{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:12:36Z","timestamp":1790255556086,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T00:00:00Z","timestamp":1604102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007929","name":"Institute for Translational Medicine and Therapeutics","doi-asserted-by":"publisher","award":["UL1TR000003"],"award-info":[{"award-number":["UL1TR000003"]}],"id":[{"id":"10.13039\/100007929","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DGE-1321851"],"award-info":[{"award-number":["DGE-1321851"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009160","name":"Lawrence Ellison Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009160","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K12GM081259"],"award-info":[{"award-number":["K12GM081259"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K22NS09131401"],"award-info":[{"award-number":["K22NS09131401"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["MDA277268"],"award-info":[{"award-number":["MDA277268"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM099836"],"award-info":[{"award-number":["R01GM099836"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS088322"],"award-info":[{"award-number":["R01NS088322"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006920","name":"University of Pennsylvania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","award":["R01CA235760"],"award-info":[{"award-number":["R01CA235760"]}],"id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","award":["R01CA243520"],"award-info":[{"award-number":["R01CA243520"]}],"id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.celrep.2020.108418","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T10:34:07Z","timestamp":1606818847000},"page":"108418","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":64,"title":["TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson\u2019s Disease"],"prefix":"10.1016","volume":"33","author":[{"given":"Guixin","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilshan S.","family":"Harischandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Ghaisas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wil","family":"Prall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangqian","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Maghames","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban","family":"Luna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korrie L.","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana P.","family":"Torrente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin C.","family":"Luk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Shorter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2020.108418_bib1","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1126\/science.292.5521.1552","article-title":"Impairment of the ubiquitin-proteasome system by protein aggregation","volume":"292","author":"Bence","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.108418_bib2","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1038\/nrm2277","article-title":"Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies","volume":"8","author":"Bernardi","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2020.108418_bib3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nrn3887","article-title":"Spreading of pathology in neurodegenerative diseases: a focus on human studies","volume":"16","author":"Brettschneider","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2020.108418_bib4","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nrn2652","article-title":"Tests to assess motor phenotype in mice: a user\u2019s guide","volume":"10","author":"Brooks","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2020.108418_bib5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0076-6879(98)90029-5","article-title":"Analysis of chaperone function using citrate synthase as nonnative substrate protein","volume":"290","author":"Buchner","year":"1998","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.celrep.2020.108418_bib6","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/nature03986","article-title":"Molecular recycling within amyloid fibrils","volume":"436","author":"Carulla","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2020.108418_bib7","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1016\/j.celrep.2017.03.010","article-title":"Enhanced degradation of misfolded proteins promotes tumorigenesis","volume":"18","author":"Chen","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2020.108418_bib8","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/s41467-018-03499-z","article-title":"TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14","volume":"9","author":"Chen","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2020.108418_bib9","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev.biochem.75.101304.123901","article-title":"Protein misfolding, functional amyloid, and human disease","volume":"75","author":"Chiti","year":"2006","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.celrep.2020.108418_bib10","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1038\/onc.2010.462","article-title":"SUMO E3 ligase activity of TRIM proteins","volume":"30","author":"Chu","year":"2011","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2020.108418_bib11","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.cell.2012.09.038","article-title":"Operational plasticity enables hsp104 to disaggregate diverse amyloid and nonamyloid clients","volume":"151","author":"DeSantis","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108418_bib12","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/nrd.2018.110","article-title":"Gene therapy for neurological disorders: progress and prospects","volume":"17","author":"Deverman","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.celrep.2020.108418_bib13","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/nrm3660","article-title":"Protein rescue from aggregates by powerful molecular chaperone machines","volume":"14","author":"Doyle","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2020.108418_bib14","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1016\/j.cell.2012.02.022","article-title":"The amyloid state of proteins in human diseases","volume":"148","author":"Eisenberg","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108418_bib15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nbt.1515","article-title":"Intravascular AAV9 preferentially targets neonatal neurons and adult astrocytes","volume":"27","author":"Foust","year":"2009","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2020.108418_bib16","doi-asserted-by":"crossref","first-page":"10392","DOI":"10.1074\/jbc.RA119.007743","article-title":"Defining \u03b1-synuclein species responsible for Parkinson\u2019s disease phenotypes in mice","volume":"294","author":"Froula","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2020.108418_bib17","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ncb748","article-title":"alpha-Synuclein is phosphorylated in synucleinopathy lesions","volume":"4","author":"Fujiwara","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2020.108418_bib18","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.molcel.2015.07.012","article-title":"Human Hsp70 Disaggregase Reverses Parkinson\u2019s-Linked \u03b1-Synuclein Amyloid Fibrils","volume":"59","author":"Gao","year":"2015","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2020.108418_bib19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s11481-016-9650-4","article-title":"Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson\u2019s Disease","volume":"11","author":"Ghosh","year":"2016","journal-title":"J.