{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:32:04Z","timestamp":1793748724069,"version":"4.6.1"},"reference-count":86,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030_153074"],"award-info":[{"award-number":["310030_153074"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["310030B_173338\/1"],"award-info":[{"award-number":["310030B_173338\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["CRSII_ 154414\/1"],"award-info":[{"award-number":["CRSII_ 154414\/1"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["694181"],"award-info":[{"award-number":["694181"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2012-262"],"award-info":[{"award-number":["2012-262"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2015-00635"],"award-info":[{"award-number":["2015-00635"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U01AI095473"],"award-info":[{"award-number":["U01AI095473"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003006","name":"Eidgen\u00f6ssische Technische Hochschule Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003006","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008307","name":"Promedica Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008307","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.celrep.2019.04.106","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T10:32:33Z","timestamp":1559039553000},"page":"2665-2678.e3","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":155,"title":["Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract"],"prefix":"10.1016","volume":"27","author":[{"given":"Markus","family":"Furter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael E.","family":"Sellin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar C.","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolf-Dietrich","family":"Hardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2019.04.106_bib1","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/nature07067","article-title":"Self-destructive cooperation mediated by phenotypic noise","volume":"454","author":"Ackermann","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.04.106_bib2","doi-asserted-by":"crossref","first-page":"5882","DOI":"10.1128\/IAI.70.10.5882-5886.2002","article-title":"Expression and characterization of flagella in nonmotile enteroinvasive Escherichia coli isolated from diarrhea cases","volume":"70","author":"Andrade","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2019.04.106_bib3","doi-asserted-by":"crossref","first-page":"e652","DOI":"10.1016\/j.crohns.2013.05.006","article-title":"Human colonic mucus is a reservoir for antimicrobial peptides","volume":"7","author":"Antoni","year":"2013","journal-title":"J.\u00a0Crohn\u2019s Colitis"},{"key":"10.1016\/j.celrep.2019.04.106_bib4","doi-asserted-by":"crossref","first-page":"G922","DOI":"10.1152\/ajpgi.2001.280.5.G922","article-title":"The adherent gastrointestinal mucus gel layer: thickness and physical state in\u00a0vivo","volume":"280","author":"Atuma","year":"2001","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.celrep.2019.04.106_bib5","doi-asserted-by":"crossref","first-page":"10771","DOI":"10.1073\/pnas.1305923110","article-title":"Bacteriophage adhering to mucus provide a non-host-derived immunity","volume":"110","author":"Barr","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.04.106_bib6","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1128\/IAI.71.5.2839-2858.2003","article-title":"Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host","volume":"71","author":"Barthel","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2019.04.106_bib7","doi-asserted-by":"crossref","first-page":"e1000902","DOI":"10.1371\/journal.ppat.1000902","article-title":"Muc2 protects against lethal infectious colitis by disassociating pathogenic and commensal bacteria from the colonic mucosa","volume":"6","author":"Bergstrom","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2019.04.106_bib8","doi-asserted-by":"crossref","first-page":"13833","DOI":"10.1073\/pnas.1611400113","article-title":"Gram-positive bacteria are held at a distance in the colon mucus by the lectin-like protein ZG16","volume":"113","author":"Bergstr\u00f6m","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.04.106_bib9","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1126\/science.aaf7419","article-title":"A sentinel goblet cell guards the colonic crypt by triggering Nlrp6-dependent Muc2 secretion","volume":"352","author":"Birchenough","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.04.106_bib10","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1084\/jem.139.5.1189","article-title":"The route of enteric infection in normal mice","volume":"139","author":"Carter","year":"1974","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2019.04.106_bib11","doi-asserted-by":"crossref","first-page":"14321","DOI":"10.1073\/pnas.0903438106","article-title":"Helicobacter pylori moves through mucus by reducing mucin viscoelasticity","volume":"106","author":"Celli","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.04.106_bib12","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.chom.2010.09.005","article-title":"miR-146a mediates protective innate immune tolerance in the neonate intestine","volume":"8","author":"Chassin","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2019.04.106_bib13","doi-asserted-by":"crossref","first-page":"e46476","DOI":"10.1371\/journal.pone.0046476","article-title":"The antimicrobial peptide cathelicidin protects mice from Escherichia coli O157:H7-mediated disease","volume":"7","author":"Chromek","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2019.04.106_bib14","doi-asserted-by":"crossref","first-page":"e1601661","DOI":"10.1126\/sciadv.1601661","article-title":"Helical and rod-shaped bacteria swim in helical trajectories with little additional propulsion from helical shape","volume":"2","author":"Constantino","year":"2016","journal-title":"Sci. Adv."