{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:14:01Z","timestamp":1789874041168,"version":"4.0.1"},"reference-count":86,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T00:00:00Z","timestamp":1626998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["101001791 AIM.imaging.CKD"],"award-info":[{"award-number":["101001791 AIM.imaging.CKD"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["GH 276\/1-1 Project-ID 457840828"],"award-info":[{"award-number":["GH 276\/1-1 Project-ID 457840828"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"BMBF Bonn","doi-asserted-by":"publisher","award":["031L0045"],"award-info":[{"award-number":["031L0045"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"BMBF Bonn","doi-asserted-by":"publisher","award":["01KU1216"],"award-info":[{"award-number":["01KU1216"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"BMBF Bonn","doi-asserted-by":"publisher","award":["031L0052"],"award-info":[{"award-number":["031L0052"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["AN372\/16-2"],"award-info":[{"award-number":["AN372\/16-2"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB\/TRR219 Project-ID 322900939"],"award-info":[{"award-number":["SFB\/TRR219 Project-ID 322900939"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["24-1"],"award-info":[{"award-number":["24-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["BO3755\/13-1 Project-ID 454024652"],"award-info":[{"award-number":["BO3755\/13-1 Project-ID 454024652"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["STOP-FSGS- 01GM1901A"],"award-info":[{"award-number":["STOP-FSGS- 01GM1901A"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.celrep.2021.109526","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T10:39:15Z","timestamp":1629801555000},"page":"109526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":57,"title":["Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria"],"prefix":"10.1016","volume":"36","author":[{"given":"Kathrin","family":"Gianmoena","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Gasparoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina","family":"Jashari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Gabrys","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Grgas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Ghallab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl","family":"Nordstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Gasparoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Reinders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Edlund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricio","family":"Godoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Schriewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Hayen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian A.","family":"Hudert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Damm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Seehofer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas S.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Boor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Anders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manga","family":"Motrapu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias S.","family":"Schiergens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maren","family":"Falk-Paulsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Rosenstiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clivia","family":"Lisowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Salido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemarie","family":"Marchan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn","family":"Walter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan G.","family":"Hengstler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Cadenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2021.109526_bib1","doi-asserted-by":"crossref","first-page":"9047821","DOI":"10.1155\/2016\/9047821","article-title":"High fat diet-induced skeletal muscle wasting is decreased by mesenchymal stem cells administration: implications on oxidative stress, ubiquitin proteasome pathway activation, and myonuclear apoptosis","volume":"2016","author":"Abrigo","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.celrep.2021.109526_bib2","doi-asserted-by":"crossref","first-page":"R87","DOI":"10.1186\/gb-2012-13-10-r87","article-title":"methylKit: a comprehensive R package for the analysis of genome-wide DNA methylation profiles","volume":"13","author":"Akalin","year":"2012","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2021.109526_bib3","doi-asserted-by":"crossref","first-page":"3068365","DOI":"10.1155\/2018\/3068365","article-title":"Kidney stone disease: an update on current concepts","volume":"2018","author":"Alelign","year":"2018","journal-title":"Adv. Urol."},{"key":"10.1016\/j.celrep.2021.109526_bib4","doi-asserted-by":"crossref","first-page":"e5287","DOI":"10.1136\/bmj.e5287","article-title":"Kidney stones and kidney function loss: a cohort study","volume":"345","author":"Alexander","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.celrep.2021.109526_bib5","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrm3072","article-title":"CREB and the CRTC co-activators: sensors for hormonal and metabolic signals","volume":"12","author":"Altarejos","year":"2011","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2021.109526_bib6","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2021.109526_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.0959-9673.2006.00465.x","article-title":"Mouse models in non-alcoholic fatty liver disease and steatohepatitis research","volume":"87","author":"Anstee","year":"2006","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.celrep.2021.109526_bib8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J.