{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:16:10Z","timestamp":1790766970235,"version":"4.1.0"},"reference-count":85,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T00:00:00Z","timestamp":1628208000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000088","name":"Directorate for Social, Behavioral and Economic Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0B5219N"],"award-info":[{"award-number":["G0B5219N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["G0C8519N"],"award-info":[{"award-number":["G0C8519N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"European Research Council","doi-asserted-by":"publisher","award":["282131"],"award-info":[{"award-number":["282131"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["C14\/18\/105"],"award-info":[{"award-number":["C14\/18\/105"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["OT\/14\/121"],"award-info":[{"award-number":["OT\/14\/121"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004040","name":"KU Leuven","doi-asserted-by":"publisher","award":["PF\/10\/019"],"award-info":[{"award-number":["PF\/10\/019"]}],"id":[{"id":"10.13039\/501100004040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"H2020 Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["721432"],"award-info":[{"award-number":["721432"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011851","name":"Kom op tegen kanker","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011851","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016882","name":"European Resuscitation Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016882","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.celrep.2021.109618","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T10:51:20Z","timestamp":1629802280000},"page":"109618","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Fetal hematopoietic stem cell homing is controlled by VEGF regulating the integrity and oxidative status of the stromal-vascular bone marrow niches"],"prefix":"10.1016","volume":"36","author":[{"given":"Marion","family":"Mesnieres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Marei","family":"B\u00f6hm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Peredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Trompet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Valle-Tenney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manmohan","family":"Bajaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikky","family":"Corthout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Nefyodova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruben","family":"Cardoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Baatsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Munck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andras","family":"Nagy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jody J.","family":"Haigh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Khurana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine M.","family":"Verfaillie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christa","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2021.109618_bib1","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S1074-7613(03)00201-2","article-title":"Long-term hematopoietic stem cells require stromal cell-derived factor-1 for colonizing bone marrow during ontogeny","volume":"19","author":"Ara","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.109618_bib2","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.canlet.2011.12.012","article-title":"Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury","volume":"327","author":"Azzam","year":"2012","journal-title":"Cancer Lett."},{"key":"10.1016\/j.celrep.2021.109618_bib3","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41556-019-0444-9","article-title":"Dynamic responses of the haematopoietic stem cell niche to diverse stresses","volume":"22","author":"Batsivari","year":"2020","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2021.109618_bib4","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.devcel.2019.08.013","article-title":"Activation of Skeletal Stem and Progenitor Cells for Bone Regeneration Is Driven by PDGFR\u03b2 Signaling","volume":"51","author":"B\u00f6hm","year":"2019","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib5","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1002\/jbmr.3728","article-title":"Parathyroid Hormone Remodels Bone Transitional Vessels and the Leptin Receptor-Positive Pericyte Network in Mice","volume":"34","author":"Caire","year":"2019","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.celrep.2021.109618_bib6","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1038\/nature02040","article-title":"Osteoblastic cells regulate the haematopoietic stem cell niche","volume":"425","author":"Calvi","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109618_bib7","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1038\/nature07547","article-title":"Endochondral ossification is required for haematopoietic stem-cell niche formation","volume":"457","author":"Chan","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109618_bib8","doi-asserted-by":"crossref","first-page":"5043483","DOI":"10.1155\/2016\/5043483","article-title":"Role of Microvessel Density and Vascular Endothelial Growth Factor in Angiogenesis of Hematological Malignancies","volume":"2016","author":"Chand","year":"2016","journal-title":"Bone Marrow Res."},{"key":"10.1016\/j.celrep.2021.109618_bib9","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1038\/ncb3385","article-title":"Metabolic regulation of stem cell function in tissue homeostasis and organismal ageing","volume":"18","author":"Chandel","year":"2016","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2021.109618_bib10","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.stem.2019.10.006","article-title":"Apelin+ Endothelial Niche Cells Control Hematopoiesis and Mediate Vascular Regeneration after Myeloablative Injury","volume":"25","author":"Chen","year":"2019","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib11","doi-asserted-by":"crossref","first-page":"E75","DOI":"10.1371\/journal.pbio.0020075","article-title":"Circulation and chemotaxis of fetal hematopoietic stem cells","volume":"2","author":"Christensen","year":"2004","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2021.109618_bib12","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.exphem.2013.01.009","article-title":"The migration of hematopoietic progenitors from the fetal liver to the fetal bone marrow: lessons learned and possible clinical applications","volume":"41","author":"Ciriza","year":"2013","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.celrep.2021.109618_bib13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ydbio.2004.01.011","article-title":"Distinguishing the contributions of the perichondrium, cartilage, and vascular endothelium to skeletal