{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:42:27Z","timestamp":1791362547117,"version":"4.3.1"},"reference-count":60,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2019,11]]},"DOI":"10.1016\/j.celrep.2019.10.056","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T10:45:10Z","timestamp":1574160310000},"page":"2123-2133.e4","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":102,"title":["Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer\u2019s Disease Mouse Model"],"prefix":"10.1016","volume":"29","author":[{"given":"Emily A.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna K.","family":"Gillespie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo Yeon","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loren M.","family":"Frank","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2019.10.056_bib1","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1002\/cne.1099","article-title":"Hippocampal dependent learning ability correlates with N-methyl-D-aspartate (NMDA) receptor levels in CA3 neurons of young and aged rats","volume":"432","author":"Adams","year":"2001","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.celrep.2019.10.056_bib2","doi-asserted-by":"crossref","first-page":"13707","DOI":"10.1523\/JNEUROSCI.4040-10.2010","article-title":"Apolipoprotein E4 causes age- and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice","volume":"30","author":"Andrews-Zwilling","year":"2010","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2019.10.056_bib3","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0140-6736(10)61349-9","article-title":"Alzheimer\u2019s disease","volume":"377","author":"Ballard","year":"2011","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2019.10.056_bib4","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.neurobiolaging.2010.05.017","article-title":"Sex differences in the association of the apolipoprotein E epsilon 4 allele with incidence of dementia, cognitive impairment, and decline","volume":"33","author":"Beydoun","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.celrep.2019.10.056_bib5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fnagi.2013.00050","article-title":"Relation of neuropathology with cognitive decline among older persons without dementia","volume":"5","author":"Boyle","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.celrep.2019.10.056_bib6","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/0006-8993(86)91483-6","article-title":"Hippocampal sharp waves: their origin and significance","volume":"398","author":"Buzs\u00e1ki","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2019.10.056_bib7","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1002\/hipo.22488","article-title":"Hippocampal sharp wave-ripple: a cognitive biomarker for episodic memory and planning","volume":"25","author":"Buzs\u00e1ki","year":"2015","journal-title":"Hippocampus"},{"key":"10.1016\/j.celrep.2019.10.056_bib8","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.neuron.2012.06.014","article-title":"Transient slow gamma synchrony underlies hippocampal memory replay","volume":"75","author":"Carr","year":"2012","journal-title":"Neuron"},{"issue":"Suppl 1","key":"10.1016\/j.celrep.2019.10.056_bib9","first-page":"S405","article-title":"Characterizing the preclinical stages of Alzheimer\u2019s disease and the prospect of presymptomatic intervention","volume":"33","author":"Caselli","year":"2013","journal-title":"J.\u00a0Alzheimers Dis."},{"key":"10.1016\/j.celrep.2019.10.056_bib10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1056\/NEJMoa0809437","article-title":"Longitudinal modeling of age-related memory decline and the APOE \u03b54 effect","volume":"361","author":"Caselli","year":"2009","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2019.10.056_bib11","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.neuron.2007.11.035","article-title":"New experiences enhance coordinated neural activity in the hippocampus","volume":"57","author":"Cheng","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2019.10.056_bib12","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0165-0270(00)00288-0","article-title":"Passive and active place avoidance as a tool of spatial memory research in rats","volume":"102","author":"Cimadevilla","year":"2000","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.celrep.2019.10.056_bib13","doi-asserted-by":"crossref","first-page":"8118","DOI":"10.1523\/JNEUROSCI.3130-14.2015","article-title":"Progressive functional impairments of hippocampal neurons in a tauopathy mouse model","volume":"35","author":"Ciupek","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2019.10.056_bib14","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.10.056_bib15","article-title":"Age-associated changes in waking hippocampal sharp-wave ripples","author":"Cowen","year":"2018","journal-title":"Hippocampus"},{"key":"10.1016\/j.celrep.2019.10.056_bib16","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1212\/01.wnl.0000271376.19515.c6","article-title":"Spatial cognition and the human navigation network in AD and MCI","volume":"69","author":"deIpolyi","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2019.10.056_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/hipo.20707","article-title":"Disruption of ripple-associated hippocampal activity during rest impairs spatial learning in the rat","volume":"20","author":"Ego-Stengel","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.celrep.2019.10.056_bib18","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"key":"10.1016\/j.celrep.2019.10.056_bib19","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1126\/science.aax0758","article-title":"Long-duration hippocampal sharp wave ripples improve memory","volume":"364","author":"Fern\u00e1ndez-Ruiz","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.10.056_bib20","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.1523\/JNEUROSCI.1265-08.2008","article-title":"Sequence reactivation