{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:08:37Z","timestamp":1791443317802,"version":"4.3.3"},"reference-count":81,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:00:00Z","timestamp":1606953600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["MetaboHUB-ANR-11-INSB-0010"],"award-info":[{"award-number":["MetaboHUB-ANR-11-INSB-0010"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["FC 2015-1\/115"],"award-info":[{"award-number":["FC 2015-1\/115"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 112-2013-0100202"],"award-info":[{"award-number":["PIP 112-2013-0100202"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["ING20160435108"],"award-info":[{"award-number":["ING20160435108"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT-2015-0055"],"award-info":[{"award-number":["PICT-2015-0055"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT-2017-1317"],"award-info":[{"award-number":["PICT-2017-1317"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-18-CE15-0004-01"],"award-info":[{"award-number":["ANR-18-CE15-0004-01"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","award":["ANRS2014-049"],"award-info":[{"award-number":["ANRS2014-049"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","award":["ANRS2014-CI-2"],"award-info":[{"award-number":["ANRS2014-CI-2"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","award":["ANRS 2020-1"],"award-info":[{"award-number":["ANRS 2020-1"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.celrep.2020.108547","type":"journal-article","created":{"date-parts":[[2020,12,29]],"date-time":"2020-12-29T10:34:04Z","timestamp":1609238044000},"page":"108547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Host-Derived Lipids from Tuberculous Pleurisy Impair Macrophage Microbicidal-Associated Metabolic Activity"],"prefix":"10.1016","volume":"33","author":[{"given":"Jos\u00e9 Luis","family":"Mar\u00edn Franco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1108-2449","authenticated-orcid":false,"given":"Melanie","family":"Genoula","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Corral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Duette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3111-6546","authenticated-orcid":false,"given":"Malena","family":"Ferreyra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Maio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Bel\u00e9n","family":"Dolotowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar Emiliano","family":"Aparicio-Trejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Pati\u00f1o-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Charton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"M\u00e9tais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Fuentes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Soldan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo Jos\u00e9","family":"Mora\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domingo","family":"Palmero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mat\u00edas","family":"Ostrowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Schierloh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"S\u00e1nchez-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Hern\u00e1ndez-Pando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Pedraza-Chaverri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4482-2199","authenticated-orcid":false,"given":"Yoann","family":"Rombouts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Hudrisier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Layre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"V\u00e9rollet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Maridonneau-Parini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0047-5885","authenticated-orcid":false,"given":"Olivier","family":"Neyrolles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Del Carmen","family":"Sasiain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4620-8491","authenticated-orcid":false,"given":"Geanncarlo","family":"Lugo-Villarino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Balboa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2020.108547_bib1","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.chom.2018.10.005","article-title":"Mitochondria-derived vesicles deliver antimicrobial reactive oxygen species to control phagosome-localized Staphylococcus aureus","volume":"24","author":"Abuaita","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2020.108547_bib2","doi-asserted-by":"crossref","first-page":"e1007100","DOI":"10.1371\/journal.ppat.1007100","article-title":"PPAR\u03b3 is critical for Mycobacterium tuberculosis induction of Mcl-1 and limitation of human macrophage apoptosis","volume":"14","author":"Arnett","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2020.108547_bib3","doi-asserted-by":"crossref","first-page":"785","DOI":"10.2217\/fmb-2017-0168","article-title":"Dual role of hypoxia-inducible factor 1 \u03b1 in experimental pulmonary tuberculosis: its implication as a new therapeutic target","volume":"13","author":"Baay-Guzman","year":"2018","journal-title":"Future Microbiol."},{"key":"10.1016\/j.celrep.2020.108547_bib4","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1172\/JCI23949","article-title":"Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase-dependent lipoxin production","volume":"115","author":"Bafica","year":"2005","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2020.108547_bib5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1039\/an9729700142","article-title":"An improved colour reagent for the determination of blood glucose by the oxidase system","volume":"97","author":"Barham","year":"1972","journal-title":"Analyst (Lond.)"