{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T17:46:01Z","timestamp":1792259161346,"version":"4.4.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022278","name":"Fondation des Gueules Cass\u00e9es","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-11-IDEX-0004-02"],"award-info":[{"award-number":["ANR-11-IDEX-0004-02"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-LABX-73"],"award-info":[{"award-number":["ANR-10-LABX-73"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-15-CE37-0004-01"],"award-info":[{"award-number":["ANR-15-CE37-0004-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.celrep.2020.02.099","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T10:41:33Z","timestamp":1584441693000},"page":"3682-3690.e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"title":["Changes in Gut Microbiota by Chronic Stress Impair the Efficacy of Fluoxetine"],"prefix":"10.1016","volume":"30","author":[{"given":"Eleni","family":"Siopi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gr\u00e9goire","family":"Chevalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lida","family":"Katsimpardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soham","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Bigot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Moigneu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Eberl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Marie","family":"Lledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2020.02.099_bib1","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","article-title":"Gut microbiota regulation of tryptophan metabolism in health and disease","volume":"23","author":"Agus","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2020.02.099_bib2","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41586-018-0262-4","article-title":"Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus","volume":"559","author":"Anacker","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2020.02.099_bib3","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/npp.2013.5","article-title":"Hippocampal granule neuron number and dentate gyrus volume in antidepressant-treated and untreated major depression","volume":"38","author":"Boldrini","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.celrep.2020.02.099_bib4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1128\/jb.121.1.70-76.1975","article-title":"Tryptophan catabolism in Bacillus megaterium","volume":"121","author":"Bouknight","year":"1975","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.celrep.2020.02.099_bib5","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1176\/appi.ajp.161.4.598","article-title":"Lower hippocampal volume in patients suffering from depression: a meta-analysis","volume":"161","author":"Campbell","year":"2004","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.celrep.2020.02.099_bib6","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/mp.2012.77","article-title":"The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner","volume":"18","author":"Clarke","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.celrep.2020.02.099_bib7","doi-asserted-by":"crossref","first-page":"D141","DOI":"10.1093\/nar\/gkn879","article-title":"The Ribosomal Database Project: improved alignments and new tools for rRNA analysis","volume":"37","author":"Cole","year":"2009","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2020.02.099_bib8","doi-asserted-by":"crossref","first-page":"7735","DOI":"10.1038\/ncomms8735","article-title":"Microbiota and host determinants of behavioural phenotype in maternally separated mice","volume":"6","author":"De Palma","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2020.02.099_bib9","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbi.2015.04.004","article-title":"Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour","volume":"48","author":"Desbonnet","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.celrep.2020.02.099_bib10","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.clnu.2012.11.027","article-title":"The ingestion of different dietary proteins by humans induces large changes in the plasma tryptophan ratio, a predictor of brain tryptophan uptake and serotonin synthesis","volume":"32","author":"Fernstrom","year":"2013","journal-title":"Clin. Nutr."},{"issue":"Suppl 2","key":"10.1016\/j.celrep.2020.02.099_bib11","doi-asserted-by":"crossref","first-page":"46S","DOI":"10.1038\/sj.npp.1395369","article-title":"Serotonin and hippocampal neurogenesis","volume":"21","author":"Gould","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.celrep.2020.02.099_bib12","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/j.psyneuen.2008.07.010","article-title":"Multifaceted strain-specific effects in a mouse model of depression and of antidepressant reversal","volume":"33","author":"Ibarguen-Vargas","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.celrep.2020.02.099_bib13","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1747-5341-3-14","article-title":"Effectiveness of antidepressants: an evidence myth constructed from a thousand randomized trials?","volume":"3","author":"Ioannidis","year":"2008","journal-title":"Philos. Ethics Humanit. Med."