{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T14:46:27Z","timestamp":1792853187576,"version":"4.5.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,4]],"date-time":"2021-08-04T00:00:00Z","timestamp":1628035200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB29010000"],"award-info":[{"award-number":["XDB29010000"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004206","name":"Osaka University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004739","name":"Youth Innovation Promotion Association of the Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["2017117"],"award-info":[{"award-number":["2017117"]}],"id":[{"id":"10.13039\/501100004739","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","award":["2018ZX10733403"],"award-info":[{"award-number":["2018ZX10733403"]}],"id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014974","name":"Institute of Biophysics, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014974","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.celrep.2021.109600","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T10:47:54Z","timestamp":1629802074000},"page":"109600","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Structural basis of malarial parasite RIFIN-mediated immune escape against LAIR1"],"prefix":"10.1016","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7654-6662","authenticated-orcid":false,"given":"Yijia","family":"Xie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3824-1243","authenticated-orcid":false,"given":"Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxun","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George F.","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2021.109600_bib1","doi-asserted-by":"crossref","first-page":"7013","DOI":"10.1128\/IAI.70.12.7013-7021.2002","article-title":"Recognition of variant Rifin antigens by human antibodies induced during natural Plasmodium falciparum infections","volume":"70","author":"Abdel-Latif","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2021.109600_bib2","doi-asserted-by":"crossref","first-page":"6229","DOI":"10.1128\/IAI.71.11.6229-6233.2003","article-title":"Antibodies to Plasmodium falciparum rifin proteins are associated with rapid parasite clearance and asymptomatic infections","volume":"71","author":"Abdel-Latif","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2021.109600_bib3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1107\/S0907444909052925","article-title":"PHENIX: A comprehensive Python-based system for macromolecular structure solution","volume":"66","author":"Adams","year":"2010","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.celrep.2021.109600_bib4","doi-asserted-by":"crossref","first-page":"e36806","DOI":"10.7554\/eLife.36806","article-title":"NK cells inhibit Plasmodium falciparum growth in red blood cells via antibody-dependent cellular cytotoxicity","volume":"7","author":"Arora","year":"2018","journal-title":"eLife"},{"issue":"W1","key":"10.1016\/j.celrep.2021.109600_bib5","doi-asserted-by":"crossref","first-page":"W344","DOI":"10.1093\/nar\/gkw408","article-title":"ConSurf 2016: An improved methodology to estimate and visualize evolutionary conservation in macromolecules","volume":"44","author":"Ashkenazy","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2021.109600_bib6","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1186\/s12936-015-0784-2","article-title":"A comparative study of the localization and membrane topology of members of the RIFIN, STEVOR and PfMC-2TM protein families in Plasmodium falciparum-infected erythrocytes","volume":"14","author":"Bachmann","year":"2015","journal-title":"Malar. J."},{"key":"10.1016\/j.celrep.2021.109600_bib7","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1111\/j.1600-065X.2008.00653.x","article-title":"The extended human leukocyte receptor complex: Diverse ways of modulating immune responses","volume":"224","author":"Barrow","year":"2008","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2021.109600_bib8","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1146\/annurev-micro-092412-155730","article-title":"Plasmodium nesting: Remaking the erythrocyte from the inside out","volume":"67","author":"Boddey","year":"2013","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2021.109600_bib9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S1359-6101(00)00007-1","article-title":"LIRs\/ILTs\/MIRs, inhibitory and stimulatory Ig-superfamily receptors expressed in myeloid and lymphoid cells","volume":"11","author":"Borges","year":"2000","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.celrep.2021.109600_bib10","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1182\/blood-2009-10-246322","article-title":"Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: Unexpected implications for collagen binding by platelet receptor GPVI","volume":"115","author":"Brondijk","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2021.109600_bib11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0166-6851(98)00144-3","article-title":"stevor and rif are Plasmodium falciparum multicopy gene families which potentially encode variant antigens","volume":"97","author":"Cheng","year":"1998","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.celrep.2021.109600_bib12","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1146\/annurev-immunol-032713-120220","article-title":"Malaria immunity in man and mosquito: Insights into unsolved mysteries of a deadly infectious disease","volume":"32","author":"Crompton","year":"2014","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2021.109600_bib13","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1107\/S0907444904019158","article-title":"Coot: Model-building tools for molecular graphics","volume":"60","author":"Emsley","year":"2004","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.celrep.2021.109600_bib14","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1038\/nm.3812","article-title":"RIFINs are adhesins implicated in severe Plasmodium falciparum malaria","volume":"21","author":"Goel","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2021.109600_bib15","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.3389\/fmicb.2016.01617","article-title":"Immune escape strategies of malaria parasites","volume":"7","author":"Gomes","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.celrep.2021.109600_bib16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41586-020-2530-3","article-title":"Structural basis for RIFIN-mediated activation of LILRB1 in malaria","volume":"587","author":"Harrison","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109600_bib17","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0166-6851(88)90040-0","article-title":"Two approximately 300 kilodalton Plasmodium falciparum proteins at the surface membrane of infected erythrocytes","volume":"27","author":"Howard","year":"1988","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.celrep.2021.109600_bib18","doi-asserted-by":"crossref","first-page":"e27311","DOI":"10.7554\/eLife.27311","article-title":"The