{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:55:05Z","timestamp":1792277705219,"version":"4.4.0"},"reference-count":63,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004721","name":"University of Tokyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16KK0206"],"award-info":[{"award-number":["JP16KK0206"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP26461428"],"award-info":[{"award-number":["JP26461428"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K08437"],"award-info":[{"award-number":["JP18K08437"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K19580"],"award-info":[{"award-number":["JP16K19580"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16H06277"],"award-info":[{"award-number":["JP16H06277"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP17K09016"],"award-info":[{"award-number":["JP17K09016"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18K16122"],"award-info":[{"award-number":["JP18K16122"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP18KK0230"],"award-info":[{"award-number":["JP18KK0230"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004095","name":"Kyowa Hakko Kirin","doi-asserted-by":"publisher","award":["6430082"],"award-info":[{"award-number":["6430082"]}],"id":[{"id":"10.13039\/501100004095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004095","name":"Kyowa Hakko Kirin","doi-asserted-by":"publisher","award":["5552630"],"award-info":[{"award-number":["5552630"]}],"id":[{"id":"10.13039\/501100004095","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004091","name":"Kumamoto University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004091","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19fm0208012"],"award-info":[{"award-number":["JP19fm0208012"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP16ek0109026"],"award-info":[{"award-number":["JP16ek0109026"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP17ek0109083"],"award-info":[{"award-number":["JP17ek0109083"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18ek0109346"],"award-info":[{"award-number":["JP18ek0109346"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.celrep.2019.09.016","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T10:37:46Z","timestamp":1571135866000},"page":"724-735.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":89,"title":["The Nature of the HTLV-1 Provirus in Naturally Infected Individuals Analyzed by the Viral DNA-Capture-Seq Approach"],"prefix":"10.1016","volume":"29","author":[{"given":"Hiroo","family":"Katsuya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saiful","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjy Jek Yang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jumpei","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Miyazato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misaki","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Inada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori C.","family":"Iwase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Uchiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Hata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoo","family":"Sato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Yagishita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsumi","family":"Araya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takaharu","family":"Ueno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kisato","family":"Nosaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahito","family":"Tokunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Yamagishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Uchimaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atae","family":"Utsunomiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihisa","family":"Yamano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1495-7810","authenticated-orcid":false,"given":"Yorifumi","family":"Satou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2019.09.016_bib1","doi-asserted-by":"crossref","first-page":"20160272","DOI":"10.1098\/rstb.2016.0272","article-title":"Human T-cell leukaemia virus type 1: parasitism and pathogenesis","volume":"372","author":"Bangham","year":"2017","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.celrep.2019.09.016_bib2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/bioinformatics\/bts004","article-title":"Estimating abundances of retroviral insertion sites from DNA fragment length data","volume":"28","author":"Berry","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2019.09.016_bib3","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nature21386","article-title":"Integrated genomic and molecular characterization of cervical cancer","volume":"543","author":"Helen F. Graham Cancer Center &Research Institute at Christiana Care Health Services","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.09.016_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.09.016_bib5","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1128\/jvi.64.3.1278-1282.1990","article-title":"Sequence variants of human T-cell lymphotropic virus type I from patients with tropical spastic paraparesis and adult T-cell leukemia do not distinguish neurological from leukemic isolates","volume":"64","author":"Daenke","year":"1990","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2019.09.016_bib6","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2019.09.016_bib7","doi-asserted-by":"crossref","first-page":"7278","DOI":"10.1128\/JVI.02239-09","article-title":"APOBEC3G generates nonsense mutations in human T-cell leukemia virus type 1 proviral genomes in\u00a0vivo","volume":"84","author":"Fan","year":"2010","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2019.09.016_bib8","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1126\/science.2992082","article-title":"The pX protein of HTLV-I is a transcriptional activator of its long terminal repeats","volume":"229","author":"Felber","year":"1985","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.09.016_bib9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/gm568","article-title":"Development and validation of a new high-throughput method to investigate the clonality of HTLV-1-infected cells based on provirus integration sites","volume":"6","author":"Firouzi","year":"2014","journal-title":"Genome Med."