{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:29:00Z","timestamp":1785446940805,"version":"3.56.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,23]],"date-time":"2020-01-23T00:00:00Z","timestamp":1579737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY016813"],"award-info":[{"award-number":["R01EY016813"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["M2016030"],"award-info":[{"award-number":["M2016030"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001590","name":"Health Research Board","doi-asserted-by":"publisher","award":["HRB-HRA\/2013.290"],"award-info":[{"award-number":["HRB-HRA\/2013.290"]}],"id":[{"id":"10.13039\/501100001590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["SFI 15\/CDA\/3497"],"award-info":[{"award-number":["SFI 15\/CDA\/3497"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002081","name":"Irish Research Council","doi-asserted-by":"publisher","award":["IRCLA\/2017\/295"],"award-info":[{"award-number":["IRCLA\/2017\/295"]}],"id":[{"id":"10.13039\/501100002081","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021528","name":"Royal Victorian Eye and Ear Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021528","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.celrep.2020.01.064","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T10:58:24Z","timestamp":1582023504000},"page":"2209-2224.e5","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":53,"title":["Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration"],"prefix":"10.1016","volume":"30","author":[{"given":"Kelly","family":"Mulfaul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ema","family":"Ozaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilisha","family":"Fernando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiva","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen R.","family":"Chirco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Connolly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Greene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvydas","family":"Maminishkis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert G.","family":"Salomon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail","family":"Linetsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Natoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Mullins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Doyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2020.01.064_bib1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.preteyeres.2009.11.003","article-title":"The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited","volume":"29","author":"Anderson","year":"2010","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.celrep.2020.01.064_bib3","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1167\/iovs.10-6002","article-title":"Expression of complement component 3 (C3) from an adenovirus leads to pathology in the murine retina","volume":"52","author":"Cashman","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.celrep.2020.01.064_bib4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.exer.2015.09.003","article-title":"Selective accumulation of the complement membrane attack complex in aging choriocapillaris","volume":"146","author":"Chirco","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.celrep.2020.01.064_bib5","doi-asserted-by":"crossref","first-page":"14682","DOI":"10.1073\/pnas.222551899","article-title":"Drusen proteome analysis: An approach to the etiology of age-related macular degeneration","volume":"99","author":"Crabb","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.01.064_bib6","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ophtha.2008.09.055","article-title":"Complement component C3 and risk of age-related macular degeneration","volume":"116","author":"Despriet","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.celrep.2020.01.064_bib7","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1096\/fj.11-195396","article-title":"Inhibition of TLR2 promotes graft function in a murine model of renal transplant ischemia-reperfusion injury","volume":"26","author":"Farrar","year":"2012","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2020.01.064_bib8","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1016\/j.ajpath.2017.06.015","article-title":"A proinflammatory function of toll-like receptor 2 in the retinal pigment epithelium as a novel target for reducing choroidal neovascularization in age-related macular degeneration","volume":"187","author":"Feng","year":"2017","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2020.01.064_bib9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12974-016-0514-x","article-title":"The broad-spectrum chemokine inhibitor NR58-3.14.3 modulates macrophage-mediated inflammation in the diseased retina","volume":"13","author":"Fernando","year":"2016","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.celrep.2020.01.064_bib10","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.4049\/jimmunol.1500937","article-title":"Retinal pigment epithelial cells mitigate the effects of complement attack by endocytosis of C5b-9","volume":"195","author":"Georgiannakis","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.01.064_bib11","doi-asserted-by":"crossref","first-page":"42027","DOI":"10.1074\/jbc.M305460200","article-title":"Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration","volume":"278","author":"Gu","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2020.01.064_bib12","doi-asserted-by":"crossref","first-page":"856","DOI":"10.3109\/02713683.2015.1067326","article-title":"toll-like receptors 2 