},{"key":"10.1016\/j.celrep.2020.02.099_bib14","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/mp.2011.50","article-title":"Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice","volume":"17","author":"Jacobsen","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.celrep.2020.02.099_bib15","doi-asserted-by":"crossref","first-page":"2324","DOI":"10.1038\/npp.2016.35","article-title":"SSRI augmentation by 5-hydroxytryptophan slow release: Mouse pharmacodynamic proof of concept","volume":"41","author":"Jacobsen","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.celrep.2020.02.099_bib16","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2015.03.016","article-title":"Altered fecal microbiota composition in patients with major depressive disorder","volume":"48","author":"Jiang","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.celrep.2020.02.099_bib17","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0140-6736(16)31460-X","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015","volume":"388","author":"Kassebaum","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2020.02.099_bib18","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1634\/stemcells.2007-0921","article-title":"BM88\/Cend1 expression levels are critical for proliferation and differentiation of subventricular zone-derived neural precursor cells","volume":"26","author":"Katsimpardi","year":"2008","journal-title":"Stem Cells"},{"key":"10.1016\/j.celrep.2020.02.099_bib19","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.celrep.2020.02.099_bib20","doi-asserted-by":"crossref","first-page":"43859","DOI":"10.1038\/srep43859","article-title":"Microbiota alteration is associated with the development of stress-induced despair behavior","volume":"7","author":"Marin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2020.02.099_bib21","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.celrep.2016.04.074","article-title":"Ly6C(hi) Monocytes Provide a Link between Antibiotic-Induced Changes in Gut Microbiota and Adult Hippocampal Neurogenesis","volume":"15","author":"M\u00f6hle","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2020.02.099_bib22","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1111\/nmo.12378","article-title":"Correlation between the human fecal microbiota and depression","volume":"26","author":"Naseribafrouei","year":"2014","journal-title":"Neurogastroenterol. Motil."},{"key":"10.1016\/j.celrep.2020.02.099_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","article-title":"Neurobiology of depression","volume":"34","author":"Nestler","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2020.02.099_bib24","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.bbr.2014.07.027","article-title":"Serotonin, tryptophan metabolism and the brain-gut-microbiome axis","volume":"277","author":"O\u2019Mahony","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.celrep.2020.02.099_bib25","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1523\/JNEUROSCI.0237-07.2007","article-title":"Antidepressant-induced neurogenesis in the hippocampus of adult nonhuman primates","volume":"27","author":"Perera","year":"2007","journal-title":"J.\u00a0Neurosci."},{"issue":"Suppl 1","key":"10.1016\/j.celrep.2020.02.099_bib26","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1002\/1520-6394(2000)12:1+<2::AID-DA2>3.0.CO;2-4","article-title":"Role of serotonergic and noradrenergic systems in the pathophysiology of depression and anxiety disorders","volume":"12","author":"Ressler","year":"2000","journal-title":"Depress. Anxiety"},{"key":"10.1016\/j.celrep.2020.02.099_bib27","doi-asserted-by":"crossref","first-page":"e291","DOI":"10.1038\/tp.2013.65","article-title":"The effects of congenital brain serotonin deficiency on responses to chronic fluoxetine","volume":"3","author":"Sachs","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.celrep.2020.02.099_bib28","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/nn1969","article-title":"Adult hippocampal neurogenesis in depression","volume":"10","author":"Sahay","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2020.02.099_bib29","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.02.099_bib30","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1038\/npp.2013.21","article-title":"Behavioral and neurobiological effects of deep brain stimulation in a mouse model of high anxiety- and depression-like behavior","volume":"38","author":"Schmuckermair","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.celrep.2020.02.099_bib31","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1021\/cn300127h","article-title":"Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice","volume":"4","author":"Siesser","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.celrep.2020.02.099_bib33","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.biopsych.2008.02.022","article-title":"Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal","volume":"64","author":"Surget","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.celrep.2020.02.099_bib34","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/mp.2011.48","article-title":"Antidepressants recruit new neurons to improve stress response regulation","volume":"16","author":"Surget","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.celrep.2020.02.099_bib35","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1194\/jlr.M002774","article-title":"The gut microbiota modulates host energy and lipid metabolism in mice","volume":"51","author":"Velagapudi","year":"2010","journal-title":"J.\u00a0Lipid Res."},{"key":"10.1016\/j.celrep.2020.02.099_bib36","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13073-016-0296-x","article-title":"Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions","volume":"8","author":"Zhang","year":"2016","journal-title":"Genome Med."},{"key":"10.1016\/j.celrep.2020.02.099_bib37","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/mp.2016.44","article-title":"Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host\u2019s metabolism","volume":"21","author":"Zheng","year":"2016","journal-title":"Mol. Psychiatry"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720302734?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720302734?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:35:55Z","timestamp":1778841355000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124720302734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":36,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S2211124720302734"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2020.02.099","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes in Gut Microbiota by Chronic Stress Impair the Efficacy of Fluoxetine","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2020.02.099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors.","name":"copyright","label":"Copyright"}]}}