{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:54:34Z","timestamp":1785311674902,"version":"3.55.0"},"reference-count":121,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,21]],"date-time":"2021-08-21T00:00:00Z","timestamp":1629504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["R1313"],"award-info":[{"award-number":["R1313"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP170005"],"award-info":[{"award-number":["RP170005"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R21OD022981"],"award-info":[{"award-number":["1R21OD022981"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R21HG006726"],"award-info":[{"award-number":["1R21HG006726"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MH107474"],"award-info":[{"award-number":["R01MH107474"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R21GM110190"],"award-info":[{"award-number":["1R21GM110190"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01GM109938"],"award-info":[{"award-number":["R01GM109938"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P40ODO18537"],"award-info":[{"award-number":["P40ODO18537"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["1352978"],"award-info":[{"award-number":["1352978"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007856","name":"Baylor College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015587","name":"Bowdoin College","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006447","name":"Universit\u00e4t Z\u00fcrich","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009726","name":"Foundation for Angelman Syndrome Therapeutics","doi-asserted-by":"publisher","award":["FT2016-002"],"award-info":[{"award-number":["FT2016-002"]}],"id":[{"id":"10.13039\/100009726","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007920","name":"University of Massachusetts Medical School","doi-asserted-by":"publisher","award":["2P40OD010949"],"award-info":[{"award-number":["2P40OD010949"]}],"id":[{"id":"10.13039\/100007920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.celrep.2021.109700","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T17:37:10Z","timestamp":1631641030000},"page":"109700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Multiplexed drug-based selection and counterselection genetic manipulations in Drosophila"],"prefix":"10.1016","volume":"36","author":[{"given":"Nick","family":"Matinyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mansi S.","family":"Karkhanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yezabel","family":"Gonzalez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antrix","family":"Jain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4166-9555","authenticated-orcid":false,"given":"Alexander","family":"Saltzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Malovannaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Sarrion-Perdigones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman A.","family":"Dierick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen J.T.","family":"Venken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2021.109700_bib1","doi-asserted-by":"crossref","first-page":"5904","DOI":"10.1021\/bi700199g","article-title":"Exploration of new chromophore structures leads to the identification of improved blue fluorescent proteins","volume":"46","author":"Ai","year":"2007","journal-title":"Biochemistry"},{"key":"10.1016\/j.celrep.2021.109700_bib2","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1093\/nar\/19.18.5037","article-title":"Comparison of several promoters and polyadenylation signals for use in heterologous gene expression in cultured Drosophila cells","volume":"19","author":"Angelichio","year":"1991","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2021.109700_bib3","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.ydbio.2008.03.007","article-title":"Septate junctions are required for ommatidial integrity and blood-eye barrier function in Drosophila","volume":"317","author":"Banerjee","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.celrep.2021.109700_bib4","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1534\/genetics.106.056945","article-title":"Site-specific transformation of Drosophila via phiC31 integrase-mediated cassette exchange","volume":"173","author":"Bateman","year":"2006","journal-title":"Genetics"},{"key":"10.1016\/j.celrep.2021.109700_bib5","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0092-8674(00)81800-0","article-title":"A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function","volume":"87","author":"Baumgartner","year":"1996","journal-title":"Cell"},{"issue":"R2","key":"10.1016\/j.celrep.2021.109700_bib6","doi-asserted-by":"crossref","first-page":"R207","DOI":"10.1093\/hmg\/ddz135","article-title":"The fruit fly at the interface of diagnosis and pathogenic mechanisms of rare and common human diseases","volume":"28","author":"Bellen","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2021.109700_bib7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ymeth.2013.12.002","article-title":"Targeted genome engineering techniques in Drosophila","volume":"68","author":"Beumer","year":"2014","journal-title":"Methods"},{"key":"10.1016\/j.celrep.2021.109700_bib8","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrg1503","article-title":"Drosophila, the golden bug, emerges as a tool for human genetics","volume":"6","author":"Bier","year":"2005","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.celrep.2021.109700_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1534\/genetics.117.1113","article-title":"Advances