},{"key":"10.1016\/j.celrep.2019.04.106_bib15","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.chom.2013.10.009","article-title":"Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut","volume":"14","author":"Cullender","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2019.04.106_bib16","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1111\/j.1365-2958.2006.05271.x","article-title":"In\u00a0vivo, fliC expression by Salmonella enterica serovar Typhimurium is heterogeneous, regulated by ClpX, and anatomically restricted","volume":"61","author":"Cummings","year":"2006","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.celrep.2019.04.106_bib17","doi-asserted-by":"crossref","first-page":"e83688","DOI":"10.1371\/journal.pone.0083688","article-title":"Mucus properties and goblet cell quantification in mouse, rat and human ileal Peyer\u2019s patches","volume":"8","author":"Ermund","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2019.04.106_bib18","doi-asserted-by":"crossref","first-page":"G341","DOI":"10.1152\/ajpgi.00046.2013","article-title":"Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer\u2019s patches","volume":"305","author":"Ermund","year":"2013","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.celrep.2019.04.106_bib19","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/ni1346","article-title":"Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages","volume":"7","author":"Franchi","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2019.04.106_bib20","doi-asserted-by":"crossref","first-page":"e1000307","DOI":"10.1371\/journal.pgen.1000307","article-title":"A simple screen to identify promoters conferring high levels of phenotypic noise","volume":"4","author":"Freed","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2019.04.106_bib21","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/s41586-018-0395-5","article-title":"Neonatal selection by Toll-like receptor 5 influences long-term gut microbiota composition","volume":"560","author":"Fulde","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.04.106_bib22","doi-asserted-by":"crossref","first-page":"G430","DOI":"10.1152\/ajpgi.00405.2011","article-title":"An ex\u00a0vivo method for studying mucus formation, properties, and thickness in human colonic biopsies and mouse small and large intestinal explants","volume":"302","author":"Gustafsson","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.celrep.2019.04.106_bib23","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-1-61779-513-8_14","article-title":"Ex\u00a0vivo measurements of mucus secretion by colon explants","volume":"842","author":"Gustafsson","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2019.04.106_bib24","first-page":"1242","article-title":"The role of the bacterial flagellum in adhesion and virulence","volume":"2","author":"Haiko","year":"2013","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.celrep.2019.04.106_bib25","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.4049\/jimmunol.174.3.1675","article-title":"The Salmonella pathogenicity island (SPI)-2 and SPI-1 type III secretion systems allow Salmonella serovar typhimurium to trigger colitis via MyD88-dependent and MyD88-independent mechanisms","volume":"174","author":"Hapfelmeier","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2019.04.106_bib26","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1128\/iai.22.3.763-770.1978","article-title":"Intestinal colonization and virulence of Salmonella in mice","volume":"22","author":"Hohmann","year":"1978","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2019.04.106_bib27","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/291238a0","article-title":"Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines","volume":"291","author":"Hoiseth","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.04.106_bib28","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1128\/jb.145.2.1082-1084.1981","article-title":"Passive rotation of flagella on paralyzed Salmonella typhimurium (mot) mutants by external rotatory driving force","volume":"145","author":"Ishihara","year":"1981","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.celrep.2019.04.106_bib29","doi-asserted-by":"crossref","first-page":"164","DOI":"10.15252\/embr.201439263","article-title":"The composition of the gut microbiota shapes the colon mucus barrier","volume":"16","author":"Jakobsson","year":"2015","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2019.04.106_bib30","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0922-4106(94)90229-1","article-title":"Interferon-gamma modulates cAMP-induced mucin exocytosis without affecting mucin gene expression in a human colonic goblet cell line","volume":"267","author":"Jarry","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.celrep.2019.04.106_bib31","doi-asserted-by":"crossref","first-page":"e41009","DOI":"10.1371\/journal.pone.0041009","article-title":"Fast renewal of the distal colonic mucus layers by the surface goblet cells as measured by in\u00a0vivo labeling of mucin glycoproteins","volume":"7","author":"Johansson","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2019.04.106_bib32","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-1-61779-513-8_13","article-title":"Preservation of mucus in histological sections, immunostaining of mucins in fixed tissue, and localization of bacteria with