{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:51:11Z","timestamp":1790736671277,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014547","name":"Parker Institute for Cancer Immunotherapy","doi-asserted-by":"publisher","award":["K08CA230188"],"award-info":[{"award-number":["K08CA230188"]}],"id":[{"id":"10.13039\/100014547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014547","name":"Parker Institute for Cancer Immunotherapy","doi-asserted-by":"publisher","award":["S10OD016318-01"],"award-info":[{"award-number":["S10OD016318-01"]}],"id":[{"id":"10.13039\/100014547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014547","name":"Parker Institute for Cancer Immunotherapy","doi-asserted-by":"publisher","award":["S10RR025518-01"],"award-info":[{"award-number":["S10RR025518-01"]}],"id":[{"id":"10.13039\/100014547","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE-1147470"],"award-info":[{"award-number":["DGE-1147470"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1DP2AR069953"],"award-info":[{"award-number":["1DP2AR069953"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001845","name":"Scleroderma Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001845","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.celrep.2020.108180","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T10:42:53Z","timestamp":1600771373000},"page":"108180","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity"],"prefix":"10.1016","volume":"32","author":[{"given":"Rebecca","family":"Leylek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela","family":"Alc\u00e1ntara-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Granja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Chavez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8823-7632","authenticated-orcid":false,"given":"Kimberly","family":"Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4041-2096","authenticated-orcid":false,"given":"Oscar R.","family":"Diaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5167-537X","authenticated-orcid":false,"given":"Ansuman T.","family":"Satpathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard Y.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4430-8862","authenticated-orcid":false,"given":"Juliana","family":"Idoyaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2020.108180_bib1","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41590-020-0731-4","article-title":"The activation trajectory of plasmacytoid dendritic cells in\u00a0vivo during a viral infection","volume":"21","author":"Abbas","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2020.108180_bib2","doi-asserted-by":"crossref","first-page":"eaam8458","DOI":"10.1126\/scitranslmed.aam8458","article-title":"Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8","volume":"10","author":"Ah Kioon","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2020.108180_bib3","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.immuni.2017.11.001","article-title":"High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization","volume":"47","author":"Alc\u00e1ntara-Hern\u00e1ndez","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2020.108180_bib4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41590-017-0012-z","article-title":"Diversification of human plasmacytoid predendritic cells in response to a single stimulus","volume":"19","author":"Alculumbre","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2020.108180_bib5","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.4049\/jimmunol.164.4.1855","article-title":"Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells","volume":"164","author":"Anderson","year":"2000","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.108180_bib6","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s13075-015-0572-y","article-title":"Identification of NF-\u03baB and PLCL2 as new susceptibility genes and highlights on a potential role of IRF8 through interferon signature modulation in systemic sclerosis","volume":"17","author":"Arismendi","year":"2015","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.celrep.2020.108180_bib7","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/s41590-019-0449-3","article-title":"An Nfil3-Zeb2-Id2 pathway imposes Irf8 enhancer switching during cDC1 development","volume":"20","author":"Bagadia","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2020.108180_bib8","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.cell.2014.04.005","article-title":"Single-cell trajectory detection uncovers progression and regulatory coordination in human B cell development","volume":"157","author":"Bendall","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108180_bib9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1681\/ASN.2017030270","article-title":"Opposing Roles of Dendritic Cell Subsets in Experimental GN","volume":"29","author":"Br\u00e4hler","year":"2018","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2020.108180_bib10","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/nmeth.2688","article-title":"Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position","volume":"10","author":"Buenrostro","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2020.108180_bib11","doi-asserted-by":"crossref","first-page":"21.29.1","DOI":"10.1002\/0471142727.mb2129s109","article-title":"ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide","volume":"109","author":"Buenrostro","year":"2015","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"10.1016\/j.celrep.2020.108180_bib12","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1038\/s41588-019-0505-9","article-title":"Landscape of stimulation-responsive chromatin across diverse human immune cells","volume":"51","author":"Calderon","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2020.108180_bib13","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.ccell.2016.10.002","article-title":"A Druggable TCF4- and BRD4-Dependent Transcriptional Network Sustains Malignancy in Blastic Plasmacytoid Dendritic Cell Neoplasm","volume":"30","author":"Ceribelli","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2020.108180_bib14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2008.09.016","article-title":"Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development","volume":"135","author":"Cisse","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108180_bib15","doi-asserted-by":"crossref","first-page":"e0126385","DOI":"10.1371\/journal.pone.0126385","article-title":"The\u00a0+37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C\/EBP\u03b1, PU.1, and Additional Ets Factors","volume":"10","author":"Cooper","year":"2015","journal-title":"PLOS ONE"},{"key":"10.1016\/j.celrep.2020.108180_bib16","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ng.3646","article-title":"Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution","volume":"48","author":"Corces","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2020.108180_bib17","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/nmeth.4396","article-title":"An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues","volume":"14","author":"Corces","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2020.108180_bib18","doi-asserted-by":"crossref","first-page":"eaav1898","DOI":"10.1126\/science.aav1898","article-title":"The