{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:32:57Z","timestamp":1790778777680,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T00:00:00Z","timestamp":1628812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.celrep.2021.109657","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T10:30:43Z","timestamp":1631010643000},"page":"109657","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Specific impact of \u03b25t on proteasome subunit composition in cortical thymic epithelial cells"],"prefix":"10.1016","volume":"36","author":[{"given":"Izumi","family":"Ohigashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yousuke","family":"Takahama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2021.109657_bib1","doi-asserted-by":"crossref","first-page":"966","DOI":"10.4049\/jimmunol.1801288","article-title":"PSMB11 orchestrates the development of CD4 and CD8 thymocytes via regulation of gene expression in cortical thymic epithelial cells","volume":"202","author":"Apavaloaei","year":"2019","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109657_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109546","article-title":"PSMB11 regulates gene expression in cortical thymic epithelial cells","volume":"36","author":"Apavaloaei","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.109657_bib3","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.chembiol.2010.05.027","article-title":"Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit \u03b25t","volume":"17","author":"Florea","year":"2010","journal-title":"Chem. Biol."},{"key":"10.1016\/j.celrep.2021.109657_bib4","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/s41467-018-03309-6","article-title":"Benchmarking common quantification strategies for large-scale phosphoproteomics","volume":"9","author":"Hogrebe","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2021.109657_bib5","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1084\/jem.20080829","article-title":"Delta-like 4 is the essential, nonredundant ligand for Notch1 during thymic T\u00a0cell lineage commitment","volume":"205","author":"Koch","year":"2008","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2021.109657_bib6","doi-asserted-by":"crossref","first-page":"7740","DOI":"10.1074\/jbc.RA118.007347","article-title":"Proteolytic dynamics of human 20S thymoproteasome","volume":"294","author":"Kuckelkorn","year":"2019","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.109657_bib7","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1126\/science.1141915","article-title":"Regulation of CD8+ T\u00a0cell development by thymus-specific proteasomes","volume":"316","author":"Murata","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.109657_bib8","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/s41590-018-0186-z","article-title":"The immunoproteasome and thymoproteasome: functions, evolution and human disease","volume":"19","author":"Murata","year":"2018","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2021.109657_bib9","doi-asserted-by":"crossref","first-page":"20572","DOI":"10.1073\/pnas.1213069109","article-title":"Thymic nurse cells provide microenvironment for secondary T\u00a0cell receptor \u03b1 rearrangement in cortical thymocytes","volume":"109","author":"Nakagawa","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109657_bib10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.immuni.2009.10.009","article-title":"Thymoproteasome shapes immunocompetent repertoire of CD8+ T\u00a0cells","volume":"32","author":"Nitta","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.109657_bib11","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1016\/j.celrep.2019.10.079","article-title":"Trans-omics impact of thymoproteasome in cortical thymic epithelial cells","volume":"29","author":"Ohigashi","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.109657_bib12","doi-asserted-by":"crossref","first-page":"e20201904","DOI":"10.1084\/jem.20201904","article-title":"The thymoproteasome hardwires the TCR repertoire of CD8+ T\u00a0cells in the cortex independent of negative selection","volume":"218","author":"Ohigashi","year":"2021","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2021.109657_bib13","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1002\/cbic.201800650","article-title":"A review on quantitative multiplexed proteomics","volume":"20","author":"Pappireddi","year":"2019","journal-title":"ChemBioChem"},{"key":"10.1016\/j.celrep.2021.109657_bib14","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.4049\/jimmunol.1203042","article-title":"Thymocyte selection regulates the homeostasis of IL-7-expressing thymic cortical epithelial cells in\u00a0vivo","volume":"191","author":"Ribeiro","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109657_bib15","doi-asserted-by":"crossref","first-page":"7484","DOI":"10.1038\/ncomms8484","article-title":"Thymoproteasomes produce unique peptide motifs for positive selection of CD8(+) T\u00a0cells","volume":"6","author":"Sasaki","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2021.109657_bib16","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/ni.3237","article-title":"TCR affinity for thymoproteasome-dependent positively selecting peptides conditions antigen responsiveness in CD8(+) T\u00a0cells","volume":"16","author":"Takada","year":"2015","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2021.109657_bib17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/nri.2017.12","article-title":"Generation of diversity in thymic epithelial cells","volume":"17","author":"Takahama","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2021.109657_bib18","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1038\/s41467-019-11879-2","article-title":"Dynamic changes in epithelial cell morphology control thymic organ size during atrophy and regeneration","volume":"10","author":"Venables","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2021.109657_bib19","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1073\/pnas.1222244110","article-title":"Thymoproteasome subunit-\u03b25T generates peptide-MHC complexes specialized for positive selection","volume":"110","author":"Xing","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721011001?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721011001?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:25:13Z","timestamp":1761909913000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124721011001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":19,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S2211124721011001"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109657","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Specific impact of \u03b25t on proteasome subunit composition in cortical thymic epithelial cells","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109657","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109546","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"name":"copyright","label":"Copyright"}],"article-number":"109657"}}