FISH","volume":"842","author":"Johansson","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2019.04.106_bib33","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nri.2016.88","article-title":"Immunological aspects of intestinal mucus and mucins","volume":"16","author":"Johansson","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2019.04.106_bib34","doi-asserted-by":"crossref","first-page":"15064","DOI":"10.1073\/pnas.0803124105","article-title":"The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria","volume":"105","author":"Johansson","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.04.106_bib35","doi-asserted-by":"crossref","first-page":"e12238","DOI":"10.1371\/journal.pone.0012238","article-title":"Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis model","volume":"5","author":"Johansson","year":"2010","journal-title":"PLoS ONE"},{"issue":"Suppl 1","key":"10.1016\/j.celrep.2019.04.106_bib36","doi-asserted-by":"crossref","first-page":"4659","DOI":"10.1073\/pnas.1006451107","article-title":"The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions","volume":"108","author":"Johansson","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.04.106_bib37","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1136\/gutjnl-2012-303207","article-title":"Bacteria penetrate the normally impenetrable inner colon mucus layer in both murine colitis models and patients with ulcerative colitis","volume":"63","author":"Johansson","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2019.04.106_bib38","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1600-065X.2011.01070.x","article-title":"The streptomycin mouse model for Salmonella diarrhea: functional analysis of the microbiota, the pathogen\u2019s virulence factors, and the host\u2019s mucosal immune response","volume":"245","author":"Kaiser","year":"2012","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2019.04.106_bib39","doi-asserted-by":"crossref","first-page":"8527","DOI":"10.1038\/s41598-017-08938-3","article-title":"Mucus organisation is shaped by colonic content; a new view","volume":"7","author":"Kamphuis","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2019.04.106_bib40","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.chom.2013.10.015","article-title":"TLR5 stops commensals in their tracks","volume":"14","author":"Koch","year":"2013","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2019.04.106_bib41","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1038\/nature10394","article-title":"Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity","volume":"477","author":"Kofoed","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.04.106_bib42","doi-asserted-by":"crossref","first-page":"e01611","DOI":"10.1128\/mBio.01611-14","article-title":"A nutrient-tunable bistable switch controls motility in Salmonella enterica serovar Typhimurium","volume":"5","author":"Koirala","year":"2014","journal-title":"MBio"},{"key":"10.1016\/j.celrep.2019.04.106_bib43","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/dnares\/dsm018","article-title":"Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes","volume":"14","author":"Kurokawa","year":"2007","journal-title":"DNA Res."},{"key":"10.1016\/j.celrep.2019.04.106_bib44","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1128\/IAI.00077-09","article-title":"Salmonella enterica serovar typhimurium pathogenicity island 1-encoded type III secretion system translocases mediate intimate attachment to nonphagocytic cells","volume":"77","author":"Lara-Tejero","year":"2009","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2019.04.106_bib45","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1529\/biophysj.105.069401","article-title":"Swimming in circles: motion of bacteria near solid boundaries","volume":"90","author":"Lauga","year":"2006","journal-title":"Biophys. J."},{"key":"10.1016\/j.celrep.2019.04.106_bib46","doi-asserted-by":"crossref","first-page":"8292","DOI":"10.1038\/ncomms9292","article-title":"The outer mucus layer hosts a distinct intestinal microbial niche","volume":"6","author":"Li","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2019.04.106_bib47","doi-asserted-by":"crossref","first-page":"e1007566","DOI":"10.1371\/journal.ppat.1007566","article-title":"MUC1 is a receptor for the Salmonella SiiE adhesin that enables apical invasion into enterocytes","volume":"15","author":"Li","year":"2019","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2019.04.106_bib48","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1084\/jem.20050625","article-title":"Postnatal acquisition of endotoxin tolerance in intestinal epithelial cells","volume":"203","author":"Lotz","year":"2006","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2019.04.106_bib49","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/eji.200636745","article-title":"Faithful activation of an extra-bright red fluorescent protein in \u201cknock-in\u201d Cre-reporter mice ideally suited for lineage tracing studies","volume":"37","author":"Luche","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2019.04.106_bib50","doi-asserted-by":"crossref","first-page":"33275","DOI":"10.1074\/jbc.M204935200","article-title":"Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine","volume":"277","author":"Madison","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2019.04.106_bib51","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.chom.2016.02.021","article-title":"Host Selection of Microbiota via Differential Adhesion","volume":"19","author":"McLoughlin","year":"2016","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2019.04.106_bib52","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1136\/gut.2007.141481","article-title":"Secreted