chromatin accessibility landscape of primary human cancers","volume":"362","author":"Corces","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.108180_bib19","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/s41590-019-0450-x","article-title":"Cryptic activation of an Irf8 enhancer governs cDC1 fate specification","volume":"20","author":"Durai","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2020.108180_bib20","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.immuni.2019.08.008","article-title":"Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells","volume":"51","author":"Dutertre","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2020.108180_bib21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2020.108180_bib22","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature13835","article-title":"Genetic and epigenetic fine mapping of causal autoimmune disease variants","volume":"518","author":"Farh","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2020.108180_bib23","doi-asserted-by":"crossref","first-page":"4138","DOI":"10.1038\/sj.emboj.7601824","article-title":"The Kruppel-like factor KLF4 is a critical regulator of monocyte differentiation","volume":"26","author":"Feinberg","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2020.108180_bib24","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1093\/database\/bax028","article-title":"GeneHancer: genome-wide integration of enhancers and target genes in GeneCards","volume":"2017","author":"Fishilevich","year":"2017","journal-title":"Database (Oxford)"},{"key":"10.1016\/j.celrep.2020.108180_bib25","doi-asserted-by":"crossref","first-page":"6816","DOI":"10.1038\/sj.onc.1210764","article-title":"Transcriptional control of granulocyte and monocyte development","volume":"26","author":"Friedman","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2020.108180_bib26","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.immuni.2010.11.023","article-title":"Continuous expression of the transcription factor e2-2 maintains the cell fate of mature plasmacytoid dendritic cells","volume":"33","author":"Ghosh","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2020.108180_bib27","doi-asserted-by":"crossref","first-page":"e1002178","DOI":"10.1371\/journal.pgen.1002178","article-title":"Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy","volume":"7","author":"Gorlova","year":"2011","journal-title":"PLOS Genet."},{"key":"10.1016\/j.celrep.2020.108180_bib28","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/ni.3197","article-title":"Batf3 maintains autoactivation of Irf8 for commitment of a CD8\u03b1(+) conventional DC clonogenic progenitor","volume":"16","author":"Grajales-Reyes","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2020.108180_bib29","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.immuni.2016.11.006","article-title":"Isoform-Specific Expression and Feedback Regulation of E Protein TCF4 Control Dendritic Cell Lineage Specification","volume":"46","author":"Grajkowska","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2020.108180_bib30","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1038\/s41587-019-0332-7","article-title":"Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia","volume":"37","author":"Granja","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2020.108180_bib31","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/nri3712","article-title":"Dendritic cells, monocytes and macrophages: a unified nomenclature based on ontogeny","volume":"14","author":"Guilliams","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2020.108180_bib32","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.1164206","article-title":"Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T\u00a0cell immunity","volume":"322","author":"Hildner","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.108180_bib33","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.1093\/nar\/gkx441","article-title":"Kr\u00fcppel-like factors compete for promoters and enhancers to fine-tune transcription","volume":"45","author":"Ilsley","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2020.108180_bib34","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/biostatistics\/kxj037","article-title":"Adjusting batch effects in microarray expression data using empirical Bayes methods","volume":"8","author":"Johnson","year":"2007","journal-title":"Biostatistics"},{"key":"10.1016\/j.celrep.2020.108180_bib35","doi-asserted-by":"crossref","first-page":"981","DOI":"10.4049\/jimmunol.1900396","article-title":"KLF12 Regulates Mouse NK Cell Proliferation","volume":"203","author":"Lam","year":"2019","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.108180_bib36","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/nmeth.4666","article-title":"Computational correction of index switching in multiplexed sequencing libraries","volume":"15","author":"Larsson","year":"2018","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2020.108180_bib37","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1084\/jem.20150642","article-title":"Leukemia-associated activating mutation of Flt3 expands dendritic cells and alters T\u00a0cell responses","volume":"213","author":"Lau","year":"2016","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2020.108180_bib38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/bs.ircmb.2019.10.002","article-title":"The versatile plasmacytoid dendritic cell: function, heterogeneity, and plasticity","volume":"349","author":"Leylek","year":"2019","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.celrep.2020.108180_bib39","doi-asserted-by":"crossref","first-page":"3736","DOI":"10.1016\/j.celrep.2019.11.042","article-title":"Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population","volume":"29","author":"Leylek","year":"2019","journal-title":"Cell Rep."