{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:11:56Z","timestamp":1793329916500,"version":"4.5.0"},"reference-count":81,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.celrep.2020.108041","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T10:46:40Z","timestamp":1597142800000},"page":"108041","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":172,"title":["Efficient Strategies for Microglia Replacement in the Central Nervous System"],"prefix":"10.1016","volume":"32","author":[{"given":"Zhen","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanxia","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ti-Fei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijie","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2020.108041_bib1","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.neuron.2017.03.042","article-title":"iPSC-derived human microglia-like cells to study neurological diseases","volume":"94","author":"Abud","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2020.108041_bib2","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1038\/nn2014","article-title":"Local self-renewal can sustain CNS microglia maintenance and function throughout adult life","volume":"10","author":"Ajami","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2020.108041_bib3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nbt.4314","article-title":"Dimensionality reduction for visualizing single-cell data using UMAP","volume":"37","author":"Becht","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2020.108041_bib4","doi-asserted-by":"crossref","first-page":"E1738","DOI":"10.1073\/pnas.1525528113","article-title":"New tools for studying microglia in the mouse and human CNS","volume":"113","author":"Bennett","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.108041_bib5","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.neuron.2018.05.014","article-title":"A combination of ontogeny and CNS environment establishes microglial identity","volume":"98","author":"Bennett","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2020.108041_bib6","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.immuni.2015.06.012","article-title":"Genetic cell ablation reveals clusters of local self-renewing microglia in the mammalian central nervous system","volume":"43","author":"Bruttger","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2020.108041_bib7","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"issue":"Suppl.","key":"10.1016\/j.celrep.2020.108041_bib8","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1200\/jco.2014.32.15_suppl.2023","article-title":"A phase 2 study of orally administered PLX3397 in patients with recurrent glioblastoma","volume":"32","author":"Butowski","year":"2014","journal-title":"J.\u00a0Clin. Oncol."},{"key":"10.1016\/j.celrep.2020.108041_bib9","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1038\/ni.3585","article-title":"Sall1 is a transcriptional regulator defining microglia identity and function","volume":"17","author":"Buttgereit","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2020.108041_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40425-017-0257-y","article-title":"Colony-stimulating factor 1 receptor (CSF1R) inhibitors in cancer therapy","volume":"5","author":"Cannarile","year":"2017","journal-title":"J.\u00a0Immunother. Cancer"},{"key":"10.1016\/j.celrep.2020.108041_bib11","doi-asserted-by":"crossref","first-page":"E8547","DOI":"10.1073\/pnas.1805055115","article-title":"Mutation-independent rhodopsin gene therapy by knockdown and replacement with a single AAV vector","volume":"115","author":"Cideciyan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.108041_bib12","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1084\/jem.20180247","article-title":"Peripherally derived macrophages can engraft the brain independent of irradiation and maintain an identity distinct from microglia","volume":"215","author":"Cronk","year":"2018","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2020.108041_bib13","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature10907","article-title":"Wild-type microglia arrest pathology in a mouse model of Rett syndrome","volume":"484","author":"Derecki","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2020.108041_bib14","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.it.2012.10.002","article-title":"The role of microglia in brain maintenance: implications for Rett syndrome","volume":"34","author":"Derecki","year":"2013","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2020.108041_bib15","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.stemcr.2017.04.023","article-title":"Directed differentiation of human pluripotent stem cells to microglia","volume":"8","author":"Douvaras","year":"2017","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.celrep.2020.108041_bib16","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neuroscience.2016.03.056","article-title":"The role of insulin-like growth factor 1 (IGF-1) in brain development, maturation and neuroplasticity","volume":"325","author":"Dyer","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2020.108041_bib17","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.neuron.2014.02.040","article-title":"Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain","volume":"82","author":"Elmore","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2020.108041_bib18","doi-asserted-by":"crossref","first-page":"e0122912","DOI":"10.1371\/journal.pone.0122912","article-title":"Characterizing newly repopulated microglia in the adult mouse: impacts on animal behavior, cell morphology, and neuroinflammation","volume":"10","author":"Elmore","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2020.108041_bib19","doi-asserted-by":"crossref","first-page":"e26317","DOI":"10.1371\/journal.pone.0026317","article-title":"Absence of colony stimulation factor-1 receptor results in loss of microglia, disrupted brain development and