{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T17:05:51Z","timestamp":1786986351501,"version":"build-2736575974"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T00:00:00Z","timestamp":1588291200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T00:00:00Z","timestamp":1587513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009845","name":"Ovarian Cancer Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009845","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HDO72489"],"award-info":[{"award-number":["HDO72489"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001111","name":"Cancer Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001111","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2020,5]]},"DOI":"10.1016\/j.celrep.2020.107631","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T10:46:07Z","timestamp":1589280367000},"page":"107631","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["In\u00a0Vivo Cell Fate Tracing Provides No Evidence for Mesenchymal to Epithelial Transition in Adult Fallopian Tube and Uterus"],"prefix":"10.1016","volume":"31","author":[{"given":"Arnab","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shafiq M.","family":"Syed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler J.","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose M.","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Houairia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumedha","family":"Negi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep S.","family":"Tanwar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2020.107631_bib1","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1002\/mrd.20858","article-title":"A mesenchymal perspective of m\u00fcllerian duct differentiation and regression in Amhr2-lacZ mice","volume":"75","author":"Arango","year":"2008","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.celrep.2020.107631_bib2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1242\/dev.120.1.189","article-title":"A novel member of the transmembrane serine\/threonine kinase receptor family is specifically expressed in the gonads and in mesenchymal cells adjacent to the m\u00fcllerian duct","volume":"120","author":"Baarends","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.celrep.2020.107631_bib3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1126\/science.1082095","article-title":"LRP: role in vascular wall integrity and protection from atherosclerosis","volume":"300","author":"Boucher","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.107631_bib4","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/01.pgp.0000101082.35393.84","article-title":"Atypical epithelial proliferation in fallopian tubes in prophylactic salpingo-oophorectomy specimens from BRCA1 and BRCA2 germline mutation carriers","volume":"23","author":"Carcangiu","year":"2004","journal-title":"Int. J. of Gynecol. Pathol."},{"key":"10.1016\/j.celrep.2020.107631_bib5","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.stem.2017.05.017","article-title":"Lineage tracing across 10 years","volume":"20","author":"Chari","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2020.107631_bib6","doi-asserted-by":"crossref","first-page":"5619","DOI":"10.1158\/0008-5472.CAN-08-1274","article-title":"Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice","volume":"68","author":"Daikoku","year":"2008","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2020.107631_bib7","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ygyno.2011.04.022","article-title":"Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes","volume":"122","author":"Daikoku","year":"2011","journal-title":"Gynecol. Oncol."},{"key":"10.1016\/j.celrep.2020.107631_bib8","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1523\/JNEUROSCI.22-09-03445.2002","article-title":"Neuronal deficiency of presenilin 1 inhibits amyloid plaque formation and corrects hippocampal long-term potentiation but not a cognitive defect of amyloid precursor protein [V717I] transgenic mice","volume":"22","author":"Dewachter","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2020.107631_bib9","first-page":"462","article-title":"Development of epithelial and mesenchymal regionalization of the human fetal utero-vaginal anlagen","volume":"222","author":"Fritsch","year":"2013","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.celrep.2020.107631_bib10","first-page":"3031","article-title":"In\u00a0vivo genetic cell lineage tracing reveals that oviductal secretory cells self-renew and give rise to ciliated cells","volume":"144","author":"Ghosh","year":"2017","journal-title":"Development"},{"key":"10.1016\/j.celrep.2020.107631_bib49","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ydbio.2017.01.015","article-title":"Differential Wnt signaling activity limits epithelial gland development to the anti-mesometrial side of the mouse uterus","volume":"423","author":"Goad","year":"2017","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2020.107631_bib11","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.ydbio.2006.09.046","article-title":"The origin of the m\u00fcllerian duct in chick and mouse","volume":"302","author":"Guioli","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2020.107631_bib12","doi-asserted-by":"crossref","first-page":"66077","DOI":"10.18632\/oncotarget.11808","article-title":"Epithelialization of mouse ovarian tumor cells originating in the fallopian tube stroma","volume":"7","author":"Hua","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2020.107631_bib13","doi-asserted-by":"crossref","first-page":"e44285","DOI":"10.1371\/journal.pone.0044285","article-title":"Stromal-to-epithelial