{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:05:34Z","timestamp":1785855934340,"version":"3.56.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,5,4]],"date-time":"2019-05-04T00:00:00Z","timestamp":1556928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["FDT20170739035"],"award-info":[{"award-number":["FDT20170739035"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003762","name":"Institut Pasteur","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["PLBIO16-181"],"award-info":[{"award-number":["PLBIO16-181"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["310917"],"award-info":[{"award-number":["310917"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.celrep.2019.05.014","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T12:24:29Z","timestamp":1559651069000},"page":"2847-2858.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Breakage-Fusion-Bridge Events Trigger Complex Genome Rearrangements and Amplifications in Developmentally Arrested T Cell Lymphomas"],"prefix":"10.1016","volume":"27","author":[{"given":"Joy J.","family":"Bianchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentine","family":"Murigneux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Bedora-Faure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chlo\u00e9","family":"Lescale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Deriano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"D1","key":"10.1016\/j.celrep.2019.05.014_bib1","doi-asserted-by":"crossref","first-page":"D992","DOI":"10.1093\/nar\/gkv1123","article-title":"NCG 5.0: updates of a manually curated repository of cancer genes and associated properties from cancer mutational screenings","volume":"44","author":"An","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2019.05.014_bib2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2019.05.014_bib3","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/gcc.1115","article-title":"Duplication or amplification of chromosome band 11q23, including the unrearranged MLL gene, is a recurrent abnormality in therapy-related MDS and AML, and is closely related to mutation of the TP53 gene and to previous therapy with alkylating agents","volume":"31","author":"Andersen","year":"2001","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.celrep.2019.05.014_bib4","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkl198","article-title":"MEME: discovering and analyzing DNA and protein sequence motifs","volume":"34","author":"Bailey","year":"2006","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2019.05.014_bib5","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.cell.2013.01.006","article-title":"Identification of early replicating fragile sites that contribute to genome instability","volume":"152","author":"Barlow","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.05.014_bib6","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1440-1711.1998.00709.x","article-title":"Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements","volume":"76","author":"Barnden","year":"1998","journal-title":"Immunol. Cell Biol."},{"issue":"Suppl","key":"10.1016\/j.celrep.2019.05.014_bib7","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1016\/S0092-8674(02)00675-X","article-title":"The mechanism and regulation of chromosomal V(D)J recombination","volume":"109","author":"Bassing","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.05.014_bib8","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0092-8674(03)00566-X","article-title":"Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors","volume":"114","author":"Bassing","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.05.014_bib9","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1101\/gr.6522707","article-title":"Architectures of somatic genomic rearrangement in human cancer amplicons at sequence-level resolution","volume":"17","author":"Bignell","year":"2007","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2019.05.014_bib10","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/bioinformatics\/btr670","article-title":"Control-FREEC: a tool for assessing copy number and allelic content using next-generation sequencing data","volume":"28","author":"Boeva","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2019.05.014_bib11","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/onc.2017.402","article-title":"Transcribing malignancy: transcription-associated genomic instability in cancer","volume":"37","author":"Boulianne","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2019.05.014_bib12","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1016\/j.celrep.2017.01.057","article-title":"Lineage-Specific Genes Are Prominent DNA Damage Hotspots during Leukemic Transformation of B Cell Precursors","volume":"18","author":"Boulianne","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2019.05.014_bib13","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1038\/ng.128","article-title":"Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing","volume":"40","author":"Campbell","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2019.05.014_bib14","first-page":"e50087","article-title":"Combined immunofluorescence and DNA FISH on 3D-preserved interphase nuclei to study changes in 3D nuclear organization","volume":"72","author":"Chaumeil","year":"2013","journal-title":"J.\u00a0Vis. Exp"},{"key":"10.1016\/j.celrep.2019.05.014_bib15","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1084\/jem.20150477","article-title":"RAG-induced DNA lesions activate proapoptotic BIM to suppress lymphomagenesis in p53-deficient mice","volume":"213","author":"Delbridge","year":"2016","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2019.05.014_bib16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/ng.806","article-title":"A framework for variation discovery and genotyping using next-generation DNA sequencing data","volume":"43","author":"DePristo","year":"2011","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2019.05.014_bib17","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1146\/annurev-genet-110711-155540","article-title":"Modernizing the nonhomologous end-joining repertoire: alternative and classical NHEJ share the stage","volume":"47","author":"Deriano","year":"2013","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.celrep.2019.05.014_bib18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature09755","article-title":"The RAG2 C terminus suppresses genomic instability and lymphomagenesis","volume":"471","author":"Deriano","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.05.014_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2019.05.014_bib20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/356215a0","article-title":"Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours","volume":"356","author":"Donehower","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.05.014_bib21","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1101\/gad.252148.114","article-title":"The evolution of thymic lymphomas in p53 knockout