{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T19:23:18Z","timestamp":1791400998725,"version":"4.3.3"},"reference-count":66,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T00:00:00Z","timestamp":1576800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003741","name":"Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003741","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007737","name":"St. Jude Children's Research Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020636","name":"Ministerio de Educaci\u00f3n y Formaci\u00f3n Profesional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020636","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019378","name":"Concert Pharmaceuticals","doi-asserted-by":"publisher","award":["648201"],"award-info":[{"award-number":["648201"]}],"id":[{"id":"10.13039\/100019378","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["2017 SGR 324"],"award-info":[{"award-number":["2017 SGR 324"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["BIO2012-31043"],"award-info":[{"award-number":["BIO2012-31043"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003030","name":"Ag\u00e8ncia de Gesti\u00f3 d'Ajuts Universitaris i de Recerca","doi-asserted-by":"publisher","award":["BIO2015-70092-R"],"award-info":[{"award-number":["BIO2015-70092-R"]}],"id":[{"id":"10.13039\/501100003030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["BIO2016-78310-R"],"award-info":[{"award-number":["BIO2016-78310-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R35NS097974"],"award-info":[{"award-number":["R35NS097974"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.celrep.2019.12.080","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T11:06:17Z","timestamp":1580209577000},"page":"1117-1128.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation"],"prefix":"10.1016","volume":"30","author":[{"given":"Cristina","family":"Batlle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiguo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maura","family":"Coughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Messing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Pesarrodona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elzbieta","family":"Szulc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Salvatella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Joo","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Paul","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Ventura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2019.12.080_bib1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0378-1119(00)00032-9","article-title":"Molecular characterization of a mouse heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its tissue-specific expression","volume":"245","author":"Akagi","year":"2000","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2019.12.080_bib2","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1006\/abbi.2000.1938","article-title":"A nuclear matrix-associated factor, SAF-B, interacts with specific isoforms of AUF1\/hnRNP D","volume":"380","author":"Arao","year":"2000","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.celrep.2019.12.080_bib3","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1074\/jbc.RA118.007222","article-title":"The role of liquid-liquid phase separation in aggregation of the TDP-43 low-complexity domain","volume":"294","author":"Babinchak","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2019.12.080_bib4","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrm.2017.27","article-title":"Alternative splicing as a regulator of development and tissue identity","volume":"18","author":"Baralle","year":"2017","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2019.12.080_bib5","doi-asserted-by":"crossref","first-page":"D204","DOI":"10.1093\/nar\/gku989","article-title":"UniProt: a hub for protein information","volume":"43","author":"Bateman","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2019.12.080_bib6","first-page":"2524","article-title":"HNRNPDL-related muscular dystrophy: expanding the clinical, morphological and MRI phenotypes","volume":"266","author":"Berardo","year":"2019","journal-title":"J.\u00a0Neurol."},{"key":"10.1016\/j.celrep.2019.12.080_bib7","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.bbapap.2010.04.001","article-title":"Molecular mechanism of Thioflavin-T binding to amyloid fibrils","volume":"1804","author":"Biancalana","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2019.12.080_bib8","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.molcel.2017.02.013","article-title":"Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics","volume":"65","author":"Boeynaems","year":"2017","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2019.12.080_bib9","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.tcb.2018.02.004","article-title":"Protein Phase Separation: A New Phase in Cell Biology","volume":"28","author":"Boeynaems","year":"2018","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.celrep.2019.12.080_bib10","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.celrep.2018.06.070","article-title":"Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity","volume":"24","author":"Bogaert","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2019.12.080_bib11","doi-asserted-by":"crossref","first-page":"8678","DOI":"10.1093\/nar\/gku582","article-title":"Free mRNA in excess upon polysome dissociation is a scaffold for protein multimerization to form stress