{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:19:43Z","timestamp":1790371183693,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.celrep.2019.04.107","type":"journal-article","created":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T10:32:27Z","timestamp":1559039547000},"page":"2725-2736.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia"],"prefix":"10.1016","volume":"27","author":[{"given":"Arnab","family":"Nayak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo J.","family":"Lopez-Davila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterini","family":"Kefalakes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Holler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresia","family":"Kraft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamta","family":"Amrute-Nayak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2019.04.107_bib1","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1172\/JCI200420174","article-title":"Cancer cachexia is regulated by selective targeting of skeletal muscle gene products","volume":"114","author":"Acharyya","year":"2004","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2019.04.107_bib2","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nrc3829","article-title":"Cancer cachexia: understanding the molecular basis","volume":"14","author":"Argil\u00e9s","year":"2014","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2019.04.107_bib3","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s11064-007-9564-x","article-title":"Elevated inflammatory markers in a group of amyotrophic lateral sclerosis patients from northern India","volume":"33","author":"Babu","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.celrep.2019.04.107_bib4","first-page":"136","article-title":"Muscle paralysis and myosin loss in a patient with cancer cachexia","volume":"26","author":"Banduseela","year":"2007","journal-title":"Acta Myol."},{"key":"10.1016\/j.celrep.2019.04.107_bib5","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/ehf2.12184","article-title":"Cardiac muscle wasting in individuals with cancer cachexia","volume":"4","author":"Barkhudaryan","year":"2017","journal-title":"ESC Heart Fail."},{"key":"10.1016\/j.celrep.2019.04.107_bib6","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1101\/gad.1787609","article-title":"An operational definition of epigenetics","volume":"23","author":"Berger","year":"2009","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2019.04.107_bib7","doi-asserted-by":"crossref","first-page":"2763","DOI":"10.1101\/gad.200113.112","article-title":"Genome-wide identification of enhancers in skeletal muscle: the role of MyoD1","volume":"26","author":"Blum","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2019.04.107_bib8","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/1440-1681.12559","article-title":"Skeletal muscle regeneration in cancer cachexia","volume":"43","author":"Bossola","year":"2016","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.celrep.2019.04.107_bib9","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/jcsm.12233","article-title":"Small-molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia","volume":"8","author":"Bowen","year":"2017","journal-title":"J.\u00a0Cachexia Sarcopenia Muscle"},{"key":"10.1016\/j.celrep.2019.04.107_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.devcel.2012.11.020","article-title":"SUMO: a multifaceted modifier of chromatin structure and function","volume":"24","author":"Cube\u00f1as-Potts","year":"2013","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2019.04.107_bib11","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.cmet.2008.09.002","article-title":"Skeletal muscle is a primary target of SOD1G93A-mediated toxicity","volume":"8","author":"Dobrowolny","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2019.04.107_bib12","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/emboj.2011.33","article-title":"The SUMO system controls nucleolar partitioning of a novel mammalian ribosome biogenesis complex","volume":"30","author":"Finkbeiner","year":"2011","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2019.04.107_bib13","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1146\/annurev-biochem-061909-093311","article-title":"Sumoylation: a regulatory protein modification in health and disease","volume":"82","author":"Flotho","year":"2013","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.celrep.2019.04.107_bib14","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/nrm3011","article-title":"The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition","volume":"11","author":"Gareau","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2019.04.107_bib15","first-page":"225","article-title":"Signaling pathways perturbing muscle mass","volume":"13","author":"Glass","year":"2010","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"10.1016\/j.celrep.2019.04.107_bib16","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1128\/MCB.25.6.2273-2287.2005","article-title":"Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors","volume":"25","author":"Gr\u00e9goire","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2019.04.107_bib17","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1126\/science.8209258","article-title":"Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation","volume":"264","author":"Gurney","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.04.107_bib18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/embor.2008.3","article-title":"The nucleolar SUMO-specific protease SENP3 reverses SUMO modification of nucleophosmin and is required for rRNA