{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T15:58:59Z","timestamp":1792166339653,"version":"4.4.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,12]],"date-time":"2021-05-12T00:00:00Z","timestamp":1620777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA08748"],"award-info":[{"award-number":["P30CA08748"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000861","name":"Burroughs Wellcome Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000861","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000884","name":"Cancer Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000884","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017050","name":"Cycle for Survival","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI100874"],"award-info":[{"award-number":["AI100874"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI130043"],"award-info":[{"award-number":["AI130043"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI155558"],"award-info":[{"award-number":["AI155558"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.celrep.2021.109210","type":"journal-article","created":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T11:22:14Z","timestamp":1622546534000},"page":"109210","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":107,"title":["Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function"],"prefix":"10.1016","volume":"35","author":[{"given":"Sam","family":"Sheppard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endi K.","family":"Santosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen M.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Violante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Giovanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin R.","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming O.","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph C.","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2021.109210_bib1","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/j.immuni.2019.04.009","article-title":"Cytomegalovirus infection drives avidity selection of natural killer cells","volume":"50","author":"Adams","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.109210_bib2","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.4049\/jimmunol.1004085","article-title":"2-Deoxy D-glucose prevents cell surface expression of NKG2D ligands through inhibition of N-linked glycosylation","volume":"188","author":"Andresen","year":"2012","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109210_bib3","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1126\/science.1070884","article-title":"Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors","volume":"296","author":"Arase","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.109210_bib4","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1093\/bioinformatics\/btu170","article-title":"Trimmomatic: A flexible trimmer for Illumina sequence data","volume":"30","author":"Bolger","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2021.109210_bib5","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cmet.2016.08.011","article-title":"LDHA-associated lactic acid production blunts tumor immunosurveillance by T and NK cells","volume":"24","author":"Brand","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2021.109210_bib6","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1126\/science.1060042","article-title":"Vital involvement of a natural killer cell activation receptor in resistance to viral infection","volume":"292","author":"Brown","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.109210_bib7","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1016\/j.cell.2013.05.016","article-title":"Posttranscriptional control of T\u00a0cell effector function by aerobic glycolysis","volume":"153","author":"Chang","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109210_bib8","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.4049\/jimmunol.143.4.1283","article-title":"Mechanisms of T\u00a0cell activation by the calcium ionophore ionomycin","volume":"143","author":"Chatila","year":"1989","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109210_bib9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1084\/jem.194.1.29","article-title":"Murine cytomegalovirus is regulated by a discrete subset of natural killer cells reactive with monoclonal antibody to Ly49H","volume":"194","author":"Daniels","year":"2001","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2021.109210_bib10","doi-asserted-by":"crossref","first-page":"107855","DOI":"10.1016\/j.celrep.2020.107855","article-title":"Inflammation-induced lactate leads to rapid loss of hepatic tissue-resident NK cells","volume":"32","author":"Dodard","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.109210_bib11","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/s41590-019-0388-z","article-title":"The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc","volume":"20","author":"Dong","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2021.109210_bib12","doi-asserted-by":"crossref","first-page":"4477","DOI":"10.4049\/jimmunol.1401558","article-title":"mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function","volume":"193","author":"Donnelly","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109210_bib13","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1182\/blood-2006-07-035972","article-title":"Inhibitory effect of tumor cell-derived lactic acid on human T\u00a0cells","volume":"109","author":"Fischer","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2021.109210_bib14","doi-asserted-by":"crossref","first-page":"6394","DOI":"10.4049\/jimmunol.181.9.6394","article-title":"Ly49h-deficient C57BL\/6 mice: A new mouse cytomegalovirus-susceptible model remains resistant to unrelated pathogens controlled by the NK gene complex","volume":"181","author":"Fodil-Cornu","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109210_bib15","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S1074-7613(02)00323-0","article-title":"The CD28 signaling pathway regulates glucose metabolism","volume":"16","author":"Frauwirth","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.109210_bib16","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.immuni.2019.04.015","article-title":"Distinct surface expression of activating receptor Ly49H drives differential expansion of NK cell clones upon murine cytomegalovirus