{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T06:37:48Z","timestamp":1781851068838,"version":"3.54.5"},"reference-count":60,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000874","name":"NARSAD","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.celrep.2021.108828","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T20:59:30Z","timestamp":1615323570000},"page":"108828","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["The M domain in UNC-13 regulates the probability of neurotransmitter release"],"prefix":"10.1016","volume":"34","author":[{"given":"Haowen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0227-856X","authenticated-orcid":false,"given":"Seema","family":"Sheoran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet E.","family":"Richmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyao","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhitao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2021.108828_bib1","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/14764","article-title":"Drosophila UNC-13 is essential for synaptic transmission","volume":"2","author":"Aravamudan","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2021.108828_bib2","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nrn876","article-title":"Diversification of synaptic strength: presynaptic elements","volume":"3","author":"Atwood","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2021.108828_bib3","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/22768","article-title":"Munc13-1 is essential for fusion competence of glutamatergic synaptic vesicles","volume":"400","author":"Augustin","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.108828_bib4","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1042\/bj3370363","article-title":"Differential expression of two novel Munc13 proteins in rat brain","volume":"337","author":"Augustin","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/j.celrep.2021.108828_bib5","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1523\/JNEUROSCI.21-01-00010.2001","article-title":"The cerebellum-specific Munc13 isoform Munc13-3 regulates cerebellar synaptic transmission and motor learning in mice","volume":"21","author":"Augustin","year":"2001","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.108828_bib6","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nsmb1001","article-title":"A minimal domain responsible for Munc13 activity","volume":"12","author":"Basu","year":"2005","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2021.108828_bib7","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1523\/JNEUROSCI.4908-06.2007","article-title":"Munc13-1 C1 domain activation lowers the energy barrier for synaptic vesicle fusion","volume":"27","author":"Basu","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.108828_bib8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0896-6273(00)80520-6","article-title":"Munc13-1 is a presynaptic phorbol ester receptor that enhances neurotransmitter release","volume":"21","author":"Betz","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.108828_bib9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0896-6273(01)00272-0","article-title":"Functional interaction of the active zone proteins Munc13-1 and RIM1 in synaptic vesicle priming","volume":"30","author":"Betz","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.108828_bib10","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1038\/nn.4364","article-title":"Active zone scaffolds differentially accumulate Unc13 isoforms to tune Ca(2+) channel-vesicle coupling","volume":"19","author":"B\u00f6hme","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2021.108828_bib11","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/genetics\/77.1.71","article-title":"The genetics of Caenorhabditis elegans","volume":"77","author":"Brenner","year":"1974","journal-title":"Genetics"},{"key":"10.1016\/j.celrep.2021.108828_bib12","doi-asserted-by":"crossref","first-page":"25273","DOI":"10.1074\/jbc.270.42.25273","article-title":"Mammalian homologues of Caenorhabditis elegans unc-13 gene define novel family of C2-domain proteins","volume":"270","author":"Brose","year":"1995","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.108828_bib13","doi-asserted-by":"crossref","first-page":"e07728","DOI":"10.7554\/eLife.07728","article-title":"The active-zone protein Munc13 controls the use-dependence of presynaptic voltage-gated calcium channels","volume":"4","author":"Calloway","year":"2015","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2021.108828_bib14","doi-asserted-by":"crossref","first-page":"15293","DOI":"10.1038\/ncomms15293","article-title":"Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming","volume":"8","author":"Camacho","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2021.108828_bib15","doi-asserted-by":"crossref","first-page":"8336","DOI":"10.1523\/JNEUROSCI.5128-12.2013","article-title":"The Munc13 proteins differentially regulate readily releasable pool dynamics and calcium-dependent recovery at a central synapse","volume":"33","author":"Chen","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.108828_bib16","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.neuron.2011.01.005","article-title":"RIM proteins activate vesicle priming by reversing autoinhibitory homodimerization of Munc13","volume":"69","author":"Deng","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.108828_bib17","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S0896-6273(00)80338-4","article-title":"Heterogeneity of release probability, facilitation, and depletion at central synapses","volume":"18","author":"Dobrunz","year":"1997","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.108828_bib18","doi-asserted-by":"crossref","first-page":"11650","DOI":"10.1074\/jbc.273.19.11650","article-title":"Catalytic domain of phosphoinositide-specific phospholipase C (PLC). Mutational analysis of residues within the active site and hydrophobic ridge of plcdelta1","volume":"273","author":"Ellis","year":"1998","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.108828_bib19","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.conb.2011.02.003","article-title":"Short-term