{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T12:02:07Z","timestamp":1792324927512,"version":"4.4.0"},"reference-count":76,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T00:00:00Z","timestamp":1579305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1044295"],"award-info":[{"award-number":["APP1044295"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1066172"],"award-info":[{"award-number":["APP1066172"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1103689"],"award-info":[{"award-number":["APP1103689"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1122484"],"award-info":[{"award-number":["APP1122484"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1127821"],"award-info":[{"award-number":["APP1127821"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1139763"],"award-info":[{"award-number":["APP1139763"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006691","name":"Harvard Medical School","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["CE140100003"],"award-info":[{"award-number":["CE140100003"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["DP170101863"],"award-info":[{"award-number":["DP170101863"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.celrep.2020.01.058","type":"journal-article","created":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T10:40:16Z","timestamp":1581417616000},"page":"1670-1681.e7","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":324,"title":["NAD+ Repletion Rescues Female Fertility during Reproductive Aging"],"prefix":"10.1016","volume":"30","author":[{"given":"Michael J.","family":"Bertoldo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dave R.","family":"Listijono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wing-Hong Jonathan","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelique H.","family":"Riepsamen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dale M.","family":"Goss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dulama","family":"Richani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing L.","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saabah","family":"Mahbub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jared M.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Habibalahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Guo Nicholas","family":"Loh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil A.","family":"Youngson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayanthi","family":"Maniam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley S.A.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaisa","family":"Selesniemi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Bustamante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria B.","family":"Marinova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn-Jee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurin","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael M.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Stefanie","family":"Mikolaizak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Araki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Le Couteur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret J.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty A.","family":"Walters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Goldys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"O\u2019Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Gilchrist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayden A.","family":"Homer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1599-7574","authenticated-orcid":false,"given":"Lindsay E.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2020.01.058_bib1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1477-7827-10-49","article-title":"The effects of oxidative stress on female reproduction: a review","volume":"10","author":"Agarwal","year":"2012","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.celrep.2020.01.058_bib2","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1007\/s10815-017-0975-6","article-title":"Obesity results with smaller oocyte in in\u00a0vitro fertilization\/intracytoplasmic sperm injection cycles-a prospective study","volume":"34","author":"Atzmon","year":"2017","journal-title":"J.\u00a0Assist. Reprod. Genet."},{"key":"10.1016\/j.celrep.2020.01.058_bib3","doi-asserted-by":"crossref","first-page":"15113","DOI":"10.1073\/pnas.261574398","article-title":"Identification of a small molecule inhibitor of Sir2p","volume":"98","author":"Bedalov","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.01.058_bib4","doi-asserted-by":"crossref","first-page":"36334","DOI":"10.1074\/jbc.M508660200","article-title":"Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms","volume":"280","author":"Berger","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2020.01.058_bib5","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0092-8674(04)00416-7","article-title":"Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans","volume":"117","author":"Bieganowski","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.01.058_bib6","doi-asserted-by":"crossref","first-page":"45099","DOI":"10.1074\/jbc.M205670200","article-title":"Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1","volume":"277","author":"Bitterman","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2020.01.058_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11306-017-1310-z","article-title":"Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach","volume":"14","author":"Bustamante","year":"2017","journal-title":"Metabolomics"},{"key":"10.1016\/j.celrep.2020.01.058_bib8","doi-asserted-by":"crossref","first-page":"10794","DOI":"10.1073\/pnas.1934713100","article-title":"Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice","volume":"100","author":"Cheng","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.01.058_bib9","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/jcp.24457","article-title":"Measurement