infection","volume":"50","author":"Grassmann","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.109210_bib17","doi-asserted-by":"crossref","first-page":"e1002202","DOI":"10.1371\/journal.pbio.1002202","article-title":"Lactate regulates metabolic and pro-inflammatory circuits in control of T\u00a0cell migration and effector functions","volume":"13","author":"Haas","year":"2015","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2021.109210_bib18","doi-asserted-by":"crossref","first-page":"6047","DOI":"10.1073\/pnas.1920413117","article-title":"Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T\u00a0cell stemness and antitumor immunity","volume":"117","author":"Hermans","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109210_bib19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/nature24057","article-title":"Glucose feeds the TCA cycle via circulating lactate","volume":"551","author":"Hui","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109210_bib20","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.4049\/jimmunol.1202702","article-title":"Tumor-derived lactate modifies antitumor immune response: Effect on myeloid-derived suppressor cells and NK cells","volume":"191","author":"Husain","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109210_bib21","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.4049\/jimmunol.1501783","article-title":"Metabolic reprogramming supports IFN-\u03b3 production by CD56bright NK Cells","volume":"196","author":"Keating","year":"2016","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109210_bib22","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.4049\/jimmunol.1402099","article-title":"Activation-specific metabolic requirements for NK cell IFN-\u03b3 production","volume":"194","author":"Keppel","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109210_bib23","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1089\/ars.2007.1714","article-title":"Differential toxic mechanisms of 2-deoxy-d-glucose versus 2-fluorodeoxy-d-glucose in hypoxic and normoxic tumor cells","volume":"9","author":"Kurtoglu","year":"2007","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.celrep.2021.109210_bib24","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1093\/nar\/gkv047","article-title":"Regulation of mammalian nucleotide metabolism and biosynthesis","volume":"43","author":"Lane","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2021.109210_bib60","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.celrep.2021.109210_bib25","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/s41590-018-0176-1","article-title":"Epigenetic control of innate and adaptive immune memory","volume":"19","author":"Lau","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2021.109210_bib26","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1038\/s41467-018-04719-2","article-title":"Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice","volume":"9","author":"Loftus","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2021.109210_bib27","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2021.109210_bib28","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.immuni.2019.09.003","article-title":"Metabolic profiling using stable isotope tracing reveals distinct patterns of glucose utilization by physiologically activated CD8+ T\u00a0cells","volume":"51","author":"Ma","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.109210_bib29","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.4049\/jimmunol.1402001","article-title":"Cutting edge: Stage-specific requirement of IL-18 for antiviral NK cell expansion","volume":"194","author":"Madera","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109210_bib30","doi-asserted-by":"crossref","first-page":"e95128","DOI":"10.1172\/jci.insight.95128","article-title":"Glycolytic requirement for NK cell cytotoxicity and cytomegalovirus control","volume":"2","author":"Mah","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2021.109210_bib31","doi-asserted-by":"crossref","first-page":"109209-1","DOI":"10.1016\/j.celrep.2021.109209","article-title":"Reliance on Cox10 and oxidative metabolism for antigen-specific NK cell expansion","volume":"35","author":"Mah-Som","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.109210_bib32","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/ni.2936","article-title":"The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during NK cell development and activation of NK cells","volume":"15","author":"Mar\u00e7ais","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2021.109210_bib33","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1600-065X.2008.00759.x","article-title":"New insights into the regulation and function of serine\/threonine kinases in T lymphocytes","volume":"228","author":"Matthews","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2021.109210_bib34","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1002\/ijc.26410","article-title":"Tumor lactic acidosis suppresses CTL function by inhibition of p38 and JNK\/c-Jun activation","volume":"131","author":"Mendler","year":"2012","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.celrep.2021.109210_bib35","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.celrep.2018.01.040","article-title":"Early TCR signaling induces rapid aerobic glycolysis enabling distinct acute T\u00a0cell effector functions","volume":"22","author":"Menk","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.109210_bib36","doi-asserted-by":"crossref","first-page":"450","DOI":"10.4049\/jimmunol.177.1.450","article-title":"Four distinct patterns of memory CD8 T\u00a0cell responses to chronic murine cytomegalovirus infection","volume":"177","author":"Munks","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109210_bib37","doi-asserted-by":"crossref","first-page":"18324","DOI":"10.1073\/pnas.1112064108","article-title":"Fate mapping analysis of lymphoid cells expressing the NKp46 cell surface receptor","volume":"108","author":"Narni-Mancinelli","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109210_bib38","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1128\/CDLI.8.6.1131-1135.2001","article-title":"Calcein-acetyoxymethyl cytotoxicity assay: Standardization of a method allowing additional analyses on recovered effector cells and supernatants","volume":"8","author":"Neri","year":"2001","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.celrep.2021.109210_bib39","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/s41577-019-0139-2","article-title":"Immunometabolism and natural killer cell