forms of presynaptic plasticity","volume":"21","author":"Fioravante","year":"2011","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.celrep.2021.108828_bib20","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/nmeth.2889","article-title":"Random and targeted transgene insertion in Caenorhabditis elegans using a modified Mos1 transposon","volume":"11","author":"Fr\u00f8kj\u00e6r-Jensen","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2021.108828_bib21","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.celrep.2018.03.126","article-title":"Active zone scaffold protein ratios tune functional diversity across brain synapses","volume":"23","author":"Fulterer","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.108828_bib22","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1126\/science.1163174","article-title":"Conformational switch of syntaxin-1 controls synaptic vesicle fusion","volume":"321","author":"Gerber","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.108828_bib23","doi-asserted-by":"crossref","first-page":"e198","DOI":"10.1371\/journal.pbio.0050198","article-title":"Open syntaxin docks synaptic vesicles","volume":"5","author":"Hammarlund","year":"2007","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2021.108828_bib24","doi-asserted-by":"crossref","first-page":"e00967","DOI":"10.7554\/eLife.00967","article-title":"UNC-13L, UNC-13S, and Tomosyn form a protein code for fast and slow neurotransmitter release in Caenorhabditis elegans","volume":"2","author":"Hu","year":"2013","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2021.108828_bib25","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1523\/JNEUROSCI.2825-14.2015","article-title":"NLP-12 engages different UNC-13 proteins to potentiate tonic and evoked release","volume":"35","author":"Hu","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.108828_bib26","doi-asserted-by":"crossref","first-page":"14687","DOI":"10.1523\/JNEUROSCI.2060-14.2014","article-title":"Munc13-3 superprimes synaptic vesicles at granule cell-to-basket cell synapses in the mouse cerebellum","volume":"34","author":"Ishiyama","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.108828_bib27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nature11320","article-title":"Molecular machines governing exocytosis of synaptic vesicles","volume":"490","author":"Jahn","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.108828_bib28","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.cell.2004.06.029","article-title":"Calmodulin and Munc13 form a Ca2+ sensor\/effector complex that controls short-term synaptic plasticity","volume":"118","author":"Junge","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.108828_bib29","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1083\/jcb.201606086","article-title":"ELKS1 localizes the synaptic vesicle priming protein bMunc13-2 to a specific subset of active zones","volume":"216","author":"Kawabe","year":"2017","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2021.108828_bib30","doi-asserted-by":"crossref","first-page":"3441","DOI":"10.1091\/mbc.11.10.3441","article-title":"Expression of multiple UNC-13 proteins in the Caenorhabditis elegans nervous system","volume":"11","author":"Kohn","year":"2000","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.celrep.2021.108828_bib31","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0896-6273(00)80848-X","article-title":"Facilitation of synaptic transmission by EGL-30 Gq\u03b1 and EGL-8 PLC\u03b2: DAG binding to UNC-13 is required to stimulate acetylcholine release","volume":"24","author":"Lackner","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.108828_bib32","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.neuron.2017.07.004","article-title":"Molecular mechanisms of synaptic vesicle priming by Munc13 and Munc18","volume":"95","author":"Lai","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.108828_bib33","doi-asserted-by":"crossref","first-page":"15079","DOI":"10.1073\/pnas.1314427110","article-title":"Superpriming of synaptic vesicles after their recruitment to the readily releasable pool","volume":"110","author":"Lee","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.108828_bib34","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1016\/j.celrep.2019.08.018","article-title":"A hyperactive form of unc-13 enhances Ca2+ sensitivity and synaptic vesicle release probability in C.\u00a0elegans","volume":"28","author":"Li","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.108828_bib35","doi-asserted-by":"crossref","first-page":"e13696","DOI":"10.7554\/eLife.13696","article-title":"Functional synergy between the Munc13 C-terminal C1 and C2 domains","volume":"5","author":"Liu","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2021.108828_bib36","doi-asserted-by":"crossref","first-page":"e40585","DOI":"10.7554\/eLife.40585","article-title":"Heterodimerization of UNC-13\/RIM regulates synaptic vesicle release probability but not priming in C.\u00a0elegans","volume":"8","author":"Liu","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2021.108828_bib37","doi-asserted-by":"crossref","first-page":"6049","DOI":"10.1523\/JNEUROSCI.0403-19.2019","article-title":"Ablation of all synaptobrevin vSNAREs blocks evoked but not spontaneous neurotransmitter release at neuromuscular synapses","volume":"39","author":"Liu","year":"2019","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.108828_bib38","doi-asserted-by":"crossref","first-page":"8257","DOI":"10.1523\/JNEUROSCI.0550-08.2008","article-title":"Phorbol esters modulate spontaneous and Ca2+-evoked transmitter release via acting on both Munc13 and protein kinase C","volume":"28","author":"Lou","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.108828_bib39","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1016\/j.cub.2005.10.049","article-title":"UNC-13 interaction with syntaxin is required for synaptic transmission","volume":"15","author":"Madison","year":"2005","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2021.108828_bib40","doi-asserted-by":"crossref","first-page":"5729","DOI":"10.1073\/pnas.88.13.5729","article-title":"A phorbol ester\/diacylglycerol-binding protein encoded by