{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T19:39:47Z","timestamp":1778960387675,"version":"3.51.4"},"reference-count":72,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA213201"],"award-info":[{"award-number":["CA213201"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI142040"],"award-info":[{"award-number":["AI142040"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK113423"],"award-info":[{"award-number":["DK113423"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI144196"],"award-info":[{"award-number":["AI144196"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["CHE-1565788"],"award-info":[{"award-number":["CHE-1565788"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["SL0101"],"award-info":[{"award-number":["SL0101"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.celrep.2020.107931","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T10:39:55Z","timestamp":1595327995000},"page":"107931","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["RSK2 Maintains Adult Estrogen Homeostasis by Inhibiting ERK1\/2-Mediated Degradation of Estrogen Receptor Alpha"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9436-7270","authenticated-orcid":false,"given":"Katarzyna A.","family":"Ludwik","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary M.","family":"Sandusky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2605-9356","authenticated-orcid":false,"given":"Kimberly M.","family":"Stauffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9315-8525","authenticated-orcid":false,"given":"Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelli L.","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George A.","family":"O\u2019Doherty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas P.","family":"Stricker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8380-9240","authenticated-orcid":false,"given":"Deborah A.","family":"Lannigan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2020.107931_bib1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.cmet.2011.08.005","article-title":"Estrogen receptors and the metabolic network","volume":"14","author":"Barros","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2020.107931_bib2","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1093\/toxsci\/54.1.138","article-title":"The estrogen receptor relative binding affinities of 188 natural and xenochemicals: structural diversity of ligands","volume":"54","author":"Blair","year":"2000","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.celrep.2020.107931_bib3","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1258\/la.2007.06003e","article-title":"A sparing procedure to clear the mouse mammary fat pad of epithelial components for transplantation analysis","volume":"42","author":"Brill","year":"2008","journal-title":"Lab. Anim."},{"key":"10.1016\/j.celrep.2020.107931_bib4","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/wdev.172","article-title":"Endocrine hormones and local signals during the development of the mouse mammary gland","volume":"4","author":"Brisken","year":"2015","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"10.1016\/j.celrep.2020.107931_bib5","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1002\/j.1460-2075.1996.tb00571.x","article-title":"Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation","volume":"15","author":"Bunone","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2020.107931_bib6","doi-asserted-by":"crossref","first-page":"e35538","DOI":"10.1371\/journal.pone.0035538","article-title":"Mouse estrous cycle identification tool and images","volume":"7","author":"Byers","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2020.107931_bib7","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S1097-2765(05)00004-3","article-title":"Activation of estrogen receptor alpha by S118 phosphorylation involves a ligand-dependent interaction with TFIIH and participation of CDK7","volume":"6","author":"Chen","year":"2000","journal-title":"Mol. Cell"},{"issue":"3, Suppl","key":"10.1016\/j.celrep.2020.107931_bib8","doi-asserted-by":"crossref","first-page":"1S","DOI":"10.1016\/S0010-7824(15)30002-0","article-title":"Breast cancer and hormonal contraceptives: further results","volume":"54","author":"Beral","year":"1996","journal-title":"Contraception"},{"key":"10.1016\/j.celrep.2020.107931_bib9","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1074\/jbc.273.3.1496","article-title":"Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a\/p90rsk that are inducible by MAPK","volume":"273","author":"Dalby","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2020.107931_bib10","doi-asserted-by":"crossref","first-page":"5633","DOI":"10.1021\/bi973035t","article-title":"Specific and reversible inactivation of protein tyrosine phosphatases by hydrogen peroxide: evidence for a sulfenic acid intermediate and implications for redox regulation","volume":"37","author":"Denu","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.celrep.2020.107931_bib11","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/AOG.0000000000000692","article-title":"Effects of cross-sex hormone treatment on transgender women and men","volume":"125","author":"Deutsch","year":"2015","journal-title":"Obstet. Gynecol."