in the hippocampus is impaired in aged rats","volume":"28","author":"Gerrard","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2019.10.056_bib21","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.neuron.2016.04.009","article-title":"Apolipoprotein E4 causes age-dependent disruption of slow gamma oscillations during hippocampal sharp-wave ripples","volume":"90","author":"Gillespie","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2019.10.056_bib22","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1038\/nn.2384","article-title":"Selective suppression of hippocampal ripples impairs spatial memory","volume":"12","author":"Girardeau","year":"2009","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2019.10.056_bib23","first-page":"134","article-title":"Hippocampal oscillatory activity in Alzheimer\u2019s disease: toward the identification of early biomarkers?","volume":"4","author":"Goutagny","year":"2013","journal-title":"Aging Dis."},{"key":"10.1016\/j.celrep.2019.10.056_bib24","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1016\/j.neurobiolaging.2009.10.005","article-title":"Prominent hippocampal CA3 gene expression profile in neurocognitive aging","volume":"32","author":"Haberman","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.celrep.2019.10.056_bib25","doi-asserted-by":"crossref","first-page":"e83674","DOI":"10.1371\/journal.pone.0083674","article-title":"Behaviorally activated mRNA expression profiles produce signatures of learning and enhanced inhibition in aged rats with preserved memory","volume":"8","author":"Haberman","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2019.10.056_bib26","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.neurobiolaging.2016.12.021","article-title":"Heightened cortical excitability in aged rodents with memory impairment","volume":"54","author":"Haberman","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.celrep.2019.10.056_bib27","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1212\/WNL.0b013e31828726f5","article-title":"Alzheimer disease in the United States (2010\u20132050) estimated using the 2010 census","volume":"80","author":"Hebert","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2019.10.056_bib28","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","article-title":"Alzheimer mechanisms and therapeutic strategies","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.10.056_bib29","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature20587","article-title":"Gamma frequency entrainment attenuates amyloid load and modifies microglia","volume":"540","author":"Iaccarino","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.10.056_bib30","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1126\/science.1217230","article-title":"Awake hippocampal sharp-wave ripples support spatial memory","volume":"336","author":"Jadhav","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.10.056_bib31","article-title":"Longitudinal LFP recordings from female apoE3-KI and apoE4-KI mice at rest and subsequent spatial memory performance","author":"Jones","year":"2019","journal-title":"Collaborative Research in Computational Neuroscience"},{"key":"10.1016\/j.celrep.2019.10.056_bib32","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1038\/s41583-018-0077-1","article-title":"The hippocampal sharp wave-ripple in memory retrieval for immediate use and consolidation","volume":"19","author":"Joo","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2019.10.056_bib33","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1126\/science.aac8128","article-title":"Reduced grid-cell-like representations in adults at genetic risk for Alzheimer\u2019s disease","volume":"350","author":"Kunz","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.10.056_bib34","doi-asserted-by":"crossref","first-page":"e53569","DOI":"10.1371\/journal.pone.0053569","article-title":"Apolipoprotein E4 causes age- and sex-dependent impairments of hilar GABAergic interneurons and learning and memory deficits in mice","volume":"7","author":"Leung","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2019.10.056_bib35","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2019.10.056_bib36","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.cell.2019.06.012","article-title":"Human replay spontaneously reorganizes experience","volume":"178","author":"Liu","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.10.056_bib37","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","article-title":"Pathways towards and away from Alzheimer\u2019s disease","volume":"430","author":"Mattson","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.10.056_bib38","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.celrep.2019.10.056_bib39","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1080\/01688638808408242","article-title":"Primary and working memory functioning in Alzheimer-type dementia","volume":"10","author":"Morris","year":"1988","journal-title":"J.\u00a0Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.celrep.2019.10.056_bib40","doi-asserted-by":"crossref","first-page":"22728","DOI":"10.1038\/srep22728","article-title":"Soluble amyloid beta oligomers block the learning-induced increase in hippocampal sharp wave-ripple rate and impair spatial memory formation","volume":"6","author":"Nicole","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2019.10.056_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2012.00084","article-title":"Disrupting neural activity related to awake-state sharp wave-ripple complexes prevents hippocampal learning","volume":"6","author":"Nokia","year":"2012","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.celrep.2019.10.056_bib42","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/nn2037","article-title":"Reactivation of experience-dependent cell assembly patterns in the hippocampus","volume":"11","author":"O\u2019Neill","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2019.10.056_bib43","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/j.celrep.2018.10.066","article-title":"Origin