and 4 polymorphisms in age-related macular degeneration","volume":"41","author":"G\u00fcven","year":"2016","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.celrep.2020.01.064_bib13","doi-asserted-by":"crossref","first-page":"7227","DOI":"10.1073\/pnas.0501536102","article-title":"A common haplotype in the complement regulatory gene factor H (HF1\/CFH) predisposes individuals to age-related macular degeneration","volume":"102","author":"Hageman","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.01.064_bib14","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S1350-9462(01)00010-6","article-title":"An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch\u2019s membrane interface in aging and age-related macular degeneration","volume":"20","author":"Hageman","year":"2001","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.celrep.2020.01.064_bib15","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/nm1709","article-title":"Oxidative damage-induced inflammation initiates age-related macular degeneration","volume":"14","author":"Hollyfield","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2020.01.064_bib16","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1167\/iovs.07-0432","article-title":"SOD2 knockdown mouse model of early AMD","volume":"48","author":"Justilien","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.celrep.2020.01.064_bib17","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1189\/jlb.0809588","article-title":"Pivotal advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms","volume":"88","author":"Kaczorowski","year":"2010","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.celrep.2020.01.064_bib18","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.4103\/1673-5374.147927","article-title":"Sodium iodate induced retinal degeneration: New insights from an old model","volume":"9","author":"Kannan","year":"2014","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.celrep.2020.01.064_bib19","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1016\/j.ophtha.2013.01.004","article-title":"Age-related macular degeneration and modification of systemic complement factor H production through liver transplantation","volume":"120","author":"Khandhadia","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.celrep.2020.01.064_bib20","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1096\/fj.15-280834","article-title":"The alternative complement pathway aids in vascular regression during the early stages of a murine model of proliferative retinopathy","volume":"30","author":"Kim","year":"2016","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2020.01.064_bib21","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1744-8069-7-74","article-title":"Toll-like receptor 2 contributes to chemokine gene expression and macrophage infiltration in the dorsal root ganglia after peripheral nerve injury","volume":"7","author":"Kim","year":"2011","journal-title":"Mol. Pain"},{"key":"10.1016\/j.celrep.2020.01.064_bib22","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1085\/jgp.200409062","article-title":"Toll-like receptor 4 (TLR4) of retinal pigment epithelial cells participates in transmembrane signaling in response to photoreceptor outer segments","volume":"124","author":"Kindzelskii","year":"2004","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.celrep.2020.01.064_bib23","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1126\/science.1109557","article-title":"Complement factor H polymorphism in age-related macular degeneration","volume":"308","author":"Klein","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.01.064_bib24","doi-asserted-by":"crossref","first-page":"11300","DOI":"10.1073\/pnas.0604056103","article-title":"Antioxidants reduce cone cell death in a model of retinitis pigmentosa","volume":"103","author":"Komeima","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.01.064_bib25","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/156652406776894572","article-title":"Toll-like receptors and corneal innate immunity","volume":"6","author":"Kumar","year":"2006","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.celrep.2020.01.064_bib26","doi-asserted-by":"crossref","first-page":"23717","DOI":"10.1074\/jbc.M110.214593","article-title":"Sublytic membrane-attack-complex (MAC) activation alters regulated rather than constitutive vascular endothelial growth factor (VEGF) secretion in retinal pigment epithelium monolayers","volume":"286","author":"Kunchithapautham","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2020.01.064_bib27","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1167\/iovs.05-1092","article-title":"Retinal pigment epithelium damage enhances expression of chemoattractants and migration of bone marrow-derived stem cells","volume":"47","author":"Li","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.celrep.2020.01.064_bib28","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/eye.2011.109","article-title":"Sub-lytic C5b-9 induces functional changes in retinal pigment epithelial cells consistent with age-related macular degeneration","volume":"25","author":"Lueck","year":"2011","journal-title":"Eye (Lond.)"