\u00a0Neuroimmune Pharmacol."},{"key":"10.1016\/j.celrep.2020.108418_bib20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0092-8674(00)81223-4","article-title":"Hsp104, Hsp70, and Hsp40: a novel chaperone system that rescues previously aggregated proteins","volume":"94","author":"Glover","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108418_bib21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrneurol.2012.242","article-title":"100 years of Lewy pathology","volume":"9","author":"Goedert","year":"2013","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2020.108418_bib22","doi-asserted-by":"crossref","first-page":"12932","DOI":"10.1038\/ncomms12932","article-title":"Prokineticin-2 upregulation during neuronal injury mediates a compensatory protective response against dopaminergic neuronal degeneration","volume":"7","author":"Gordon","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2020.108418_bib23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.molcel.2014.04.030","article-title":"A cellular system that degrades misfolded proteins and protects against neurodegeneration","volume":"55","author":"Guo","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2020.108418_bib24","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.cell.2018.03.002","article-title":"Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains","volume":"173","author":"Guo","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108418_bib25","doi-asserted-by":"crossref","first-page":"eaau4543","DOI":"10.1126\/scisignal.aau4543","article-title":"Manganese promotes the aggregation and prion-like cell-to-cell exosomal transmission of \u03b1-synuclein","volume":"12","author":"Harischandra","year":"2019","journal-title":"Sci. Signal."},{"key":"10.1016\/j.celrep.2020.108418_bib26","doi-asserted-by":"crossref","first-page":"23861","DOI":"10.1074\/jbc.M502697200","article-title":"Disassembling protein aggregates in the yeast cytosol. The cooperation of Hsp26 with Ssa1 and Hsp104","volume":"280","author":"Haslbeck","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2020.108418_bib27","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/nrc3139","article-title":"TRIM proteins and cancer","volume":"11","author":"Hatakeyama","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2020.108418_bib28","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.cell.2018.03.004","article-title":"Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation","volume":"173","author":"Hofweber","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108418_bib29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40478-017-0416-x","article-title":"AAV1\/2-induced overexpression of A53T-\u03b1-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson\u2019s disease","volume":"5","author":"Ip","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.celrep.2020.108418_bib30","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1002\/ana.25308","article-title":"Variation at the TRIM11 locus modifies progressive supranuclear palsy phenotype","volume":"84","author":"Jabbari","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2020.108418_bib31","first-page":"1175","article-title":"Potentiated Hsp104 variants suppress toxicity of diverse neurodegenerative disease-linked proteins","volume":"7","author":"Jackrel","year":"2014","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.celrep.2020.108418_bib32","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.cell.2013.11.047","article-title":"Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events","volume":"156","author":"Jackrel","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108418_bib33","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nature12481","article-title":"Self-propagation of pathogenic protein aggregates in neurodegenerative diseases","volume":"501","author":"Jucker","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2020.108418_bib34","doi-asserted-by":"crossref","first-page":"6045","DOI":"10.1073\/pnas.0800159105","article-title":"TRIM21 is an IgG receptor that is structurally, thermodynamically, and kinetically conserved","volume":"105","author":"Keeble","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.108418_bib35","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1146\/annurev-biochem-060208-092442","article-title":"Molecular chaperone functions in protein folding and proteostasis","volume":"82","author":"Kim","year":"2013","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.celrep.2020.108418_bib36","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jneumeth.2016.03.004","article-title":"Quantitative and semi-quantitative measurements of axonal degeneration in tissue and primary neuron cultures","volume":"266","author":"Kneynsberg","year":"2016","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.celrep.2020.108418_bib37","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nrm3810","article-title":"The amyloid state and its association with protein misfolding diseases","volume":"15","author":"Knowles","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2020.108418_bib38","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/cr.2014.46","article-title":"Structural insights into the TRIM family of ubiquitin E3 ligases","volume":"24","author":"Li","year":"2014","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2020.108418_bib39","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/s41467-019-14190-2","article-title":"TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway","volume":"11","author":"Liu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2020.108418_bib40","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1089\/hum.2010.055","article-title":"Rapid, simple, and versatile manufacturing of recombinant adeno-associated viral vectors at scale","volume":"21","author":"Lock","year":"2010","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.celrep.2020.108418_bib41","doi-asserted-by":"crossref","first-page":"20051","DOI":"10.1073\/pnas.0908005106","article-title":"Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells","volume":"106","author":"Luk","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.108418_bib42","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1126\/science.1227157","article-title":"Pathological \u03b1-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice","volume":"338","author":"Luk","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.108418_bib43","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1016\/j.celrep.2016.08.053","article-title":"Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity","volume":"16","author":"Luk","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2020.108418_bib44","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s00401-018-1829-8","article-title":"Differential \u03b1-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity","volume":"135","author":"Luna","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2020.108418_bib45","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fmolb.2016.00008","article-title":"Engineering