structure of a LAIR1-containing human antibody reveals a novel mechanism of antigen recognition","volume":"6","author":"Hsieh","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2021.109600_bib19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1471-2164-9-19","article-title":"Sub-grouping and sub-functionalization of the RIFIN multi-copy protein family","volume":"9","author":"Joannin","year":"2008","journal-title":"BMC Genomics"},{"key":"10.1016\/j.celrep.2021.109600_bib20","doi-asserted-by":"crossref","first-page":"9333","DOI":"10.1073\/pnas.96.16.9333","article-title":"Rifins: A second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum","volume":"96","author":"Kyes","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109600_bib21","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1146\/annurev.micro.55.1.673","article-title":"Antigenic variation at the infected red cell surface in malaria","volume":"55","author":"Kyes","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2021.109600_bib22","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1084\/jem.20052554","article-title":"Collagens are functional, high affinity ligands for the inhibitory immune receptor LAIR-1","volume":"203","author":"Lebbink","year":"2006","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2021.109600_bib23","doi-asserted-by":"crossref","first-page":"195","DOI":"10.4049\/jimmunol.174.1.195","article-title":"Generation of murine CTL by a hepatitis B virus-specific peptide and evaluation of the adjuvant effect of heat shock protein glycoprotein 96 and its terminal fragments","volume":"174","author":"Li","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109600_bib24","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1002\/eji.201343417","article-title":"Conserved epitopes dominate cross-CD8+ T-cell responses against influenza A H1N1 virus among Asian populations","volume":"43","author":"Liu","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2021.109600_bib25","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S1074-7613(00)80530-0","article-title":"LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes","volume":"7","author":"Meyaard","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.109600_bib26","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.cmi.2015.03.017","article-title":"Human infections with Plasmodium knowlesi\u2014Zoonotic malaria","volume":"21","author":"Millar","year":"2015","journal-title":"Clin. Microbiol. Infect."},{"key":"10.1016\/j.celrep.2021.109600_bib27","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/415673a","article-title":"The pathogenic basis of malaria","volume":"415","author":"Miller","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109600_bib28","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.celrep.2021.109600_bib29","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nature23670","article-title":"Public antibodies to malaria antigens generated by two LAIR1 insertion modalities","volume":"548","author":"Pieper","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109600_bib30","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1107\/S0907444901012471","article-title":"Pushing the boundaries of molecular replacement with maximum likelihood","volume":"57","author":"Read","year":"2001","journal-title":"Acta Crystallogr. D Biol. Crystallogr."},{"key":"10.1016\/j.celrep.2021.109600_bib31","doi-asserted-by":"crossref","first-page":"463","DOI":"10.3389\/fimmu.2016.00463","article-title":"Malaria parasites: The great escape","volume":"7","author":"R\u00e9nia","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2021.109600_bib32","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nature24994","article-title":"Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors","volume":"552","author":"Saito","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109600_bib33","doi-asserted-by":"crossref","first-page":"10439","DOI":"10.1074\/jbc.M512305200","article-title":"Efficient leukocyte Ig-like receptor signaling and crystal structure of disulfide-linked HLA-G dimer","volume":"281","author":"Shiroishi","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.109600_bib34","doi-asserted-by":"crossref","first-page":"e12715","DOI":"10.1111\/cmi.12715","article-title":"Expression dynamics and physiologically relevant functional study of STEVOR in asexual stages of Plasmodium falciparum infection","volume":"19","author":"Singh","year":"2017","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.celrep.2021.109600_bib35","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/nsmb.3213","article-title":"Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses","volume":"23","author":"Song","year":"2016","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2021.109600_bib36","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature16450","article-title":"A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens","volume":"529","author":"Tan","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109600_bib37","first-page":"461","article-title":"Progress in the synthesis of sialic acid derivatives","volume":"34","author":"Wang","year":"2014","journal-title":"Youji Huaxue"},{"key":"10.1016\/j.celrep.2021.109600_bib38","doi-asserted-by":"crossref","first-page":"369ra179","DOI":"10.1126\/scitranslmed.aai8336","article-title":"Molecular determinants of human neutralizing antibodies isolated from a patient infected with Zika virus","volume":"8","author":"Wang","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2021.109600_bib39","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1038\/s41423-019-0258-5","article-title":"Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex","volume":"17","author":"Wang","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.celrep.2021.109600_bib40","series-title":"World malaria report 2019","year":"2019"},{"key":"10.1016\/j.celrep.2021.109600_bib41","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/pro.3330","article-title":"MolProbity: More and better reference data for improved all-atom structure validation","volume":"27","author":"Williams","year":"2018","journal-title":"Protein Sci."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472101038X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472101038X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:29:45Z","timestamp":1761910185000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221112472101038X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":41,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S221112472101038X"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109600","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Structural basis of malarial parasite RIFIN-mediated immune escape against LAIR1","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109600","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"109600"}}