},{"key":"10.1016\/j.celrep.2020.01.064_bib29","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1167\/iovs.05-1622","article-title":"Confluent monolayers of cultured human fetal retinal pigment epithelium exhibit morphology and physiology of native tissue","volume":"47","author":"Maminishkis","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.celrep.2020.01.064_bib30","doi-asserted-by":"crossref","first-page":"208","DOI":"10.15252\/emmm.201505613","article-title":"Increased VEGF-A promotes multiple distinct aging diseases of the eye through shared pathomechanisms","volume":"8","author":"Marneros","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.celrep.2020.01.064_bib31","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1167\/iovs.17-23532","article-title":"Irreversible photoreceptors and RPE cells damage by intravenous sodium iodate in mice is related to macrophage accumulation","volume":"59","author":"Moriguchi","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.celrep.2020.01.064_bib32","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.exer.2011.06.015","article-title":"Elevated membrane attack complex in human choroid with high risk complement factor H genotypes","volume":"93","author":"Mullins","year":"2011","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.celrep.2020.01.064_bib33","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.1016\/j.ajpath.2014.07.017","article-title":"The membrane attack complex in aging human choriocapillaris: Relationship to macular degeneration and choroidal thinning","volume":"184","author":"Mullins","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2020.01.064_bib34","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1167\/iovs.17-21672","article-title":"Retinal macrophages synthesize C3 and activate complement in AMD and in models of focal retinal degeneration","volume":"58","author":"Natoli","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.celrep.2020.01.064_bib35","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.exer.2016.04.015","article-title":"A model of progressive photo-oxidative degeneration and inflammation in the pigmented C57BL\/6J mouse retina","volume":"147","author":"Natoli","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.celrep.2020.01.064_bib36","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.3109\/02713683.2016.1139725","article-title":"The role of pyruvate in protecting 661W photoreceptor-like cells against light-induced cell death","volume":"41","author":"Natoli","year":"2016","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.celrep.2020.01.064_bib37","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1699-0463.1992.tb04040.x","article-title":"Rate-limiting components and reaction steps in complement-mediated haemolysis","volume":"100","author":"Nielsen","year":"1992","journal-title":"APMIS"},{"key":"10.1016\/j.celrep.2020.01.064_bib38","doi-asserted-by":"crossref","first-page":"4076518","DOI":"10.1155\/2017\/4076518","article-title":"Oxidative stress in retinal diseases","volume":"2017","author":"Nishimura","year":"2017","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.celrep.2020.01.064_bib39","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1073\/pnas.0408835103","article-title":"Drusen complement components C3a and C5a promote choroidal neovascularization","volume":"103","author":"Nozaki","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.01.064_bib40","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.molimm.2010.07.004","article-title":"Complement regulates TLR4-mediated inflammatory responses during intestinal ischemia reperfusion","volume":"48","author":"Pope","year":"2010","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.celrep.2020.01.064_bib41","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/ni.1923","article-title":"Complement: A key system for immune surveillance and homeostasis","volume":"11","author":"Ricklin","year":"2010","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2020.01.064_bib42","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-immunol-030409-101311","article-title":"The sterile inflammatory response","volume":"28","author":"Rock","year":"2010","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2020.01.064_bib43","doi-asserted-by":"crossref","first-page":"5282","DOI":"10.1167\/iovs.07-0282","article-title":"Eliminating complement factor D reduces photoreceptor susceptibility to light-induced damage","volume":"48","author":"Rohrer","year":"2007","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.celrep.2020.01.064_bib44","doi-asserted-by":"crossref","first-page":"E4472","DOI":"10.1073\/pnas.1702302114","article-title":"Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration","volume":"114","author":"Rowan","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.01.064_bib45","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1001\/jama.297.16.1793","article-title":"Association of CFH Y402H and LOC387715 A69S with progression of age-related macular degeneration","volume":"297","author":"Seddon","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.celrep.2020.01.064_bib46","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1167\/iovs.08-3064","article-title":"Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables","volume":"50","author":"Seddon","year":"2009","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.celrep.2020.01.064_bib47","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/ng.2741","article-title":"Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration","volume":"45","author":"Seddon","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2020.01.064_bib48","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1002\/emmm.201302692","article-title":"CCR2+ monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice","volume":"5","author":"Sennlaub","year":"2013","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.celrep.2020.01.064_bib49","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1167\/iovs.07-1072","article-title":"Complement-associated deposits in the