granules","volume":"42","author":"Bounedjah","year":"2014","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2019.12.080_bib12","doi-asserted-by":"crossref","first-page":"E8194","DOI":"10.1073\/pnas.1706197114","article-title":"Structural and hydrodynamic properties of an intrinsically disordered region of a germ cell-specific protein on phase separation","volume":"114","author":"Brady","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.12.080_bib13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.molcel.2015.09.006","article-title":"Residue-by-Residue View of In\u00a0Vitro FUS Granules that Bind the C-Terminal Domain of RNA Polymerase II","volume":"60","author":"Burke","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2019.12.080_bib14","doi-asserted-by":"crossref","first-page":"13392","DOI":"10.1073\/pnas.1304749110","article-title":"Conformations of intrinsically disordered proteins are influenced by linear sequence distributions of oppositely charged residues","volume":"110","author":"Das","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.12.080_bib15","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/nrm760","article-title":"Messenger-RNA-binding proteins and the messages they carry","volume":"3","author":"Dreyfuss","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"D1","key":"10.1016\/j.celrep.2019.12.080_bib16","doi-asserted-by":"crossref","first-page":"D427","DOI":"10.1093\/nar\/gky995","article-title":"The Pfam protein families database in 2019","volume":"47","author":"El-Gebali","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2019.12.080_bib17","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.molcel.2019.02.002","article-title":"Modeling RNA-Binding Protein Specificity In\u00a0Vivo by Precisely Registering Protein-RNA Crosslink Sites","volume":"74","author":"Feng","year":"2019","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2019.12.080_bib18","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1073\/pnas.0915166107","article-title":"Identifying the amylome, proteins capable of forming amyloid-like fibrils","volume":"107","author":"Goldschmidt","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.12.080_bib19","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.cell.2017.06.037","article-title":"Regulatory Expansion in Mammals of Multivalent hnRNP Assemblies that Globally Control Alternative Splicing","volume":"170","author":"Gueroussov","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.12.080_bib20","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1042\/BCJ20160499","article-title":"RNA-binding proteins with prion-like domains in health and disease","volume":"474","author":"Harrison","year":"2017","journal-title":"Biochem. J."},{"key":"10.1016\/j.celrep.2019.12.080_bib21","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/ajmg.a.37965","article-title":"Further defining the critical genes for the 4q21 microdeletion disorder","volume":"173","author":"Hu","year":"2017","journal-title":"Am. J. Med. Genet. A."},{"key":"10.1016\/j.celrep.2019.12.080_bib22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12859-019-2601-3","article-title":"AMYCO: evaluation of mutational impact on prion-like proteins aggregation propensity","volume":"20","author":"Iglesias","year":"2019","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.celrep.2019.12.080_bib23","doi-asserted-by":"crossref","first-page":"eaah5436","DOI":"10.1126\/scitranslmed.aah5436","article-title":"RNA binding proteins and the pathological cascade in ALS \/ FTD neurodegeneration","volume":"9","author":"Ito","year":"2017","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2019.12.080_bib24","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/embor.2009.24","article-title":"Human U1 snRNA forms a new chromatin-associated snRNP with TAF15","volume":"10","author":"Jobert","year":"2009","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2019.12.080_bib25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0378-1119(02)00926-5","article-title":"Interactions of heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its domains with high-affinity binding sites","volume":"298","author":"Kamei","year":"2002","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2019.12.080_bib26","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0378-1119(99)00020-7","article-title":"Two forms of expression and genomic structure of the human heterogeneous nuclear ribonucleoprotein D-like JKTBP gene (HNRPDL)","volume":"228","author":"Kamei","year":"1999","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2019.12.080_bib27","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.cell.2019.02.044","article-title":"Redox State Controls Phase Separation of the Yeast Ataxin-2 Protein via Reversible Oxidation of Its Methionine-Rich Low-Complexity Domain","volume":"177","author":"Kato","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.12.080_bib28","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1074\/jbc.M108477200","article-title":"Identification of the nucleocytoplasmic shuttling sequence of heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its interaction with mRNA","volume":"277","author":"Kawamura","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2019.12.080_bib29","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nature11922","article-title":"Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS","volume":"495","author":"Kim","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.12.080_bib30","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.brainres.2012.01.016","article-title":"The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease","volume":"1462","author":"King","year":"2012","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2019.12.080_bib31","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1093\/bioinformatics\/btu310","article-title":"PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition","volume":"30","author":"Lancaster","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2019.12.080_bib32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.gene.2018.11.026","article-title":"hnRNPDL