in engineering the fly genome with the CRISPR-Cas system","volume":"208","author":"Bier","year":"2018","journal-title":"Genetics"},{"key":"10.1016\/j.celrep.2021.109700_bib10","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1073\/pnas.0611511104","article-title":"An optimized transgenesis system for Drosophila using germ-line-specific phiC31 integrases","volume":"104","author":"Bischof","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109700_bib11","first-page":"3022","article-title":"Herpes simplex virus-1 thymidine kinase mutants created by semi-random sequence mutagenesis improve prodrug-mediated tumor cell killing","volume":"61","author":"Black","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2021.109700_bib12","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1242\/dev.118.2.401","article-title":"Targeted gene expression as a means of altering cell fates and generating dominant phenotypes","volume":"118","author":"Brand","year":"1993","journal-title":"Development"},{"key":"10.1016\/j.celrep.2021.109700_bib13","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1523\/JNEUROSCI.3610-04.2005","article-title":"The multiple functions of cysteine-string protein analyzed at Drosophila nerve terminals","volume":"25","author":"Bronk","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.109700_bib14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.ento.45.1.151","article-title":"Blood barriers of the insect","volume":"45","author":"Carlson","year":"2000","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.celrep.2021.109700_bib15","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nmeth.2515","article-title":"Characterization of 582 natural and synthetic terminators and quantification of their design constraints","volume":"10","author":"Chen","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2021.109700_bib16","doi-asserted-by":"crossref","first-page":"E11633","DOI":"10.1073\/pnas.1809421115","article-title":"NETSeq reveals heterogeneous nucleotide incorporation by RNA polymerase I","volume":"115","author":"Clarke","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109700_bib17","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1126\/science.2830671","article-title":"Insertional mutagenesis of the Drosophila genome with single P elements","volume":"239","author":"Cooley","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.109700_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0378-1119(95)00685-0","article-title":"FACS-optimized mutants of the green fluorescent protein (GFP)","volume":"173","author":"Cormack","year":"1996","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2021.109700_bib19","series-title":"Drosophila Methods and Protocols","author":"Dahmann","year":"2008"},{"key":"10.1016\/j.celrep.2021.109700_bib20","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1146\/annurev.mi.32.100178.002345","article-title":"Plasmid-determined resistance to antimicrobial agents","volume":"32","author":"Davies","year":"1978","journal-title":"Annu. Rev. Microbiol."},{"issue":"D1","key":"10.1016\/j.celrep.2021.109700_bib21","first-page":"D1145","article-title":"The ProteomeXchange consortium in 2020: enabling \u2018big data\u2019 approaches in proteomics","volume":"48","author":"Deutsch","year":"2020","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2021.109700_bib22","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1099\/0022-1317-82-5-1027","article-title":"The \u2018cleavage\u2019 activities of foot-and-mouth disease virus 2A site-directed mutants and naturally occurring \u20182A-like\u2019 sequences","volume":"82","author":"Donnelly","year":"2001","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.celrep.2021.109700_bib23","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s004410051170","article-title":"Wide distribution of the cysteine string proteins in Drosophila tissues revealed by targeted mutagenesis","volume":"294","author":"Eberle","year":"1998","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.celrep.2021.109700_bib24","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1089\/hum.1991.2.3-195","article-title":"Positive selectable markers for use with mammalian cells in culture","volume":"2","author":"Eglitis","year":"1991","journal-title":"Hum. Gene Ther."},{"key":"10.1016\/j.celrep.2021.109700_bib25","doi-asserted-by":"crossref","first-page":"e3647","DOI":"10.1371\/journal.pone.0003647","article-title":"A one pot, one step, precision cloning method with high throughput capability","volume":"3","author":"Engler","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2021.109700_bib26","first-page":"3813","article-title":"In\u00a0vivo cancer gene therapy by adenovirus-mediated transfer of a bifunctional yeast cytosine deaminase\/uracil phosphoribosyltransferase fusion gene","volume":"60","author":"Erbs","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2021.109700_bib27","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/s41579-018-0025-0","article-title":"Controlling vector-borne diseases by releasing modified mosquitoes","volume":"16","author":"Flores","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2021.109700_bib28","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nmeth.1318","article-title":"Enzymatic assembly of DNA molecules up to several hundred