},{"key":"10.1016\/j.celrep.2019.09.016_bib10","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1182\/blood-2015-08-662593","article-title":"Polycomb-dependent epigenetic landscape in adult T-cell leukemia","volume":"127","author":"Fujikawa","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2019.09.016_bib11","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/ng.2291","article-title":"Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators","volume":"44","author":"Fujimoto","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2019.09.016_bib12","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1086\/315897","article-title":"Phylogenetic subgroups of human T\u00a0cell lymphotropic virus (HTLV) type I in the tax gene and their association with different risks for HTLV-I-associated myelopathy\/tropical spastic paraparesis","volume":"182","author":"Furukawa","year":"2000","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2019.09.016_bib13","doi-asserted-by":"crossref","first-page":"e1006722","DOI":"10.1371\/journal.ppat.1006722","article-title":"Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in\u00a0vivo","volume":"13","author":"Furuta","year":"2017","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2019.09.016_bib14","doi-asserted-by":"crossref","first-page":"12813","DOI":"10.1128\/JVI.76.24.12813-12822.2002","article-title":"The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription","volume":"76","author":"Gaudray","year":"2002","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2019.09.016_bib15","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3389\/fmicb.2012.00388","article-title":"Epidemiological Aspects and World Distribution of HTLV-1 Infection","volume":"3","author":"Gessain","year":"2012","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.celrep.2019.09.016_bib16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(85)92734-5","article-title":"Antibodies to human T-lymphotropic virus type-I in patients with tropical spastic paraparesis","volume":"2","author":"Gessain","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2019.09.016_bib17","doi-asserted-by":"crossref","first-page":"3113","DOI":"10.1182\/blood-2010-10-312926","article-title":"The host genomic environment of the provirus determines the abundance of HTLV-1-infected T-cell clones","volume":"117","author":"Gillet","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2019.09.016_bib18","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1073\/pnas.92.4.1057","article-title":"Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I","volume":"92","author":"Grossman","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.09.016_bib19","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1158\/0008-5472.CAN-03-1452","article-title":"Graft-versus-Tax response in adult T-cell leukemia patients after hematopoietic stem cell transplantation","volume":"64","author":"Harashima","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2019.09.016_bib20","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/nm1389","article-title":"Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I","volume":"12","author":"Hasegawa","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2019.09.016_bib21","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/ng.3178","article-title":"Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism","volume":"47","author":"Hu","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2019.09.016_bib22","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1200\/JCO.2016.67.7732","article-title":"Multicenter Phase II Study of Lenalidomide in Relapsed or Recurrent Adult T-Cell Leukemia\/Lymphoma: ATLL-002","volume":"34","author":"Ishida","year":"2016","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.celrep.2019.09.016_bib23","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1111\/cas.13343","article-title":"Mogamulizumab for relapsed adult T-cell leukemia-lymphoma: Updated follow-up analysis of phase I and II studies","volume":"108","author":"Ishida","year":"2017","journal-title":"Cancer Sci."},{"key":"10.1016\/j.celrep.2019.09.016_bib24","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/intimm\/3.8.761","article-title":"Predominant recognition of human T\u00a0cell leukemia virus type I (HTLV-I) pX gene products by human CD8+ cytotoxic T\u00a0cells directed against HTLV-I-infected cells","volume":"3","author":"Kannagi","year":"1991","journal-title":"Int. Immunol."},{"key":"10.1016\/j.celrep.2019.09.016_bib25","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1038\/ng.3415","article-title":"Integrated molecular analysis of adult T\u00a0cell leukemia\/lymphoma","volume":"47","author":"Kataoka","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2019.09.016_bib26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1182\/blood-2017-01-761874","article-title":"Prognostic relevance of integrated genetic profiling in adult T-cell leukemia\/lymphoma","volume":"131","author":"Kataoka","year":"2018","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2019.09.016_bib27","doi-asserted-by":"crossref","first-page":"2570","DOI":"10.1182\/blood-2015-03-632489","article-title":"Treatment and survival among 1594 patients with ATL","volume":"126","author":"Katsuya","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2019.09.016_bib28","first-page":"273","article-title":"Defective human T-cell leukemia virus in adult T-cell leukemia patients","volume":"2","author":"Konishi","year":"1984","journal-title":"Mol. Biol. Med."