olfactory deficits","volume":"6","author":"Erblich","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2020.108041_bib20","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/nn.4631","article-title":"Microglia turnover with aging and in an Alzheimer\u2019s model via long-term in\u00a0vivo single-cell imaging","volume":"20","author":"F\u00fcger","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2020.108041_bib21","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/ni.3423","article-title":"Origin, fate and dynamics of macrophages at central nervous system interfaces","volume":"17","author":"Goldmann","year":"2016","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2020.108041_bib22","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1056\/NEJMoa1211851","article-title":"TREM2 variants in Alzheimer\u2019s disease","volume":"368","author":"Guerreiro","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2020.108041_bib23","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.stem.2013.12.001","article-title":"In\u00a0vivo direct reprogramming of reactive glial cells into functional neurons after brain injury and in an Alzheimer\u2019s disease model","volume":"14","author":"Guo","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2020.108041_bib24","doi-asserted-by":"crossref","first-page":"e0188830","DOI":"10.1371\/journal.pone.0188830","article-title":"Cellular selectivity of AAV serotypes for gene delivery in neurons and astrocytes by neonatal intracerebroventricular injection","volume":"12","author":"Hammond","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2020.108041_bib25","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.neuron.2019.07.002","article-title":"Development of a chimeric model to study and manipulate human microglia in\u00a0vivo","volume":"103","author":"Hasselmann","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2020.108041_bib26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41421-018-0011-8","article-title":"Dual extra-retinal origins of microglia in the model of retinal microglia repopulation","volume":"4","author":"Huang","year":"2018","journal-title":"Cell Discov."},{"key":"10.1016\/j.celrep.2020.108041_bib27","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41593-018-0090-8","article-title":"Repopulated microglia are solely derived from the proliferation of residual microglia after acute depletion","volume":"21","author":"Huang","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2020.108041_bib28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer\u2019s disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2020.108041_bib29","doi-asserted-by":"crossref","first-page":"eaat7554","DOI":"10.1126\/science.aat7554","article-title":"Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation","volume":"363","author":"Jord\u00e3o","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.108041_bib30","doi-asserted-by":"crossref","first-page":"4106","DOI":"10.1128\/MCB.20.11.4106-4114.2000","article-title":"Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion","volume":"20","author":"Jung","year":"2000","journal-title":"Mol. Cell. Biol."},{"issue":"80","key":"10.1016\/j.celrep.2020.108041_bib31","first-page":"50556","article-title":"Parabiosis in mice: a detailed protocol","author":"Kamran","year":"2013","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.celrep.2020.108041_bib32","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1002\/glia.23204","article-title":"Siglec-H is a microglia-specific marker that discriminates microglia from CNS-associated macrophages and CNS-infiltrating monocytes","volume":"65","author":"Konishi","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2020.108041_bib33","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","article-title":"Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u2019s disease","volume":"45","author":"Lambert","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2020.108041_bib34","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1016\/j.neuron.2018.02.002","article-title":"Elevated TREM2 gene dosage reprograms microglia responsivity and ameliorates pathological phenotypes in Alzheimer\u2019s disease models","volume":"97","author":"Lee","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2020.108041_bib35","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10637-019-00745-z","article-title":"A phase I study of pexidartinib, a colony-stimulating factor 1 receptor inhibitor, in Asian patients with advanced solid tumors","volume":"38","author":"Lee","year":"2020","journal-title":"Invest. New Drugs"},{"key":"10.1016\/j.celrep.2020.108041_bib36","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1038\/s41593-019-0433-0","article-title":"TREM2 function impedes tau seeding in neuritic plaques","volume":"22","author":"Leyns","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2020.108041_bib37","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1056\/NEJMcibr1713887","article-title":"Cellular reprogramming in the retina\u2014seeing the light","volume":"378","author":"Lu","year":"2018","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2020.108041_bib38","doi-asserted-by":"crossref","first-page":"4845","DOI":"10.1038\/s41467-018-07295-7","article-title":"Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells","volume":"9","author":"Lund","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2020.108041_bib39","doi-asserted-by":"crossref","first-page":"4697","DOI":"10.4049\/jimmunol.166.7.4697","article-title":"Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice","volume":"166","author":"Mack","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.108041_bib40","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.neuron.2017.12.002","article-title":"Microglial ramification, surveillance, and interleukin-1beta release are regulated by the two-pore domain K(+) channel