{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:37:07Z","timestamp":1790696227618,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T00:00:00Z","timestamp":1608768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100022514","name":"Canadian Society of Transplantation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022514","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018959","name":"Fondation Desmarest","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018959","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006489","name":"Commissariat \u00e0 l&apos;\u00c9nergie Atomique et aux \u00c9nergies Alternatives","doi-asserted-by":"publisher","award":["ANR-10- IAIHU-06"],"award-info":[{"award-number":["ANR-10- IAIHU-06"]}],"id":[{"id":"10.13039\/501100006489","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013116","name":"Merz Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013116","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.celrep.2020.108654","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T10:39:15Z","timestamp":1611052755000},"page":"108654","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Loss of floor plate Netrin-1 impairs midline crossing of corticospinal axons and leads to mirror movements"],"prefix":"10.1016","volume":"34","author":[{"given":"Oriane","family":"Pourchet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Pierre","family":"Morel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quentin","family":"Welniarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nad\u00e8ge","family":"Sarrazin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Marti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Heck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Gall\u00e9a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Doulazmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Roig Puiggros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7613-0819","authenticated-orcid":false,"given":"Juan Antonio","family":"Moreno-Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Vidailhet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Trembleau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Faure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Ch\u00e9dotal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Roze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Dusart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2020.108654_bib1","doi-asserted-by":"crossref","first-page":"e74454","DOI":"10.1371\/journal.pone.0074454","article-title":"Differential joint-specific corticospinal tract projections within the cervical enlargement","volume":"8","author":"Asante","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2020.108654_bib2","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/nm1331","article-title":"Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury","volume":"11","author":"Bareyre","year":"2005","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2020.108654_bib3","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neuroscience.2020.05.050","article-title":"Corticospinal Pathways and Interactions Underpinning Dexterous Forelimb Movement of the Rodent","volume":"450","author":"Basista","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2020.108654_bib4","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.celrep.2014.10.037","article-title":"A simple method for 3D analysis of immunolabeled axonal tracts in a transparent nervous system","volume":"9","author":"Belle","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2020.108654_bib5","doi-asserted-by":"crossref","first-page":"4407","DOI":"10.1523\/JNEUROSCI.19-11-04407.1999","article-title":"Floor plate and netrin-1 are involved in the migration and survival of inferior olivary neurons","volume":"19","author":"Bloch-Gallego","year":"1999","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2020.108654_bib6","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.neuron.2020.05.037","article-title":"Remotely produced and axon-derived netrin-1 instructs GABAergic neuron migration and dopaminergic substantia nigra development","volume":"107","author":"Brignani","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2020.108654_bib7","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.pneurobio.2008.02.001","article-title":"Molecular mechanisms of axon guidance in the developing corticospinal tract","volume":"85","author":"Canty","year":"2008","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.celrep.2020.108654_bib8","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0960-9822(98)70017-X","article-title":"Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1","volume":"8","author":"Cohen","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2020.108654_bib9","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nature22331","article-title":"Floor-plate-derived netrin-1 is dispensable for commissural axon guidance","volume":"545","author":"Dominici","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2020.108654_bib10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1749-8104-3-21","article-title":"Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling","volume":"3","author":"Faulkner","year":"2008","journal-title":"Neural Dev."},{"key":"10.1016\/j.celrep.2020.108654_bib11","doi-asserted-by":"crossref","first-page":"10346","DOI":"10.1523\/JNEUROSCI.22-23-10346.2002","article-title":"The netrin 1 receptors Unc5h3 and Dcc are necessary at multiple choice points for the guidance of corticospinal tract axons","volume":"22","author":"Finger","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2020.108654_bib12","doi-asserted-by":"crossref","first-page":"3333","DOI":"10.1093\/brain\/awt258","article-title":"RAD51 deficiency disrupts the corticospinal lateralization of motor control","volume":"136","author":"Gallea","year":"2013","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2020.108654_bib13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ymeth.2016.11.016","article-title":"DiAna, an ImageJ tool for object-based 3D co-localization and distance analysis","volume":"115","author":"Gilles","year":"2017","journal-title":"Methods"},{"key":"10.1016\/j.celrep.2020.108654_bib14","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1126\/science.aan3721","article-title":"Control of species-dependent cortico-motoneuronal connections underlying manual dexterity","volume":"357","author":"Gu","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2020.108654_bib15","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1471-2105-15-9","article-title":"A generic classification-based method for segmentation of nuclei in 3D images of early embryos","volume":"15","author":"Gul-Mohammed","year":"2014","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.celrep.2020.108654_bib16","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cell.2004.07.024","article-title":"Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities","volume":"118","author":"Harfe","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108654_bib17","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1523\/JNEUROSCI.5254-10.2011","article-title":"The UNC5C netrin receptor regulates dorsal guidance of mouse hindbrain axons","volume":"31","author":"Kim","year":"2011","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2020.108654_bib18","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1111\/j.1471-4159.2004.02460.x","article-title":"Netrin-1 is crucial for the establishment of the dorsal column-medial lemniscal system","volume":"89","author":"Kubota","year":"2004","journal-title":"J.