kilobases","volume":"6","author":"Gibson","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2021.109700_bib29","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s00018-011-0670-1","article-title":"Selectable genetic markers for nematode transgenesis","volume":"68","author":"Giordano-Santini","year":"2011","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.celrep.2021.109700_bib30","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nmeth.1494","article-title":"An antibiotic selection marker for nematode transgenesis","volume":"7","author":"Giordano-Santini","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2021.109700_bib31","doi-asserted-by":"crossref","first-page":"e56","DOI":"10.1093\/nar\/gkv113","article-title":"Gene-specific cell labeling using MiMIC transposons","volume":"43","author":"Gnerer","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2021.109700_bib32","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1534\/genetics.113.160713","article-title":"Highly specific and efficient CRISPR\/Cas9-catalyzed homology-directed repair in Drosophila","volume":"196","author":"Gratz","year":"2014","journal-title":"Genetics"},{"key":"10.1016\/j.celrep.2021.109700_bib33","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0378-1119(85)90281-1","article-title":"Nucleotide sequence of the Bacillus subtilis ribosomal RNA operon, rrnB","volume":"37","author":"Green","year":"1985","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2021.109700_bib34","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0378-1119(83)90223-8","article-title":"Plasmid-encoded hygromycin B resistance: the sequence of hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiae","volume":"25","author":"Gritz","year":"1983","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2021.109700_bib35","first-page":"1775","article-title":"Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31","volume":"166","author":"Groth","year":"2004","journal-title":"Genetics"},{"key":"10.1016\/j.celrep.2021.109700_bib36","first-page":"820","article-title":"Polyubiquitin-regulated DsRed marker for transgenic insects","volume":"31","author":"Handler","year":"2001","journal-title":"Biotechniques"},{"key":"10.1016\/j.celrep.2021.109700_bib37","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1146\/annurev.en.36.010191.001111","article-title":"Prospects for gene transformation in insects","volume":"36","author":"Handler","year":"1991","journal-title":"Annu. Rev. Entomol."},{"key":"10.1016\/j.celrep.2021.109700_bib38","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1242\/dev.120.8.2121","article-title":"Expression of baculovirus P35 prevents cell death in Drosophila","volume":"120","author":"Hay","year":"1994","journal-title":"Development"},{"key":"10.1016\/j.celrep.2021.109700_bib39","doi-asserted-by":"crossref","first-page":"8229","DOI":"10.1073\/pnas.140142697","article-title":"A repressible female-specific lethal genetic system for making transgenic insect strains suitable for a sterile-release program","volume":"97","author":"Heinrich","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109700_bib40","doi-asserted-by":"crossref","first-page":"349","DOI":"10.4161\/fly.4.4.13304","article-title":"Transgenic tools for members of the genus Drosophila with sequenced genomes","volume":"4","author":"Holtzman","year":"2010","journal-title":"Fly (Austin)"},{"key":"10.1016\/j.celrep.2021.109700_bib41","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/S0965-1748(02)00085-1","article-title":"Fluorescent transformation markers for insect transgenesis","volume":"32","author":"Horn","year":"2002","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.celrep.2021.109700_bib42","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0378-1119(89)90359-4","article-title":"Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension","volume":"77","author":"Horton","year":"1989","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2021.109700_bib43","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0092-8674(80)90430-4","article-title":"Sequence of three copies of the gene for the major Drosophila heat shock induced protein and their flanking regions","volume":"21","author":"Ingolia","year":"1980","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109700_bib44","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1093\/oxfordjournals.jbchem.a123128","article-title":"The blasticidin S resistance gene (bsr) selectable in a single copy state in the Bacillus subtilis chromosome","volume":"107","author":"Itaya","year":"1990","journal-title":"J.\u00a0Biochem."},{"key":"10.1016\/j.celrep.2021.109700_bib45","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.celrep.2012.09.011","article-title":"A GAL4-driver line resource for Drosophila neurobiology","volume":"2","author":"Jenett","year":"2012","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.109700_bib46","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1128\/AEM.64.1.82-87.1998","article-title":"The sequence of spacers between the consensus sequences modulates the strength of prokaryotic promoters","volume":"64","author":"Jensen","year":"1998","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.celrep.2021.109700_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.51539","article-title":"An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms","volume":"8","author":"Kanca","year":"2019","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2021.109700_bib48","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1038\/s41467-020-16020-2","article-title":"A