\u00a0R. Stat. Soc. B"},{"key":"10.1016\/j.celrep.2021.109526_bib9","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1073\/pnas.96.3.1129","article-title":"Role of mitochondrial lactate dehydrogenase and lactate oxidation in the intracellular lactate shuttle","volume":"96","author":"Brooks","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109526_bib10","doi-asserted-by":"crossref","first-page":"4150","DOI":"10.1038\/s41467-018-06611-5","article-title":"Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control","volume":"9","author":"Brosch","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2021.109526_bib11","doi-asserted-by":"crossref","first-page":"609","DOI":"10.2478\/10004-1254-64-2013-2428","article-title":"Oxalate: from the environment to kidney stones","volume":"64","author":"Brzica","year":"2013","journal-title":"Arh. Hig. Rada Toksikol."},{"issue":"1, Suppl","key":"10.1016\/j.celrep.2021.109526_bib12","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/j.jhep.2014.12.012","article-title":"NAFLD: a multisystem disease","volume":"62","author":"Byrne","year":"2015","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.celrep.2021.109526_bib13","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/0004563214529937","article-title":"The comparability of oxalate excretion and oxalate:creatinine ratio in the investigation of primary hyperoxaluria: review of data from a referral centre","volume":"52","author":"Clifford-Mobley","year":"2015","journal-title":"Ann. Clin. Biochem."},{"key":"10.1016\/j.celrep.2021.109526_bib14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2021.109526_bib15","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/mt.2016.4","article-title":"Inhibition of glycolate oxidase with Dicer-substrate siRNA reduces calcium oxalate deposition in a mouse model of primary hyperoxaluria type 1","volume":"24","author":"Dutta","year":"2016","journal-title":"Mol. Ther."},{"key":"10.1016\/j.celrep.2021.109526_bib16","doi-asserted-by":"crossref","first-page":"bav050","DOI":"10.1093\/database\/bav050","article-title":"A general concept for consistent documentation of computational analyses","volume":"2015","author":"Ebert","year":"2015","journal-title":"Database (Oxford)"},{"key":"10.1016\/j.celrep.2021.109526_bib17","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4149\/endo_2013_01_27","article-title":"Association of nonalcoholic fatty liver disease (NAFLD) with urolithiasis","volume":"47","author":"Einollahi","year":"2013","journal-title":"Endocr. Regul."},{"key":"10.1016\/j.celrep.2021.109526_bib18","first-page":"2244","article-title":"Diabetic kidney stone formers excrete more oxalate and have lower urine pH than nondiabetic stone formers","volume":"183","author":"Eisner","year":"2010","journal-title":"J.\u00a0Urol."},{"key":"10.1016\/j.celrep.2021.109526_bib19","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1681\/ASN.2017040390","article-title":"Hydroxyproline metabolism and oxalate synthesis in primary hyperoxaluria","volume":"29","author":"Fargue","year":"2018","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2021.109526_bib20","doi-asserted-by":"crossref","first-page":"e61343","DOI":"10.1371\/journal.pone.0061343","article-title":"Effect of adiponectin on kidney crystal formation in metabolic syndrome model mice via inhibition of inflammation and apoptosis","volume":"8","author":"Fujii","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2021.109526_bib21","doi-asserted-by":"crossref","first-page":"8525","DOI":"10.3748\/wjg.v20.i26.8525","article-title":"High fat diet feeding results in gender specific steatohepatitis and inflammasome activation","volume":"20","author":"Ganz","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.celrep.2021.109526_bib22","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1016\/j.jhep.2015.11.018","article-title":"Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases","volume":"64","author":"Ghallab","year":"2016","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.celrep.2021.109526_bib23","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1002\/hep.30213","article-title":"Bile microinfarcts in cholestasis are initiated by rupture of the apical hepatocyte membrane and cause shunting of bile to sinusoidal blood","volume":"69","author":"Ghallab","year":"2019","journal-title":"Hepatology"},{"key":"10.1016\/j.celrep.2021.109526_bib24","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s00204-013-1078-5","article-title":"Recent advances in 2D and 3D in\u00a0vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME","volume":"87","author":"Godoy","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.celrep.2021.109526_bib25","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1007\/s00204-016-1761-4","article-title":"Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue","volume":"90","author":"Godoy","year":"2016","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.celrep.2021.109526_bib26","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1007\/s00204-014-1400-x","article-title":"Toxicogenomics directory of chemically exposed human hepatocytes","volume":"88","author":"Grinberg","year":"2014","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.celrep.2021.109526_bib27","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1002\/jor.24292","article-title":"Regulatory mechanisms and clinical manifestations of musculoskeletal aging","volume":"37","author":"Grote","year":"2019","journal-title":"J.\u00a0Orthop. Res."