of ATP in single oocytes: impact of maturation and cumulus cells on levels and consumption","volume":"229","author":"Dalton","year":"2014","journal-title":"J.\u00a0Cell. Physiol."},{"key":"10.1016\/j.celrep.2020.01.058_bib10","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S0140-6736(14)60834-5","article-title":"Fertility preservation in women with cancer","volume":"384","author":"De Vos","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2020.01.058_bib11","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11357-019-00052-8","article-title":"Age- and AD-related redox state of NADH in subcellular compartments by fluorescence lifetime imaging microscopy","volume":"41","author":"Dong","year":"2019","journal-title":"Geroscience"},{"key":"10.1016\/j.celrep.2020.01.058_bib12","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.celrep.2019.01.007","article-title":"Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring","volume":"26","author":"Ear","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2020.01.058_bib13","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.fertnstert.2013.11.004","article-title":"The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening","volume":"101","author":"Franasiak","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.celrep.2020.01.058_bib14","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1095\/biolreprod.109.083162","article-title":"Transformation-related protein 53 expression in the early mouse embryo compromises preimplantation embryonic development by preventing the formation of a proliferating inner cell mass","volume":"83","author":"Ganeshan","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2020.01.058_bib15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.yexcr.2017.06.020","article-title":"The induction of tumour suppressor protein P53 limits the entry of cells into the pluripotent inner cell mass lineage in the mouse embryo","volume":"358","author":"Ganeshan","year":"2017","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.celrep.2020.01.058_bib16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbamcr.2015.09.030","article-title":"Functional hyperspectral imaging captures subtle details of cell metabolism in olfactory neurosphere cells, disease-specific models of neurodegenerative disorders","volume":"1863","author":"Gosnell","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2020.01.058_bib17","doi-asserted-by":"crossref","first-page":"23453","DOI":"10.1038\/srep23453","article-title":"Quantitative non-invasive cell characterisation and discrimination based on multispectral autofluorescence features","volume":"6","author":"Gosnell","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2020.01.058_bib18","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/humupd\/dmx035","article-title":"Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errors","volume":"24","author":"Greaney","year":"2018","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.celrep.2020.01.058_bib19","doi-asserted-by":"crossref","first-page":"38837","DOI":"10.1074\/jbc.M106779200","article-title":"Identification of a class of small molecule inhibitors of the sirtuin family of NAD-dependent deacetylases by phenotypic screening","volume":"276","author":"Grozinger","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2020.01.058_bib20","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.jtos.2019.03.003","article-title":"Novel automated non invasive detection of ocular surface squamous neoplasia using multispectral autofluorescence imaging","volume":"17","author":"Habibalahi","year":"2019","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.celrep.2020.01.058_bib21","first-page":"7436","article-title":"FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel\u00a0mechanism for induction of tumor cell apoptosis","volume":"63","author":"Hasmann","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2020.01.058_bib22","doi-asserted-by":"crossref","first-page":"R61","DOI":"10.1530\/REP-13-0163","article-title":"The APC\/C in female mammalian meiosis I","volume":"146","author":"Homer","year":"2013","journal-title":"Reproduction"},{"key":"10.1016\/j.celrep.2020.01.058_bib23","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1101\/gad.328105","article-title":"Mad2 prevents aneuploidy and premature proteolysis of cyclin B and securin during meiosis I in mouse oocytes","volume":"19","author":"Homer","year":"2005","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2020.01.058_bib24","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1126\/science.1175326","article-title":"A spindle assembly checkpoint protein