},{"key":"10.1016\/j.celrep.2020.108547_bib6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10875-007-9084-0","article-title":"Host innate immune response to Mycobacterium tuberculosis","volume":"27","author":"Bhatt","year":"2007","journal-title":"J.\u00a0Clin. Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib7","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1042\/BST20150107","article-title":"Metabolic signatures linked to macrophage polarization: from glucose metabolism to oxidative phosphorylation","volume":"43","author":"Bosc\u00e1","year":"2015","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.celrep.2020.108547_bib8","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.4049\/jimmunol.1600266","article-title":"HIF-1\u03b1 Is An Essential Mediator of IFN-\u03b3-dependent immunity to Mycobacterium tuberculosis","volume":"197","author":"Braverman","year":"2016","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib9","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1189\/jlb.4A0914-441R","article-title":"Increased monocyte turnover is associated with interstitial macrophage accumulation and pulmonary tissue damage in SIV-infected rhesus macaques","volume":"97","author":"Cai","year":"2015","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.celrep.2020.108547_bib10","first-page":"1147","article-title":"Lipid mediators in innate immunity against tuberculosis: opposing roles of PGE 2 and LXA 4 in the induction of macrophage death","volume":"97","author":"Chen","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2020.108547_bib11","doi-asserted-by":"crossref","first-page":"1250684","DOI":"10.1126\/science.1250684","article-title":"MTOR- and HIF-1\u03b1-mediated aerobic glycolysis as metabolic basis for trained immunity","volume":"345","author":"Cheng","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.108547_bib12","first-page":"1147","article-title":"Microanatomic distribution of myeloid heme oxygenase-1 protects against free radical-mediated immunopathology in human tuberculosis","volume":"97","author":"Chinta","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2020.108547_bib13","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.tibs.2016.01.001","article-title":"Mitochondrial cristae: where beauty meets functionality","volume":"41","author":"Cogliati","year":"2016","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.celrep.2020.108547_bib14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.chom.2018.08.001","article-title":"Alveolar macrophages provide an early Mycobacterium tuberculosis niche and initiate dissemination","volume":"24","author":"Cohen","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2020.108547_bib15","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nri3859","article-title":"Eicosanoid storm in infection and inflammation","volume":"15","author":"Dennis","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib16","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/000456329703400205","article-title":"Elevated concentrations of interleukins and leukotriene in response to Mycobacterium tuberculosis infection","volume":"34","author":"el-Ahmady","year":"1997","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.celrep.2020.108547_bib17","doi-asserted-by":"crossref","first-page":"2441","DOI":"10.1084\/jem.20112607","article-title":"PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T\u00a0cells","volume":"209","author":"Finlay","year":"2012","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2020.108547_bib18","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.4049\/jimmunol.168.6.2828","article-title":"Dualism of oxidized lipoproteins in provoking and attenuating the oxidative burst in macrophages: role of peroxisome proliferator-activated receptor-\u03b3","volume":"168","author":"Fischer","year":"2002","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12890-016-0185-5","article-title":"Mycobacteria infect different cell types in the human lung and cause species dependent cellular changes in infected cells","volume":"16","author":"Ganbat","year":"2016","journal-title":"BMC Pulm. Med."},{"key":"10.1016\/j.celrep.2020.108547_bib20","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1038\/s41467-017-01919-0","article-title":"Mitochondrial dynamics controls anti-tumour innate immunity by regulating CHIP-IRF1 axis stability","volume":"8","author":"Gao","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2020.108547_bib21","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3389\/fimmu.2018.00459","article-title":"Formation of foamy macrophages by tuberculous pleural effusions is triggered by the interleukin-10\/signal transducer and activator of transcription 3 axis through ACAT upregulation","volume":"9","author":"Genoula","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib22","doi-asserted-by":"crossref","first-page":"e1008929","DOI":"10.1371\/journal.ppat.1008929","article-title":"Fatty acid oxidation of alternatively activated macrophages prevents foam cell formation, but Mycobacterium tuberculosis counteracts this process via HIF-1\u03b1 activation","volume":"16","author":"Genoula","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2020.108547_bib23","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.smim.2016.10.007","article-title":"Metabolic reprogramming & inflammation: fuelling the host response to pathogens","volume":"28","author":"Gleeson","year":"2016","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib24","doi-asserted-by":"crossref","first-page":"6568","DOI":"10.4081\/idr.2016.6568","article-title":"Tuberculosis biomarkers: from diagnosis to protection","volume":"8","author":"Goletti","year":"2016","journal-title":"Infect. Dis. Rep."