extensively regulates transcription and alternative splicing","volume":"687","author":"Li","year":"2019","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2019.12.080_bib33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/mus.26077","article-title":"Untangling the complexity of limb-girdle muscular dystrophies","volume":"58","author":"Liewluck","year":"2018","journal-title":"Muscle Nerve"},{"key":"10.1016\/j.celrep.2019.12.080_bib34","first-page":"943","article-title":"Identification of differential expression of genes in hepatocellular carcinoma by suppression subtractive hybridization combined cDNA microarray","volume":"18","author":"Liu","year":"2007","journal-title":"Oncol. Rep."},{"key":"10.1016\/j.celrep.2019.12.080_bib35","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/j.neuron.2017.07.025","article-title":"TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics","volume":"95","author":"Mackenzie","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2019.12.080_bib36","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1126\/science.aar7366","article-title":"RNA buffers the phase separation behavior of prion-like RNA binding proteins","volume":"360","author":"Maharana","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.12.080_bib37","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2016.02.037","article-title":"Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease","volume":"1647","author":"March","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2019.12.080_bib38","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.gene.2012.06.088","article-title":"Domains involved in TAF15 subcellular localisation: dependence on cell type and ongoing transcription","volume":"506","author":"Marko","year":"2012","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2019.12.080_bib39","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.cell.2015.09.015","article-title":"Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization","volume":"163","author":"Molliex","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.12.080_bib40","doi-asserted-by":"crossref","first-page":"E9782","DOI":"10.1073\/pnas.1806174115","article-title":"Structural characterization of the D290V mutation site in hnRNPA2 low-complexity-domain polymers","volume":"115","author":"Murray","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.12.080_bib41","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41594-019-0250-x","article-title":"Molecular interactions underlying liquid-liquid phase separation of the FUS low-complexity domain","volume":"26","author":"Murthy","year":"2019","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2019.12.080_bib42","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12934-015-0284-7","article-title":"The prion-like RNA-processing protein HNRPDL forms inherently toxic amyloid-like inclusion bodies in bacteria","volume":"14","author":"Navarro","year":"2015","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.celrep.2019.12.080_bib43","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s41582-019-0157-5","article-title":"Bridging biophysics and neurology: aberrant phase transitions in neurodegenerative disease","volume":"15","author":"Nedelsky","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2019.12.080_bib44","first-page":"1","article-title":"Genetic basis of limb-girdle muscular dystrophies: the 2014 update","volume":"33","author":"Nigro","year":"2014","journal-title":"Acta Myol."},{"key":"10.1016\/j.celrep.2019.12.080_bib45","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.cell.2015.07.047","article-title":"A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation","volume":"162","author":"Patel","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.12.080_bib46","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.molcel.2018.04.007","article-title":"A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation","volume":"70","author":"Peskett","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2019.12.080_bib47","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1126\/science.1857966","article-title":"Transcription-dependent and transcription-independent nuclear transport of hnRNP proteins","volume":"253","author":"Pi\u00f1ol-Roma","year":"1991","journal-title":"Science"},{"key":"10.1016\/j.celrep.2019.12.080_bib48","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/355730a0","article-title":"Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm","volume":"355","author":"Pi\u00f1ol-Roma","year":"1992","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2019.12.080_bib49","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.molcel.2017.12.022","article-title":"Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation","volume":"69","author":"Ryan","year":"2018","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2019.12.080_bib50","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.nmd.2018.05.007","article-title":"). 229th ENMC international workshop: Limb girdle muscular dystrophies \u2013 Nomenclature and reformed classification Naarden, the Netherlands, 17\u201319 March 2017","volume":"28","author":"Straub","year":"2018","journal-title":"Neuromuscul. Disord."