functions in prophase I arrest and prometaphase progression","volume":"326","author":"Homer","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.01.058_bib25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/(SICI)1098-2795(199609)45:1<31::AID-MRD4>3.0.CO;2-T","article-title":"Maternal age effect on early human embryonic development and blastocyst formation","volume":"45","author":"Janny","year":"1996","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.celrep.2020.01.058_bib26","doi-asserted-by":"crossref","first-page":"4576","DOI":"10.1073\/pnas.83.12.4576","article-title":"Promotion of the Whitten effect in female mice by synthetic analogs of male urinary constituents","volume":"83","author":"Jemiolo","year":"1986","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.01.058_bib27","doi-asserted-by":"crossref","first-page":"e1001147","DOI":"10.1371\/journal.pgen.1001147","article-title":"Cdc20 is critical for meiosis I and fertility of female mice","volume":"6","author":"Jin","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2020.01.058_bib28","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1083\/jcb.150.5.975","article-title":"Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5","volume":"150","author":"Kapoor","year":"2000","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2020.01.058_bib29","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1172\/JCI42020","article-title":"Sirt3 protects in\u00a0vitro-fertilized mouse preimplantation embryos against oxidative stress-induced p53-mediated developmental arrest","volume":"120","author":"Kawamura","year":"2010","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2020.01.058_bib30","first-page":"55","article-title":"A survey of spectral unmixing algorithms","volume":"14","author":"Keshava","year":"2003","journal-title":"Linc. Lab. J."},{"key":"10.1016\/j.celrep.2020.01.058_bib31","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1109\/79.974727","article-title":"Spectral unmixing","volume":"19","author":"Keshava","year":"2002","journal-title":"IEEE Signal Process. Mag."},{"key":"10.1016\/j.celrep.2020.01.058_bib32","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1117\/12.410362","article-title":"Algorithm taxonomy for hyperspectral unmixing","volume":"4049","author":"Keshava","year":"2000","journal-title":"Proceedings of the Algorithms for Multispectral, Hyperspectral, and Ultraspectral Imagery VI"},{"key":"10.1016\/j.celrep.2020.01.058_bib33","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.ccr.2011.09.004","article-title":"SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC\/C activity","volume":"20","author":"Kim","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2020.01.058_bib34","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1089\/ars.2017.7451","article-title":"Evaluating Cell Metabolism Through Autofluorescence Imaging of NAD(P)H and FAD","volume":"30","author":"Kolenc","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.celrep.2020.01.058_bib35","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1126\/science.285.5434.1733","article-title":"A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy","volume":"285","author":"Komarov","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.01.058_bib36","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4103\/0974-1208.86080","article-title":"Ovarian hyperstimulation syndrome","volume":"4","author":"Kumar","year":"2011","journal-title":"J.\u00a0Hum. Reprod. Sci."},{"key":"10.1016\/j.celrep.2020.01.058_bib37","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1530\/jrf.0.1090153","article-title":"Differential regulation of mouse embryo development and viability by amino acids","volume":"109","author":"Lane","year":"1997","journal-title":"J.\u00a0Reprod. Fertil."},{"key":"10.1016\/j.celrep.2020.01.058_bib38","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1095\/biolreprod.106.056838","article-title":"Culture of zygotes\u00a0increases TRP53 [corrected] expression in B6 mouse embryos, which reduces embryo viability","volume":"76","author":"Li","year":"2007","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2020.01.058_bib39","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1095\/biolreprod.111.097741","article-title":"The effect of Trp53 gene-dosage and parent-of-origin of inheritance on mouse gamete and embryo function in\u00a0vitro","volume":"86","author":"Li","year":"2012","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2020.01.058_bib40","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/humrep\/dew020","article-title":"Extending prematuration with cAMP modulators enhances the cumulus contribution to oocyte antioxidant defence and oocyte quality via gap junctions","volume":"31","author":"Li","year":"2016","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.celrep.2020.01.058_bib41","doi-asserted-by":"crossref","first-page":"15792","DOI":"10.1038\/s41598-017-15952-y","article-title":"Statistically strong label-free quantitative identification of native fluorophores in a biological sample","volume":"7","author":"Mahbub","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2020.01.058_bib42","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.psyneuen.2009.10.013","article-title":"Palatable cafeteria diet ameliorates anxiety and depression-like symptoms