enteric antimicrobial activity localises to the mucus surface layer","volume":"57","author":"Meyer-Hoffert","year":"2008","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2019.04.106_bib53","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/ni1344","article-title":"Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf","volume":"7","author":"Miao","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2019.04.106_bib54","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1073\/pnas.0913087107","article-title":"Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome","volume":"107","author":"Miao","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.04.106_bib55","doi-asserted-by":"crossref","first-page":"041914","DOI":"10.1103\/PhysRevE.82.041914","article-title":"Mean square displacement analysis of single-particle trajectories with localization error: Brownian motion in an isotropic medium","volume":"82","author":"Michalet","year":"2010","journal-title":"Phys. Rev. E Stat. Nonlin. Soft Matter Phys."},{"key":"10.1016\/j.celrep.2019.04.106_bib56","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/msb.2011.7","article-title":"RNAi screen of Salmonella invasion shows role of COPI in membrane targeting of cholesterol and Cdc42","volume":"7","author":"Misselwitz","year":"2011","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.celrep.2019.04.106_bib57","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1128\/IAI.00581-10","article-title":"Salmonella enterica serovar Typhimurium binds to HeLa cells via Fim-mediated reversible adhesion and irreversible type three secretion system 1-mediated docking","volume":"79","author":"Misselwitz","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2019.04.106_bib58","doi-asserted-by":"crossref","first-page":"e1002810","DOI":"10.1371\/journal.ppat.1002810","article-title":"Near surface swimming of Salmonella Typhimurium explains target-site selection and cooperative invasion","volume":"8","author":"Misselwitz","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2019.04.106_bib59","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.chom.2011.11.013","article-title":"Salmonella gut invasion involves TTSS-2-dependent epithelial traversal, basolateral exit, and uptake by epithelium-sampling lamina propria phagocytes","volume":"11","author":"M\u00fcller","year":"2012","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2019.04.106_bib60","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3389\/fimmu.2012.00310","article-title":"Intestinal antimicrobial peptides during homeostasis, infection, and disease","volume":"3","author":"Muniz","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2019.04.106_bib61","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jcmgh.2016.02.003","article-title":"Functional Characterization of Inflammatory Bowel Disease-Associated Gut Dysbiosis in Gnotobiotic Mice","volume":"2","author":"Nagao-Kitamoto","year":"2016","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.celrep.2019.04.106_bib62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dmm.017400","article-title":"How informative is the mouse for human gut microbiota research?","volume":"8","author":"Nguyen","year":"2015","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.celrep.2019.04.106_bib63","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature17406","article-title":"Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia","volume":"532","author":"Okumura","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.04.106_bib64","doi-asserted-by":"crossref","first-page":"G327","DOI":"10.1152\/ajpgi.00422.2010","article-title":"Importance and regulation of the colonic mucus barrier in a mouse model of colitis","volume":"300","author":"Petersson","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.celrep.2019.04.106_bib65","doi-asserted-by":"crossref","first-page":"e1002018","DOI":"10.1371\/journal.ppat.1002018","article-title":"Citrobacter rodentium is an unstable pathogen showing evidence of significant genomic flux","volume":"7","author":"Petty","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2019.04.106_bib66","doi-asserted-by":"crossref","first-page":"e99820","DOI":"10.1371\/journal.pone.0099820","article-title":"Defined single-gene and multi-gene deletion mutant collections in Salmonella enterica sv Typhimurium","volume":"9","author":"Porwollik","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2019.04.106_bib67","doi-asserted-by":"crossref","first-page":"3525","DOI":"10.1021\/acs.langmuir.7b00439","article-title":"Landing Dynamics of Swimming Bacteria on a Polymeric Surface: Effect of Surface Properties","volume":"33","author":"Qi","year":"2017","journal-title":"Langmuir"},{"key":"10.1016\/j.celrep.2019.04.106_bib68","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1038\/ismej.2014.3","article-title":"Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission","volume":"8","author":"Rooks","year":"2014","journal-title":"ISME J."