transition during postpartum endometrial regeneration","volume":"7","author":"Huang","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2020.107631_bib41","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ng1003","article-title":"Requirement of Bmpr1a for Mullerian duct regression during male sexual development","volume":"32","author":"Jamin","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2020.107631_bib14","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1073\/pnas.1117135109","article-title":"High-grade serous ovarian cancer arises from fallopian tube in a mouse model","volume":"109","author":"Kim","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.107631_bib15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cell.2012.01.002","article-title":"Lineage tracing","volume":"148","author":"Kretzschmar","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.107631_bib16","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/01.pas.0000180854.28831.77","article-title":"The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome","volume":"30","author":"Medeiros","year":"2006","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.celrep.2020.107631_bib17","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.1093\/nar\/27.19.e27","article-title":"Gene targeting restricted to mouse striated muscle lineage","volume":"27","author":"Miniou","year":"1999","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2020.107631_bib48","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1038\/nprot.2013.153","article-title":"In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture","volume":"8","author":"Miyoshi","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2020.107631_bib18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000364935","article-title":"Molecular genetics of m\u00fcllerian duct formation, regression and differentiation","volume":"8","author":"Mullen","year":"2014","journal-title":"Sex Dev."},{"key":"10.1016\/j.celrep.2020.107631_bib19","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.ydbio.2007.03.027","article-title":"Cellular mechanisms of m\u00fcllerian duct formation in the mouse","volume":"306","author":"Orvis","year":"2007","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2020.107631_bib20","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1093\/humupd\/dmy035","article-title":"The role of mesenchymal-epithelial transition in endometrial function","volume":"25","author":"Owusu-Akyaw","year":"2019","journal-title":"Hum. Reprod. Update"},{"key":"10.1016\/j.celrep.2020.107631_bib21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0012-1606(86)90356-8","article-title":"Epithelial and mesenchymal cell differentiation in the fetal rat genital ducts: changes in the expression of cytokeratin and vimentin type of intermediate filaments and desmosomal plaque proteins","volume":"117","author":"Paranko","year":"1986","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2020.107631_bib22","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1089\/scd.2012.0435","article-title":"Mesenchymal-to-epithelial transition contributes to endometrial regeneration following natural and artificial decidualization","volume":"22","author":"Patterson","year":"2013","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.celrep.2020.107631_bib23","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41556-018-0195-z","article-title":"Mesenchymal-epithelial transition in development and reprogramming","volume":"21","author":"Pei","year":"2019","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2020.107631_bib24","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.ccr.2013.10.013","article-title":"Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models","volume":"24","author":"Perets","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2020.107631_bib25","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1095\/biolreprod.114.124388","article-title":"A novel class of interstitial cells in the mouse and monkey female reproductive tracts","volume":"92","author":"Peri","year":"2015","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2020.107631_bib45","doi-asserted-by":"crossref","first-page":"10482","DOI":"10.1073\/pnas.152238499","article-title":"Early restriction of peripheral and proximal cell lineages during formation of the lung","volume":"99","author":"Perl","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.107631_bib26","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/path.1000","article-title":"Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer","volume":"195","author":"Piek","year":"2001","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.celrep.2020.107631_bib27","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1038\/s41388-017-0097-8","article-title":"PTEN loss in the fallopian tube induces hyperplasia and ovarian tumor formation","volume":"37","author":"Russo","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2020.107631_bib40","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to Im- ageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2020.107631_bib28","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/path.4353","article-title":"A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development","volume":"233","author":"Sherman-Baust","year":"2014","journal-title":"J.\u00a0Pathol."