},{"key":"10.1016\/j.celrep.2020.108547_bib25","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.celrep.2019.12.015","article-title":"Mycobacterium tuberculosis limits host glycolysis and IL-1\u03b2 by restriction of PFK-M via microRNA-21","volume":"30","author":"Hackett","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2020.108547_bib26","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/hmg\/ddm378","article-title":"ALOX5 variants associated with susceptibility to human pulmonary tuberculosis","volume":"17","author":"Herb","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2020.108547_bib27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.coi.2017.08.001","article-title":"Protective immunity against tuberculosis: what does it look like and how do we find it?","volume":"48","author":"Huang","year":"2017","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib28","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.immuni.2016.09.016","article-title":"Metabolic reprogramming mediated by the mTORC2-IRF4 signaling axis is essential for macrophage alternative activation","volume":"45","author":"Huang","year":"2016","journal-title":"Immunity."},{"key":"10.1016\/j.celrep.2020.108547_bib29","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1084\/jem.20172020","article-title":"Growth of Mycobacterium tuberculosis in\u00a0vivo segregates with host macrophage metabolism and ontogeny","volume":"215","author":"Huang","year":"2018","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2020.108547_bib30","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1126\/science.aal3535","article-title":"Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages","volume":"356","author":"Ip","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.108547_bib31","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1126\/science.1059796","article-title":"Targeting of HIF-\u03b1 to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation","volume":"292","author":"Jaakkola","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.108547_bib32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.cellimm.2013.01.010","article-title":"Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin","volume":"281","author":"Jaguin","year":"2013","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib33","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1086\/315771","article-title":"Interleukin-1 signaling is essential for host defense during murine pulmonary tuberculosis","volume":"182","author":"Juffermans","year":"2000","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2020.108547_bib34","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/eji.200535496","article-title":"Alternative activation deprives macrophages of a coordinated defense program to Mycobacterium tuberculosis","volume":"36","author":"Kahnert","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib35","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/cr.2015.68","article-title":"Metabolic reprogramming in macrophages and dendritic cells in innate immunity","volume":"25","author":"Kelly","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2020.108547_bib36","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1742-4690-4-31","article-title":"Isolated receptor binding domains of HTLV-1 and HTLV-2 envelopes bind Glut-1 on activated CD4+ and CD8+ T\u00a0cells","volume":"4","author":"Kinet","year":"2007","journal-title":"Retrovirology"},{"key":"10.1016\/j.celrep.2020.108547_bib37","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1478-811X-10-2","article-title":"Strain specific transcriptional response in Mycobacterium tuberculosis infected macrophages","volume":"10","author":"Koo","year":"2012","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.celrep.2020.108547_bib38","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/cr.2015.123","article-title":"Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16(+) monocyte population via the IL-10\/STAT3 axis","volume":"25","author":"Lastrucci","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2020.108547_bib39","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.chembiol.2011.10.013","article-title":"A comparative lipidomics platform for chemotaxonomic analysis of Mycobacterium tuberculosis","volume":"18","author":"Layre","year":"2011","journal-title":"Chem. Biol."},{"key":"10.1016\/j.celrep.2020.108547_bib40","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jchromb.2013.06.014","article-title":"LC-MS\/MS method for rapid and concomitant quantification of pro-inflammatory and pro-resolving polyunsaturated fatty acid metabolites","volume":"932","author":"Le Faouder","year":"2013","journal-title":"J.\u00a0Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.celrep.2020.108547_bib81","first-page":"20345583","article-title":"Update on tuberculous pleural effusion","author":"Light","year":"2010","journal-title":"Respirology"},{"key":"10.1016\/j.celrep.2020.108547_bib41","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.3389\/fimmu.2018.01346","article-title":"Mycobacterium tuberculosis invasion of the human lung: first contact","volume":"9","author":"Maertzdorf","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib42","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/nm.4073","article-title":"Inflammatory signaling in human tuberculosis granulomas is spatially organized","volume":"22","author":"Marakalala","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2020.108547_bib43","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1146\/annurev.immunol.021908.132532","article-title":"Alternative activation of macrophages: an immunologic functional