drug-inducible sex-separation technique for insects","volume":"11","author":"Kandul","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2021.109700_bib49","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0378-1119(90)90091-5","article-title":"Use of the human elongation factor 1 \u03b1 promoter as a versatile and efficient expression system","volume":"91","author":"Kim","year":"1990","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2021.109700_bib50","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1534\/genetics.114.166389","article-title":"A co-CRISPR strategy for efficient genome editing in Caenorhabditis elegans","volume":"197","author":"Kim","year":"2014","journal-title":"Genetics"},{"key":"10.1016\/j.celrep.2021.109700_bib51","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1242\/dev.096081","article-title":"Efficient site-specific transgenesis and enhancer activity tests in medaka using PhiC31 integrase","volume":"140","author":"Kirchmaier","year":"2013","journal-title":"Development"},{"key":"10.1016\/j.celrep.2021.109700_bib52","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1266\/ggs.17-00024","article-title":"piggyBac- and phiC31 integrase-mediated transgenesis in Drosophila prolongata","volume":"92","author":"Kudo","year":"2018","journal-title":"Genes Genet. Syst."},{"key":"10.1016\/j.celrep.2021.109700_bib53","doi-asserted-by":"crossref","first-page":"e788","DOI":"10.1371\/journal.pntd.0000788","article-title":"piggybac- and PhiC31-mediated genetic transformation of the Asian tiger mosquito, Aedes albopictus (Skuse)","volume":"4","author":"Labb\u00e9","year":"2010","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.celrep.2021.109700_bib54","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/nn1681","article-title":"Genetic mosaic with dual binary transcriptional systems in Drosophila","volume":"9","author":"Lai","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2021.109700_bib55","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0896-6273(00)80701-1","article-title":"Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis","volume":"22","author":"Lee","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.109700_bib56","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/geno.2000.6451","article-title":"A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA","volume":"73","author":"Lee","year":"2001","journal-title":"Genomics"},{"key":"10.1016\/j.celrep.2021.109700_bib57","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nmeth1010","article-title":"Harnessing homologous recombination in\u00a0vitro to generate recombinant DNA via SLIC","volume":"4","author":"Li","year":"2007","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2021.109700_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.38709","article-title":"An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila","volume":"7","author":"Li-Kroeger","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2021.109700_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1242\/dev.191411","article-title":"Using Drosophila to drive the diagnosis and understand the mechanisms of rare human diseases","volume":"147","author":"Link","year":"2020","journal-title":"Development"},{"key":"10.1016\/j.celrep.2021.109700_bib60","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.neuron.2006.08.028","article-title":"Refined spatial manipulation of neuronal function by combinatorial restriction of transgene expression","volume":"52","author":"Luan","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.109700_bib61","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1039\/C5IB00274E","article-title":"Synthetic biology: insights into biological computation","volume":"8","author":"Manzoni","year":"2016","journal-title":"Integr. Biol."},{"key":"10.1016\/j.celrep.2021.109700_bib62","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ibmb.2003.03.001","article-title":"Insect population control using female specific pro-drug activation","volume":"34","author":"Markaki","year":"2004","journal-title":"Insect Biochem. Mol. Biol."},{"key":"10.1016\/j.celrep.2021.109700_bib63","series-title":"Determining effective drug concentrations for selection & counterselection genetics in Drosophila melanogaster","author":"Matinyan","year":"2021"},{"issue":"Pt, Suppl 1","key":"10.1016\/j.celrep.2021.109700_bib64","doi-asserted-by":"crossref","first-page":"jeb218198","DOI":"10.1242\/jeb.218198","article-title":"How to turn an organism into a model organism in 10 \u2018easy\u2019 steps","volume":"223","author":"Matthews","year":"2020","journal-title":"J.\u00a0Exp. Biol."},{"key":"10.1016\/j.celrep.2021.109700_bib65","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1534\/g3.113.006411","article-title":"Variation in meiotic recombination frequencies between allelic transgenes inserted at different sites in the Drosophila melanogaster genome","volume":"3","author":"McMahan","year":"2013","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.celrep.2021.109700_bib66","doi-asserted-by":"crossref","first-page":"e59264","DOI":"10.1371\/journal.pone.0059264","article-title":"Next-generation site-directed transgenesis in the malaria vector mosquito Anopheles gambiae: self-docking strains expressing germline-specific phiC31 integrase","volume":"8","author":"Meredith","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2021.109700_bib67","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1534\/g3.116.029330","article-title":"Third chromosome balancer inversions disrupt protein-coding genes and influence distal recombination events in Drosophila melanogaster","volume":"6","author":"Miller","year":"2016","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.celrep.2021.109700_bib68","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1534\/g3.118.200021","article-title":"The molecular and genetic characterization of second chromosome balancers in Drosophila melanogaster","volume":"8","author":"Miller","year":"2018","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.celrep.2021.109700_bib69","first-page":"5","article-title":"Selection of transfected mammalian cells","volume":"Chapter 9","author":"Mortensen","year":"2009","journal-title":"Curr. Protoc. Mol. Biol."