development","volume":"269","author":"Colnot","year":"2004","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2021.109618_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/bdrc.20194","article-title":"Establishment and regulation of the HSC niche: Roles of osteoblastic and vascular compartments","volume":"90","author":"Coskun","year":"2010","journal-title":"Birth Defects Res. C Embryo Today"},{"key":"10.1016\/j.celrep.2021.109618_bib15","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.celrep.2014.09.013","article-title":"Development of the fetal bone marrow niche and regulation of HSC quiescence and homing ability by emerging osteolineage cells","volume":"9","author":"Co\u015fkun","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.109618_bib16","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nri.2017.53","article-title":"Adult haematopoietic stem cell niches","volume":"17","author":"Crane","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2021.109618_bib17","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cell.2013.06.037","article-title":"Role of PFKFB3-driven glycolysis in vessel sprouting","volume":"154","author":"De Bock","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib18","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1006\/bbrc.1999.0163","article-title":"Excessive extramedullary hematopoiesis in Cbfa1-deficient mice with a congenital lack of bone marrow","volume":"255","author":"Deguchi","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2021.109618_bib19","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1002\/jbmr.3190","article-title":"Integrin-linked kinase regulates bone formation by controlling cytoskeletal organization and modulating BMP and Wnt signaling in osteoprogenitors","volume":"32","author":"Dejaeger","year":"2017","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.celrep.2021.109618_bib20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nature11885","article-title":"Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches","volume":"495","author":"Ding","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109618_bib21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nature10783","article-title":"Endothelial and perivascular cells maintain haematopoietic stem cells","volume":"481","author":"Ding","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109618_bib22","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1172\/JCI97794","article-title":"Vhl deletion in osteoblasts boosts cellular glycolysis and improves global glucose metabolism","volume":"128","author":"Dirckx","year":"2018","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2021.109618_bib23","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1242\/dev.117952","article-title":"Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone development","volume":"142","author":"Duan","year":"2015","journal-title":"Development"},{"key":"10.1016\/j.celrep.2021.109618_bib24","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.stem.2017.11.006","article-title":"Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML","volume":"22","author":"Duarte","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib25","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.stem.2018.04.015","article-title":"Blood Development: Hematopoietic Stem Cell Dependence and Independence","volume":"22","author":"Dzierzak","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1152\/physrev.00001.2017","article-title":"Endothelial Cell Metabolism","volume":"98","author":"Eelen","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.celrep.2021.109618_bib27","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nature11926","article-title":"CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance","volume":"495","author":"Greenbaum","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109618_bib28","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.stem.2009.01.006","article-title":"Engraftment and reconstitution of hematopoiesis is dependent on VEGFR2-mediated regeneration of sinusoidal endothelial cells","volume":"4","author":"Hooper","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib29","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1182\/blood-2014-03-559369","article-title":"Antioxidant N-acetyl-L-cysteine increases engraftment of human hematopoietic stem cells in immune-deficient mice","volume":"124","author":"Hu","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2021.109618_bib30","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature17624","article-title":"Distinct bone marrow blood vessels differentially regulate haematopoiesis","volume":"532","author":"Itkin","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109618_bib31","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1007\/s00018-012-1085-3","article-title":"Vascular endothelial growth factor signaling in acute myeloid leukemia","volume":"70","author":"Kampen","year":"2013","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.celrep.2021.109618_bib32","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.cell.2005.05.026","article-title":"SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells","volume":"121","author":"Kiel","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib33","doi-asserted-by":"crossref","first-page":"28.6.1","DOI":"10.1002\/0471142727.mb2806s111","article-title":"Assaying Cell Cycle Status Using Flow Cytometry","volume":"111","author":"Kim","year":"2015","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"10.1016\/j.celrep.2021.109618_bib34","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1182\/blood-2005-10-4135","article-title":"Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors","volume":"108","author":"Kim","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2021.109618_bib35","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0092-8674(00)80258-5","article-title":"Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts","volume":"89","author":"Komori","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib36","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/nature12612","article-title":"Arteriolar niches maintain haematopoietic stem cell quiescence","volume":"502","author":"Kunisaki","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109618_bib37","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nature13145","article-title":"Coupling of angiogenesis and osteogenesis by a specific vessel subtype in bone","volume":"507","author":"Kusumbe","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109618_bib38","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/nature17638","article-title":"Age-dependent modulation of vascular niches for haematopoietic stem cells","volume":"532","author":"Kusumbe","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109618_bib39","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1210\/er.2017-00064","article-title":"Energy Metabolism of the Osteoblast: Implications for Osteoporosis","volume":"38","author":"Lee","year":"2017","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.celrep.2021.109618_bib40","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.exphem.2008.06.009","article-title":"Bone marrow sinusoidal endothelial cells undergo nonapoptotic cell death and are replaced by proliferating sinusoidal cells in\u00a0situ to maintain the vascular niche following lethal irradiation","volume":"36","author":"Li","year":"2008","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.celrep.2021.109618_bib41","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00223-012-9689-z","article-title":"Role and regulation of vascularization processes in endochondral bones","volume":"92","author":"Maes","year":"2013","journal-title":"Calcif. Tissue Int."