},{"key":"10.1016\/j.celrep.2020.107931_bib12","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1158\/0008-5472.CAN-09-3988","article-title":"Estrogen regulation and physiopathologic significance of alternative promoters in breast cancer","volume":"70","author":"Dutertre","year":"2010","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2020.107931_bib13","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.1158\/0008-5472.CAN-07-0746","article-title":"Positive cross-regulatory loop ties GATA-3 to estrogen receptor alpha expression in breast cancer","volume":"67","author":"Eeckhoute","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2020.107931_bib14","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.steroids.2009.12.010","article-title":"RSK in tumorigenesis: connections to steroid signaling","volume":"75","author":"Eisinger-Mathason","year":"2010","journal-title":"Steroids"},{"key":"10.1016\/j.celrep.2020.107931_bib15","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1095\/biolreprod65.3.680","article-title":"Cellular turnover in the mammary gland is correlated with systemic levels of progesterone and not 17beta-estradiol during the estrous cycle","volume":"65","author":"Fata","year":"2001","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2020.107931_bib16","doi-asserted-by":"crossref","first-page":"14718","DOI":"10.1073\/pnas.0706933104","article-title":"Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice","volume":"104","author":"Feng","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.107931_bib17","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.jmb.2017.02.011","article-title":"When worlds collide-mechanisms at the interface between phosphorylation and ubiquitination","volume":"429","author":"Filip\u010d\u00edk","year":"2017","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.celrep.2020.107931_bib18","doi-asserted-by":"crossref","first-page":"15578","DOI":"10.1073\/pnas.192561299","article-title":"Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium","volume":"99","author":"F\u00f6rster","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.107931_bib19","doi-asserted-by":"crossref","first-page":"8487","DOI":"10.1038\/ncomms9487","article-title":"Stem and progenitor cell division kinetics during postnatal mouse mammary gland development","volume":"6","author":"Giraddi","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2020.107931_bib20","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1038\/onc.2008.473","article-title":"Activation of the unliganded estrogen receptor by prolactin in breast cancer cells","volume":"28","author":"Gonz\u00e1lez","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2020.107931_bib21","doi-asserted-by":"crossref","first-page":"2496","DOI":"10.1158\/1055-9965.EPI-10-0747","article-title":"Oral contraceptive use and breast cancer: a prospective study of young women","volume":"19","author":"Hunter","year":"2010","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.celrep.2020.107931_bib22","doi-asserted-by":"crossref","first-page":"a003186","DOI":"10.1101\/cshperspect.a003186","article-title":"Mammary gland growth factors: roles in normal development and in cancer","volume":"2","author":"Hynes","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.celrep.2020.107931_bib23","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.beem.2015.04.008","article-title":"Estrogen receptor alpha and beta in health and disease","volume":"29","author":"Jia","year":"2015","journal-title":"Best Pract. Res. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2020.107931_bib24","doi-asserted-by":"crossref","first-page":"5769","DOI":"10.1158\/1078-0432.CCR-07-0822","article-title":"Phosphorylation of estrogen receptor-alpha at Ser167 is indicative of longer disease-free and overall survival in breast cancer patients","volume":"13","author":"Jiang","year":"2007","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2020.107931_bib25","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1128\/MCB.18.4.1978","article-title":"pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167","volume":"18","author":"Joel","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2020.107931_bib26","doi-asserted-by":"crossref","first-page":"13317","DOI":"10.1074\/jbc.273.21.13317","article-title":"Estradiol-induced phosphorylation of serine 118 in the estrogen receptor is independent of p42\/p44 mitogen-activated protein kinase","volume":"273","author":"Joel","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2020.107931_bib27","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1126\/science.270.5241.1491","article-title":"Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase","volume":"270","author":"Kato","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.107931_bib28","doi-asserted-by":"crossref","first-page":"38078","DOI":"10.1038\/srep38078","article-title":"Uterine glands impact uterine receptivity, luminal fluid homeostasis and blastocyst implantation","volume":"6","author":"Kelleher","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2020.107931_bib29","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1021\/acs.orglett.7b00945","article-title":"Stereoselective synthesis and evaluation of C6\u2033-substituted 5a-carbasugar analogues of SL0101 as inhibitors of RSK1\/2","volume":"19","author":"Li","year":"2017","journal-title":"Org. Lett."},{"key":"10.1016\/j.celrep.2020.107931_bib30","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1097-2765(00)80259-2","article-title":"The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation","volume":"5","author":"Lonard","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2020.107931_bib31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1093\/emph\/eox009","article-title":"Oral contraceptives cause evolutionarily novel increases in hormone exposure: A risk factor for breast cancer","volume":"2017","author":"Lovett","year":"2017","journal-title":"Evol. Med. Public Health"},{"key":"10.1016\/j.celrep.2020.107931_bib32","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1158\/1535-7163.MCT-16-0106","article-title":"Development of a RSK inhibitor as a novel therapy for triple-negative breast cancer","volume":"15","author":"Ludwik","year":"2016","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.celrep.2020.107931_bib33","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1158\/0008-5472.CAN-17-2063","article-title":"ER\u03b1-mediated nuclear sequestration of RSK2 is required for ER+ breast cancer tumorigenesis","volume":"78","author":"Ludwik","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2020.107931_bib34","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.3390\/cancers11121826","article-title":"Molecular targeting therapy against EGFR family in breast cancer: progress and future potentials","volume":"11","author":"Maennling","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.celrep.2020.107931_bib35","doi-asserted-by":"crossref","first-page":"e113175","DOI":"10.1371\/journal.pone.0113175","article-title":"Differential