mice","volume":"28","author":"Dudgeon","year":"2014","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2019.05.014_bib22","doi-asserted-by":"crossref","first-page":"5357","DOI":"10.1073\/pnas.090013497","article-title":"Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity","volume":"97","author":"Gisselsson","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.05.014_bib23","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrc1164","article-title":"Origins of chromosome translocations in childhood leukaemia","volume":"3","author":"Greaves","year":"2003","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2019.05.014_bib24","doi-asserted-by":"crossref","first-page":"380","DOI":"10.4049\/jimmunol.149.2.380","article-title":"Identification and distribution of the costimulatory receptor CD28 in the mouse","volume":"149","author":"Gross","year":"1992","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2019.05.014_bib25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.ccr.2006.01.004","article-title":"Block of T\u00a0cell development in P53-deficient mice accelerates development of lymphomas with characteristic RAG-dependent cytogenetic alterations","volume":"9","author":"Haines","year":"2006","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2019.05.014_bib26","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1146\/annurev-immunol-030409-101320","article-title":"The response to and repair of RAG-mediated DNA double-strand breaks","volume":"30","author":"Helmink","year":"2012","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2019.05.014_bib27","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1101\/gr.113555.110","article-title":"Comprehensive long-span paired-end-tag mapping reveals characteristic patterns of structural variations in epithelial cancer genomes","volume":"21","author":"Hillmer","year":"2011","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2019.05.014_bib28","doi-asserted-by":"crossref","first-page":"10269","DOI":"10.1073\/pnas.1410112111","article-title":"Developmental propagation of V(D)J recombination-associated DNA breaks and translocations in mature B cells via dicentric chromosomes","volume":"111","author":"Hu","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.05.014_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0960-9822(00)00002-6","article-title":"Tumor spectrum analysis in p53-mutant mice","volume":"4","author":"Jacks","year":"1994","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2019.05.014_bib30","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.05.014_bib31","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2019.05.014_bib32","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.cell.2013.02.023","article-title":"Criteria for inference of chromothripsis in cancer genomes","volume":"152","author":"Korbel","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.05.014_bib33","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1101\/gr.092759.109","article-title":"Circos: an information aesthetic for comparative genomics","volume":"19","author":"Krzywinski","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2019.05.014_bib34","doi-asserted-by":"crossref","first-page":"10529","DOI":"10.1038\/ncomms10529","article-title":"RAG2 and XLF\/Cernunnos interplay reveals a novel role for the RAG complex in DNA repair","volume":"7","author":"Lescale","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2019.05.014_bib35","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","article-title":"Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia","volume":"368","author":"Ley","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2019.05.014_bib36","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2019.05.014_bib37","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nature13115","article-title":"Constitutional and somatic rearrangement of chromosome 21 in acute lymphoblastic leukaemia","volume":"508","author":"Li","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.05.014_bib38","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1128\/MCB.18.6.3495","article-title":"No requirement for V(D)J recombination in p53-deficient thymic lymphoma","volume":"18","author":"Liao","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2019.05.014_bib39","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.4161\/cbt.8.13.8924","article-title":"MLL fusions: pathways to leukemia","volume":"8","author":"Liu","year":"2009","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.celrep.2019.05.014_bib40","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2019.05.014_bib41","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/j.cell.2015.11.054","article-title":"Chromothripsis and Kataegis Induced by Telomere Crisis","volume":"163","author":"Maciejowski","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.05.014_bib42","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.dnarep.2006.05.015","article-title":"Recombinase, chromosomal translocations and lymphoid neoplasia: targeting mistakes and repair failures","volume":"5","author":"Marculescu","year":"2006","journal-title":"DNA Repair (Amst.)"},{"key":"10.1016\/j.celrep.2019.05.014_bib43","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nature13317","article-title":"Cell competition is a tumour suppressor mechanism in the thymus","volume":"509","author":"Martins","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.05.014_bib44","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1101\/gr.107524.110","article-title":"The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data","volume":"20","author":"McKenna","year":"2010","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2019.05.014_bib45","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/j.celrep.2015.08.034","article-title":"Off-Target V(D)J Recombination Drives Lymphomagenesis and Is Escalated by Loss of the Rag2 C Terminus","volume":"12","author":"Miju\u0161kovi\u0107","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2019.05.014_bib46","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1073\/pnas.0511259103","article-title":"53BP1 and p53 synergize to suppress genomic instability and lymphomagenesis","volume":"103","author":"Morales","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.05.014_bib47","first-page":"131","article-title":"V(D)J recombination is not required for the\u00a0development of lymphoma in p53-deficient mice","volume":"9","author":"Nacht","year":"1998","journal-title":"Cell Growth Differ."},{"key":"10.1016\/j.celrep.2019.05.014_bib48","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/gcc.21942","article-title":"Illegitimate V(D)J recombination involving nonantigen receptor loci in lymphoid malignancy","volume":"51","author":"Onozawa","year":"2012","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.celrep.2019.05.014_bib49","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature02355","article-title":"A non-B-DNA structure at the Bcl-2 major breakpoint region is cleaved by the RAG complex","volume":"428","author":"Raghavan","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.05.014_bib50","doi-asserted-by":"crossref","first-page":"i333","DOI":"10.1093\/bioinformatics\/bts378","article-title":"DELLY: structural variant discovery by integrated paired-end and split-read analysis","volume":"28","author":"Rausch","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2019.05.014_bib51","doi-asserted-by":"crossref","DOI":"10.1128\/microbiolspec.MDNA3-0041-2014","article-title":"V(D)J Recombination: Mechanism, Errors, and Fidelity","volume":"2","author":"Roth","year":"2014","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.celrep.2019.05.014_bib52","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev-genet-110410-132552","article-title":"V(D)J recombination: mechanisms of initiation","volume":"45","author":"Schatz","year":"2011","journal-title":"Annu. Rev. Genet."