},{"key":"10.1016\/j.celrep.2019.12.080_bib51","doi-asserted-by":"crossref","first-page":"e80237","DOI":"10.1371\/journal.pone.0080237","article-title":"Identification of novel markers that demarcate the nucleolus during severe stress and chemotherapeutic treatment","volume":"8","author":"Su","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2019.12.080_bib52","first-page":"498","article-title":"Limb girdle muscular dystrophy D3 HNRNPDL related in a Chinese family with distal muscle weakness caused by a mutation in the prion-like domain","volume":"266","author":"Sun","year":"2019","journal-title":"J.\u00a0Neurol."},{"key":"10.1016\/j.celrep.2019.12.080_bib53","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.3390\/ijms9081504","article-title":"TFIP11, CCNL1 and EWSR1 Protein-protein Interactions, and Their Nuclear Localization","volume":"9","author":"Tannukit","year":"2008","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2019.12.080_bib54","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/oxfordjournals.jbchem.a021964","article-title":"Cloning and characterization of a cDNA encoding a novel heterogeneous nuclear ribonucleoprotein-like protein and its expression in myeloid leukemia cells","volume":"123","author":"Tsuchiya","year":"1998","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.celrep.2019.12.080_bib55","doi-asserted-by":"crossref","first-page":"e31486","DOI":"10.7554\/eLife.31486","article-title":"Pi-Pi contacts are an overlooked protein feature relevant to phase separation","volume":"7","author":"Vernon","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2019.12.080_bib56","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1093\/hmg\/ddu127","article-title":"A defect in the RNA-processing protein HNRPDL causes limb-girdle muscular dystrophy 1G (LGMD1G)","volume":"23","author":"Vieira","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2019.12.080_bib57","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.cell.2018.06.006","article-title":"A Molecular Grammar Governing the Driving Forces for Phase Separation of Prion-like RNA Binding Proteins","volume":"174","author":"Wang","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.12.080_bib58","doi-asserted-by":"crossref","first-page":"e98049","DOI":"10.15252\/embj.201798049","article-title":"Tau protein liquid-liquid phase separation can initiate tau aggregation","volume":"37","author":"Wegmann","year":"2018","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2019.12.080_bib59","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.bpj.2012.07.008","article-title":"Binding of Congo red to amyloid protofibrils of the Alzheimer A\u03b2(9-40) peptide probed by molecular dynamics simulations","volume":"103","author":"Wu","year":"2012","journal-title":"Biophys. J."},{"key":"10.1016\/j.celrep.2019.12.080_bib60","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/cbf.1468","article-title":"Overexpression of JKTBP1 induces androgen-independent LNCaP cell proliferation through activation of epidermal growth factor-receptor (EGF-R)","volume":"26","author":"Wu","year":"2008","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.celrep.2019.12.080_bib61","doi-asserted-by":"crossref","first-page":"17809","DOI":"10.1073\/pnas.1414004111","article-title":"Self-assembled FUS binds active chromatin and regulates gene transcription","volume":"111","author":"Yang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2019.12.080_bib62","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cell.2017.06.022","article-title":"Splicing Activation by Rbfox Requires Self-Aggregation through Its Tyrosine-Rich Domain","volume":"170","author":"Ying","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2019.12.080_bib63","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/abbs\/gmy085","article-title":"Oncogenic heterogeneous nuclear ribonucleoprotein D-like promotes the growth of human colon cancer SW620 cells via its regulation of cell-cycle","volume":"50","author":"Zhang","year":"2018","journal-title":"Acta Biochim. Biophys. Sin. (Shanghai)"},{"key":"10.1016\/j.celrep.2019.12.080_bib64","doi-asserted-by":"crossref","first-page":"5453","DOI":"10.1242\/jcs.02669","article-title":"Identification of the sequence determinants mediating the nucleo-cytoplasmic shuttling of TIAR and TIA-1 RNA-binding proteins","volume":"118","author":"Zhang","year":"2005","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.celrep.2019.12.080_bib65","doi-asserted-by":"crossref","first-page":"e86195","DOI":"10.1371\/journal.pone.0086195","article-title":"Growth arrest specific 2 is up-regulated in chronic myeloid leukemia cells and required for their growth","volume":"9","author":"Zhou","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2019.12.080_bib66","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/sj.onc.1200854","article-title":"A topogenic role for the oncogenic N-terminus of TLS: nucleolar localization when transcription is inhibited","volume":"14","author":"Zinszner","year":"1997","journal-title":"Oncogene"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719317450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124719317450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:49:55Z","timestamp":1761907795000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124719317450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S2211124719317450"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2019.12.080","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2019.12.080","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s).","name":"copyright","label":"Copyright"}]}}