of gamma frequency power during hippocampal sharp-wave ripples","volume":"25","author":"Oliva","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2019.10.056_bib44","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/nature05289","article-title":"A network dysfunction perspective on neurodegenerative diseases","volume":"443","author":"Palop","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.10.056_bib45","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1126\/science.aaa9633","article-title":"PLACE CELLS. Autoassociative dynamics in the generation of sequences of hippocampal place cells","volume":"349","author":"Pfeiffer","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.10.056_bib46","doi-asserted-by":"crossref","first-page":"E6379","DOI":"10.1073\/pnas.1518257112","article-title":"Diversity of sharp-wave-ripple LFP signatures reveals differentiated brain-wide dynamical events","volume":"112","author":"Ramirez-Villegas","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.10.056_bib47","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1016\/j.neuron.2018.09.041","article-title":"Dissecting the synapse- and frequency-dependent network mechanisms of in\u00a0vivo hippocampal sharp wave-ripples","volume":"100","author":"Ramirez-Villegas","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2019.10.056_bib48","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.coph.2013.10.002","article-title":"Preventing cognitive decline in preclinical Alzheimer\u2019s disease","volume":"14","author":"Riedel","year":"2014","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.celrep.2019.10.056_bib49","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s41467-019-08725-w","article-title":"Subcortical electrophysiological activity is detectable with high-density EEG source imaging","volume":"10","author":"Seeber","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2019.10.056_bib50","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.neuron.2009.11.016","article-title":"Rewarded outcomes enhance reactivation of experience in the hippocampus","volume":"64","author":"Singer","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2019.10.056_bib51","doi-asserted-by":"crossref","first-page":"6587","DOI":"10.1523\/JNEUROSCI.20-17-06587.2000","article-title":"Circuit-specific alterations in hippocampal synaptophysin immunoreactivity predict spatial learning impairment in aged rats","volume":"20","author":"Smith","year":"2000","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2019.10.056_bib52","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.celrep.2019.10.056_bib53","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1146\/annurev-neuro-061010-113720","article-title":"The cognitive neuroscience of human memory since H.M","volume":"34","author":"Squire","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2019.10.056_bib54","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.neuroscience.2003.10.011","article-title":"Marked regional differences of brain human apolipoprotein E expression in targeted replacement mice","volume":"124","author":"Sullivan","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2019.10.056_bib55","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1126\/science.aau8956","article-title":"Coupled ripple oscillations between the medial temporal lobe and neocortex retrieve human memory","volume":"363","author":"Vaz","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.10.056_bib56","doi-asserted-by":"crossref","first-page":"5650","DOI":"10.1523\/JNEUROSCI.3069-15.2016","article-title":"Age is associated with reduced sharp-wave ripple frequency and altered patterns of neuronal variability","volume":"36","author":"Wiegand","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2019.10.056_bib57","doi-asserted-by":"crossref","first-page":"6877","DOI":"10.1523\/JNEUROSCI.1744-05.2005","article-title":"Age-associated alterations of hippocampal place cells are subregion specific","volume":"25","author":"Wilson","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2019.10.056_bib58","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1001\/archneurol.2011.31","article-title":"Cognitive decline in prodromal Alzheimer disease and mild cognitive impairment","volume":"68","author":"Wilson","year":"2011","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.celrep.2019.10.056_bib59","series-title":"Proceedings of the 2011 Annual Conference on Human Factors in Computing Systems\u2014CHI \u201911","first-page":"143","article-title":"The aligned rank transform for nonparametric factorial analyses using only ANOVA procedures","author":"Wobbrock","year":"2011"},{"key":"10.1016\/j.celrep.2019.10.056_bib60","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.brainres.2018.11.006","article-title":"Detection and localization of interictal ripples with magnetoencephalography in the presurgical evaluation of drug-resistant insular epilepsy","volume":"1706","author":"Yin","year":"2019","journal-title":"Brain Res."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719313701?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719313701?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:48:51Z","timestamp":1761907731000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124719313701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":60,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["S2211124719313701"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2019.10.056","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/596569","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early Hippocampal Sharp-Wave Ripple Deficits Predict Later Learning and Memory Impairments in an Alzheimer\u2019s Disease Mouse Model","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2019.10.056","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s).","name":"copyright","label":"Copyright"}]}}