THIK-1","volume":"97","author":"Madry","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2020.108041_bib41","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1038\/s41593-019-0525-x","article-title":"Stem-cell-derived human microglia transplanted in mouse brain to study human disease","volume":"22","author":"Mancuso","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2020.108041_bib42","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1038\/nn2015","article-title":"Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions","volume":"10","author":"Mildner","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2020.108041_bib43","doi-asserted-by":"crossref","first-page":"11159","DOI":"10.1523\/JNEUROSCI.6209-10.2011","article-title":"Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer\u2019s disease","volume":"31","author":"Mildner","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2020.108041_bib44","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1073\/pnas.1214387110","article-title":"Reprogramming of adult rod photoreceptors prevents retinal degeneration","volume":"110","author":"Montana","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.108041_bib45","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1038\/nm.4189","article-title":"Efficient derivation of microglia-like cells from human pluripotent stem cells","volume":"22","author":"Muffat","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2020.108041_bib46","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by microglia is necessary for normal brain development","volume":"333","author":"Paolicelli","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.108041_bib47","doi-asserted-by":"crossref","first-page":"5703","DOI":"10.1158\/1078-0432.CCR-16-3261","article-title":"First-in-human study of AMG 820, a monoclonal anti-colony-stimulating factor 1 receptor antibody, in patients with advanced solid tumors","volume":"23","author":"Papadopoulos","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2020.108041_bib48","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/s41593-018-0296-9","article-title":"Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE","volume":"22","author":"Parhizkar","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2020.108041_bib49","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.cell.2013.11.030","article-title":"Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor","volume":"155","author":"Parkhurst","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108041_bib50","doi-asserted-by":"crossref","first-page":"8139","DOI":"10.1523\/JNEUROSCI.5200-13.2014","article-title":"Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa","volume":"34","author":"Peng","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2020.108041_bib51","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1038\/nm1201-1356","article-title":"Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment","volume":"7","author":"Priller","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2020.108041_bib52","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.cell.2019.08.053","article-title":"Microglia biology: one century of evolving concepts","volume":"179","author":"Prinz","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108041_bib53","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1084\/jem.20150479","article-title":"Impact of peripheral myeloid cells on amyloid-\u03b2 pathology in Alzheimer\u2019s disease-like mice","volume":"212","author":"Prokop","year":"2015","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2020.108041_bib54","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.cell.2018.05.027","article-title":"A milieu molecule for TGF-beta required for microglia function in the nervous system","volume":"174","author":"Qin","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108041_bib55","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.celrep.2017.07.004","article-title":"The lifespan and turnover of microglia in the human brain","volume":"20","author":"R\u00e9u","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2020.108041_bib56","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2020.108041_bib57","doi-asserted-by":"crossref","first-page":"5206","DOI":"10.1038\/s41467-018-07548-5","article-title":"Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge","volume":"9","author":"Shemer","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2020.108041_bib58","first-page":"387","article-title":"Dendritic organization in the neurons of the visual and motor cortices of the cat","volume":"87","author":"Sholl","year":"1953","journal-title":"J.\u00a0Anat."},{"key":"10.1016\/j.celrep.2020.108041_bib59","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.tins.2019.09.004","article-title":"Cien a\u00f1os de microgl\u00eda: milestones in a century of microglial research","volume":"42","author":"Sierra","year":"2019","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.celrep.2020.108041_bib60","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1096\/fj.04-1517fje","article-title":"Bone marrow stem cells have the ability to populate the entire central nervous system into fully differentiated parenchymal microglia","volume":"18","author":"Simard","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2020.108041_bib61","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1038\/s41467-019-11674-z","article-title":"Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer\u2019s disease model","volume":"10","author":"Spangenberg","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2020.108041_bib62","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1101\/lm.029348.112","article-title":"The effect of insulin and insulin-like growth factors on hippocampus- and amygdala-dependent long-term memory formation","volume":"21","author":"Stern","year":"2014","journal-title":"Learn. Mem."