processing","volume":"9","author":"Haindl","year":"2008","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2019.04.107_bib19","doi-asserted-by":"crossref","first-page":"19961","DOI":"10.1074\/jbc.M201799200","article-title":"Association of the human SUMO-1 protease SENP2 with the nuclear pore","volume":"277","author":"Hang","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2019.04.107_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molcel.2005.03.012","article-title":"SUMO: a history of modification","volume":"18","author":"Hay","year":"2005","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2019.04.107_bib21","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1038\/s41467-018-04957-4","article-title":"Site-specific characterization of endogenous SUMOylation across species and organs","volume":"9","author":"Hendriks","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2019.04.107_bib22","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1038\/emboj.2009.210","article-title":"SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation","volume":"28","author":"Huang","year":"2009","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2019.04.107_bib23","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1128\/MCB.01830-05","article-title":"Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2","volume":"26","author":"Itahana","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2019.04.107_bib24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1152\/jappl.2000.89.1.81","article-title":"Skeletal muscle mass and distribution in 468 men and women aged 18-88 yr.","volume":"89","author":"Janssen","year":"2000","journal-title":"J.\u00a0Appl. Physiol."},{"key":"10.1016\/j.celrep.2019.04.107_bib25","doi-asserted-by":"crossref","first-page":"361","DOI":"10.4161\/epi.24234","article-title":"Transcriptional regulation by the Set7 lysine methyltransferase","volume":"8","author":"Keating","year":"2013","journal-title":"Epigenetics"},{"key":"10.1016\/j.celrep.2019.04.107_bib26","doi-asserted-by":"crossref","first-page":"3573","DOI":"10.1242\/dev.136226","article-title":"The histone methyltransferase Setd7 promotes pancreatic progenitor identity","volume":"143","author":"Kofent","year":"2016","journal-title":"Development"},{"key":"10.1016\/j.celrep.2019.04.107_bib27","doi-asserted-by":"crossref","first-page":"C626","DOI":"10.1152\/ajpcell.00442.2005","article-title":"De novo myofibrillogenesis in C2C12 cells: evidence for the independent assembly of M bands and Z disks","volume":"290","author":"Kontrogianni-Konstantopoulos","year":"2006","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.celrep.2019.04.107_bib28","doi-asserted-by":"crossref","first-page":"jcs211904","DOI":"10.1242\/jcs.211904","article-title":"SUMO-specific proteases and isopeptidases of the SENP family at a glance","volume":"131","author":"Kunz","year":"2018","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.celrep.2019.04.107_bib29","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.stem.2018.02.005","article-title":"SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation","volume":"22","author":"Lee","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2019.04.107_bib30","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1073\/pnas.1019619108","article-title":"Methyltransferase Set7\/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1)","volume":"108","author":"Liu","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.04.107_bib31","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s10974-009-9189-6","article-title":"The vertebrate muscle Z-disc: sarcomere anchor for structure and signalling","volume":"30","author":"Luther","year":"2009","journal-title":"J.\u00a0Muscle Res. Cell Motil."},{"key":"10.1016\/j.celrep.2019.04.107_bib32","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.neuroscience.2009.05.049","article-title":"Tumor necrosis factor alpha and interferon gamma cooperatively induce oxidative stress and motoneuron death in rat spinal cord embryonic explants","volume":"162","author":"Mir","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2019.04.107_bib33","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.tibs.2007.05.002","article-title":"Modification in reverse: the SUMO proteases","volume":"32","author":"Mukhopadhyay","year":"2007","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.celrep.2019.04.107_bib34","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.devcel.2005.10.007","article-title":"The SUMO pathway is essential for nuclear integrity and chromosome segregation in mice","volume":"9","author":"Nacerddine","year":"2005","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2019.04.107_bib35","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1186\/s13059-014-0422-2","article-title":"SUMO-specific proteases\/isopeptidases: SENPs and beyond","volume":"15","author":"Nayak","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2019.04.107_bib36","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.molcel.2014.05.011","article-title":"The SUMO-specific isopeptidase SENP3 regulates MLL1\/MLL2 methyltransferase complexes and controls osteogenic differentiation","volume":"55","author":"Nayak","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2019.04.107_bib37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13072-017-0122-8","article-title":"Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes","volume":"10","author":"Nayak","year":"2017","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.celrep.2019.04.107_bib38","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nprot.2006.27","article-title":"Protocol for the fast chromatin immunoprecipitation (ChIP) method","volume":"1","author":"Nelson","year":"2006","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2019.04.107_bib39","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1101\/gad.967202","article-title":"Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation","volume":"16","author":"Nishioka","year":"2002","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2019.04.107_bib40","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.molcel.2009.03.013","article-title":"Direct binding of CoREST1 to SUMO-2\/3 contributes to gene-specific repression by the LSD1\/CoREST1\/HDAC complex","volume":"34","author":"Ouyang","year":"2009","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2019.04.107_bib41","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0304-3940(00)01177-0","article-title":"Circulating levels of tumour necrosis factor-alpha and its soluble receptors are increased in the blood of patients with amyotrophic lateral sclerosis","volume":"287","author":"Poloni","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.celrep.2019.04.107_bib42","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1038\/oncsis.2016.3","article-title":"Understanding cachexia as a cancer metabolism syndrome","volume":"5","author":"Porporato","year":"2016","journal-title":"Oncogenesis"},{"key":"10.1016\/j.celrep.2019.04.107_bib43","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00412-013-0429-6","article-title":"The SUMO system: a master organizer of nuclear protein assemblies","volume":"122","author":"Raman","year":"2013","journal-title":"Chromosoma"},{"key":"10.1016\/j.celrep.2019.04.107_bib44","doi-asserted-by":"crossref","first-page":"4474","DOI":"10.1128\/MCB.00801-14","article-title":"mTOR signaling regulates nucleolar targeting of the SUMO-specific isopeptidase SENP3","volume":"34","author":"Raman","year":"2014","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2019.04.107_bib45","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1146\/annurev.genet.38.072902.091907","article-title":"Epigenetic regulation of cellular memory\u00a0by\u00a0the Polycomb and Trithorax group proteins","volume":"38","author":"Ringrose","year":"2004","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.celrep.2019.04.107_bib46","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1016\/j.yexcr.2006.03.016","article-title":"Ubc9 expression is essential for myotube formation in C2C12","volume":"312","author":"Riquelme","year":"2006","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.celrep.2019.04.107_bib47","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3389\/fonc.2018.00041","article-title":"Epigenetic Regulators in the Development, Maintenance, and Therapeutic Targeting of Acute Myeloid Leukemia","volume":"8","author":"Sun","year":"2018","journal-title":"Front. Oncol."},{"key":"10.1016\/j.celrep.2019.04.107_bib48","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1083\/jcb.201010090","article-title":"The histone methyltransferase Set7\/9 promotes myoblast differentiation and myofibril assembly","volume":"194","author":"Tao","year":"2011","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2019.04.107_bib49","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/S1097-2765(01)00405-1","article-title":"Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase","volume":"8","author":"Wang","year":"2001","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2019.04.107_bib50","doi-asserted-by":"crossref","first-page":"5516","DOI":"10.1073\/pnas.1216596110","article-title":"Methylation of SUV39H1 by SET7\/9 results in heterochromatin relaxation and genome instability","volume":"110","author":"Wang","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.04.107_bib51","doi-asserted-by":"crossref","first-page":"878","DOI":"10.15252\/embr.201438534","article-title":"SUMO2 is essential while SUMO3 is dispensable for mouse embryonic development","volume":"15","author":"Wang","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2019.04.107_bib52","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/s41591-018-0054-2","article-title":"Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle","volume":"24","author":"Wang","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2019.04.107_bib53","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1002\/ar.22981","article-title":"Localization of sarcomeric proteins during myofibril assembly in cultured mouse primary skeletal myotubes","volume":"297","author":"White","year":"2014","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.celrep.2019.04.107_bib54","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1083\/jcb.200807185","article-title":"Nucleolar protein B23\/nucleophosmin regulates the vertebrate SUMO pathway through SENP3 and SENP5 proteases","volume":"183","author":"Yun","year":"2008","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2019.04.107_bib55","doi-asserted-by":"crossref","first-page":"6498","DOI":"10.1128\/MCB.22.18.6498-6508.2002","article-title":"Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex","volume":"22","author":"Zhang","year":"2002","journal-title":"Mol. Cell. Biol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112471930587X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112471930587X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:39:31Z","timestamp":1761907171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221112471930587X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":55,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S221112471930587X"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2019.04.107","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Regulation of SETD7 Methyltransferase by SENP3 Is Crucial for Sarcomere Organization and Cachexia","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2019.04.107","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s).","name":"copyright","label":"Copyright"}]}}