following an adverse early environment","volume":"35","author":"Maniam","year":"2010","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.celrep.2020.01.058_bib43","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1016\/j.fertnstert.2010.10.026","article-title":"Polycystic ovary syndrome and maternal obesity affect oocyte size in in\u00a0vitro fertilization\/intracytoplasmic sperm injection cycles","volume":"95","author":"Marquard","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.celrep.2020.01.058_bib44","doi-asserted-by":"crossref","first-page":"e42357","DOI":"10.1371\/journal.pone.0042357","article-title":"Age-associated changes in oxidative stress and NAD+ metabolism in human tissue","volume":"7","author":"Massudi","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2020.01.058_bib45","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.cmet.2016.09.013","article-title":"Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice","volume":"24","author":"Mills","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2020.01.058_bib46","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1472-6483(10)61810-X","article-title":"Chromosome mosaicism in cleavage-stage human embryos: evidence of a maternal age effect","volume":"4","author":"Munn\u00e9","year":"2002","journal-title":"Reprod. Biomed. Online"},{"key":"10.1016\/j.celrep.2020.01.058_bib47","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1016\/S0021-9258(18)48675-9","article-title":"Studies on the Biosynthesis of Nicotinamide Adenine Dinucleotide. I. Enzymic Synthesis of Niacin Ribonucleotides from 3-Hydroxyanthranilic Acid in Mammalian Tissues","volume":"238","author":"Nishizuka","year":"1963","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2020.01.058_bib48","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.15252\/embj.201386907","article-title":"SIRT2 induces the checkpoint kinase BubR1 to increase lifespan","volume":"33","author":"North","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2020.01.058_bib49","series-title":"Assisted Reproductive Technology in Australia and New Zealand 2016","year":"2016"},{"key":"10.1016\/j.celrep.2020.01.058_bib50","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1095\/biolreprod56.1.229","article-title":"Evidence for the requirement of autocrine growth factors for development of mouse preimplantation embryos in\u00a0vitro","volume":"56","author":"O\u2019Neill","year":"1997","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2020.01.058_bib51","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/0304-4165(85)90280-6","article-title":"Purification of quinolinic acid phosphoribosyltransferase from rat liver and brain","volume":"841","author":"Okuno","year":"1985","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2020.01.058_bib52","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1158\/1535-7163.MCT-09-0971","article-title":"SIRT inhibitors induce cell death and p53 acetylation through targeting both SIRT1 and SIRT2","volume":"9","author":"Peck","year":"2010","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.celrep.2020.01.058_bib53","doi-asserted-by":"crossref","first-page":"3857","DOI":"10.1158\/0008-5472.CAN-16-3079","article-title":"Nicotinic Acid Phosphoribosyltransferase Regulates Cancer Cell Metabolism, Susceptibility\u00a0to NAMPT Inhibitors, and DNA Repair","volume":"77","author":"Piacente","year":"2017","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2020.01.058_bib54","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0021-9258(18)64789-1","article-title":"Biosynthesis of diphosphopyridine nucleotide. I. Identification of intermediates","volume":"233","author":"Preiss","year":"1958","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2020.01.058_bib55","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0021-9258(18)64790-8","article-title":"Biosynthesis of diphosphopyridine nucleotide. II. Enzymatic aspects","volume":"233","author":"Preiss","year":"1958","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2020.01.058_bib56","doi-asserted-by":"crossref","first-page":"e12698","DOI":"10.1111\/acel.12698","article-title":"Sirt2-BubR1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality","volume":"17","author":"Qiu","year":"2018","journal-title":"Aging Cell"},{"key":"10.1016\/j.celrep.2020.01.058_bib57","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.cmet.2018.02.011","article-title":"Therapeutic Potential of NAD-Boosting Molecules: The In\u00a0Vivo Evidence","volume":"27","author":"Rajman","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2020.01.058_bib58","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1364\/BOE.8.001488","article-title":"Fluorescence quenching of free and bound NADH in HeLa cells determined by hyperspectral imaging and unmixing of cell autofluorescence","volume":"8","author":"Rehman","year":"2017","journal-title":"Biomed. Opt. Express"},{"key":"10.1016\/j.celrep.2020.01.058_bib59","doi-asserted-by":"crossref","first-page":"e0126194","DOI":"10.1371\/journal.pone.0126194","article-title":"Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes","volume":"10","author":"Riepsamen","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2020.01.058_bib60","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.fertnstert.2013.11.125","article-title":"Digital