{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:38:27Z","timestamp":1790746707189,"version":"4.1.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA193815"],"award-info":[{"award-number":["CA193815"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.celrep.2021.108948","type":"journal-article","created":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T11:39:47Z","timestamp":1617709187000},"page":"108948","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Fascin inhibitor increases intratumoral dendritic cell activation and anti-cancer immunity"],"prefix":"10.1016","volume":"35","author":[{"given":"Yufeng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming O.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Jillian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-Yun","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2021.108948_bib1","doi-asserted-by":"crossref","first-page":"5981","DOI":"10.4049\/jimmunol.1102868","article-title":"Lipopolysaccharide-activated dendritic cells: \u201cexhausted\u201d or alert and waiting?","volume":"188","author":"Abdi","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.108948_bib2","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/nri819","article-title":"Cytotoxic T lymphocytes: all roads lead to death","volume":"2","author":"Barry","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2021.108948_bib3","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.4049\/jimmunol.171.4.1825","article-title":"The human fascin gene promoter is highly active in mature dendritic cells due to a stage-specific enhancer","volume":"171","author":"Bros","year":"2003","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.108948_bib4","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0022-2836(78)90345-5","article-title":"Separation and interaction of the major components of sea urchin actin gel","volume":"125","author":"Bryan","year":"1978","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.celrep.2021.108948_bib5","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/s41586-019-1914-8","article-title":"Tertiary lymphoid structures improve immunotherapy and survival in melanoma","volume":"577","author":"Cabrita","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.108948_bib6","doi-asserted-by":"crossref","first-page":"2702","DOI":"10.3389\/fimmu.2019.02702","article-title":"Long-Term Exposure to Inflammation Induces Differential Cytokine Patterns and Apoptosis in Dendritic Cells","volume":"10","author":"Carstensen","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2021.108948_bib7","doi-asserted-by":"crossref","first-page":"7526","DOI":"10.1038\/ncomms8526","article-title":"Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells","volume":"6","author":"Chabaud","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2021.108948_bib8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/nature21349","article-title":"Elements of cancer immunity and the cancer-immune set point","volume":"541","author":"Chen","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.108948_bib9","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/nature08978","article-title":"Migrastatin analogues target fascin to block tumour metastasis","volume":"464","author":"Chen","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.108948_bib10","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nprot.2014.004","article-title":"Determining the macropinocytic index of cells through a quantitative image-based assay","volume":"9","author":"Commisso","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2021.108948_bib11","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/ncb3169","article-title":"Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver","volume":"17","author":"Costa-Silva","year":"2015","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2021.108948_bib12","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2021.108948_bib13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/j.1365-2613.2007.00539.x","article-title":"The mouse mammary carcinoma 4T1: characterization of the cellular landscape of primary tumours and metastatic tumour foci","volume":"88","author":"DuPr\u00e9","year":"2007","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.celrep.2021.108948_bib14","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1016\/j.cub.2014.05.023","article-title":"Fascin plays a role in stress fiber organization and focal adhesion disassembly","volume":"24","author":"Elkhatib","year":"2014","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2021.108948_bib15","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1172\/JCI93123","article-title":"Thioesterase-mediated control of cellular calcium homeostasis enables hepatic ER stress","volume":"128","author":"Ersoy","year":"2018","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2021.108948_bib16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.3389\/fimmu.2012.00331","article-title":"Novel murine dendritic cell lines: a powerful auxiliary tool for dendritic cell research","volume":"3","author":"Fuertes Marraco","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2021.108948_bib17","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.immuni.2018.09.024","article-title":"Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-\u03b3 and IL-12","volume":"49","author":"Garris","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.108948_bib18","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ceb.2008.01.005","article-title":"Assembly and biological role of podosomes and invadopodia","volume":"20","author":"Gimona","year":"2008","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.celrep.2021.108948_bib19","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.immuni.2018.01.010","article-title":"NKp46 Receptor-Mediated Interferon-\u03b3 Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis","volume":"48","author":"Glasner","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.108948_bib20","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1054\/bjoc.2000.1395","article-title":"Fascin, an actin-bundling protein associated with cell motility, is upregulated in hormone receptor negative breast cancer","volume":"83","author":"Grothey","year":"2000","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.celrep.2021.108948_bib21","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.molonc.2016.03.006","article-title":"Improving fascin inhibitors to block tumor cell migration and metastasis","volume":"10","author":"Han","year":"2016","journal-title":"Mol. Oncol."