roles of ER\u03b1 and ER\u03b2 in normal and neoplastic development in the mouse mammary gland","volume":"9","author":"Mehta","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2020.107931_bib36","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1097-2765(02)00445-8","article-title":"Reversible oxidation and inactivation of protein tyrosine phosphatases in\u00a0vivo","volume":"9","author":"Meng","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2020.107931_bib37","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1186\/1471-2407-12-585","article-title":"Phosphorylation of p90RSK is associated with increased response to neoadjuvant chemotherapy in ER-positive breast cancer","volume":"12","author":"Moon","year":"2012","journal-title":"BMC Cancer"},{"key":"10.1016\/j.celrep.2020.107931_bib38","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1056\/NEJMoa1700732","article-title":"Contemporary hormonal contraception and the risk of breast cancer","volume":"377","author":"M\u00f8rch","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2020.107931_bib39","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1073\/pnas.96.5.1858","article-title":"Proteasome-dependent degradation of the human estrogen receptor","volume":"96","author":"Nawaz","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.107931_bib40","doi-asserted-by":"crossref","first-page":"R26","DOI":"10.1186\/bcr3627","article-title":"Next-generation transcriptome sequencing of the premenopausal breast epithelium using specimens from a normal human breast tissue bank","volume":"16","author":"Pardo","year":"2014","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.celrep.2020.107931_bib41","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jsbmb.2017.08.013","article-title":"Hypoxia induced phosphorylation of estrogen receptor at serine 118 in the absence of ligand","volume":"174","author":"Park","year":"2017","journal-title":"J.\u00a0Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.celrep.2020.107931_bib42","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1101\/gad.2025611","article-title":"Sustained activation of the HER1-ERK1\/2-RSK signaling pathway controls myoepithelial cell fate in human mammary tissue","volume":"25","author":"Pasic","year":"2011","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2020.107931_bib43","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1126\/science.1147674","article-title":"DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression","volume":"319","author":"Perillo","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.107931_bib44","first-page":"P617","article-title":"Differences in the onset of puberty in selected inbred mouse strains","volume":"14","author":"Pinter","year":"2007","journal-title":"Endocr. Abstr."},{"key":"10.1016\/j.celrep.2020.107931_bib45","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S1097-2765(03)00090-X","article-title":"Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling","volume":"11","author":"Reid","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2020.107931_bib46","doi-asserted-by":"crossref","first-page":"R127","DOI":"10.1530\/JME-15-0300","article-title":"Mechanisms of uterine estrogen signaling during early pregnancy in mice: an update","volume":"56","author":"Robertshaw","year":"2016","journal-title":"J.\u00a0Mol. Endocrinol."},{"issue":"Suppl 1","key":"10.1016\/j.celrep.2020.107931_bib47","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/rheumatology\/XXVIII.suppl_1.13","article-title":"Oral contraceptives and the risk of rheumatoid arthritis: a meta-analysis of a conflicting literature","volume":"28","author":"Romieu","year":"1989","journal-title":"Br. J. Rheumatol."},{"key":"10.1016\/j.celrep.2020.107931_bib48","doi-asserted-by":"crossref","first-page":"e00070-18","DOI":"10.1128\/MCB.00070-18","article-title":"Signaling pathways involved in the regulation of mRNA translation","volume":"38","author":"Roux","year":"2018","journal-title":"Mol. Cell. Biol."},{"issue":"Suppl 2","key":"10.1016\/j.celrep.2020.107931_bib49","first-page":"S77","article-title":"Estrogen-growth factor interactions and their contributions to neurological disorders","volume":"48","author":"Scharfman","year":"2008","journal-title":"Headache"},{"key":"10.1016\/j.celrep.2020.107931_bib50","doi-asserted-by":"crossref","first-page":"R134","DOI":"10.1186\/bcr3334","article-title":"Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland","volume":"14","author":"Shehata","year":"2012","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.celrep.2020.107931_bib51","first-page":"24","article-title":"Comprehensive RNA sequencing of healthy human endometrium at two time points of the menstrual cycle","volume":"96","author":"Sigurgeirsson","year":"2017","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2020.107931_bib52","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1677\/joe.1.06725","article-title":"Estrogen-triggered delays in mammary gland gene expression during the estrous cycle: evidence for a novel timing system","volume":"190","author":"Silberstein","year":"2006","journal-title":"J.\u00a0Endocrinol."},{"key":"10.1016\/j.celrep.2020.107931_bib53","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ejca.2017.07.012","article-title":"Menopausal hormone therapy and cancer risk: An overestimated risk?","volume":"84","author":"Simin","year":"2017","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.celrep.2020.107931_bib54","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.4161\/cc.5.17.3191","article-title":"Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants","volume":"5","author":"Tanaka","year":"2006","journal-title":"Cell Cycle"},{"key":"10.1016\/j.celrep.2020.107931_bib55","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1096\/fj.14-265637","article-title":"A kinetic model identifies phosphorylated estrogen receptor-\u03b1 (ER\u03b1) as a critical regulator of ER\u03b1 dynamics in breast cancer","volume":"29","author":"Tian","year":"2015","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2020.107931_bib56","doi-asserted-by":"crossref","first-page":"eaan2507","DOI":"10.1126\/science.aan2507","article-title":"A pathology atlas of the human cancer transcriptome","volume":"357","author":"Uhlen","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.107931_bib57","doi-asserted-by":"crossref","first-page":"5417","DOI":"10.1128\/MCB.25.13.5417-5428.2005","article-title":"Differential regulation of estrogen-inducible proteolysis and transcription by the estrogen receptor alpha N terminus","volume":"25","author":"Valley","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2020.107931_bib58","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1677\/JME-07-0067","article-title":"Temporal variation in estrogen receptor-alpha protein turnover in the presence of estrogen","volume":"40","author":"Valley","year":"2008","journal-title":"J.