{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:30:42Z","timestamp":1789648242633,"version":"4.0.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T00:00:00Z","timestamp":1569196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001674","name":"Fondation Leducq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001674","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.celrep.2019.09.063","type":"journal-article","created":{"date-parts":[[2019,11,3]],"date-time":"2019-11-03T08:51:38Z","timestamp":1572771098000},"page":"1274-1286.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":101,"title":["Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1"],"prefix":"10.1016","volume":"29","author":[{"given":"Valentina","family":"Debattisti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Horn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghavendra","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin L.","family":"Seifert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marshall W.","family":"Hogarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davi A.","family":"Mazala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai Ting","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Horvath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti K.","family":"Jaiswal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"Hajn\u00f3czky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2019.09.063_bib1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.bbabio.2008.03.026","article-title":"Altered threshold of the mitochondrial permeability transition pore in Ullrich congenital muscular dystrophy","volume":"1777","author":"Angelin","year":"2008","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2019.09.063_bib2","doi-asserted-by":"crossref","first-page":"10955","DOI":"10.1038\/ncomms10955","article-title":"MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration","volume":"7","author":"Antony","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2019.09.063_bib3","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/nature01573","article-title":"Defective membrane repair in dysferlin-deficient muscular dystrophy","volume":"423","author":"Bansal","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.09.063_bib4","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nature10234","article-title":"Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter","volume":"476","author":"Baughman","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.09.063_bib5","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.bbamcr.2017.01.015","article-title":"Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics","volume":"1864","author":"Bhosale","year":"2017","journal-title":"Biochim Biophys Acta Mol Cell Res"},{"key":"10.1016\/j.celrep.2019.09.063_bib6","doi-asserted-by":"crossref","first-page":"21996","DOI":"10.1073\/pnas.0911496106","article-title":"Characterization and temporal development of cores in a mouse model of malignant hyperthermia","volume":"106","author":"Boncompagni","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.09.063_bib7","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1085\/jgp.200910397","article-title":"IP(3)-dependent, post-tetanic calcium transients induced by electrostimulation of adult skeletal muscle fibers","volume":"136","author":"Casas","year":"2010","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.celrep.2019.09.063_bib8","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1177\/1073858414558336","article-title":"Membrane Injury and Repair in the Muscular Dystrophies","volume":"21","author":"Cooper","year":"2015","journal-title":"Neuroscientist"},{"key":"10.1016\/j.celrep.2019.09.063_bib9","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.cmet.2013.04.020","article-title":"MICU1 controls both the threshold and cooperative activation of the mitochondrial Ca2+ uniporter","volume":"17","author":"Csord\u00e1s","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2019.09.063_bib10","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature10230","article-title":"A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter","volume":"476","author":"De Stefani","year":"2011","journal-title":"Nature"},{"issue":"85","key":"10.1016\/j.celrep.2019.09.063_bib11","article-title":"Imaging cell membrane injury and subcellular processes involved in repair","author":"Defour","year":"2014","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.celrep.2019.09.063_bib12","doi-asserted-by":"crossref","first-page":"e1306","DOI":"10.1038\/cddis.2014.272","article-title":"Dysferlin regulates cell membrane repair by facilitating injury-triggered acid sphingomyelinase secretion","volume":"5","author":"Defour","year":"2014","journal-title":"Cell Death Dis."},{"issue":"32","key":"10.1016\/j.celrep.2019.09.063_bib13","first-page":"1520","article-title":"DNA transfection of mammalian skeletal muscles using in\u00a0vivo electroporation","author":"DiFranco","year":"2009","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.celrep.2019.09.063_bib14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.cell.2008.02.042","article-title":"RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice","volume":"133","author":"Durham","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.09.063_bib15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.molmet.2013.10.005","article-title":"Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock","volume":"3","author":"Dyar","year":"2013","journal-title":"Mol. Metab."