{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T12:56:36Z","timestamp":1783515396809,"version":"3.55.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,11,10]],"date-time":"2020-11-10T00:00:00Z","timestamp":1604966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001407","name":"Department of Biotechnology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["BT\/PR10394\/MED\/29\/1128\/2016"],"award-info":[{"award-number":["BT\/PR10394\/MED\/29\/1128\/2016"]}],"id":[{"id":"10.13039\/501100001407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.celrep.2020.108451","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T10:34:53Z","timestamp":1606818893000},"page":"108451","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["HIV Skews a Balanced Mtb-Specific Th17 Response in Latent Tuberculosis Subjects to a Pro-inflammatory Profile Independent of Viral Load"],"prefix":"10.1016","volume":"33","author":[{"given":"Srabanti","family":"Rakshit","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9813-3527","authenticated-orcid":false,"given":"Nitin","family":"Hingankar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3643-3639","authenticated-orcid":false,"given":"Shuba Varshini","family":"Alampalli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6996-4786","authenticated-orcid":false,"given":"Vasista","family":"Adiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharath K.","family":"Sundararaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravat Nalini","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4341-9090","authenticated-orcid":false,"given":"Greg","family":"Finak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anto Jesuraj","family":"Uday Kumar J","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7351-485X","authenticated-orcid":false,"given":"Chirag","family":"Dhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"D\u2019Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi Govind","family":"Virkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manisha","family":"Ghate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhuri R.","family":"Thakar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh S.","family":"Paranjape","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"De Rosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3706-3403","authenticated-orcid":false,"given":"Tom H.M.","family":"Ottenhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annapurna","family":"Vyakarnam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2020.108451_bib1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/ni1467","article-title":"Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells","volume":"8","author":"Acosta-Rodriguez","year":"2007","journal-title":"Nat. Immunol."},{"issue":"Suppl 1","key":"10.1016\/j.celrep.2020.108451_bib2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/odi.12390","article-title":"HIV-TB co-infection: mechanisms that drive reactivation of Mycobacterium tuberculosis in HIV infection","volume":"22","author":"Ahmed","year":"2016","journal-title":"Oral Dis."},{"key":"10.1016\/j.celrep.2020.108451_bib3","doi-asserted-by":"crossref","first-page":"10843","DOI":"10.1128\/JVI.01838-13","article-title":"Preferential HIV infection of CCR6+ Th17 cells is associated with higher levels of virus receptor expression and lack of CCR5 ligands","volume":"87","author":"Alvarez","year":"2013","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2020.108451_bib4","doi-asserted-by":"crossref","first-page":"e01728","DOI":"10.1128\/JVI.01728-18","article-title":"HIV Infection Functionally Impairs Mycobacterium tuberculosis-Specific CD4 and CD8 T-Cell Responses","volume":"93","author":"Amelio","year":"2019","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2020.108451_bib5","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1128\/CVI.00217-16","article-title":"Multifunctional T Cell Response to DosR and Rpf Antigens Is Associated with Protection in Long-Term Mycobacterium tuberculosis-Infected Individuals in Colombia","volume":"23","author":"Arroyo","year":"2016","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.celrep.2020.108451_bib6","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/s12879-017-2301-4","article-title":"Comparing interferon-gamma release assays with tuberculin skin test for identifying latent tuberculosis infection that progresses to active tuberculosis: systematic review and meta-analysis","volume":"17","author":"Auguste","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.celrep.2020.108451_bib7","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/cyto.a.22317","article-title":"Flow-cytometric analysis of rare antigen-specific T\u00a0cells","volume":"83","author":"Bacher","year":"2013","journal-title":"Cytometry A"},{"key":"10.1016\/j.celrep.2020.108451_bib8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/nrmicro.2017.128","article-title":"Pathogenesis of HIV-1 and Mycobacterium tuberculosis co-infection","volume":"16","author":"Bell","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2020.108451_bib9","doi-asserted-by":"crossref","first-page":"852418","DOI":"10.1155\/2013\/852418","article-title":"Loss and dysregulation