\u00a0Neurochem."},{"key":"10.1016\/j.celrep.2020.108654_bib19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev.neuro.31.060407.125547","article-title":"Descending pathways in motor control","volume":"31","author":"Lemon","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2020.108654_bib37","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<121::AID-GENE6>3.0.CO;2-T","article-title":"Cre recombinase expression in the floorplate, notochord and gut epithelium in transgenic embryos driven by the Hoxa-1 enhancer III","volume":"26","author":"Li","year":"2000","journal-title":"Genesis"},{"key":"10.1016\/j.celrep.2020.108654_bib20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.mcn.2009.04.008","article-title":"Differential roles of Netrin-1 and its receptor DCC in inferior olivary neuron migration","volume":"41","author":"Marcos","year":"2009","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.celrep.2020.108654_bib21","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1212\/WNL.0000000000001290","article-title":"Congenital mirror movements: from piano player to opera singer","volume":"84","author":"M\u00e9neret","year":"2015","journal-title":"Neurology"},{"key":"10.1016\/j.celrep.2020.108654_bib22","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1172\/JCI95442","article-title":"Mutations in the netrin-1 gene cause congenital mirror movements","volume":"127","author":"M\u00e9neret","year":"2017","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2020.108654_bib23","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.neuron.2018.12.024","article-title":"Synergistic Activity of Floor-Plate- and Ventricular-Zone-Derived Netrin-1 in Spinal Cord Commissural Axon Guidance","volume":"101","author":"Moreno-Bravo","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2020.108654_bib24","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/dvdy.24549","article-title":"Loss of Dcc in the spinal cord is sufficient to cause a deficit in lateralized motor control and the switch to a hopping gait","volume":"247","author":"Peng","year":"2018","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.celrep.2020.108654_bib25","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/j.cell.2016.05.007","article-title":"Mapping of Brain Activity by Automated Volume Analysis of Immediate Early Genes","volume":"165","author":"Renier","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108654_bib26","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1749-8104-3-34","article-title":"Semaphorin-6A controls guidance of corticospinal tract axons at multiple choice points","volume":"3","author":"R\u00fcnker","year":"2008","journal-title":"Neural Dev."},{"key":"10.1016\/j.celrep.2020.108654_bib27","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/S0092-8674(00)81795-X","article-title":"Netrin-1 is required for commissural axon guidance in the developing vertebrate nervous system","volume":"87","author":"Serafini","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2020.108654_bib28","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.1523\/JNEUROSCI.4848-13.2014","article-title":"EphA4-mediated ipsilateral corticospinal tract misprojections are necessary for bilateral voluntary movements but not bilateral stereotypic locomotion","volume":"34","author":"Serradj","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2020.108654_bib29","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.expneurol.2005.06.017","article-title":"Assessing behavioural function following a pyramidotomy lesion of the corticospinal tract in adult mice","volume":"195","author":"Starkey","year":"2005","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.celrep.2020.108654_bib30","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1242\/dev.044529","article-title":"Netrins: versatile extracellular cues with diverse functions","volume":"138","author":"Sun","year":"2011","journal-title":"Development"},{"key":"10.1016\/j.celrep.2020.108654_bib31","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.neuron.2017.03.007","article-title":"Netrin1 Produced by Neural Progenitors, Not Floor Plate Cells, Is Required for Axon Guidance in the Spinal Cord","volume":"94","author":"Varadarajan","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2020.108654_bib32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fnana.2015.00075","article-title":"One hand clapping: lateralization of motor control","volume":"9","author":"Welniarz","year":"2015","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.celrep.2020.108654_bib33","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41598-017-00514-z","article-title":"Non cell-autonomous role of DCC in the guidance of the corticospinal tract at the midline","volume":"7","author":"Welniarz","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2020.108654_bib34","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1002\/dneu.22455","article-title":"The corticospinal tract: Evolution, development, and human disorders","volume":"77","author":"Welniarz","year":"2017","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.celrep.2020.108654_bib35","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1002\/hbm.24512","article-title":"The supplementary motor area modulates interhemispheric interactions during movement preparation","volume":"40","author":"Welniarz","year":"2019","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.celrep.2020.108654_bib36","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.neuron.2018.12.025","article-title":"Long-Range Guidance of Spinal Commissural Axons by Netrin1 and Sonic Hedgehog from Midline Floor Plate Cells","volume":"101","author":"Wu","year":"2019","journal-title":"Neuron"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720316430?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124720316430?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:11:14Z","timestamp":1761909074000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124720316430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S2211124720316430"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2020.108654","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2020.02.20.958595","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loss of floor plate Netrin-1 impairs midline crossing of corticospinal axons and leads to mirror movements","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2020.108654","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"108654"}}