 protects from fatal circulatory failure during systemic virus infection of mice","volume":"209","author":"Frebel","year":"2012","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2019.04.004_bib8","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1073\/pnas.0711200105","article-title":"Platelets prevent IFN-alpha\/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus","volume":"105","author":"Iannacone","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.celrep.2019.04.004_bib9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature21706","article-title":"The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors","volume":"544","author":"Lefran\u00e7ais","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.04.004_bib10","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1084\/jem.170.1.269","article-title":"Major histocompatibility complex-linked susceptibility or resistance to disease caused by a noncytopathic virus varies with the disease parameter evaluated","volume":"170","author":"Leist","year":"1989","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2019.04.004_bib11","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1182\/blood-2011-08-376822","article-title":"Platelets support a protective immune response to LCMV by preventing splenic necrosis","volume":"121","author":"Loria","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2019.04.004_bib12","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/imr.12344","article-title":"Sialic acids and autoimmune disease","volume":"269","author":"Mahajan","year":"2016","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2019.04.004_bib13","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13059-016-0974-4","article-title":"The Ensembl Variant Effect Predictor","volume":"17","author":"McLaren","year":"2016","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2019.04.004_bib14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1534\/g3.115.022087","article-title":"The Mouse Universal Genotyping Array: from substrains to subspecies","volume":"6","author":"Morgan","year":"2015","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.celrep.2019.04.004_bib15","doi-asserted-by":"crossref","first-page":"4372","DOI":"10.1128\/jvi.67.7.4372-4378.1993","article-title":"Vaccination to prevent persistent viral infection","volume":"67","author":"Oldstone","year":"1993","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2019.04.004_bib16","doi-asserted-by":"crossref","first-page":"E7814","DOI":"10.1073\/pnas.1804674115","article-title":"Lymphocytic choriomeningitis virus Clone 13 infection causes either persistence or acute death dependent on IFN-1, cytotoxic T lymphocytes (CTLs), and host genetics","volume":"115","author":"Oldstone","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.celrep.2019.04.004_bib17","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/70938","article-title":"Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway","volume":"5","author":"Puglielli","year":"1999","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2019.04.004_bib18","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.chom.2017.07.008","article-title":"Interferon-gamma-driven iNOS: a molecular pathway to terminal shock in arenavirus hemorrhagic fever","volume":"22","author":"Remy","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2019.04.004_bib19","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev-virology-101416-042001","article-title":"New World Arenavirus Biology","volume":"4","author":"Sarute","year":"2017","journal-title":"Annu. Rev. Virol."},{"key":"10.1016\/j.celrep.2019.04.004_bib20","doi-asserted-by":"crossref","first-page":"e1003073","DOI":"10.1371\/journal.ppat.1003073","article-title":"Lymphocytic choriomeningitis virus infection in FVB mouse produces hemorrhagic disease","volume":"8","author":"Schnell","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2019.04.004_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.antiviral.2014.10.001","article-title":"Animal models of viral hemorrhagic fever","volume":"112","author":"Smith","year":"2014","journal-title":"Antiviral Res."},{"issue":"Suppl 2","key":"10.1016\/j.celrep.2019.04.004_bib22","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1863-2378.2012.01469.x","article-title":"Lassa fever in West Africa: evidence for an expanded region of endemicity","volume":"59","author":"Sogoba","year":"2012","journal-title":"Zoonoses Public Health"},{"key":"10.1016\/j.celrep.2019.04.004_bib23","doi-asserted-by":"crossref","first-page":"e2858","DOI":"10.1371\/journal.pntd.0002858","article-title":"The role of platelets in the pathogenesis of viral hemorrhagic fevers","volume":"8","author":"Zapata","year":"2014","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.celrep.2019.04.004_bib24","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1084\/jem.20102538","article-title":"Hemophagocytosis causes a consumptive anemia of inflammation","volume":"208","author":"Zoller","year":"2011","journal-title":"J.\u00a0Exp. Med."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719304590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719304590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:28:56Z","timestamp":1777624136000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124719304590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":24,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["S2211124719304590"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2019.04.004","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2019,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of a Locus in Mice that Regulates the Collateral Damage and Lethality of Virus Infection","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2019.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s).","name":"copyright","label":"Copyright"}]}}