},{"key":"10.1016\/j.celrep.2021.109700_bib70","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/dvdy.23989","article-title":"Site-directed zebrafish transgenesis into single landing sites with the phiC31 integrase system","volume":"242","author":"Mosimann","year":"2013","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.celrep.2021.109700_bib71","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ajhg.2011.07.003","article-title":"Mutations in DNAJC5, encoding cysteine-string protein alpha, cause autosomal-dominant adult-onset neuronal ceroid lipofuscinosis","volume":"89","author":"Noskov\u00e1","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.celrep.2021.109700_bib72","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1093\/mutage\/gei016","article-title":"Resistance to the antibiotic Zeocin by stable expression of the Sh ble gene does not fully suppress Zeocin-induced DNA cleavage in human cells","volume":"20","author":"Oliva-Trastoy","year":"2005","journal-title":"Mutagenesis"},{"key":"10.1016\/j.celrep.2021.109700_bib73","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nbt1172","article-title":"Engineering and characterization of a superfolder green fluorescent protein","volume":"24","author":"P\u00e9delacq","year":"2006","journal-title":"Nat. Biotechnol."},{"issue":"D1","key":"10.1016\/j.celrep.2021.109700_bib74","doi-asserted-by":"crossref","first-page":"D442","DOI":"10.1093\/nar\/gky1106","article-title":"The PRIDE database and related tools and resources in 2019: improving support for quantification data","volume":"47","author":"Perez-Riverol","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2021.109700_bib75","doi-asserted-by":"crossref","first-page":"9715","DOI":"10.1073\/pnas.0803697105","article-title":"Tools for neuroanatomy and neurogenetics in Drosophila","volume":"105","author":"Pfeiffer","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109700_bib76","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1534\/genetics.110.119917","article-title":"Refinement of tools for targeted gene expression in Drosophila","volume":"186","author":"Pfeiffer","year":"2010","journal-title":"Genetics"},{"key":"10.1016\/j.celrep.2021.109700_bib77","doi-asserted-by":"crossref","first-page":"6626","DOI":"10.1073\/pnas.1204520109","article-title":"Using translational enhancers to increase transgene expression in Drosophila","volume":"109","author":"Pfeiffer","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109700_bib78","first-page":"437","article-title":"Vectors for P-mediated transformation in Drosophila","volume":"10","author":"Pirrotta","year":"1988","journal-title":"Biotechnology"},{"key":"10.1016\/j.celrep.2021.109700_bib79","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1038\/nprot.2014.117","article-title":"Efficient \u03a6C31 integrase-mediated site-specific germline transformation of Anopheles gambiae","volume":"9","author":"Pondeville","year":"2014","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2021.109700_bib80","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2144\/000112242","article-title":"Gentamicin and other cassettes for chromosomal gene replacement in Escherichia coli","volume":"41","author":"Poteete","year":"2006","journal-title":"Biotechniques"},{"key":"10.1016\/j.celrep.2021.109700_bib81","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.cell.2010.02.025","article-title":"The Q system: a repressible binary system for transgene expression, lineage tracing, and mosaic analysis","volume":"141","author":"Potter","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109700_bib82","doi-asserted-by":"crossref","first-page":"e76019","DOI":"10.1371\/journal.pone.0076019","article-title":"Efficient and rapid C. elegans transgenesis by bombardment and hygromycin B selection","volume":"8","author":"Radman","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2021.109700_bib83","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.plasmid.2013.02.003","article-title":"Plasmid R6K replication control","volume":"69","author":"Rakowski","year":"2013","journal-title":"Plasmid"},{"key":"10.1016\/j.celrep.2021.109700_bib84","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1089\/cmb.1997.4.311","article-title":"Improved splice site detection in Genie","volume":"4","author":"Reese","year":"1997","journal-title":"J.\u00a0Comput. Biol."