perspective","volume":"27","author":"Martinez","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib44","doi-asserted-by":"crossref","first-page":"16022","DOI":"10.1038\/cddiscovery.2016.22","article-title":"Hypoxia and classical activation limits Mycobacterium tuberculosis survival by Akt-dependent glycolytic shift in macrophages","volume":"2","author":"Matta","year":"2016","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.celrep.2020.108547_bib45","doi-asserted-by":"crossref","first-page":"e1004265","DOI":"10.1371\/journal.ppat.1004265","article-title":"Pathogenicity of Mycobacterium tuberculosis is expressed by regulating metabolic thresholds of the host macrophage","volume":"10","author":"Mehrotra","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2020.108547_bib46","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1615\/CritRevImmunol.v32.i6.10","article-title":"M1 and M2 macrophages: oracles of health and disease","volume":"32","author":"Mills","year":"2012","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib47","doi-asserted-by":"crossref","first-page":"6166","DOI":"10.4049\/jimmunol.164.12.6166","article-title":"M-1\/M-2 macrophages and the Th1\/Th2 paradigm","volume":"164","author":"Mills","year":"2000","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib48","doi-asserted-by":"crossref","first-page":"17072","DOI":"10.1038\/nmicrobiol.2017.72","article-title":"Nitric oxide prevents a pathogen-permissive granulocytic inflammation during tuberculosis","volume":"2","author":"Mishra","year":"2017","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.celrep.2020.108547_bib49","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/jcb.25074","article-title":"Regulation of hypoxia-inducible factor-1a by reactive oxygen species: new developments in an old debate","volume":"116","author":"Movafagh","year":"2015","journal-title":"J.\u00a0Cell. Biochem."},{"key":"10.1016\/j.celrep.2020.108547_bib50","doi-asserted-by":"crossref","first-page":"3000","DOI":"10.4049\/jimmunol.1700174","article-title":"Correction: GM-CSF induces inflammatory macrophages by regulating glycolysis and lipid metabolism","volume":"198","author":"Na","year":"2017","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib51","doi-asserted-by":"crossref","first-page":"e0163298","DOI":"10.1371\/journal.pone.0163298","article-title":"Role of LTA4H polymorphism in tuberculosis-associated immune reconstitution inflammatory syndrome occurrence and clinical severity in patients infected with HIV","volume":"11","author":"Narendran","year":"2016","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2020.108547_bib52","doi-asserted-by":"crossref","first-page":"11475","DOI":"10.1038\/s41598-018-29659-1","article-title":"Hypoxia increases neutrophil-driven matrix destruction after exposure to Mycobacterium tuberculosis","volume":"8","author":"Ong","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2020.108547_bib53","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1365-2249.2003.02387.x","article-title":"LTB4 is present in exudative pleural effusions and contributes actively to neutrophil recruitment in the inflamed pleural space","volume":"135","author":"Pace","year":"2004","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib54","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1002\/bies.201300084","article-title":"The Warburg effect then and now: from cancer to inflammatory diseases","volume":"35","author":"Palsson-McDermott","year":"2013","journal-title":"BioEssays"},{"key":"10.1016\/j.celrep.2020.108547_bib55","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","article-title":"Pyruvate kinase M2 regulates hif-1\u03b1 activity and il-1\u03b2 induction and is a critical determinant of the Warburg effect in LPS-activated macrophages","volume":"21","author":"Palsson-Mcdermott","year":"2015","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2020.108547_bib56","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3389\/fcimb.2019.00335","article-title":"Plasma eicosanoid levels in tuberculosis and tuberculosis-diabetes co-morbidity are associated with lung pathology and bacterial burden","volume":"9","author":"Pavan Kumar","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.celrep.2020.108547_bib57","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.celrep.2019.12.033","article-title":"Dual RNA-seq of Mtb-infected macrophages in\u00a0vivo reveals ontologically distinct host-pathogen interactions","volume":"30","author":"Pisu","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2020.108547_bib58","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.tube.2007.07.003","article-title":"Gene expression profiles of bronchoalveolar cells in pulmonary TB","volume":"88","author":"Raju","year":"2008","journal-title":"Tuberculosis (Edinb.)"},{"key":"10.1016\/j.celrep.2020.108547_bib59","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.it.2017.08.006","article-title":"Mitochondrial dynamics at the interface of immune cell metabolism and function","volume":"39","author":"Rambold","year":"2018","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib60","doi-asserted-by":"crossref","first-page":"E650","DOI":"10.3390\/microorganisms7120650","article-title":"Association of leukotriene A4 hydrolase with tuberculosis susceptibility using genomic data in Portugal","volume":"7","author":"Rito","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.celrep.2020.108547_bib61","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/nature06905","article-title":"NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1\u03b1","volume":"453","author":"Rius","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2020.108547_bib62","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/ni.1781","article-title":"Foamy