},{"issue":"W1","key":"10.1016\/j.celrep.2020.108180_bib40","doi-asserted-by":"crossref","first-page":"W158","DOI":"10.1093\/nar\/gkz348","article-title":"WashU Epigenome Browser update 2019","volume":"47","author":"Li","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2020.108180_bib41","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13059-019-1642-2","article-title":"Identification of transcription factor binding sites using ATAC-seq","volume":"20","author":"Li","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2020.108180_bib42","first-page":"685","article-title":"AP-1 (Fos\/Jun) transcription factors in hematopoietic differentiation and apoptosis","volume":"12","author":"Liebermann","year":"1998","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.celrep.2020.108180_bib43","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.1630","article-title":"GREAT improves functional interpretation of cis-regulatory regions","volume":"28","author":"McLean","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2020.108180_bib44","doi-asserted-by":"crossref","first-page":"2638","DOI":"10.4049\/jimmunol.0902960","article-title":"Dendritic cell (DC)-specific targeting reveals Stat3 as a negative regulator of DC function","volume":"184","author":"Melillo","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.108180_bib45","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev-immunol-020711-074950","article-title":"The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting","volume":"31","author":"Merad","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2020.108180_bib46","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2020.108180_bib47","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1101\/gr.177881.114","article-title":"Tn5 transposase and tagmentation procedures for massively scaled sequencing projects","volume":"24","author":"Picelli","year":"2014","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2020.108180_bib48","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"issue":"W1","key":"10.1016\/j.celrep.2020.108180_bib49","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2020.108180_bib50","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.immuni.2018.12.027","article-title":"Plasmacytoid Dendritic Cells: Development, Regulation, and Function","volume":"50","author":"Reizis","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2020.108180_bib51","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/s41587-019-0206-z","article-title":"Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T\u00a0cell exhaustion","volume":"37","author":"Satpathy","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2020.108180_bib52","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1084\/jem.20130443","article-title":"Transcription factor Runx2 controls the development and migration of plasmacytoid dendritic cells","volume":"210","author":"Sawai","year":"2013","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2020.108180_bib53","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nmeth.4401","article-title":"chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data","volume":"14","author":"Schep","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2020.108180_bib54","doi-asserted-by":"crossref","first-page":"eaag3009","DOI":"10.1126\/science.aag3009","article-title":"Mapping the human DC lineage through the integration of high-dimensional techniques","volume":"356","author":"See","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.108180_bib55","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nbt.3569","article-title":"Wishbone identifies bifurcating developmental trajectories from single-cell data","volume":"34","author":"Setty","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2020.108180_bib56","doi-asserted-by":"crossref","first-page":"E131","DOI":"10.1038\/ncb0502-e131","article-title":"AP-1 as a regulator of cell life and death","volume":"4","author":"Shaulian","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2020.108180_bib57","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.immuni.2016.08.013","article-title":"IRF8 Transcription Factor Controls Survival and Function of Terminally Differentiated Conventional and Plasmacytoid Dendritic Cells, Respectively","volume":"45","author":"Sichien","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2020.108180_bib58","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1038\/s41588-019-0493-9","article-title":"Chromatin activity at GWAS loci identifies T\u00a0cell states driving complex immune diseases","volume":"51","author":"Soskic","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2020.108180_bib59","doi-asserted-by":"crossref","first-page":"1259425","DOI":"10.1126\/science.1259425","article-title":"IMMUNOLOGY. An interactive reference framework for modeling a dynamic immune system","volume":"349","author":"Spitzer","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.108180_bib60","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.108180_bib61","doi-asserted-by":"crossref","first-page":"e21800","DOI":"10.1371\/journal.pone.0021800","article-title":"REVIGO summarizes and visualizes long lists of gene ontology terms","volume":"6","author":"Supek","year":"2011","journal-title":"PLOS ONE"},{"key":"10.1016\/j.celrep.2020.108180_bib62","doi-asserted-by":"crossref","first-page":"8981","DOI":"10.1073\/pnas.0402139101","article-title":"Critical roles of interferon regulatory factor 4 in CD11bhighCD8alpha-dendritic cell development","volume":"101","author":"Suzuki","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.108180_bib63","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nri3865","article-title":"The multifaceted biology of plasmacytoid dendritic cells","volume":"15","author":"Swiecki","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2020.108180_bib64","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/art.37777","article-title":"PLD4 as a novel susceptibility gene for systemic sclerosis in a Japanese population","volume":"65","author":"Terao","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.celrep.2020.108180_bib65","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.immuni.2015.04.017","article-title":"Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses","volume":"42","author":"Tussiwand","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2020.108180_bib66","doi-asserted-by":"crossref","first-page":"eaah4573","DOI":"10.1126\/science.aah4573","article-title":"Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors","volume":"356","author":"Villani","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.108180_bib67","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.devcel.2009.10.011","article-title":"A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58","volume":"17","author":"Yokoyama","year":"2009","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2020.108180_bib68","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/j.cell.2018.12.036","article-title":"The cis-Regulatory Atlas of the Mouse Immune System","volume":"176","author":"Yoshida","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108180_bib69","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1161\/ATVBAHA.116.304054","article-title":"2014 Jeffrey M. Hoeg Award Lecture: Transcriptional Control of Monocyte Development","volume":"36","author":"Zhu","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720311694?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720311694?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:05:11Z","timestamp":1761908711000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124720311694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":69,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["S2211124720311694"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2020.108180","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chromatin Landscape Underpinning Human Dendritic Cell Heterogeneity","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2020.108180","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"108180"}}