},{"key":"10.1016\/j.celrep.2021.109700_bib85","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/nmeth.3250","article-title":"Improved and expanded Q-system reagents for genetic manipulations","volume":"12","author":"Riabinina","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2021.109700_bib86","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1242\/dev.100347","article-title":"Targeted transgene integration overcomes variability of position effects in zebrafish","volume":"141","author":"Roberts","year":"2014","journal-title":"Development"},{"key":"10.1016\/j.celrep.2021.109700_bib87","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/genetics\/118.3.461","article-title":"A stable genomic source of P element transposase in Drosophila melanogaster","volume":"118","author":"Robertson","year":"1988","journal-title":"Genetics"},{"key":"10.1016\/j.celrep.2021.109700_bib88","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0923-2508(01)01221-9","article-title":"NKBOR, a mini-Tn10-based transposon for random insertion in the chromosome of Gram-negative bacteria and the rapid recovery of sequences flanking the insertion sites in Escherichia coli","volume":"152","author":"Rossignol","year":"2001","journal-title":"Res. Microbiol."},{"key":"10.1016\/j.celrep.2021.109700_bib89","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.6289436","article-title":"Genetic transformation of Drosophila with transposable element vectors","volume":"218","author":"Rubin","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.109700_bib90","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/bfgp\/2.1.57","article-title":"Transposable elements as tools for genomics and genetics in Drosophila","volume":"2","author":"Ryder","year":"2003","journal-title":"Brief. Funct. Genomics Proteomics"},{"key":"10.1016\/j.celrep.2021.109700_bib91","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1074\/mcp.TIR118.000850","article-title":"GpGrouper: A peptide grouping algorithm for gene-centric inference and quantitation of bottom-up proteomics data","volume":"17","author":"Saltzman","year":"2018","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.celrep.2021.109700_bib92","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0925-4773(01)00654-2","article-title":"Identification of a transcriptional regulatory region for germline-specific expression of vasa gene in Drosophila melanogaster","volume":"112","author":"Sano","year":"2002","journal-title":"Mech. Dev."},{"key":"10.1016\/j.celrep.2021.109700_bib93","doi-asserted-by":"crossref","first-page":"e21622","DOI":"10.1371\/journal.pone.0021622","article-title":"GoldenBraid: an iterative cloning system for standardized assembly of reusable genetic modules","volume":"6","author":"Sarrion-Perdigones","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2021.109700_bib94","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1104\/pp.113.217661","article-title":"GoldenBraid 2.0: a comprehensive DNA assembly framework for plant synthetic biology","volume":"162","author":"Sarrion-Perdigones","year":"2013","journal-title":"Plant Physiol."},{"key":"10.1016\/j.celrep.2021.109700_bib95","doi-asserted-by":"crossref","first-page":"5710","DOI":"10.1038\/s41467-019-13651-y","article-title":"Examining multiple cellular pathways at once using multiplex hextuple luciferase assaying","volume":"10","author":"Sarrion-Perdigones","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2021.109700_bib96","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nmeth.1495","article-title":"Rapid selection of transgenic C. elegans using antibiotic resistance","volume":"7","author":"Semple","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2021.109700_bib97","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1038\/nbt1037","article-title":"Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein","volume":"22","author":"Shaner","year":"2004","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2021.109700_bib98","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2021.109700_bib99","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s11693-014-9154-6","article-title":"Recent advances and opportunities in synthetic logic gates engineering in living cells","volume":"8","author":"Singh","year":"2014","journal-title":"Syst. Synth. Biol."},{"key":"10.1016\/j.celrep.2021.109700_bib100","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/j.1460-2075.1985.tb02332.x","article-title":"A transposable P vector that confers selectable G418 resistance to Drosophila larvae","volume":"4","author":"Steller","year":"1985","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2021.109700_bib101","first-page":"1640","article-title":"P transposons controlled by the heat shock promoter","volume":"6","author":"Steller","year":"1986","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2021.109700_bib102","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1534\/g3.112.002097","article-title":"Simplified insertion of transgenes onto balancer chromosomes via recombinase-mediated cassette exchange","volume":"2","author":"Sun","year":"2012","journal-title":"G3 (Bethesda)"},{"issue":"D1","key":"10.1016\/j.celrep.2021.109700_bib103","doi-asserted-by":"crossref","first-page":"D607","DOI":"10.1093\/nar\/gky1131","article-title":"STRING v11: protein-protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets","volume":"47","author":"Szklarczyk","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2021.109700_bib104","doi-asserted-by":"crossref","first-page":"7902","DOI":"10.1073\/pnas.1019507108","article-title":"Site-specific integrase-mediated transgenesis in mice via pronuclear injection","volume":"108","author":"Tasic","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109700_bib105","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1126\/science.287.5462.2474","article-title":"Insect population control