\u00a0Mol. Endocrinol."},{"key":"10.1016\/j.celrep.2020.107931_bib59","first-page":"23","article-title":"The correlation of histologic changes in the human breast with the menstrual cycle","volume":"104","author":"Vogel","year":"1981","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2020.107931_bib60","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1210\/endo.131.3.1505477","article-title":"Lactoferrin expression in the mouse reproductive tract during the natural estrous cycle: correlation with circulating estradiol and progesterone","volume":"131","author":"Walmer","year":"1992","journal-title":"Endocrinology"},{"key":"10.1016\/j.celrep.2020.107931_bib61","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1093\/emboj\/20.16.4370","article-title":"Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase","volume":"20","author":"Wang","year":"2001","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2020.107931_bib62","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s10549-008-0221-0","article-title":"Reactive oxygen species induce phosphorylation of serine 118 and 167 on estrogen receptor alpha","volume":"118","author":"Weitsman","year":"2009","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.celrep.2020.107931_bib63","doi-asserted-by":"crossref","first-page":"38448","DOI":"10.1074\/jbc.M111.268938","article-title":"Enteric commensal bacteria induce extracellular signal-regulated kinase pathway signaling via formyl peptide receptor-dependent redox modulation of dual specific phosphatase 3","volume":"286","author":"Wentworth","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2020.107931_bib64","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1095\/biolreprod.114.120170","article-title":"Uterine epithelial cell estrogen receptor alpha-dependent and -independent genomic profiles that underlie estrogen responses in mice","volume":"91","author":"Winuthayanon","year":"2014","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.celrep.2020.107931_bib65","doi-asserted-by":"crossref","first-page":"8957","DOI":"10.1128\/JVI.77.16.8957-8951.2003","article-title":"Conditional suppression of cellular genes: lentivirus vector-mediated drug-inducible RNA interference","volume":"77","author":"Wiznerowicz","year":"2003","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2020.107931_bib66","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1530\/REP-06-0302","article-title":"Circulating hormones and estrous stage predict cellular and stromal remodeling in murine uterus","volume":"133","author":"Wood","year":"2007","journal-title":"Reproduction"},{"key":"10.1016\/j.celrep.2020.107931_bib67","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1210\/mend.11.12.0019","article-title":"Targeted expression of a dominant negative epidermal growth factor receptor in the mammary gland of transgenic mice inhibits pubertal mammary duct development","volume":"11","author":"Xie","year":"1997","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.celrep.2020.107931_bib68","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S0092-8674(04)00344-7","article-title":"ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome","volume":"117","author":"Yang","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.107931_bib69","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1007\/s10549-012-2380-2","article-title":"Estrogen receptor and progesterone receptor expression in normal terminal duct lobular units surrounding invasive breast cancer","volume":"137","author":"Yang","year":"2013","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.celrep.2020.107931_bib70","doi-asserted-by":"crossref","first-page":"4223","DOI":"10.1038\/sj.emboj.7601306","article-title":"The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription","volume":"25","author":"Zhang","year":"2006","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2020.107931_bib71","doi-asserted-by":"crossref","first-page":"105787","DOI":"10.1016\/j.intimp.2019.105787","article-title":"Estradiol inhibits fMLP-induced neutrophil migration and superoxide production by upregulating MKP-2 and dephosphorylating ERK","volume":"75","author":"Zhang","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.celrep.2020.107931_bib72","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/nrc3622","article-title":"Links between oestrogen receptor activation and proteolysis: relevance to hormone-regulated cancer therapy","volume":"14","author":"Zhou","year":"2014","journal-title":"Nat. Rev. Cancer"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720309128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720309128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:39:30Z","timestamp":1778841570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124720309128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":72,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["S2211124720309128"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2020.107931","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RSK2 Maintains Adult Estrogen Homeostasis by Inhibiting ERK1\/2-Mediated Degradation of Estrogen Receptor Alpha","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2020.107931","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"107931"}}