and Evolution of Molecular Chaperones and Protein Disaggregases with Enhanced Activity","volume":"3","author":"Mack","year":"2016","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.celrep.2020.108418_bib46","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1056\/NEJMoa1706198","article-title":"Single-Dose Gene-Replacement Therapy for Spinal Muscular Atrophy","volume":"377","author":"Mendell","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2020.108418_bib47","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1038\/4042","article-title":"Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration","volume":"4","author":"Nagahara","year":"1998","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2020.108418_bib48","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nature14884","article-title":"Crucial HSP70 co-chaperone complex unlocks metazoan protein disaggregation","volume":"524","author":"Nillegoda","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2020.108418_bib49","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1146\/annurev.neuro.29.051605.113042","article-title":"Trinucleotide repeat disorders","volume":"30","author":"Orr","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2020.108418_bib50","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nri2413","article-title":"TRIM family proteins and their emerging roles in innate immunity","volume":"8","author":"Ozato","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2020.108418_bib51","doi-asserted-by":"crossref","first-page":"10058","DOI":"10.1523\/JNEUROSCI.0302-15.2015","article-title":"Fyn Kinase Regulates Microglial Neuroinflammatory Responses in Cell Culture and Animal Models of Parkinson\u2019s Disease","volume":"35","author":"Panicker","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2020.108418_bib52","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.celrep.2020.108418_bib53","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.immuni.2016.05.014","article-title":"Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma","volume":"44","author":"Posey","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2020.108418_bib54","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nature05291","article-title":"The roles of intracellular protein-degradation pathways in neurodegeneration","volume":"443","author":"Rubinsztein","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2020.108418_bib55","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/nrm3658","article-title":"Chaperone machines for protein folding, unfolding and disaggregation","volume":"14","author":"Saibil","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2020.108418_bib56","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nchembio.455","article-title":"The kinetic parameters and energy cost of the Hsp70 chaperone as a polypeptide unfoldase","volume":"6","author":"Sharma","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2020.108418_bib57","doi-asserted-by":"crossref","first-page":"e26319","DOI":"10.1371\/journal.pone.0026319","article-title":"The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free system","volume":"6","author":"Shorter","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2020.108418_bib58","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1126\/science.1098007","article-title":"Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers","volume":"304","author":"Shorter","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.108418_bib59","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/40153","article-title":"Ataxin-1 with an expanded glutamine tract alters nuclear matrix-associated structures","volume":"389","author":"Skinner","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2020.108418_bib60","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nsmb.3133","article-title":"Substrate protein folds while it is bound to the ATP-independent chaperone Spy","volume":"23","author":"Stull","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2020.108418_bib61","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrn.2016.178","article-title":"Selective neuronal vulnerability in Parkinson disease","volume":"18","author":"Surmeier","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2020.108418_bib62","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.cell.2015.01.028","article-title":"MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1","volume":"160","author":"Tang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108418_bib63","doi-asserted-by":"crossref","first-page":"e103954","DOI":"10.15252\/embj.2019103954","article-title":"The HSP110\/HSP70 disaggregation system generates spreading-competent toxic \u03b1-synuclein species","volume":"39","author":"Tittelmeier","year":"2020","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2020.108418_bib64","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrm2993","article-title":"Cellular strategies for controlling protein aggregation","volume":"11","author":"Tyedmers","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2020.108418_bib65","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.neuron.2011.08.033","article-title":"Exogenous \u03b1-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death","volume":"72","author":"Volpicelli-Daley","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2020.108418_bib66","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/nprot.2014.143","article-title":"Addition of exogenous \u03b1-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous \u03b1-synuclein to Lewy body and Lewy neurite-like aggregates","volume":"9","author":"Volpicelli-Daley","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2020.108418_bib67","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0076-6879(99)09026-6","article-title":"Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates","volume":"309","author":"Wanker","year":"1999","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.celrep.2020.108418_bib68","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.cell.2014.03.007","article-title":"Differential scales of protein quality control","volume":"157","author":"Wolff","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108418_bib69","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2018.03.003","article-title":"Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites","volume":"173","author":"Yoshizawa","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108418_bib70","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nature06721","article-title":"NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration","volume":"452","author":"Zhai","year":"2008","journal-title":"Nature"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720314078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720314078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:10:46Z","timestamp":1761909046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124720314078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":70,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S2211124720314078"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2020.108418","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson\u2019s Disease","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2020.108418","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"108418"}}