},{"key":"10.1016\/j.celrep.2019.09.016_bib29","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1093\/molbev\/msw054","article-title":"MEGA7: Molecular Evolutionary Genetics Analysis Version 7.0 for Bigger Datasets","volume":"33","author":"Kumar","year":"2016","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.celrep.2019.09.016_bib30","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows-Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2019.09.016_bib31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12977-016-0249-x","article-title":"Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis","volume":"13","author":"Ma","year":"2016","journal-title":"Retrovirology"},{"key":"10.1016\/j.celrep.2019.09.016_bib32","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1084\/jem.162.6.2169","article-title":"Origin of human T-lymphotrophic virus I-positive T\u00a0cell lines in adult T\u00a0cell leukemia. Analysis of T\u00a0cell receptor gene rearrangement","volume":"162","author":"Maeda","year":"1985","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2019.09.016_bib33","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1073\/pnas.80.6.1574","article-title":"Human T-cell leukemia-lymphoma virus (HTLV): cloning of an integrated defective provirus and flanking cellular sequences","volume":"80","author":"Manzari","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.09.016_bib34","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.1630","article-title":"GREAT improves functional interpretation of cis-regulatory regions","volume":"28","author":"McLean","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2019.09.016_bib35","doi-asserted-by":"crossref","first-page":"e1000027","DOI":"10.1371\/journal.ppat.1000027","article-title":"HTLV-1 integration into transcriptionally active genomic regions is associated with proviral expression and with HAM\/TSP","volume":"4","author":"Meekings","year":"2008","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2019.09.016_bib36","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1128\/JVI.02660-06","article-title":"Phenotypic and genotypic comparisons of human T-cell leukemia virus type 1 reverse transcriptases from infected T-cell lines and patient samples","volume":"81","author":"Mitchell","year":"2007","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2019.09.016_bib37","doi-asserted-by":"crossref","first-page":"5714","DOI":"10.1128\/JVI.02511-06","article-title":"Preferential selection of human T-cell leukemia virus type 1 provirus lacking the 5\u2032 long terminal repeat during oncogenesis","volume":"81","author":"Miyazaki","year":"2007","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2019.09.016_bib38","doi-asserted-by":"crossref","first-page":"28324","DOI":"10.1038\/srep28324","article-title":"Application of targeted enrichment to next-generation sequencing of retroviruses integrated into the host human genome","volume":"6","author":"Miyazato","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2019.09.016_bib39","first-page":"1043","article-title":"Increasing methylation of the CDKN2A gene is associated with the progression of adult T-cell leukemia","volume":"60","author":"Nosaka","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2019.09.016_bib40","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12977-017-0350-9","article-title":"Effects of host restriction factors and the HTLV-1 subtype on susceptibility to HTLV-1-associated myelopathy\/tropical spastic paraparesis","volume":"14","author":"Nozuma","year":"2017","journal-title":"Retrovirology"},{"key":"10.1016\/j.celrep.2019.09.016_bib41","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0140-6736(86)91298-5","article-title":"HTLV-I associated myelopathy, a new clinical entity","volume":"1","author":"Osame","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2019.09.016_bib42","doi-asserted-by":"crossref","first-page":"e609","DOI":"10.1016\/S2214-109X(16)30143-7","article-title":"Global burden of cancers attributable to infections in 2012: a synthetic analysis","volume":"4","author":"Plummer","year":"2016","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.celrep.2019.09.016_bib43","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1073\/pnas.77.12.7415","article-title":"Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma","volume":"77","author":"Poiesz","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.09.016_bib44","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2019.09.016_bib45","doi-asserted-by":"crossref","first-page":"15264","DOI":"10.1038\/ncomms15264","article-title":"Cis-perturbation of cancer drivers by the HTLV-1\/BLV proviruses is an early determinant of leukemogenesis","volume":"8","author":"Rosewick","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2019.09.016_bib46","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1073\/pnas.0507631103","article-title":"HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T\u00a0cell leukemia cells","volume":"103","author":"Satou","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.09.016_bib47","doi-asserted-by":"crossref","first-page":"e1001274","DOI":"10.1371\/journal.ppat.1001274","article-title":"HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in\u00a0vivo","volume":"7","author":"Satou","year":"2011","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2019.09.016_bib48","doi-asserted-by":"crossref","first-page":"3054","DOI":"10.1073\/pnas.1423199113","article-title":"The