},{"key":"10.1016\/j.celrep.2021.108948_bib22","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.biocel.2005.05.004","article-title":"Roles of fascin in human carcinoma motility and signaling: prospects for a novel biomarker?","volume":"37","author":"Hashimoto","year":"2005","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.celrep.2021.108948_bib23","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/path.2894","article-title":"The roles of fascins in health and disease","volume":"224","author":"Hashimoto","year":"2011","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.celrep.2021.108948_bib24","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1038\/s41586-019-1922-8","article-title":"B cells and tertiary lymphoid structures promote immunotherapy response","volume":"577","author":"Helmink","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.108948_bib25","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.1164206","article-title":"Batf3 deficiency reveals a critical role for CD8alpha+ dendritic cells in cytotoxic T\u00a0cell immunity","volume":"322","author":"Hildner","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.108948_bib26","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3390\/cancers11010037","article-title":"Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer","volume":"11","author":"Hodakoski","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.celrep.2021.108948_bib27","doi-asserted-by":"crossref","first-page":"7465","DOI":"10.1038\/ncomms8465","article-title":"Targeted inhibition of fascin function blocks tumour invasion and metastatic colonization","volume":"6","author":"Huang","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2021.108948_bib28","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.jmb.2018.03.009","article-title":"Structural Insights into the Induced-fit Inhibition of Fascin by a Small-Molecule Inhibitor","volume":"430","author":"Huang","year":"2018","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.celrep.2021.108948_bib29","doi-asserted-by":"crossref","first-page":"11774","DOI":"10.1073\/pnas.1410626111","article-title":"Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells","volume":"111","author":"Kim","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.108948_bib30","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1053\/j.gastro.2014.01.046","article-title":"Fascin is regulated by slug, promotes progression of pancreatic cancer in mice, and is associated with patient outcomes","volume":"146","author":"Li","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2021.108948_bib31","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1016\/j.celrep.2019.08.011","article-title":"Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments","volume":"28","author":"Lin","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.108948_bib32","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41586-020-2134-y","article-title":"A conserved dendritic-cell regulatory program limits antitumour immunity","volume":"580","author":"Maier","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.108948_bib33","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1186\/s12885-018-5128-5","article-title":"MEF2 plays a significant role in the tumor inhibitory mechanism of encapsulated RENCA cells via EGF receptor signaling in target tumor cells","volume":"18","author":"Martis","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.celrep.2021.108948_bib34","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nrm2406","article-title":"Filopodia: molecular architecture and cellular functions","volume":"9","author":"Mattila","year":"2008","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2021.108948_bib35","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.bbrc.2017.03.122","article-title":"Sigma-2 ligands and PARP inhibitors synergistically trigger cell death in breast cancer cells","volume":"486","author":"McDonald","year":"2017","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2021.108948_bib36","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0092-8674(01)00449-4","article-title":"Dendritic cells: specialized and regulated antigen processing machines","volume":"106","author":"Mellman","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.108948_bib37","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/nm.4200","article-title":"Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses","volume":"22","author":"Moynihan","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2021.108948_bib38","doi-asserted-by":"crossref","first-page":"E7536","DOI":"10.1073\/pnas.1706356114","article-title":"Foxp3-independent mechanism by which TGF-\u03b2 controls peripheral T\u00a0cell tolerance","volume":"114","author":"Oh","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.108948_bib39","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40425-017-0218-5","article-title":"Combination immunotherapy: a road map","volume":"5","author":"Ott","year":"2017","journal-title":"J.\u00a0Immunother. Cancer"},{"key":"10.1016\/j.celrep.2021.108948_bib40","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0092-8674(79)90154-5","article-title":"Formation of filopodia in coelomocytes: localization of fascin, a 58,000 dalton actin cross-linking protein","volume":"17","author":"Otto","year":"1979","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.108948_bib41","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/s41586-019-1906-8","article-title":"B cells are associated with survival and immunotherapy response in sarcoma","volume":"577","author":"Petitprez","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.108948_bib42","first-page":"1486","article-title":"Reduction of established spontaneous mammary carcinoma metastases following immunotherapy with major histocompatibility complex class II and B7.1 cell-based tumor vaccines","volume":"58","author":"Pulaski","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2021.108948_bib43","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41422-020-0355-0","article-title":"A pan-cancer blueprint of the heterogeneous tumor microenvironment revealed by single-cell profiling","volume":"30","author":"Qian","year":"2020","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2021.108948_bib44","doi-asserted-by":"crossref","first-page":"3134","DOI":"10.4049\/jimmunol.0902522","article-title":"Dendritic cell inhibition is connected to exhaustion of CD8+ T\u00a0cell polyfunctionality during chronic hepatitis C virus infection","volume":"184","author":"Rodrigue-Gervais","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.108948_bib45","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/sj.gt.3301968","article-title":"Transcriptional targeting of dendritic cells for gene therapy using the promoter of the cytoskeletal protein fascin","volume":"10","author":"Ross","year":"2003","journal-title":"Gene Ther."