responses","volume":"19","author":"O\u2019Brien","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2021.109210_bib40","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.immuni.2015.07.012","article-title":"BNIP3- and BNIP3L-mediated mitophagy promotes the generation of natural killer cell memory","volume":"43","author":"O\u2019Sullivan","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.109210_bib41","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1016\/j.celrep.2020.01.039","article-title":"Dynamic imaging of LDH inhibition in tumors reveals rapid in\u00a0vivo metabolic rewiring and vulnerability to combination therapy","volume":"30","author":"Oshima","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.109210_bib42","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nmeth.4197","article-title":"Salmon provides fast and bias-aware quantification of transcript expression","volume":"14","author":"Patro","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2021.109210_bib43","doi-asserted-by":"crossref","first-page":"1242454","DOI":"10.1126\/science.1242454","article-title":"Fueling immunity: Insights into metabolism and lymphocyte function","volume":"342","author":"Pearce","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.109210_bib44","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1038\/s41467-017-01019-z","article-title":"Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras","volume":"8","author":"Peeters","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2021.109210_bib45","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.aaf6284","article-title":"Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism","volume":"354","author":"Peng","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.109210_bib46","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.4049\/jimmunol.1900718","article-title":"Activation receptor-dependent IFN-\u03b3 production by NK cells is controlled by transcription, translation, and the proteasome","volume":"203","author":"Piersma","year":"2019","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109210_bib47","doi-asserted-by":"crossref","first-page":"8826","DOI":"10.1073\/pnas.092258599","article-title":"Recognition of a virus-encoded ligand by a natural killer cell activation receptor","volume":"99","author":"Smith","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109210_bib48","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/iub.393","article-title":"Regulation of mammalian muscle type 6-phosphofructo-1-kinase and its implication for the control of the metabolism","volume":"62","author":"Sola-Penna","year":"2010","journal-title":"IUBMB Life"},{"key":"10.1016\/j.celrep.2021.109210_bib49","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.12688\/f1000research.7563.1","article-title":"Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences","volume":"4","author":"Soneson","year":"2015","journal-title":"F1000Res."},{"key":"10.1016\/j.celrep.2021.109210_bib50","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/nri3044","article-title":"NK cell development, homeostasis and function: Parallels with CD8+ T\u00a0cells","volume":"11","author":"Sun","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2021.109210_bib51","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/nature07665","article-title":"Adaptive immune features of natural killer cells","volume":"457","author":"Sun","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109210_bib52","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1084\/jem.20111760","article-title":"Proinflammatory cytokine signaling required for the generation of natural killer cell memory","volume":"209","author":"Sun","year":"2012","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2021.109210_bib53","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.cels.2018.06.003","article-title":"Four key steps control glycolytic flux in mammalian cells","volume":"7","author":"Tanner","year":"2018","journal-title":"Cell Syst."},{"key":"10.1016\/j.celrep.2021.109210_bib54","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1084\/jem.20072446","article-title":"Continuous engagement of a self-specific activation receptor induces NK cell tolerance","volume":"205","author":"Tripathy","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2021.109210_bib55","doi-asserted-by":"crossref","first-page":"e15447","DOI":"10.1371\/journal.pone.0015447","article-title":"Evolution of allosteric citrate binding sites on 6-phosphofructo-1-kinase","volume":"5","author":"Usenik","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2021.109210_bib56","doi-asserted-by":"crossref","first-page":"C125","DOI":"10.1152\/ajpcell.00247.2006","article-title":"Multiparameter metabolic analysis reveals a close link between attenuated mitochondrial bioenergetic function and enhanced glycolysis dependency in human tumor cells","volume":"292","author":"Wu","year":"2007","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.celrep.2021.109210_bib57","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1126\/science.abb2683","article-title":"Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T\u00a0cell immunity","volume":"371","author":"Xu","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.109210_bib58","doi-asserted-by":"crossref","first-page":"R14","DOI":"10.1186\/gb-2010-11-2-r14","article-title":"Gene ontology analysis for RNA-seq: accounting for selection bias","volume":"11","author":"Young","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2021.109210_bib59","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1158\/1535-7163.MCT-07-0559","article-title":"2-Deoxyglucose induces Akt phosphorylation via a mechanism independent of LKB1\/AMP-activated protein kinase signaling activation or glycolysis inhibition","volume":"7","author":"Zhong","year":"2008","journal-title":"Mol. Cancer Ther."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721005593?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721005593?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:16:46Z","timestamp":1761909406000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124721005593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":60,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,6]]}},"alternative-id":["S2211124721005593"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109210","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109210","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109209","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"109210"}}