},{"key":"10.1016\/j.celrep.2021.109526_bib28","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1101\/gr.135350.111","article-title":"GENCODE: the reference human genome annotation for The ENCODE Project","volume":"22","author":"Harrow","year":"2012","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2021.109526_bib29","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/nrneph.2012.113","article-title":"An update on primary hyperoxaluria","volume":"8","author":"Hoppe","year":"2012","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.celrep.2021.109526_bib30","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/liv.14006","article-title":"Genetic determinants of steatosis and fibrosis progression in paediatric non-alcoholic fatty liver disease","volume":"39","author":"Hudert","year":"2019","journal-title":"Liver Int."},{"key":"10.1016\/j.celrep.2021.109526_bib31","doi-asserted-by":"crossref","first-page":"8994","DOI":"10.1038\/ncomms9994","article-title":"Genome-scale study reveals reduced metabolic adaptability in patients with non-alcoholic fatty liver disease","volume":"7","author":"Hy\u00f6tyl\u00e4inen","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2021.109526_bib32","doi-asserted-by":"crossref","first-page":"274","DOI":"10.2183\/pjab.87.274","article-title":"Studies on a unique organelle localization of a liver enzyme, serine:pyruvate (or alanine:glyoxylate) aminotransferase","volume":"87","author":"Ichiyama","year":"2011","journal-title":"Proc. Jpn. Acad., Ser. B, Phys. Biol. Sci."},{"key":"10.1016\/j.celrep.2021.109526_bib33","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1101\/gad.3.5.612","article-title":"CpG methylation of the cAMP-responsive enhancer\/promoter sequence TGACGTCA abolishes specific factor binding as well as transcriptional activation","volume":"3","author":"Iguchi-Ariga","year":"1989","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2021.109526_bib34","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1515\/bchm1.1886.10.5.391","article-title":"Ueber den Niederschlag, welchen Pikrins\u00e4ure in normalem Harn erzeugt und \u00fcber eine neue Reaction des Kreatinins","volume":"10","author":"Jaffe","year":"1886","journal-title":"Biol. Chem."},{"key":"10.1016\/j.celrep.2021.109526_bib35","doi-asserted-by":"crossref","first-page":"G637","DOI":"10.1152\/ajpgi.00331.2011","article-title":"Metabolism of [13C5]hydroxyproline in\u00a0vitro and in\u00a0vivo: implications for primary hyperoxaluria","volume":"302","author":"Jiang","year":"2012","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.celrep.2021.109526_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1615\/CritRevEukaryotGeneExpr.v13.i1.50","article-title":"Mechanisms mediating oxalate-induced alterations in renal cell functions","volume":"13","author":"Jonassen","year":"2003","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.celrep.2021.109526_bib37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10157-004-0292-0","article-title":"Crystal-induced inflammation of the kidneys: results from human studies, animal models, and tissue-culture studies","volume":"8","author":"Khan","year":"2004","journal-title":"Clin. Exp. Nephrol."},{"key":"10.1016\/j.celrep.2021.109526_bib38","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.celrep.2021.109526_bib39","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/ki.2013.207","article-title":"NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy","volume":"84","author":"Knauf","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.celrep.2021.109526_bib40","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1038\/sj.ki.5001906","article-title":"Hydroxyproline ingestion and urinary oxalate and glycolate excretion","volume":"70","author":"Knight","year":"2006","journal-title":"Kidney Int."},{"key":"10.1016\/j.celrep.2021.109526_bib41","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1053\/j.ajkd.2012.12.028","article-title":"Association of metabolic syndrome traits and severity of kidney stones: results from a nationwide survey on urolithiasis in Japan","volume":"61","author":"Kohjimoto","year":"2013","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.celrep.2021.109526_bib42","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1016\/j.ymthe.2018.05.016","article-title":"Specific inhibition of hepatic lactate dehydrogenase reduces oxalate production in mouse models of primary hyperoxaluria","volume":"26","author":"Lai","year":"2018","journal-title":"Mol. Ther."},{"key":"10.1016\/j.celrep.2021.109526_bib43","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1124\/dmd.111.040592","article-title":"Analysis of global and absorption, distribution, metabolism, and elimination gene expression in the progressive stages of human nonalcoholic fatty liver disease","volume":"39","author":"Lake","year":"2011","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.celrep.2021.109526_bib44","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.maturitas.2019.01.006","article-title":"Age-related bone loss and sarcopenia in men","volume":"122","author":"Laurent","year":"2019","journal-title":"Maturitas"},{"key":"10.1016\/j.celrep.2021.109526_bib45","first-page":"50615","article-title":"Isolation of human hepatocytes by a two-step collagenase perfusion procedure","author":"Lee","year":"2013","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.celrep.2021.109526_bib46","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.celrep.2021.109526_bib47","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1023\/B:SCAM.0000007142.36524.58","article-title":"The mouse alanine:glyoxylate aminotransferase gene (Agxt1): cloning, expression, and mapping to chromosome 1","volume":"25","author":"Li","year":"1999","journal-title":"Somat. Cell Mol. Genet."