},{"issue":"D1","key":"10.1016\/j.celrep.2020.107631_bib29","doi-asserted-by":"crossref","first-page":"D774","DOI":"10.1093\/nar\/gky922","article-title":"The mouse Gene Expression Database (GXD): 2019 update","volume":"47","author":"Smith","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2020.107631_bib30","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1600-0897.1998.tb00384.x","article-title":"Expression of vimentin and cytokeratin in eutopic and ectopic endometrium of women with adenomyosis and ovarian endometrioma","volume":"40","author":"Song","year":"1998","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.celrep.2020.107631_bib47","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1038\/5007","article-title":"Generalized lacZ expression with the ROSA26 Cre reporter strain","volume":"21","author":"Soriano","year":"1999","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2020.107631_bib31","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.stem.2019.11.012","article-title":"Endometrial axin2+ cells drive epithelial homeostasis, regeneration, and cancer following oncogenic transformation","volume":"26","author":"Syed","year":"2020","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2020.107631_bib50","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002906","article-title":"Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1","volume":"8","author":"Tanwar","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2020.107631_bib32","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1210\/endo.137.1.8536608","article-title":"Developmental expression of a candidate m\u00fcllerian inhibiting substance type II receptor","volume":"137","author":"Teixeira","year":"1996","journal-title":"Endocrinology"},{"key":"10.1016\/j.celrep.2020.107631_bib33","first-page":"657","article-title":"M\u00fcllerian inhibiting substance: an instructive developmental hormone with diagnostic and possible therapeutic applications","volume":"22","author":"Teixeira","year":"2001","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.celrep.2020.107631_bib44","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/nm.1865","article-title":"An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice","volume":"14","author":"Traykova-Brauch","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2020.107631_bib46","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.1092436","article-title":"Defining the epithelial stem cell niche in skin","volume":"303","author":"Tumbar","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.107631_bib34","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.cmet.2015.10.018","article-title":"Pdgfr\u03b2+ mural preadipocytes contribute to adipocyte hyperplasia induced by high-fat-diet feeding and prolonged cold exposure in adult mice","volume":"23","author":"Vishvanath","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2020.107631_bib35","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/path.4783","article-title":"Impact of oviductal versus ovarian epithelial cell of origin on ovarian endometrioid carcinoma phenotype in the mouse","volume":"240","author":"Wu","year":"2016","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.celrep.2020.107631_bib36","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/path.4649","article-title":"In\u00a0vitro and in\u00a0vivo correlates of physiological and neoplastic human Fallopian tube stem cells","volume":"238","author":"Yamamoto","year":"2016","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.celrep.2020.107631_bib37","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1016\/j.celrep.2019.04.088","article-title":"CD34+KLF4+ stromal stem cells contribute to endometrial regeneration and repair","volume":"27","author":"Yin","year":"2019","journal-title":"Cell Rep,"},{"key":"10.1016\/j.celrep.2020.107631_bib38","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1242\/dev.02383","article-title":"M\u00fcllerian inhibiting substance regulates its receptor\/SMAD signaling and causes mesenchymal transition of the coelomic epithelial cells early in M\u00fcllerian duct regression","volume":"133","author":"Zhan","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.celrep.2020.107631_bib39","doi-asserted-by":"crossref","first-page":"e23","DOI":"10.1161\/01.ATV.0000202661.61837.93","article-title":"Generation of an adult smooth muscle cell-targeted Cre recombinase mouse model","volume":"26","author":"Zhang","year":"2006","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2020.107631_bib42","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1242\/dev.004895","article-title":"NG2 cells generate both oligodendrocytes and gray matter astrocytes","volume":"135","author":"Zhu","year":"2008","journal-title":"Development"},{"key":"10.1016\/j.celrep.2020.107631_bib43","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1242\/dev.047951","article-title":"Age-dependent fate and lineage restriction of single NG2 cells","volume":"138","author":"Zhu","year":"2011","journal-title":"Development"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720305842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720305842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T10:57:17Z","timestamp":1761908237000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124720305842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["S2211124720305842"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2020.107631","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2020,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"In\u00a0Vivo Cell Fate Tracing Provides No Evidence for Mesenchymal to Epithelial Transition in Adult Fallopian Tube and Uterus","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2020.107631","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"107631"}}