},{"key":"10.1016\/j.celrep.2019.04.106_bib69","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0016-5085(99)70393-8","article-title":"The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls","volume":"117","author":"Schultsz","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2019.04.106_bib70","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.chom.2014.07.001","article-title":"Epithelium-intrinsic NAIP\/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa","volume":"16","author":"Sellin","year":"2014","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2019.04.106_bib71","doi-asserted-by":"crossref","first-page":"e22459","DOI":"10.1371\/journal.pone.0022459","article-title":"Stromal IFN-\u03b3R-signaling modulates goblet cell function during Salmonella Typhimurium infection","volume":"6","author":"Songhet","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2019.04.106_bib72","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0168-6445(03)00064-0","article-title":"Regulation cascade of flagellar expression in Gram-negative bacteria","volume":"27","author":"Soutourina","year":"2003","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.celrep.2019.04.106_bib73","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1128\/IAI.72.7.4138-4150.2004","article-title":"Flagella and chemotaxis are required for efficient induction of Salmonella enterica serovar Typhimurium colitis in streptomycin-pretreated mice","volume":"72","author":"Stecher","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2019.04.106_bib74","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1111\/j.1462-5822.2008.01118.x","article-title":"Motility allows S. Typhimurium to benefit from the mucosal defence","volume":"10","author":"Stecher","year":"2008","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.celrep.2019.04.106_bib75","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1128\/JCM.43.7.3380-3389.2005","article-title":"Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease","volume":"43","author":"Swidsinski","year":"2005","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.celrep.2019.04.106_bib76","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/BF02388803","article-title":"The thickness of the mucus layer in different segments of the rat intestine","volume":"27","author":"Szentkuti","year":"1995","journal-title":"Histochem. J."},{"key":"10.1016\/j.celrep.2019.04.106_bib77","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ymeth.2016.09.016","article-title":"TrackMate: An open and extensible platform for single-particle tracking","volume":"115","author":"Tinevez","year":"2017","journal-title":"Methods"},{"key":"10.1016\/j.celrep.2019.04.106_bib78","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1046\/j.1365-2958.1996.00120.x","article-title":"Bacterial genetics by flow cytometry: rapid isolation of Salmonella typhimurium acid-inducible promoters by differential fluorescence induction","volume":"22","author":"Valdivia","year":"1996","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.celrep.2019.04.106_bib79","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/j.gastro.2006.04.020","article-title":"Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection","volume":"131","author":"Van der Sluis","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2019.04.106_bib80","first-page":"1851","article-title":"Quantitative insights into actin rearrangements and bacterial target site selection from Salmonella Typhimurium infection of micropatterned cells","volume":"15","author":"Vonaesch","year":"2013","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.celrep.2019.04.106_bib81","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.chom.2017.03.009","article-title":"Salmonella Typhimurium Diarrhea Reveals Basic Principles of Enteropathogen Infection and Disease-Promoted DNA Exchange","volume":"21","author":"Wotzka","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2019.04.106_bib82","doi-asserted-by":"crossref","first-page":"6445","DOI":"10.1093\/nar\/gki954","article-title":"Genome dynamics and diversity of Shigella species, the etiologic agents of bacillary dysentery","volume":"33","author":"Yang","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2019.04.106_bib83","doi-asserted-by":"crossref","first-page":"7740","DOI":"10.1128\/AEM.05318-11","article-title":"Naturally occurring motility-defective mutants of Salmonella enterica serovar Enteritidis isolated preferentially from nonhuman rather than human sources","volume":"77","author":"Yim","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.celrep.2019.04.106_bib84","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1128\/IAI.01336-13","article-title":"Repression of flagella is a common trait in field isolates of Salmonella enterica serovar Dublin and is associated with invasive human infections","volume":"82","author":"Yim","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2019.04.106_bib85","doi-asserted-by":"crossref","first-page":"3672","DOI":"10.1128\/IAI.00854-13","article-title":"The mucin Muc2 limits pathogen burdens and epithelial barrier dysfunction during Salmonella enterica serovar Typhimurium colitis","volume":"81","author":"Zarepour","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2019.04.106_bib86","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nature10510","article-title":"The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus","volume":"477","author":"Zhao","year":"2011","journal-title":"Nature"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719305868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719305868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:32:19Z","timestamp":1778841139000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124719305868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":86,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S2211124719305868"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2019.04.106","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mucus Architecture and Near-Surface Swimming Affect Distinct Salmonella Typhimurium Infection Patterns along the Murine Intestinal Tract","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2019.04.106","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s).","name":"copyright","label":"Copyright"}]}}