},{"key":"10.1016\/j.celrep.2019.09.063_bib16","first-page":"2965","article-title":"Interactions between sarco-endoplasmic reticulum and mitochondria in cardiac and skeletal muscle - pivotal roles in Ca2+ and reactive oxygen species signaling","volume":"126","author":"Eisner","year":"2013","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.celrep.2019.09.063_bib17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1083\/jcb.201312066","article-title":"Mitochondrial fusion is frequent in skeletal muscle and supports excitation-contraction coupling","volume":"205","author":"Eisner","year":"2014","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2019.09.063_bib18","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/ncomms2325","article-title":"Activity of the mitochondrial calcium uniporter varies greatly between tissues","volume":"3","author":"Fieni","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2019.09.063_bib19","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1085\/jgp.201711889","article-title":"The relationship between form and function throughout the history of excitation-contraction coupling","volume":"150","author":"Franzini-Armstrong","year":"2018","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.celrep.2019.09.063_bib20","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/s41418-018-0191-7","article-title":"Loss of mitochondrial calcium uniporter rewires skeletal muscle metabolism and substrate preference","volume":"26","author":"Gherardi","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2019.09.063_bib21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1006\/mthe.2000.0089","article-title":"Analysis of muscle creatine kinase regulatory elements in recombinant adenoviral vectors","volume":"2","author":"Hauser","year":"2000","journal-title":"Mol. Ther."},{"key":"10.1016\/j.celrep.2019.09.063_bib22","doi-asserted-by":"crossref","first-page":"420","DOI":"10.3389\/fphys.2015.00420","article-title":"Critical Role of Intracellular RyR1 Calcium Release Channels in Skeletal Muscle Function and Disease","volume":"6","author":"Hern\u00e1ndez-Ochoa","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.celrep.2019.09.063_bib23","doi-asserted-by":"crossref","first-page":"eaaj1978","DOI":"10.1126\/scisignal.aaj1978","article-title":"Mitochondrial redox signaling enables repair of injured skeletal muscle cells","volume":"10","author":"Horn","year":"2017","journal-title":"Sci. Signal."},{"key":"10.1016\/j.celrep.2019.09.063_bib24","doi-asserted-by":"crossref","first-page":"13807","DOI":"10.1073\/pnas.96.24.13807","article-title":"Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming","volume":"96","author":"Jouaville","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.09.063_bib25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1002\/embr.201337946","article-title":"MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter","volume":"15","author":"Kamer","year":"2014","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2019.09.063_bib26","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.4081\/ejh.2014.2254","article-title":"A simplified immunohistochemical classification of skeletal muscle fibres in mouse","volume":"58","author":"Kammoun","year":"2014","journal-title":"Eur. J. Histochem."},{"key":"10.1016\/j.celrep.2019.09.063_bib27","doi-asserted-by":"crossref","first-page":"121689","DOI":"10.1172\/jci.insight.121689","article-title":"The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle","volume":"3","author":"Kwong","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2019.09.063_bib28","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1212\/NXG.0000000000000059","article-title":"Homozygous deletion in MICU1 presenting with fatigue and lethargy in childhood","volume":"2","author":"Lewis-Smith","year":"2016","journal-title":"Neurol. Genet."},{"key":"10.1016\/j.celrep.2019.09.063_bib29","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/j.celrep.2016.07.011","article-title":"MICU1 Serves as a Molecular Gatekeeper to Prevent In\u00a0Vivo Mitochondrial Calcium Overload","volume":"16","author":"Liu","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2019.09.063_bib30","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/ng.2851","article-title":"Loss-of-function mutations in MICU1 cause a brain and muscle disorder linked to primary alterations in mitochondrial calcium signaling","volume":"46","author":"Logan","year":"2014","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2019.09.063_bib31","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.cell.2012.10.011","article-title":"MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival","volume":"151","author":"Mallilankaraman","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.09.063_bib32","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.celrep.2015.01.056","article-title":"The mitochondrial calcium uniporter controls skeletal muscle trophism in\u00a0vivo","volume":"10","author":"Mammucari","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2019.09.063_bib33","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/mus.880120703","article-title":"Accumulation of collagen and altered fiber-type ratios as indicators of abnormal muscle gene expression in the mdx dystrophic mouse","volume":"12","author":"Marshall","year":"1989","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.celrep.2019.09.063_bib34","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1242\/dmm.018424","article-title":"Animal models of Duchenne muscular dystrophy: from basic mechanisms to gene therapy","volume":"8","author":"McGreevy","year":"2015","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.celrep.2019.09.063_bib35","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.bbrc.2014.04.144","article-title":"Unresolved questions from the analysis of mice lacking MCU expression","volume":"449","author":"Murphy","year":"2014","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2019.09.063_bib36","first-page":"79","article-title":"A Middle Eastern Founder Mutation Expands the Genotypic and Phenotypic Spectrum of Mitochondrial MICU1 Deficiency: A Report of 13 Patients","volume":"43","author":"Musa","year":"2019","journal-title":"JIMD Rep."