multiplexed mRNA analysis of functionally important genes in single human oocytes and correlation of\u00a0changes in transcript levels with oocyte protein expression","volume":"101","author":"Riris","year":"2014","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.celrep.2020.01.058_bib61","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/j.fertnstert.2015.03.004","article-title":"Reproduction at an advanced maternal age and maternal health","volume":"103","author":"Sauer","year":"2015","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.celrep.2020.01.058_bib62","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2020.01.058_bib63","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1093\/humupd\/dmy003","article-title":"Sirtuins in gamete biology and reproductive physiology: emerging roles and therapeutic potential in female and male infertility","volume":"24","author":"Tatone","year":"2018","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.celrep.2020.01.058_bib64","doi-asserted-by":"crossref","first-page":"10609","DOI":"10.1074\/jbc.273.17.10609","article-title":"Importance of glucose-6-phosphate dehydrogenase activity for cell growth","volume":"273","author":"Tian","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2020.01.058_bib65","doi-asserted-by":"crossref","first-page":"6946","DOI":"10.1038\/ncomms7946","article-title":"Mouse oocytes depend on BubR1 for proper chromosome segregation but not for prophase I arrest","volume":"6","author":"Touati","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2020.01.058_bib66","doi-asserted-by":"crossref","first-page":"12948","DOI":"10.1038\/ncomms12948","article-title":"Nicotinamide riboside is uniquely and orally bioavailable in mice and humans","volume":"7","author":"Trammell","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2020.01.058_bib67","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0092-8674(01)00527-X","article-title":"hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase","volume":"107","author":"Vaziri","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.01.058_bib68","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.chemolab.2012.05.009","article-title":"Pre-processing of hyperspectral images. Essential steps before image analysis","volume":"117","author":"Vidal","year":"2012","journal-title":"Chemometr. Intell. Lab. Syst."},{"key":"10.1016\/j.celrep.2020.01.058_bib69","first-page":"1304","article-title":"Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress","volume":"33","author":"Wang","year":"2014","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2020.01.058_bib70","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.2337\/db13-1665","article-title":"Systemic VEGF-A neutralization ameliorates diet-induced metabolic dysfunction","volume":"63","author":"Wu","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.celrep.2020.01.058_bib71","doi-asserted-by":"crossref","first-page":"6276","DOI":"10.1523\/JNEUROSCI.4304-08.2009","article-title":"Nicotinamide mononucleotide adenylyltransferase expression in mitochondrial matrix delays Wallerian degeneration","volume":"29","author":"Yahata","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2020.01.058_bib72","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/humrep\/dem140","article-title":"Exogenous growth differentiation factor 9 in oocyte maturation media enhances subsequent embryo development and fetal viability in mice","volume":"23","author":"Yeo","year":"2008","journal-title":"Hum. Reprod."},{"key":"10.1016\/j.celrep.2020.01.058_bib73","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.cmet.2011.08.014","article-title":"Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice","volume":"14","author":"Yoshino","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2020.01.058_bib74","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1096\/fj.13-244111","article-title":"Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis","volume":"28","author":"Zhang","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2020.01.058_bib75","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.gene.2015.09.043","article-title":"Are sirtuins markers of ovarian aging?","volume":"575","author":"Zhang","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2020.01.058_bib76","doi-asserted-by":"crossref","first-page":"e47584","DOI":"10.1371\/journal.pone.0047584","article-title":"A hydrazine coupled cycling assay validates the decrease in redox ratio under starvation in Drosophila","volume":"7","author":"Zhu","year":"2012","journal-title":"PLoS ONE"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720300838?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720300838?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:51:41Z","timestamp":1761907901000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124720300838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":76,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S2211124720300838"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2020.01.058","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NAD+ Repletion Rescues Female Fertility during Reproductive Aging","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2020.01.058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s).","name":"copyright","label":"Copyright"}]}}