{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:05:57Z","timestamp":1792638357744,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T00:00:00Z","timestamp":1626825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005984","name":"Doctor Miriam and Sheldon G Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R35NS111583"],"award-info":[{"award-number":["R35NS111583"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007185","name":"University of California, Los Angeles","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.celrep.2021.109508","type":"journal-article","created":{"date-parts":[[2021,8,10]],"date-time":"2021-08-10T12:04:19Z","timestamp":1628597059000},"page":"109508","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":121,"title":["Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation"],"prefix":"10.1016","volume":"36","author":[{"given":"Blanca","family":"Diaz-Castro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Bernstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Coppola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael V.","family":"Sofroniew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baljit S.","family":"Khakh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2021.109508_bib1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/npp.2016.169","article-title":"Genetic contributions of inflammation to depression","volume":"42","author":"Barnes","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.celrep.2021.109508_bib2","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.neuron.2008.10.013","article-title":"The mystery and magic of glia: A perspective on their roles in health and disease","volume":"60","author":"Barres","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.109508_bib3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nrn.2016.159","article-title":"Functional diversity of astrocytes in neural circuit regulation","volume":"18","author":"Ben Haim","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2021.109508_bib4","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/cei.13334","article-title":"The immune system and psychiatric disease: A basic science perspective","volume":"197","author":"Bennett","year":"2019","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.celrep.2021.109508_bib5","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1038\/s41386-018-0141-6","article-title":"Neuropsychopharmacology of JNJ-55308942: Evaluation of a clinical candidate targeting P2X7 ion channels in animal models of neuroinflammation and anhedonia","volume":"43","author":"Bhattacharya","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.celrep.2021.109508_bib6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.celrep.2017.12.039","article-title":"The aging astrocyte transcriptome from multiple regions of the mouse brain","volume":"22","author":"Boisvert","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.109508_bib7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.neuron.2013.12.034","article-title":"Reactive gliosis and the multicellular response to CNS damage and disease","volume":"81","author":"Burda","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.109508_bib8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1523\/JNEUROSCI.22-01-00183.2002","article-title":"Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains","volume":"22","author":"Bushong","year":"2002","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.109508_bib9","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.neuron.2017.06.029","article-title":"Neural circuit-specialized astrocytes: Transcriptomic, proteomic, morphological, and functional evidence","volume":"95","author":"Chai","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.109508_bib10","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/s41398-020-0839-1","article-title":"Depression\u2014An underrecognized target for prevention of dementia in Alzheimer\u2019s disease","volume":"10","author":"Dafsari","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.celrep.2021.109508_bib11","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: When the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2021.109508_bib12","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1159\/000508773","article-title":"Anhedonia in depressive disorder: A narrative review","volume":"53","author":"De Fruyt","year":"2020","journal-title":"Psychopathology"},{"key":"10.1016\/j.celrep.2021.109508_bib13","doi-asserted-by":"crossref","first-page":"eaaw8546","DOI":"10.1126\/scitranslmed.aaw8546","article-title":"Astrocyte molecular signatures in Huntington\u2019s disease","volume":"11","author":"Diaz-Castro","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2021.109508_bib14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrneurol.2017.96","article-title":"A clinicopathological approach to the diagnosis of dementia","volume":"13","author":"Elahi","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2021.109508_bib15","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.neuron.2014.02.040","article-title":"Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain","volume":"82","author":"Elmore","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.109508_bib16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s00213-009-1605-5","article-title":"Anxiolytic and antidepressant actions of somatostatin: The role of sst2 and sst3 receptors","volume":"206","author":"Engin","year":"2009","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.celrep.2021.109508_bib17","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","article-title":"Reactive astrocyte nomenclature, definitions, and future directions","volume":"24","author":"Escartin","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2021.109508_bib18","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.it.2007.01.005","article-title":"Astrocytes are active players in cerebral innate immunity","volume":"28","author":"Farina","year":"2007","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2021.109508_bib19","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.biopsych.2017.05.024","article-title":"Somatostatin-positive gamma-aminobutyric acid interneuron deficits in depression: Cortical microcircuit and therapeutic perspectives","volume":"82","author":"Fee","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.celrep.2021.109508_bib20","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/bpa.12538","article-title":"Diversity of astroglial responses across human neurodegenerative disorders and brain aging","volume":"27","author":"Ferrer","year":"2017","journal-title":"Brain Pathol."