},{"key":"10.1016\/j.celrep.2019.05.014_bib53","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1093\/bioinformatics\/btt767","article-title":"Socrates: identification of genomic rearrangements in tumour genomes by re-aligning soft clipped reads","volume":"30","author":"Schr\u00f6der","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2019.05.014_bib54","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1006\/scbi.1999.0126","article-title":"Oncogene amplification in solid tumors","volume":"9","author":"Schwab","year":"1999","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.celrep.2019.05.014_bib55","doi-asserted-by":"crossref","first-page":"2258","DOI":"10.1073\/pnas.1525564113","article-title":"Transcription-associated processes cause DNA double-strand breaks and translocations in neural stem\/progenitor cells","volume":"113","author":"Schwer","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.05.014_bib56","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/0092-8674(92)90029-C","article-title":"RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement","volume":"68","author":"Shinkai","year":"1992","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.05.014_bib57","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/1471-2105-8-82","article-title":"Cinteny: flexible analysis and visualization of synteny and genome rearrangements in multiple organisms","volume":"8","author":"Sinha","year":"2007","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.celrep.2019.05.014_bib58","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/nature08645","article-title":"Complex landscapes of somatic rearrangement in human breast cancer genomes","volume":"462","author":"Stephens","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.05.014_bib59","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/nature07943","article-title":"The cancer genome","volume":"458","author":"Stratton","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.05.014_bib60","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.cell.2008.10.035","article-title":"Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity","volume":"135","author":"Tsai","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.05.014_bib61","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.cell.2017.01.002","article-title":"Endogenous DNA Damage as a Source of Genomic Instability in Cancer","volume":"168","author":"Tubbs","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.05.014_bib62","doi-asserted-by":"crossref","first-page":"e0157022","DOI":"10.1371\/journal.pone.0157022","article-title":"SARTools: A DESeq2- and EdgeR-Based R Pipeline for Comprehensive Differential Analysis of RNA-Seq Data","volume":"11","author":"Varet","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2019.05.014_bib63","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.cell.2013.04.010","article-title":"Diverse mechanisms of somatic structural variations in human cancer genomes","volume":"153","author":"Yang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.05.014_bib64","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/nrg3317","article-title":"Evolution of the cancer genome","volume":"13","author":"Yates","year":"2012","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.celrep.2019.05.014_bib65","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1177\/1535370213480717","article-title":"Mixed lineage leukemia protein in normal and leukemic stem cells","volume":"238","author":"Yip","year":"2013","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.celrep.2019.05.014_bib66","doi-asserted-by":"crossref","first-page":"e300","DOI":"10.3324\/haematol.2016.161406","article-title":"Amplification of mixed lineage leukemia gene perturbs hematopoiesis and cooperates with partial tandem duplication to induce acute myeloid leukemia","volume":"102","author":"Yip","year":"2017","journal-title":"Haematologica"},{"key":"10.1016\/j.celrep.2019.05.014_bib67","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0888-7543(89)90090-6","article-title":"Gene order, amplification, and rearrangement of chromosome band 11q23 in hematologic malignancies","volume":"5","author":"Yunis","year":"1989","journal-title":"Genomics"},{"key":"10.1016\/j.celrep.2019.05.014_bib68","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/gcc.20658","article-title":"AML\/MDS with 11q\/MLL amplification show characteristic gene expression signature and interplay of DNA copy number changes","volume":"48","author":"Zatkova","year":"2009","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.celrep.2019.05.014_bib69","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.ccr.2012.10.017","article-title":"SnapShot: Acute myeloid leukemia","volume":"22","author":"Zeisig","year":"2012","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2019.05.014_bib70","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1093\/bioinformatics\/btq293","article-title":"SVDetect: a tool to identify genomic structural variations from paired-end and mate-pair sequencing data","volume":"26","author":"Zeitouni","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2019.05.014_bib71","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1084\/jem.20100285","article-title":"ATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification","volume":"207","author":"Zha","year":"2010","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2019.05.014_bib72","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.immuni.2011.02.003","article-title":"Coupling of V(D)J recombination to the cell cycle suppresses genomic instability and lymphoid tumorigenesis","volume":"34","author":"Zhang","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2019.05.014_bib73","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0092-8674(02)00770-5","article-title":"Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations","volume":"109","author":"Zhu","year":"2002","journal-title":"Cell"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719306254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719306254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:38:59Z","timestamp":1761907139000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124719306254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":73,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S2211124719306254"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2019.05.014","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Breakage-Fusion-Bridge Events Trigger Complex Genome Rearrangements and Amplifications in Developmentally Arrested T Cell Lymphomas","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2019.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors.","name":"copyright","label":"Copyright"}]}}