},{"key":"10.1016\/j.celrep.2021.109618_bib42","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0925-4773(01)00601-3","article-title":"Impaired angiogenesis and endochondral bone formation in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188","volume":"111","author":"Maes","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1016\/j.celrep.2021.109618_bib43","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/emboj.2009.361","article-title":"Increased skeletal VEGF enhances beta-catenin activity and results in excessively ossified bones","volume":"29","author":"Maes","year":"2010","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2021.109618_bib44","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.devcel.2010.07.010","article-title":"Osteoblast precursors, but not mature osteoblasts, move into developing and fractured bones along with invading blood vessels","volume":"19","author":"Maes","year":"2010","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib45","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nrrheum.2012.36","article-title":"Hypoxia-driven pathways in bone development, regeneration and disease","volume":"8","author":"Maes","year":"2012","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.celrep.2021.109618_bib46","first-page":"729725","article-title":"Vascular endothelial growth factor-related pathways in hemato-lymphoid malignancies","volume":"2010","author":"Medinger","year":"2010","journal-title":"J.\u00a0Oncol."},{"key":"10.1016\/j.celrep.2021.109618_bib47","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/nm.3647","article-title":"Hematopoietic stem cell niche maintenance during homeostasis and regeneration","volume":"20","author":"Mendelson","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2021.109618_bib48","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1242\/dev.02568","article-title":"The journey of developing hematopoietic stem cells","volume":"133","author":"Mikkola","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.celrep.2021.109618_bib49","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.devcel.2014.03.013","article-title":"Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development","volume":"29","author":"Mizoguchi","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib50","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng1180","article-title":"PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes","volume":"34","author":"Mootha","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2021.109618_bib51","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1084\/jem.20091046","article-title":"Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow","volume":"206","author":"Morikawa","year":"2009","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2021.109618_bib52","doi-asserted-by":"crossref","first-page":"10302","DOI":"10.1073\/pnas.92.22.10302","article-title":"The purification and characterization of fetal liver hematopoietic stem cells","volume":"92","author":"Morrison","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109618_bib53","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/382635a0","article-title":"Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF\/SDF-1","volume":"382","author":"Nagasawa","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109618_bib54","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.devcel.2020.06.029","article-title":"Hematopoietic Stem Cell Metabolism during Development and Aging","volume":"54","author":"Nakamura-Ishizu","year":"2020","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib55","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0092-8674(01)00622-5","article-title":"The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formation","volume":"108","author":"Nakashima","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib56","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/ncb2730","article-title":"Quantitative imaging of haematopoietic stem and progenitor cell localization and hypoxic status in the bone marrow microenvironment","volume":"15","author":"Nombela-Arrieta","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2021.109618_bib57","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1080\/10245330701554664","article-title":"Serum levels, and bone marrow immunohistochemical expression of, vascular endothelial growth factor in patients with chronic myeloproliferative diseases","volume":"12","author":"Panteli","year":"2007","journal-title":"Hematology"},{"key":"10.1016\/j.celrep.2021.109618_bib58","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ccell.2017.08.001","article-title":"Increased Vascular Permeability in the Bone Marrow Microenvironment Contributes to Disease Progression and Drug Response in Acute Myeloid Leukemia","volume":"32","author":"Passaro","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib59","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1038\/s41580-019-0103-9","article-title":"Haematopoietic stem cell activity and interactions with the niche","volume":"20","author":"Pinho","year":"2019","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2021.109618_bib60","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1146\/annurev-physiol-021115-105134","article-title":"The Link Between Angiogenesis and Endothelial Metabolism","volume":"79","author":"Potente","year":"2017","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.celrep.2021.109618_bib61","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1074-7613(00)80216-2","article-title":"Fetal and adult hematopoietic stem cells require beta1 integrin function for colonizing fetal liver, spleen, and bone marrow","volume":"12","author":"Potocnik","year":"2000","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.109618_bib62","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.exphem.2014.08.003","article-title":"Activation of the vascular niche supports leukemic progression and resistance to chemotherapy","volume":"42","author":"Poulos","year":"2014","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.celrep.2021.109618_bib63","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.stem.2007.07.005","article-title":"Elucidation