of Th17 cells during HIV infection","volume":"2013","author":"Bixler","year":"2013","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.celrep.2020.108451_bib10","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1086\/427828","article-title":"Dynamics of cytomegalovirus (CMV)-specific T\u00a0cells in HIV-1-infected individuals progressing to AIDS with CMV end-organ disease","volume":"191","author":"Bronke","year":"2005","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2020.108451_bib11","doi-asserted-by":"crossref","first-page":"5254","DOI":"10.1172\/JCI125810","article-title":"Mechanisms of reactivation of latent tuberculosis infection due to SIV coinfection","volume":"129","author":"Buc\u015fan","year":"2019","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2020.108451_bib12","doi-asserted-by":"crossref","first-page":"e0228745","DOI":"10.1371\/journal.pone.0228745","article-title":"HIV-1 elite controllers present a high frequency of activated regulatory T and Th17 cells","volume":"15","author":"Caetano","year":"2020","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2020.108451_bib13","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.tube.2015.07.001","article-title":"A side-by-side comparison of T\u00a0cell reactivity to fifty-nine Mycobacterium tuberculosis antigens in diverse populations from five continents","volume":"95","author":"Carpenter","year":"2015","journal-title":"Tuberculosis (Edinb.)"},{"key":"10.1016\/j.celrep.2020.108451_bib14","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.imlet.2018.04.001","article-title":"Impact of antiretroviral and tuberculosis therapies on CD4+ and CD8+ HIV\/M. tuberculosis-specific T-cell in co-infected subjects","volume":"198","author":"Chiacchio","year":"2018","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.celrep.2020.108451_bib15","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.1128\/JVI.02643-10","article-title":"CD4+ T\u00a0cells, including Th17 and cycling subsets, are intact in the gut mucosa of HIV-1-infected long-term nonprogressors","volume":"85","author":"Ciccone","year":"2011","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2020.108451_bib16","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.smim.2018.07.001","article-title":"Genome wide approaches discover novel Mycobacterium tuberculosis antigens as correlates of infection, disease, immunity and targets for vaccination","volume":"39","author":"Coppola","year":"2018","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.celrep.2020.108451_bib17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12977-015-0164-6","article-title":"Impaired Th17 polarization of phenotypically naive CD4(+) T-cells during chronic HIV-1 infection and potential restoration with early ART","volume":"12","author":"DaFonseca","year":"2015","journal-title":"Retrovirology"},{"key":"10.1016\/j.celrep.2020.108451_bib18","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1086\/529048","article-title":"Detection of polyfunctional Mycobacterium tuberculosis-specific T\u00a0cells and association with viral load in HIV-1-infected persons","volume":"197","author":"Day","year":"2008","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2020.108451_bib19","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.4049\/jimmunol.1700558","article-title":"HIV-1 Infection Is Associated with Depletion and Functional Impairment of Mycobacterium tuberculosis-Specific CD4\u00a0T Cells in Individuals with Latent Tuberculosis Infection","volume":"199","author":"Day","year":"2017","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.108451_bib20","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1128\/IAI.01126-10","article-title":"HIV-1\/mycobacterium tuberculosis coinfection immunology: how does HIV-1 exacerbate tuberculosis?","volume":"79","author":"Diedrich","year":"2011","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2020.108451_bib21","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41591-018-0319-9","article-title":"Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques","volume":"25","author":"Dijkman","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2020.108451_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1146\/annurev.immunol.21.120601.141053","article-title":"T cell dynamics in HIV-1 infection","volume":"21","author":"Douek","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2020.108451_bib23","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/COH.0b013e32833647a8","article-title":"Th17 cells and HIV infection","volume":"5","author":"Elhed","year":"2010","journal-title":"Curr. Opin. HIV AIDS"},{"key":"10.1016\/j.celrep.2020.108451_bib24","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1146\/annurev-immunol-042617-053420","article-title":"The Immune Response to Mycobacterium tuberculosis in HIV-1-Coinfected Persons","volume":"36","author":"Esmail","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2020.108451_bib25","doi-asserted-by":"crossref","first-page":"E5636","DOI":"10.1073\/pnas.1611987113","article-title":"CD4+ T-cell-independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection","volume":"113","author":"Foreman","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2020.108451_bib26","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1006\/prep.1999.1162","article-title":"Purification of his-tagged proteins by immobilized chelate affinity chromatography: the benefits from the use of organic solvent","volume":"18","author":"Franken","year":"2000","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.celrep.2020.108451_bib27","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/nm1292","article-title":"Direct access to CD4+ T\u00a0cells specific for defined antigens according to CD154 expression","volume":"11","author":"Frentsch","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2020.108451_bib28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.it.2012.01.011","article-title":"Pathogen-specific T\u00a0cell depletion and reactivation of opportunistic pathogens in HIV infection","volume":"33","author":"Geldmacher","year":"2012","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2020.108451_bib29","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1084\/jem.20100090","article-title":"Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T\u00a0cells after HIV-1 infection","volume":"207","author":"Geldmacher","year":"2010","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2020.108451_bib30","doi-asserted-by":"crossref","first-page":"e1004603","DOI":"10.1371\/journal.ppat.1004603","article-title":"Variability in tuberculosis granuloma T\u00a0cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization","volume":"11","author":"Gideon","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2020.108451_bib31","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.4049\/jimmunol.0903058","article-title":"Peripheral Blood CCR4+CCR6+and CXCR3+CCR6+ CD4+ T Cells Are Highly Permissive to HIV-1 Infection","volume":"184","author":"Gosselin","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.108451_bib32","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.2202\/1544-6115.1302","article-title":"On the operational characteristics of the Benjamini and Hochberg False Discovery Rate procedure","volume":"6","author":"Green","year":"2007","journal-title":"Stat. Appl. Genet. Mol. Biol."},{"key":"10.1016\/j.celrep.2020.108451_bib33","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jim.2014.12.003","article-title":"Qualification of a whole blood intracellular cytokine staining assay to measure mycobacteria-specific CD4 and CD8 T\u00a0cell immunity by flow cytometry","volume":"417","author":"Kagina","year":"2015","journal-title":"J.\u00a0Immunol. Methods"},{"key":"10.1016\/j.celrep.2020.108451_bib34","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1093\/infdis\/jiu505","article-title":"Impaired degranulation and proliferative capacity of Mycobacterium tuberculosis-specific CD8+ T\u00a0cells in HIV-infected individuals with latent tuberculosis","volume":"211","author":"Kalokhe","year":"2015","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2020.108451_bib35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3389\/fimmu.2017.00005","article-title":"Indian Long-term Non-Progressors Show Broad ADCC Responses with Preferential Recognition of V3 Region of Envelope and a Region from Tat Protein","volume":"8","author":"Kulkarni","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2020.108451_bib36","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1093\/infdis\/jix625","article-title":"High Turnover of Tissue Macrophages Contributes to Tuberculosis Reactivation in Simian Immunodeficiency Virus-Infected Rhesus Macaques","volume":"217","author":"Kuroda","year":"2018","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2020.108451_bib37","doi-asserted-by":"crossref","first-page":"e221","DOI":"10.1016\/S2352-3018(15)00081-8","article-title":"ART and prevention of HIV-associated tuberculosis","volume":"2","author":"Lawn","year":"2015","journal-title":"Lancet HIV"},{"key":"10.1016\/j.celrep.2020.108451_bib38","doi-asserted-by":"crossref","first-page":"2541","DOI":"10.4049\/jimmunol.1800993","article-title":"The End of the Binary Era: Revisiting the Spectrum of Tuberculosis","volume":"201","author":"Lin","year":"2018","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.108451_bib39","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/nbt.3187","article-title":"COMPASS identifies T-cell subsets correlated with clinical outcomes","volume":"33","author":"Lin","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2020.108451_bib40","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.4049\/jimmunol.1302936","article-title":"Differentiation of IL-17-producing effector and regulatory human T\u00a0cells from lineage-committed naive precursors","volume":"193","author":"Mercer","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.108451_bib41","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1093\/infdis\/jiy052","article-title":"Human Immunodeficiency Virus Infection Impairs Th1 and Th17 Mycobacterium tuberculosis-Specific T-Cell Responses","volume":"217","author":"Murray","year":"2018","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2020.108451_bib42","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/imr.12066","article-title":"CD4(+) T-cell