},{"key":"10.1016\/j.celrep.2021.109526_bib48","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbadis.2015.12.001","article-title":"Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase","volume":"1862","author":"Li","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2021.109526_bib49","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1100\/tsw.2007.117","article-title":"The physiology of obese-hyperglycemic mice [ob\/ob mice]","volume":"7","author":"Lindstr\u00f6m","year":"2007","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.celrep.2021.109526_bib50","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/978-90-481-3271-3_20","article-title":"beta-cell function in obese-hyperglycemic mice [ob\/ob Mice]","volume":"654","author":"Lindstr\u00f6m","year":"2010","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.celrep.2021.109526_bib51","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.celrep.2021.109526_bib52","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2021.109526_bib53","doi-asserted-by":"crossref","first-page":"e1004441","DOI":"10.1371\/journal.ppat.1004441","article-title":"Human cytomegalovirus drives epigenetic imprinting of the IFNG locus in NKG2Chi natural killer cells","volume":"10","author":"Luetke-Eversloh","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2021.109526_bib54","doi-asserted-by":"crossref","first-page":"W551","DOI":"10.1093\/nar\/gkr312","article-title":"BiQ Analyzer HT: locus-specific analysis of DNA methylation by high-throughput bisulfite sequencing","volume":"39","author":"Lutsik","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2021.109526_bib55","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.metabol.2017.11.003","article-title":"Nonalcoholic fatty liver disease increases risk of incident chronic kidney disease: a systematic review and meta-analysis","volume":"79","author":"Mantovani","year":"2018","journal-title":"Metabolism"},{"key":"10.1016\/j.celrep.2021.109526_bib56","doi-asserted-by":"crossref","first-page":"10","DOI":"10.14806\/ej.17.1.200","article-title":"Cutadapt removes adapter sequences from high-throughput sequencing reads","volume":"17","author":"Martin","year":"2011","journal-title":"EMBnet.journal"},{"key":"10.1016\/j.celrep.2021.109526_bib57","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1021\/ac60113a039","article-title":"Colorimetric determination of hydroxyproline","volume":"28","author":"Miyada","year":"1956","journal-title":"Anal. Chem."},{"key":"10.1016\/j.celrep.2021.109526_bib58","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1002\/hep.26661","article-title":"Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease","volume":"59","author":"Moylan","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.celrep.2021.109526_bib59","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nrneph.2017.10","article-title":"Crystal nephropathies: mechanisms of crystal-induced kidney injury","volume":"13","author":"Mulay","year":"2017","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.celrep.2021.109526_bib60","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1172\/JCI63679","article-title":"Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1\u03b2 secretion","volume":"123","author":"Mulay","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2021.109526_bib61","doi-asserted-by":"crossref","first-page":"e1001680","DOI":"10.1371\/journal.pmed.1001680","article-title":"Association of non-alcoholic fatty liver disease with chronic kidney disease: a systematic review and meta-analysis","volume":"11","author":"Musso","year":"2014","journal-title":"PLoS Med."},{"key":"10.1016\/j.celrep.2021.109526_bib62","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ejro.2016.07.004","article-title":"Association of non-alcoholic fatty liver disease with renal stone disease detected on computed tomography","volume":"3","author":"Nam","year":"2016","journal-title":"Eur. J. Radiol. Open"},{"key":"10.1016\/j.celrep.2021.109526_bib63","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s00240-008-0161-5","article-title":"Role of overweight and obesity on the urinary excretion of promoters and inhibitors of stone formation in stone formers","volume":"36","author":"Negri","year":"2008","journal-title":"Urol. Res."},{"key":"10.1016\/j.celrep.2021.109526_bib64","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.3748\/wjg.v23.i10.1747","article-title":"Non-alcoholic fatty liver disease connections with fat-free tissues: a focus on bone and skeletal muscle","volume":"23","author":"Poggiogalle","year":"2017","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.celrep.2021.109526_bib65","doi-asserted-by":"crossref","first-page":"e12092","DOI":"10.1097\/MD.0000000000012092","article-title":"Non-alcoholic fatty liver disease and the risk of urolithiasis: a systematic review and meta-analysis","volume":"97","author":"Qin","year":"2018","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.celrep.2021.109526_bib66","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"issue":"W1","key":"10.1016\/j.celrep.2021.109526_bib67","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2021.109526_bib68","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2021.109526_bib69","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2021.109526_bib70","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.2215\/CJN.10651110","article-title":"Chronic kidney disease in kidney stone formers","volume":"6","author":"Rule","year":"2011","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2021.109526_bib71","doi-asserted-by":"crossref","first-page":"18249","DOI":"10.1073\/pnas.0607218103","article-title":"Alanine-glyoxylate