},{"key":"10.1016\/j.celrep.2021.109508_bib21","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.it.2020.07.007","article-title":"The role of astrocytes in CNS inflammation","volume":"41","author":"Giovannoni","year":"2020","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2021.109508_bib22","doi-asserted-by":"crossref","first-page":"107776","DOI":"10.1016\/j.celrep.2020.107776","article-title":"Neurotoxic reactive astrocytes drive neuronal death after retinal injury","volume":"31","author":"Guttenplan","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.109508_bib23","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.biopsych.2019.10.024","article-title":"Circuits, networks, and neuropsychiatric disease: Transitioning from anatomy to imaging","volume":"87","author":"Haber","year":"2020","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.celrep.2021.109508_bib24","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41593-020-0624-8","article-title":"Disease-associated astrocytes in Alzheimer\u2019s disease and aging","volume":"23","author":"Habib","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2021.109508_bib25","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.immuni.2019.03.016","article-title":"Immune signaling in neurodegeneration","volume":"50","author":"Hammond","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.109508_bib26","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1038\/s41593-018-0242-x","article-title":"Microglia in neurodegeneration","volume":"21","author":"Hickman","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2021.109508_bib27","doi-asserted-by":"crossref","first-page":"E302","DOI":"10.1073\/pnas.1716032115","article-title":"Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes","volume":"115","author":"Itoh","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109508_bib28","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1523\/JNEUROSCI.3693-15.2016","article-title":"Dysfunctional calcium and glutamate signaling in striatal astrocytes from Huntington\u2019s disease model mice","volume":"36","author":"Jiang","year":"2016","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.109508_bib29","doi-asserted-by":"crossref","first-page":"101769","DOI":"10.1016\/j.isci.2020.101769","article-title":"scREAD: A single-cell RNA-seq database for Alzheimer\u2019s disease","volume":"23","author":"Jiang","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.celrep.2021.109508_bib30","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1146\/annurev-neuro-070918-050443","article-title":"The emerging nature of astrocyte diversity","volume":"42","author":"Khakh","year":"2019","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2021.109508_bib31","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1038\/nn.4043","article-title":"Diversity of astrocyte functions and phenotypes in neural circuits","volume":"18","author":"Khakh","year":"2015","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2021.109508_bib32","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1136\/jnnp-2017-316201","article-title":"Peripheral inflammatory markers in Alzheimer\u2019s disease: A systematic review and meta-analysis of 175 studies","volume":"88","author":"Lai","year":"2017","journal-title":"J.\u00a0Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.celrep.2021.109508_bib33","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","article-title":"Reactive astrocytes: Production, function, and therapeutic potential","volume":"46","author":"Liddelow","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.109508_bib34","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109508_bib35","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.neuron.2020.08.012","article-title":"Astrocyte crosstalk in CNS Inflammation","volume":"108","author":"Linnerbauer","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.109508_bib36","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","article-title":"Alzheimer disease: An update on pathobiology and treatment strategies","volume":"179","author":"Long","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109508_bib37","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41586-019-1195-2","article-title":"Single-cell transcriptomic analysis of Alzheimer\u2019s disease","volume":"570","author":"Mathys","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109508_bib38","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/s41582-019-0240-y","article-title":"Chronic inflammation in multiple sclerosis\u2014Seeing what was always there","volume":"15","author":"Matthews","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.celrep.2021.109508_bib39","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.neuron.2020.12.008","article-title":"Behaviorally consequential astrocytic regulation of neural circuits","volume":"109","author":"Nagai","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.109508_bib40","doi-asserted-by":"crossref","first-page":"114","DOI":"10.3389\/fnagi.2018.00114","article-title":"Deciphering the astrocyte reaction in Alzheimer\u2019s disease","volume":"10","author":"Perez-Nievas","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.celrep.2021.109508_bib41","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.biopsych.2017.05.014","article-title":"Untangling genetic risk for Alzheimer\u2019s