of the phenotypic, functional, and molecular topography of a myeloerythroid progenitor cell hierarchy","volume":"1","author":"Pronk","year":"2007","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib64","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev-cellbio-111315-124936","article-title":"Regulation of Hematopoiesis and Osteogenesis by Blood Vessel-Derived Signals","volume":"32","author":"Ramasamy","year":"2016","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2021.109618_bib65","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1083\/jcb.17.1.208","article-title":"The use of lead citrate at high pH as an electron-opaque stain in electron microscopy","volume":"17","author":"Reynolds","year":"1963","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2021.109618_bib66","doi-asserted-by":"crossref","first-page":"3231","DOI":"10.1242\/dev.02480","article-title":"Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors","volume":"133","author":"Rodda","year":"2006","journal-title":"Development"},{"key":"10.1016\/j.celrep.2021.109618_bib67","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2021.109618_bib68","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1359\/jbmr.090602","article-title":"Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF","volume":"24","author":"Schipani","year":"2009","journal-title":"J.\u00a0Bone Miner. Res."},{"key":"10.1016\/j.celrep.2021.109618_bib69","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1182\/blood-2004-01-0272","article-title":"G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow","volume":"106","author":"Semerad","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2021.109618_bib70","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-59745-182-6_5","article-title":"Flow cytometry-based cell cycle measurement of mouse hematopoietic stem and progenitor cells","volume":"430","author":"Shen","year":"2008","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2021.109618_bib71","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.stem.2016.07.004","article-title":"Proximity-Based Differential Single-Cell Analysis of the Niche to Identify Stem\/Progenitor Cell Regulators","volume":"19","author":"Silberstein","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib72","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/s13643-020-01368-9","article-title":"Increased circulating vascular endothelial growth factor in acute myeloid leukemia patients: a systematic review and meta-analysis","volume":"9","author":"Song","year":"2020","journal-title":"Syst. Rev."},{"key":"10.1016\/j.celrep.2021.109618_bib73","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1182\/blood-2013-07-516336","article-title":"Pharmacologic increase in HIF1\u03b1 enhances hematopoietic stem and progenitor homing and engraftment","volume":"123","author":"Speth","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2021.109618_bib74","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.humpath.2006.12.011","article-title":"Increased angiogenesis in chronic idiopathic myelofibrosis: vascular endothelial growth factor as a prominent angiogenic factor","volume":"38","author":"Steurer","year":"2007","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.celrep.2021.109618_bib75","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1084\/jem.20041992","article-title":"Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size","volume":"201","author":"Stier","year":"2005","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2021.109618_bib76","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109618_bib77","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.immuni.2006.10.016","article-title":"Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches","volume":"25","author":"Sugiyama","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.109618_bib78","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.stem.2010.06.020","article-title":"Regulation of the HIF-1alpha level is essential for hematopoietic stem cells","volume":"7","author":"Takubo","year":"2010","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib79","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1177\/27.10.512319","article-title":"Lead aspartate, an en bloc contrast stain particularly useful for ultrastructural enzymology","volume":"27","author":"Walton","year":"1979","journal-title":"J.\u00a0Histochem. Cytochem."},{"key":"10.1016\/j.celrep.2021.109618_bib80","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1172\/JCI31581","article-title":"The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development","volume":"117","author":"Wang","year":"2007","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2021.109618_bib81","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/S0301-472X(02)00881-0","article-title":"Roles of spleen and liver in development of the murine hematopoietic system","volume":"30","author":"Wolber","year":"2002","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.celrep.2021.109618_bib82","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1096\/fj.08-106468","article-title":"VEGF stimulation of mitochondrial biogenesis: requirement of AKT3 kinase","volume":"22","author":"Wright","year":"2008","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2021.109618_bib83","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0925-4773(01)00428-2","article-title":"Tissue specific regulation of VEGF expression during bone development requires Cbfa1\/Runx2","volume":"106","author":"Zelzer","year":"2001","journal-title":"Mech. Dev."},{"key":"10.1016\/j.celrep.2021.109618_bib84","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.stem.2014.06.008","article-title":"Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow","volume":"15","author":"Zhou","year":"2014","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.celrep.2021.109618_bib85","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/31269","article-title":"Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development","volume":"393","author":"Zou","year":"1998","journal-title":"Nature"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721010561?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721010561?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:23:22Z","timestamp":1761909802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124721010561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":85,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["S2211124721010561"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109618","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fetal hematopoietic stem cell homing is controlled by VEGF regulating the integrity and oxidative status of the stromal-vascular bone marrow niches","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109618","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"109618"}}