aminotransferase-deficient mice, a model for primary hyperoxaluria that responds to adenoviral gene transfer","volume":"103","author":"Salido","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109526_bib72","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.atherosclerosis.2019.01.029","article-title":"Does nonalcoholic fatty liver disease cause cardiovascular disease? Current knowledge and gaps","volume":"282","author":"Santos","year":"2019","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.celrep.2021.109526_bib73","doi-asserted-by":"crossref","first-page":"6224","DOI":"10.1038\/s41598-017-04574-z","article-title":"Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage","volume":"7","author":"Schenk","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2021.109526_bib74","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1093\/nar\/gkw1061","article-title":"Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction","volume":"45","author":"Schmidt","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2021.109526_bib75","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.jchromb.2017.10.032","article-title":"Oxalic acid quantification in mouse urine and primary mouse hepatocyte cell culture samples by ion exclusion chromatography-mass spectrometry","volume":"1068-1069","author":"Schriewer","year":"2017","journal-title":"J.\u00a0Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.celrep.2021.109526_bib76","doi-asserted-by":"crossref","first-page":"3442","DOI":"10.1093\/nar\/28.18.3442","article-title":"STRING: a web-server to retrieve and display the repeatedly occurring neighbourhood of a gene","volume":"28","author":"Snel","year":"2000","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2021.109526_bib77","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1097\/01.ASN.0000059310.67812.4F","article-title":"Control of oxalate formation from L-hydroxyproline in liver mitochondria","volume":"14","author":"Takayama","year":"2003","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2021.109526_bib78","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jhep.2016.05.013","article-title":"Non-alcoholic fatty liver disease and risk of incident cardiovascular disease: a meta-analysis","volume":"65","author":"Targher","year":"2016","journal-title":"J.\u00a0Hepatol."},{"key":"10.1016\/j.celrep.2021.109526_bib79","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1023\/A:1026392429112","article-title":"Charitable state-controlled foundation human tissue and cell research: ethic and legal aspects in the supply of surgically removed human tissue for research in the academic and commercial sector in Germany","volume":"4","author":"Thasler","year":"2003","journal-title":"Cell Tissue Bank."},{"key":"10.1016\/j.celrep.2021.109526_bib80","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1111\/j.1478-3231.2011.02597.x","article-title":"Clinicopathological and prognostic significance of serum and tissue Dickkopf-1 levels in human hepatocellular carcinoma","volume":"31","author":"Tung","year":"2011","journal-title":"Liver Int."},{"key":"10.1016\/j.celrep.2021.109526_bib81","doi-asserted-by":"crossref","first-page":"39082","DOI":"10.1074\/jbc.M201380200","article-title":"The role of Sp1 and AP-2 in basal and protein kinase A--induced expression of mitochondrial serine:pyruvate aminotransferase in hepatocytes","volume":"277","author":"Uchida","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.109526_bib82","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1093\/nar\/gkt111","article-title":"Enriching the gene set analysis of genome-wide data by incorporating directionality of gene expression and combining statistical hypotheses and methods","volume":"41","author":"V\u00e4remo","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2021.109526_bib83","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1001\/jamainternmed.2018.7980","article-title":"Association of urinary oxalate excretion with the risk of chronic kidney disease progression","volume":"179","author":"Waikar","year":"2019","journal-title":"JAMA Intern. Med."},{"key":"10.1016\/j.celrep.2021.109526_bib84","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3390\/ijms17030367","article-title":"Bidirectional relationships and disconnects between NAFLD and features of the metabolic syndrome","volume":"17","author":"Wainwright","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2021.109526_bib85","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1210\/er.2019-00034","article-title":"The liver as an endocrine organ-linking NAFLD and insulin resistance","volume":"40","author":"Watt","year":"2019","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.celrep.2021.109526_bib86","doi-asserted-by":"crossref","first-page":"33386","DOI":"10.1038\/srep33386","article-title":"Association of non-alcoholic fatty liver disease with major adverse cardiovascular events: a systematic review and meta-analysis","volume":"6","author":"Wu","year":"2016","journal-title":"Sci. Rep."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721009578?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721009578?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:43:54Z","timestamp":1778841834000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124721009578"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":86,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S2211124721009578"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109526","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109526","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"109526"}}