macrophages and the progression of the human tuberculosis granuloma","volume":"10","author":"Russell","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib63","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.chom.2010.06.002","article-title":"Mycobacterium tuberculosis wears what it eats","volume":"8","author":"Russell","year":"2010","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2020.108547_bib64","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/978-1-4939-2450-9_9","article-title":"Construction of conditional knockdown mutants in mycobacteria","volume":"1285","author":"Schnappinger","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2020.108547_bib65","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1378\/chest.99.4.883","article-title":"Tuberculous pleural effusion. Twenty-year experience","volume":"99","author":"Seibert","year":"1991","journal-title":"Chest"},{"key":"10.1016\/j.celrep.2020.108547_bib66","doi-asserted-by":"crossref","first-page":"11635","DOI":"10.1038\/ncomms11635","article-title":"HIF-1\u03b1-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity","volume":"7","author":"Semba","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2020.108547_bib67","doi-asserted-by":"crossref","first-page":"18176","DOI":"10.1038\/srep18176","article-title":"Infection with Mycobacterium tuberculosis induces the Warburg effect in mouse lungs","volume":"5","author":"Shi","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2020.108547_bib68","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1016\/j.celrep.2019.02.091","article-title":"Tuberculosis Exacerbates HIV-1 Infection through IL-10\/STAT3-Dependent Tunneling Nanotube Formation in Macrophages","volume":"26","author":"Souriant","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.celrep.2020.108547_bib69","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3389\/fphys.2015.00070","article-title":"Warburg revisited: lessons for innate immunity and sepsis","volume":"6","author":"Srivastava","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.celrep.2020.108547_bib70","doi-asserted-by":"crossref","first-page":"e0132249","DOI":"10.1371\/journal.pone.0132249","article-title":"Lesion-specific immune response in granulomas of patients with pulmonary tuberculosis: a pilot study","volume":"10","author":"Subbian","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2020.108547_bib71","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1\u03b2 through HIF-1\u03b1","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2020.108547_bib72","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.cell.2011.12.023","article-title":"Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections","volume":"148","author":"Tobin","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108547_bib73","doi-asserted-by":"crossref","first-page":"e67828","DOI":"10.1371\/journal.pone.0067828","article-title":"An enzyme that inactivates the inflammatory mediator leukotriene B4 restricts mycobacterial infection","volume":"8","author":"Tobin","year":"2013","journal-title":"PLoS One."},{"key":"10.1016\/j.celrep.2020.108547_bib74","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/jcp.22.2.158","article-title":"Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen","volume":"22","author":"Trinder","year":"1969","journal-title":"J.\u00a0Clin. Pathol."},{"key":"10.1016\/j.celrep.2020.108547_bib75","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.it.2017.03.001","article-title":"Macrophage immunometabolism: where are we (going)?","volume":"38","author":"Van den Bossche","year":"2017","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib76","first-page":"981","article-title":"Tuberculous pleural effusions: advances and controversies","volume":"7","author":"Vorster","year":"2015","journal-title":"J.\u00a0Thorac. Dis."},{"key":"10.1016\/j.celrep.2020.108547_bib77","doi-asserted-by":"crossref","first-page":"582","DOI":"10.4049\/jimmunol.0902352","article-title":"Elevated mitochondrial reactive oxygen species generation affects the immune response via hypoxia-inducible factor-1\u03b1 in long-lived Mclk1\u00a0+\/\u2212 mouse mutants","volume":"184","author":"Wang","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2020.108547_bib78","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.immuni.2015.02.002","article-title":"Mitochondria in the regulation of innate and adaptive immunity","volume":"42","author":"Weinberg","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2020.108547_bib79","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature09973","article-title":"TLR signalling augments macrophage bactericidal activity through mitochondrial ROS","volume":"472","author":"West","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2020.108547_bib80","series-title":"Global tuberculosis report 2019 (WHO\/CDS\/TB\/2019.15)","year":"2019"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720315369?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720315369?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:29:42Z","timestamp":1777624182000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124720315369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":81,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S2211124720315369"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2020.108547","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.03.23.001818","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Host-Derived Lipids from Tuberculous Pleurisy Impair Macrophage Microbicidal-Associated Metabolic Activity","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2020.108547","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"108547"}}