human retina","volume":"49","author":"Seth","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.celrep.2020.01.064_bib50","doi-asserted-by":"crossref","first-page":"12054","DOI":"10.1074\/jbc.M117.790568","article-title":"Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells","volume":"292","author":"Shindou","year":"2017","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2020.01.064_bib51","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s00262-006-0221-z","article-title":"Activation of complement C3, C5, and C9 genes in tumors treated by photodynamic therapy","volume":"56","author":"Stott","year":"2007","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.celrep.2020.01.064_bib52","doi-asserted-by":"crossref","first-page":"297ra116","DOI":"10.1126\/scitranslmed.aab1482","article-title":"Inhibition of the alternative complement pathway preserves photoreceptors after retinal injury","volume":"7","author":"Sweigard","year":"2015","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2020.01.064_bib53","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1096\/fj.14-251041","article-title":"The alternative complement pathway regulates pathological angiogenesis in the retina","volume":"28","author":"Sweigard","year":"2014","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2020.01.064_bib54","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/intimm\/13.7.933","article-title":"Discrimination of bacterial lipoproteins by toll-like receptor 6","volume":"13","author":"Takeuchi","year":"2001","journal-title":"Int. Immunol."},{"key":"10.1016\/j.celrep.2020.01.064_bib55","doi-asserted-by":"crossref","first-page":"10","DOI":"10.4049\/jimmunol.169.1.10","article-title":"Cutting edge: role of toll-like receptor 1 in mediating immune response to microbial lipoproteins","volume":"169","author":"Takeuchi","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.01.064_bib56","doi-asserted-by":"crossref","first-page":"8789","DOI":"10.1073\/pnas.1523061113","article-title":"Protective responses to sublytic complement in the retinal pigment epithelium","volume":"113","author":"Tan","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.01.064_bib57","first-page":"2903","article-title":"The complement membrane attack complex triggers intracellular Ca2+ fluxes leading to NLRP3 inflammasome activation","volume":"126","author":"Triantafilou","year":"2013","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.celrep.2020.01.064_bib58","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0161-5890(86)90171-9","article-title":"Increased hemolytic activity of the trypsin-cleaved ninth component of complement","volume":"23","author":"Tschopp","year":"1986","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.celrep.2020.01.064_bib59","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/ng.2640","article-title":"A functional variant in the CFI gene confers a high risk of age-related macular degeneration","volume":"45","author":"van de Ven","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2020.01.064_bib60","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1021\/tx500216a","article-title":"Detection and biological activities of carboxyethylpyrrole ethanolamine phospholipids (CEP-EPs)","volume":"27","author":"Wang","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.celrep.2020.01.064_bib61","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1038\/nature09421","article-title":"Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands","volume":"467","author":"West","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2020.01.064_bib62","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/S2214-109X(13)70145-1","article-title":"Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: A systematic review and meta-analysis","volume":"2","author":"Wong","year":"2014","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.celrep.2020.01.064_bib63","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1056\/NEJMoa072618","article-title":"Complement C3 variant and the risk of age-related macular degeneration","volume":"357","author":"Yates","year":"2007","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2020.01.064_bib64","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1002\/path.4669","article-title":"Molecular response of chorioretinal endothelial cells to complement injury: Implications for macular degeneration","volume":"238","author":"Zeng","year":"2016","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.celrep.2020.01.064_bib65","doi-asserted-by":"crossref","first-page":"16182","DOI":"10.1073\/pnas.0604255103","article-title":"Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium","volume":"103","author":"Zhou","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.01.064_bib66","doi-asserted-by":"crossref","first-page":"5625","DOI":"10.4049\/jimmunol.1301903","article-title":"Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis","volume":"191","author":"Zou","year":"2013","journal-title":"J.\u00a0Immunol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720300899?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720300899?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:51:25Z","timestamp":1761907885000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124720300899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":65,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["S2211124720300899"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2020.01.064","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2020.01.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020","name":"copyright","label":"Copyright"}]}}