},{"key":"10.1016\/j.celrep.2019.09.063_bib37","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1016\/j.celrep.2017.02.032","article-title":"Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca2+ Signals Is Controlled by the Stoichiometry of MICU1\/2 and MCU","volume":"18","author":"Paillard","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2019.09.063_bib38","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1038\/ncb2868","article-title":"The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter","volume":"15","author":"Pan","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2019.09.063_bib39","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.molcel.2014.01.013","article-title":"MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity","volume":"53","author":"Patron","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2019.09.063_bib40","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1006\/bbrc.1999.0213","article-title":"Early decrease of IIx myosin heavy chain transcripts in Duchenne muscular dystrophy","volume":"255","author":"Pedemonte","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2019.09.063_bib41","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nature09358","article-title":"MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake","volume":"467","author":"Perocchi","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.09.063_bib42","doi-asserted-by":"crossref","first-page":"e55785","DOI":"10.1371\/journal.pone.0055785","article-title":"MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling","volume":"8","author":"Plovanich","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2019.09.063_bib43","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1038\/emboj.2013.157","article-title":"The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit","volume":"32","author":"Raffaello","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2019.09.063_bib44","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1074\/mcp.M112.023127","article-title":"Identification of disease specific pathways using in\u00a0vivo SILAC proteomics in dystrophin deficient mdx mouse","volume":"12","author":"Rayavarapu","year":"2013","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.celrep.2019.09.063_bib45","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1083\/jcb.200403102","article-title":"In\u00a0vivo monitoring of Ca(2+) uptake into mitochondria of mouse skeletal muscle during contraction","volume":"166","author":"Rudolf","year":"2004","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2019.09.063_bib46","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1126\/science.1242993","article-title":"EMRE is an essential component of the mitochondrial calcium uniporter complex","volume":"342","author":"Sancak","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.09.063_bib47","doi-asserted-by":"crossref","first-page":"25124","DOI":"10.1074\/jbc.M803871200","article-title":"Essential role for uncoupling protein-3 in mitochondrial adaptation to fasting but not in fatty acid oxidation or fatty acid anion export","volume":"283","author":"Seifert","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2019.09.063_bib48","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1093\/brain\/awx237","article-title":"A null mutation in MICU2 causes abnormal mitochondrial calcium homeostasis and a severe neurodevelopmental disorder","volume":"140","author":"Shamseldin","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2019.09.063_bib49","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/mus.21211","article-title":"Preclinical drug trials in the mdx mouse: assessment of reliable and sensitive outcome measures","volume":"39","author":"Spurney","year":"2009","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.celrep.2019.09.063_bib50","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1111\/j.1476-5381.2009.00316.x","article-title":"The cyclophilin inhibitor Debio 025 normalizes mitochondrial function, muscle apoptosis and ultrastructural defects in Col6a1-\/- myopathic mice","volume":"157","author":"Tiepolo","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.celrep.2019.09.063_bib51","doi-asserted-by":"crossref","first-page":"4388","DOI":"10.1073\/pnas.1702938114","article-title":"Proteolytic control of the mitochondrial calcium uniporter complex","volume":"114","author":"Tsai","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.09.063_bib52","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.molcel.2016.10.001","article-title":"A MICU1 Splice Variant Confers High Sensitivity to the Mitochondrial Ca2+ Uptake Machinery of Skeletal Muscle","volume":"64","author":"Vecellio Reane","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2019.09.063_bib53","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/cdd.2016.127","article-title":"Mitochondria mediate cell membrane repair and contribute to Duchenne muscular dystrophy","volume":"24","author":"Vila","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2019.09.063_bib54","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/embj.201386523","article-title":"Structural and mechanistic insights into MICU1 regulation of mitochondrial calcium uptake","volume":"33","author":"Wang","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2019.09.063_bib55","doi-asserted-by":"crossref","first-page":"25722","DOI":"10.1074\/jbc.M302165200","article-title":"Functional defects in six ryanodine receptor isoform-1 (RyR1) mutations associated with malignant hyperthermia and their impact on skeletal excitation-contraction coupling","volume":"278","author":"Yang","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2019.09.063_bib56","doi-asserted-by":"crossref","first-page":"e13005","DOI":"10.14814\/phy2.13005","article-title":"Physical exercise in aging human skeletal muscle increases mitochondrial calcium uniporter expression levels and affects mitochondria dynamics","volume":"4","author":"Zampieri","year":"2016","journal-title":"Physiol. Rep."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719312604?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719312604?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:46:03Z","timestamp":1761907563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124719312604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":56,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["S2211124719312604"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2019.09.063","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulation of Mitochondrial Ca2+ Uptake and Sarcolemma Repair Underlie Muscle Weakness and Wasting in Patients and Mice Lacking MICU1","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2019.09.063","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Authors.","name":"copyright","label":"Copyright"}]}}