retrovirus HTLV-1 inserts an ectopic CTCF-binding site into the human genome","volume":"113","author":"Satou","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.09.016_bib49","doi-asserted-by":"crossref","first-page":"6913","DOI":"10.1038\/s41598-017-07307-4","article-title":"Dynamics and mechanisms of clonal expansion of HIV-1-infected cells in a humanized mouse model","volume":"7","author":"Satou","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2019.09.016_bib50","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1073\/pnas.80.12.3618","article-title":"Human adult T-cell leukemia virus: complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA","volume":"80","author":"Seiki","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.09.016_bib51","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-2141.1991.tb08051.x","article-title":"Diagnostic criteria and classification of clinical subtypes of adult T-cell leukaemia-lymphoma. A report from the Lymphoma Study Group (1984-87)","volume":"79","author":"Shimoyama","year":"1991","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.celrep.2019.09.016_bib52","doi-asserted-by":"crossref","first-page":"e55943","DOI":"10.1371\/journal.pone.0055943","article-title":"Highly precise measurement of HIV DNA by droplet digital PCR","volume":"8","author":"Strain","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2019.09.016_bib53","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1111\/bjh.13302","article-title":"Clinical outcomes of a novel therapeutic vaccine with Tax peptide-pulsed dendritic cells for adult T\u00a0cell leukaemia\/lymphoma in a pilot study","volume":"169","author":"Suehiro","year":"2015","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.celrep.2019.09.016_bib54","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/ng.2295","article-title":"Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma","volume":"44","author":"Sung","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2019.09.016_bib55","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1182\/blood.V84.9.3080.3080","article-title":"A novel diagnostic method of adult T-cell leukemia: monoclonal integration of human T-cell lymphotropic virus type I provirus DNA detected by inverse polymerase chain reaction","volume":"84","author":"Takemoto","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2019.09.016_bib56","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1182\/blood.V88.8.3065.bloodjournal8883065","article-title":"Two types of defective human T-lymphotropic virus type I provirus in adult T-cell leukemia","volume":"88","author":"Tamiya","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2019.09.016_bib57","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1182\/blood-2013-06-508861","article-title":"An animal model of adult T-cell leukemia: humanized mice with HTLV-1-specific immunity","volume":"123","author":"Tezuka","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2019.09.016_bib58","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1182\/blood.V50.3.481.481","article-title":"Adult T-cell leukemia: clinical and hematologic features of 16 cases","volume":"50","author":"Uchiyama","year":"1977","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2019.09.016_bib59","doi-asserted-by":"crossref","first-page":"2695","DOI":"10.1099\/0022-1317-79-11-2695","article-title":"Evidence for a post-Columbian introduction of human T-cell lymphotropic virus [type I] [corrected] in Latin America","volume":"79","author":"Van Dooren","year":"1998","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.celrep.2019.09.016_bib60","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1093\/molbev\/msh053","article-title":"The low evolutionary rate of human T-cell lymphotropic virus type-1 confirmed by analysis of vertical transmission chains","volume":"21","author":"Van Dooren","year":"2004","journal-title":"Mol. Biol. Evol."},{"key":"10.1016\/j.celrep.2019.09.016_bib61","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/S1473-3099(07)70081-6","article-title":"Human T-lymphotropic virus 1: recent knowledge about an ancient infection","volume":"7","author":"Verdonck","year":"2007","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.celrep.2019.09.016_bib62","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1099\/0022-1317-75-12-3655","article-title":"Phylogenetic classification of human T\u00a0cell leukaemia\/lymphoma virus type I genotypes in five major molecular and geographical subtypes","volume":"75","author":"Vidal","year":"1994","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.celrep.2019.09.016_bib63","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0925-5710(97)00077-7","article-title":"HTLV-1-associated diseases","volume":"66","author":"Watanabe","year":"1997","journal-title":"Int. J. Hematol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719311933?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719311933?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:33:30Z","timestamp":1778841210000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124719311933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":63,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S2211124719311933"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2019.09.016","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Nature of the HTLV-1 Provirus in Naturally Infected Individuals Analyzed by the Viral DNA-Capture-Seq Approach","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2019.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors.","name":"copyright","label":"Copyright"}]}}