},{"key":"10.1016\/j.celrep.2021.108948_bib46","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s41568-019-0144-6","article-title":"Tertiary lymphoid structures in the era of cancer immunotherapy","volume":"19","author":"Saut\u00e8s-Fridman","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2021.108948_bib47","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.ejcb.2014.08.002","article-title":"Conditional expression of fascin increases tumor progression in a mouse model of intestinal cancer","volume":"93","author":"Schoumacher","year":"2014","journal-title":"Eur. J. Cell Biol."},{"key":"10.1016\/j.celrep.2021.108948_bib48","doi-asserted-by":"crossref","first-page":"3772","DOI":"10.1073\/pnas.0500658102","article-title":"Synthetic analogues of migrastatin that inhibit mammary tumor metastasis in mice","volume":"102","author":"Shan","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.108948_bib49","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1126\/science.aaa8172","article-title":"The future of immune checkpoint therapy","volume":"348","author":"Sharma","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.108948_bib50","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/s41577-019-0257-x","article-title":"B cells, plasma cells and antibody repertoires in the tumour microenvironment","volume":"20","author":"Sharonov","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2021.108948_bib51","doi-asserted-by":"crossref","first-page":"2604","DOI":"10.3389\/fimmu.2018.02604","article-title":"Importance of EMT Factor ZEB1 in cDC1 \u201cMutuDC Line\u201d Mediated Induction of Th1 Immune Response","volume":"9","author":"Smita","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2021.108948_bib52","doi-asserted-by":"crossref","first-page":"38886","DOI":"10.1074\/jbc.M111.286245","article-title":"Signal transducers and activators of transcription 3 (STAT3) directly regulates cytokine-induced fascin expression and is required for breast cancer cell migration","volume":"286","author":"Snyder","year":"2011","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.108948_bib53","doi-asserted-by":"crossref","first-page":"30082","DOI":"10.1074\/jbc.M114.591719","article-title":"A signal transducer and activator of transcription 3\u00b7Nuclear Factor \u03baB (Stat3\u00b7NF\u03baB) complex is necessary for the expression of fascin in metastatic breast cancer cells in response to interleukin (IL)-6 and tumor necrosis factor (TNF)-\u03b1","volume":"289","author":"Snyder","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.108948_bib54","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev.iy.09.040191.001415","article-title":"The dendritic cell system and its role in immunogenicity","volume":"9","author":"Steinman","year":"1991","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2021.108948_bib55","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1741-7015-11-52","article-title":"Association of fascin-1 with mortality, disease progression and metastasis in carcinomas: a systematic review and meta-analysis","volume":"11","author":"Tan","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.celrep.2021.108948_bib56","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.4049\/jimmunol.0902223","article-title":"Matrix architecture dictates three-dimensional migration modes of human macrophages: differential involvement of proteases and podosome-like structures","volume":"184","author":"Van Goethem","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.108948_bib57","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.3390\/cancers12082287","article-title":"Anti-Metastasis Fascin Inhibitors Decrease the Growth of Specific Subtypes of Cancers","volume":"12","author":"Wang","year":"2020","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.celrep.2021.108948_bib58","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1158\/2159-8290.CD-18-0367","article-title":"Fundamental Mechanisms of Immune Checkpoint Blockade Therapy","volume":"8","author":"Wei","year":"2018","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2021.108948_bib59","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1126\/science.1099153","article-title":"Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling","volume":"305","author":"West","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.108948_bib60","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.4049\/jimmunol.1001667","article-title":"Fascin1 promotes cell migration of mature dendritic cells","volume":"186","author":"Yamakita","year":"2011","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.108948_bib61","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1615\/CritRevImmunol.v32.i1.20","article-title":"Functions of fascin in dendritic cells","volume":"32","author":"Yamashiro","year":"2012","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.celrep.2021.108948_bib62","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1016\/S0021-9258(18)89183-9","article-title":"Purification and characterization of an F-actin-bundling 55-kilodalton protein from HeLa cells","volume":"260","author":"Yamashiro-Matsumura","year":"1985","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.108948_bib63","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.ccr.2008.12.019","article-title":"Orai1 and STIM1 are critical for breast tumor cell migration and metastasis","volume":"15","author":"Yang","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2021.108948_bib64","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/978-1-62703-008-3_17","article-title":"Mouse models for tumor metastasis","volume":"928","author":"Yang","year":"2012","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2021.108948_bib65","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1074\/jbc.M112.427971","article-title":"Molecular mechanism of fascin function in filopodial formation","volume":"288","author":"Yang","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.108948_bib66","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.cell.2019.10.003","article-title":"Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma","volume":"179","author":"Zhang","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.108948_bib67","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1016\/j.immuni.2019.03.009","article-title":"Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species","volume":"50","author":"Zilionis","year":"2019","journal-title":"Immunity"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472100262X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472100262X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:15:30Z","timestamp":1761909330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221112472100262X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["S221112472100262X"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2021.108948","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fascin inhibitor increases intratumoral dendritic cell activation and anti-cancer immunity","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.108948","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"108948"}}