using a dominant, repressible, lethal genetic system","volume":"287","author":"Thomas","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.109700_bib106","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0896-6273(01)00427-5","article-title":"A trimeric protein complex functions as a synaptic chaperone machine","volume":"31","author":"Tobaben","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.109700_bib107","doi-asserted-by":"crossref","first-page":"8074","DOI":"10.1021\/bi00348a036","article-title":"Biosynthesis of puromycin by Streptomyces alboniger: characterization of puromycin N-acetyltransferase","volume":"24","author":"Vara","year":"1985","journal-title":"Biochemistry"},{"key":"10.1016\/j.celrep.2021.109700_bib108","doi-asserted-by":"crossref","first-page":"3571","DOI":"10.1242\/dev.005686","article-title":"Transgenesis upgrades for Drosophila melanogaster","volume":"134","author":"Venken","year":"2007","journal-title":"Development"},{"key":"10.1016\/j.celrep.2021.109700_bib109","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ymeth.2014.02.025","article-title":"Chemical mutagens, transposons, and transgenes to interrogate gene function in Drosophila melanogaster","volume":"68","author":"Venken","year":"2014","journal-title":"Methods"},{"key":"10.1016\/j.celrep.2021.109700_bib110","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1126\/science.1134426","article-title":"P[acman]: a BAC transgenic platform for targeted insertion of large DNA fragments in D. melanogaster","volume":"314","author":"Venken","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.109700_bib111","doi-asserted-by":"crossref","first-page":"e114","DOI":"10.1093\/nar\/gkn486","article-title":"Recombineering-mediated tagging of Drosophila genomic constructs for in\u00a0vivo localization and acute protein inactivation","volume":"36","author":"Venken","year":"2008","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2021.109700_bib112","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nmeth.1331","article-title":"Versatile P[acman] BAC libraries for transgenesis studies in Drosophila melanogaster","volume":"6","author":"Venken","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2021.109700_bib113","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1534\/genetics.110.121285","article-title":"A molecularly defined duplication set for the X chromosome of Drosophila melanogaster","volume":"186","author":"Venken","year":"2010","journal-title":"Genetics"},{"key":"10.1016\/j.celrep.2021.109700_bib114","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/nmeth.1662","article-title":"MiMIC: a highly versatile transposon insertion resource for engineering Drosophila melanogaster genes","volume":"8","author":"Venken","year":"2011","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2021.109700_bib115","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/wdev.214","article-title":"Genome engineering: Drosophila melanogaster and beyond","volume":"5","author":"Venken","year":"2016","journal-title":"Wiley Interdiscip. Rev. Dev. Biol."},{"key":"10.1016\/j.celrep.2021.109700_bib116","first-page":"385","article-title":"Promoters to express cloned genes uniformly in Drosophila","volume":"62","author":"Vincent","year":"1997","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2021.109700_bib117","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1534\/g3.115.016808","article-title":"Tools for anopheles gambiae transgenesis","volume":"5","author":"Volohonsky","year":"2015","journal-title":"G3 (Bethesda)"},{"key":"10.1016\/j.celrep.2021.109700_bib118","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/2417","article-title":"A new logic for DNA engineering using recombination in Escherichia coli","volume":"20","author":"Zhang","year":"1998","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2021.109700_bib119","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuron.2012.01.029","article-title":"Identification of CSP\u03b1 clients reveals a role in dynamin 1 regulation","volume":"74","author":"Zhang","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.109700_bib120","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.1007\/s11033-013-2639-7","article-title":"p\u0394TubHA4C, a new versatile vector for constitutive expression in Drosophila","volume":"40","author":"Zhang","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.celrep.2021.109700_bib121","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1534\/g3.114.013979","article-title":"A versatile two-step CRISPR- and RMCE-based strategy for efficient genome engineering in Drosophila","volume":"4","author":"Zhang","year":"2014","journal-title":"G3 (Bethesda)"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721011475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721011475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:45:15Z","timestamp":1778841915000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124721011475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":121,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S2211124721011475"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109700","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multiplexed drug-based selection and counterselection genetic manipulations in Drosophila","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109700","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1016\/j.xpro.2021.100783","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"109700"}}