depletion in HIV infection: mechanisms of immunological failure","volume":"254","author":"Okoye","year":"2013","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2020.108451_bib43","doi-asserted-by":"crossref","first-page":"e1002464","DOI":"10.1371\/journal.ppat.1002464","article-title":"Tuberculosis and HIV co-infection","volume":"8","author":"Pawlowski","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2020.108451_bib44","doi-asserted-by":"crossref","first-page":"11948","DOI":"10.1038\/s41598-017-10773-5","article-title":"Circulating Mycobacterium tuberculosis DosR latency antigen-specific, polyfunctional, regulatory IL10+ Th17 CD4 T-cells differentiate latent from active tuberculosis","volume":"7","author":"Rakshit","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2020.108451_bib45","doi-asserted-by":"crossref","first-page":"e130540","DOI":"10.1172\/jci.insight.130540","article-title":"BCG revaccination boosts adaptive polyfunctional Th1\/Th17 and innate effectors in IGRA+ and IGRA- Indian adults","volume":"4","author":"Rakshit","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2020.108451_bib46","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.tube.2016.07.018","article-title":"Selective reduction of IFN-\u03b3 single positive mycobacteria-specific CD4+ T\u00a0cells in HIV-1 infected individuals with latent tuberculosis infection","volume":"101","author":"Riou","year":"2016","journal-title":"Tuberculosis (Edinb.)"},{"key":"10.1016\/j.celrep.2020.108451_bib47","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/cyto.a.21015","article-title":"SPICE: exploration and analysis of post-cytometric complex multivariate datasets","volume":"79","author":"Roederer","year":"2011","journal-title":"Cytometry A"},{"key":"10.1016\/j.celrep.2020.108451_bib48","first-page":"126","article-title":"Factors regulating Th17 cells: a review","volume":"1","author":"Seki","year":"2016","journal-title":"Biomed. Res. Clin. Pract."},{"key":"10.1016\/j.celrep.2020.108451_bib49","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.virol.2010.01.017","article-title":"Nuclear matrix protein SMAR1 represses HIV-1 LTR mediated transcription through chromatin remodeling","volume":"400","author":"Sreenath","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.celrep.2020.108451_bib50","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1742-6405-8-35","article-title":"Establishment of reference CD4+ T\u00a0cell values for adult Indian population","volume":"8","author":"Thakar","year":"2011","journal-title":"AIDS Res. Ther."},{"key":"10.1016\/j.celrep.2020.108451_bib51","doi-asserted-by":"crossref","first-page":"F53","DOI":"10.1084\/jem.194.10.f53","article-title":"Regulatory role of T\u00a0cells producing both interferon gamma and interleukin 10 in persistent infection","volume":"194","author":"Trinchieri","year":"2001","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2020.108451_bib52","doi-asserted-by":"crossref","first-page":"12385","DOI":"10.1128\/JVI.00609-14","article-title":"Cross-clade ultrasensitive PCR-based assays to measure HIV persistence in large-cohort studies","volume":"88","author":"Vandergeeten","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2020.108451_bib53","doi-asserted-by":"crossref","first-page":"698","DOI":"10.3389\/fimmu.2017.00698","article-title":"Th17 Polarization under Hypoxia Results in Increased IL-10 Production in a Pathogen-Independent Manner","volume":"8","author":"Volchenkov","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2020.108451_bib54","series-title":"Global Tuberculosis Report","year":"2019"},{"key":"10.1016\/j.celrep.2020.108451_bib55","series-title":"HIV factsheets 2019","year":"2019"},{"key":"10.1016\/j.celrep.2020.108451_bib56","doi-asserted-by":"crossref","first-page":"e49526","DOI":"10.1371\/journal.pone.0049526","article-title":"High CCR5 density on central memory CD4+ T\u00a0cells in acute HIV-1 infection is mostly associated with rapid disease progression","volume":"7","author":"Yang","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2020.108451_bib57","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/mi.2015.74","article-title":"Foxp3(+) T\u00a0cells expressing ROR\u03b3t represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation","volume":"9","author":"Yang","year":"2016","journal-title":"Mucosal Immunol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720314406?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720314406?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:11:15Z","timestamp":1761909075000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124720314406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":57,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S2211124720314406"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2020.108451","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HIV Skews a Balanced Mtb-Specific Th17 Response in Latent Tuberculosis Subjects to a Pro-inflammatory Profile Independent of Viral Load","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2020.108451","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020","name":"copyright","label":"Copyright"}],"article-number":"108451"}}