the unc-13 gene of Caenorhabditis elegans","volume":"88","author":"Maruyama","year":"1991","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.108828_bib41","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.neuron.2017.07.015","article-title":"A C1-C2 module in Munc13 inhibits calcium-dependent neurotransmitter release","volume":"95","author":"Michelassi","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.108828_bib42","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/s12311-015-0645-0","article-title":"Fast cerebellar reflex circuitry requires synaptic vesicle priming by munc13-3","volume":"14","author":"Netrakanti","year":"2015","journal-title":"Cerebellum"},{"key":"10.1016\/j.celrep.2021.108828_bib43","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.neuron.2017.07.017","article-title":"Unc13 Aligns SNAREs and superprimes synaptic vesicles","volume":"95","author":"Palfreyman","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.108828_bib44","doi-asserted-by":"crossref","first-page":"a005702","DOI":"10.1101\/cshperspect.a005702","article-title":"Short-term presynaptic plasticity","volume":"4","author":"Regehr","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.celrep.2021.108828_bib45","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1038\/14755","article-title":"UNC-13 is required for synaptic vesicle fusion in C. elegans","volume":"2","author":"Richmond","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2021.108828_bib46","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/S0896-6273(00)80146-4","article-title":"Definition of the readily releasable pool of vesicles at hippocampal synapses","volume":"16","author":"Rosenmund","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.108828_bib47","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S0896-6273(02)00568-8","article-title":"Differential control of vesicle priming and short-term plasticity by Munc13 isoforms","volume":"33","author":"Rosenmund","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.108828_bib48","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/s41593-017-0041-9","article-title":"Synaptic weight set by Munc13-1 supramolecular assemblies","volume":"21","author":"Sakamoto","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2021.108828_bib49","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2021.108828_bib50","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1021\/bi0476127","article-title":"Intramolecular occlusion of the diacylglycerol-binding site in the C1 domain of munc13-1","volume":"44","author":"Shen","year":"2005","journal-title":"Biochemistry"},{"key":"10.1016\/j.celrep.2021.108828_bib51","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/nsmb.1758","article-title":"Munc13 C2B domain is an activity-dependent Ca2+ regulator of synaptic exocytosis","volume":"17","author":"Shin","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2021.108828_bib52","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1046\/j.1523-1755.1998.00942.x","article-title":"Cloning of a novel gene in the human kidney homologous to rat munc13s: its potential role in diabetic nephropathy","volume":"53","author":"Song","year":"1998","journal-title":"Kidney Int."},{"key":"10.1016\/j.celrep.2021.108828_bib53","doi-asserted-by":"crossref","first-page":"a005637","DOI":"10.1101\/cshperspect.a005637","article-title":"Synaptic vesicle exocytosis","volume":"3","author":"S\u00fcdhof","year":"2011","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.celrep.2021.108828_bib54","doi-asserted-by":"crossref","first-page":"E4548","DOI":"10.1073\/pnas.1606383113","article-title":"Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength","volume":"113","author":"Taschenberger","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.108828_bib55","doi-asserted-by":"crossref","first-page":"9037","DOI":"10.1073\/pnas.122623799","article-title":"Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming","volume":"99","author":"Varoqueaux","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.108828_bib56","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.1128\/MCB.25.14.5973-5984.2005","article-title":"Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse","volume":"25","author":"Varoqueaux","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2021.108828_bib57","doi-asserted-by":"crossref","first-page":"8040","DOI":"10.1523\/JNEUROSCI.2350-06.2006","article-title":"UNC-13 and UNC-10\/rim localize synaptic vesicles to specific membrane domains","volume":"26","author":"Weimer","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.108828_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1098\/rstb.1986.0056","article-title":"The structure of the nervous system of the nematode caenorhabditis elegans","volume":"314","author":"White","year":"1986","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"10.1016\/j.celrep.2021.108828_bib58","doi-asserted-by":"crossref","first-page":"e22567","DOI":"10.7554\/eLife.22567","article-title":"Mechanistic insights into neurotransmitter release and presynaptic plasticity from the crystal structure of Munc13-1 C1C2BMUN","volume":"6","author":"Xu","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2021.108828_bib59","doi-asserted-by":"crossref","first-page":"e01180","DOI":"10.7554\/eLife.01180","article-title":"Position of UNC-13 in the active zone regulates synaptic vesicle release probability and release kinetics","volume":"2","author":"Zhou","year":"2013","journal-title":"eLife"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472100142X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472100142X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:13:44Z","timestamp":1761909224000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221112472100142X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":60,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S221112472100142X"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2021.108828","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The M domain in UNC-13 regulates the probability of neurotransmitter release","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.108828","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"108828"}}