Disease","volume":"83","author":"Pimenova","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.celrep.2021.109508_bib42","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/schbul\/sby038","article-title":"The emerging immunogenetic architecture of schizophrenia","volume":"44","author":"Pouget","year":"2018","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.celrep.2021.109508_bib43","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nrn3722","article-title":"Microglia and brain macrophages in the molecular age: From origin to neuropsychiatric disease","volume":"15","author":"Prinz","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2021.109508_bib44","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nrn3381","article-title":"The brain reward circuitry in mood disorders","volume":"14","author":"Russo","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2021.109508_bib45","doi-asserted-by":"crossref","first-page":"13939","DOI":"10.1073\/pnas.0907143106","article-title":"Cell-type-specific isolation of ribosome-associated mRNA from complex tissues","volume":"106","author":"Sanz","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109508_bib46","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.cell.2018.07.028","article-title":"Molecular diversity and specializations among the cells of the adult mouse brain","volume":"174","author":"Saunders","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109508_bib47","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1093\/ijnp\/pyy083","article-title":"Making sense of rodent models of anhedonia","volume":"21","author":"Scheggi","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.celrep.2021.109508_bib48","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1085\/jgp.201210949","article-title":"Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses","volume":"141","author":"Shigetomi","year":"2013","journal-title":"J.\u00a0Gen. Physiol."},{"key":"10.1016\/j.celrep.2021.109508_bib49","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nrn3898","article-title":"Astrocyte barriers to neurotoxic inflammation","volume":"16","author":"Sofroniew","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2021.109508_bib50","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.it.2020.07.004","article-title":"Astrocyte reactivity: Subtypes, states, and functions in CNS innate immunity","volume":"41","author":"Sofroniew","year":"2020","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2021.109508_bib51","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.biopsych.2015.02.004","article-title":"Long noncoding RNA-directed epigenetic regulation of gene expression is associated with anxiety-like behavior in mice","volume":"78","author":"Spadaro","year":"2015","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.celrep.2021.109508_bib52","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.neuron.2016.11.030","article-title":"New transgenic mouse lines for selectively targeting astrocytes and studying calcium signals in astrocyte processes in\u00a0situ and in\u00a0vivo","volume":"92","author":"Srinivasan","year":"2016","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.109508_bib53","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.neuron.2018.08.001","article-title":"Defective inflammatory pathways in never-treated depressed patients are associated with poor treatment response","volume":"99","author":"Syed","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.109508_bib54","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/ana.24901","article-title":"The gut microbiome in human neurological disease: A review","volume":"81","author":"Tremlett","year":"2017","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.celrep.2021.109508_bib55","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1002\/glia.23143","article-title":"An astroglial basis of major depressive disorder? An overview","volume":"65","author":"Wang","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.celrep.2021.109508_bib56","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/0006-8993(95)01415-2","article-title":"Endotoxin produces a depressive-like episode in rats","volume":"711","author":"Yirmiya","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2021.109508_bib57","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.neuron.2018.08.015","article-title":"Reducing astrocyte calcium signaling in\u00a0vivo alters striatal microcircuits and causes repetitive behavior","volume":"99","author":"Yu","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.109508_bib58","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/s41583-020-0264-8","article-title":"Improved tools to study astrocytes","volume":"21","author":"Yu","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2021.109508_bib59","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.neuron.2020.09.021","article-title":"Context-specific striatal astrocyte molecular responses are phenotypically exploitable","volume":"108","author":"Yu","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.109508_bib60","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1523\/JNEUROSCI.6221-11.2012","article-title":"Genomic analysis of reactive astrogliosis","volume":"32","author":"Zamanian","year":"2012","journal-title":"J.\u00a0Neurosci."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721009384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721009384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:44:12Z","timestamp":1778841852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124721009384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":60,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S2211124721009384"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109508","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular and functional properties of cortical astrocytes during peripherally induced neuroinflammation","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109508","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"109508"}}