},{"key":"10.1016\/j.celrep.2020.108041_bib63","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108041_bib64","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1038\/nn.3358","article-title":"Layer V cortical neurons require microglial support for survival during postnatal development","volume":"16","author":"Ueno","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2020.108041_bib65","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.cell.2020.03.021","article-title":"Early fate defines microglia and non-parenchymal brain macrophage development","volume":"181","author":"Utz","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108041_bib66","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1126\/science.aal3589","article-title":"Astrocyte-derived interleukin-33 promotes microglial synapse engulfment and neural circuit development","volume":"359","author":"Vainchtein","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.108041_bib67","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1084\/jem.20150478","article-title":"Replacement of brain-resident myeloid cells does not alter cerebral amyloid-\u03b2 deposition in mouse models of Alzheimer\u2019s disease","volume":"212","author":"Varvel","year":"2015","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2020.108041_bib68","doi-asserted-by":"crossref","first-page":"4742","DOI":"10.4049\/jimmunol.180.7.4742","article-title":"Homeostasis and effector function of lymphopenia-induced \u201cmemory-like\u201d T\u00a0cells in constitutively T\u00a0cell-depleted mice","volume":"180","author":"Voehringer","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.108041_bib69","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.molmed.2018.11.005","article-title":"Microglia in central nervous system inflammation and multiple sclerosis pathology","volume":"25","author":"Voet","year":"2019","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.celrep.2020.108041_bib70","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1038\/nature14444","article-title":"Wild-type microglia do not reverse pathology in mouse models of Rett syndrome","volume":"521","author":"Wang","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2020.108041_bib71","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.cell.2015.01.049","article-title":"TREM2 lipid sensing sustains the microglial response in an Alzheimer\u2019s disease model","volume":"160","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108041_bib72","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.cell.2019.05.006","article-title":"Single-cell multi-omic integration compares and contrasts features of brain cell identity","volume":"177","author":"Welch","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108041_bib73","doi-asserted-by":"crossref","first-page":"6915","DOI":"10.4049\/jimmunol.175.10.6915","article-title":"Differentiation to the CCR2+ inflammatory phenotype in\u00a0vivo is a constitutive, time-limited property of blood monocytes and is independent of local inflammatory mediators","volume":"175","author":"Xu","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.108041_bib74","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1038\/s41467-020-15411-9","article-title":"Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain","volume":"11","author":"Xu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2020.108041_bib75","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.neuron.2016.06.015","article-title":"TREM2 binds to apolipoproteins, including APOE and CLU\/APOJ, and thereby facilitates uptake of amyloid-beta by microglia","volume":"91","author":"Yeh","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2020.108041_bib76","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","article-title":"Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis","volume":"38","author":"Yona","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2020.108041_bib77","doi-asserted-by":"crossref","first-page":"14716","DOI":"10.1038\/ncomms14716","article-title":"Nrl knockdown by AAV-delivered CRISPR\/Cas9 prevents retinal degeneration in mice","volume":"8","author":"Yu","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2020.108041_bib78","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neuron.2016.09.016","article-title":"TREM2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy","volume":"92","author":"Yuan","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2020.108041_bib79","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1126\/science.aaa1934","article-title":"Brain structure: cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq","volume":"347","author":"Zeisel","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.108041_bib80","doi-asserted-by":"crossref","first-page":"e3000134","DOI":"10.1371\/journal.pbio.3000134","article-title":"Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain","volume":"17","author":"Zhan","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2020.108041_bib81","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1038\/s41467-019-09118-9","article-title":"Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer\u2019s disease model","volume":"10","author":"Zhong","year":"2019","journal-title":"Nat. Commun."}],"updated-by":[{"DOI":"10.1016\/j.celrep.2020.108443","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,11,24]],"date-time":"2020-11-24T00:00:00Z","timestamp":1606176000000}}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720310263?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720310263?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:03:07Z","timestamp":1761908587000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124720310263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":81,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S2211124720310263"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2020.108041","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficient Strategies for Microglia Replacement in the Central Nervous System","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2020.108041","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"108041"}}