{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:01:33Z","timestamp":1783468893315,"version":"3.55.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,15]],"date-time":"2021-09-15T00:00:00Z","timestamp":1631664000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017M3A9E4061998"],"award-info":[{"award-number":["2017M3A9E4061998"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020ER53380"],"award-info":[{"award-number":["2020ER53380"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2021M3A9H5020761"],"award-info":[{"award-number":["2021M3A9H5020761"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.celrep.2021.109798","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T03:48:29Z","timestamp":1632109709000},"page":"109798","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19"],"prefix":"10.1016","volume":"37","author":[{"given":"Dong-Min","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9385-2557","authenticated-orcid":false,"given":"Yuri","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Won","family":"Seo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jooyeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0875-2584","authenticated-orcid":false,"given":"Uni","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Young","family":"Ha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaemoon","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoree","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2267-6717","authenticated-orcid":false,"given":"Jae-Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyo-Jin","family":"Ro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na Ra","family":"Yun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ho","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Sub","family":"Na","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Sik","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6179-691X","authenticated-orcid":false,"given":"Sung-Chul","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Choon-Mee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5452-0998","authenticated-orcid":false,"given":"Kyeongseok","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Gu","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Yoon","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeongseok","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinhyea","family":"Cheon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Mok","family":"Sohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Youg","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungmin","family":"Kym","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5115-3045","authenticated-orcid":false,"given":"Seung Ro","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Shin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Je","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4234-0380","authenticated-orcid":false,"given":"Woong-Yang","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Yeob","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4038-9992","authenticated-orcid":false,"given":"Hyun-Woo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Hyun","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Kyung","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon-Sook","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam-Hyuk","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2021.109798_bib1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/s41577-020-0346-x","article-title":"Dysregulation of type I interferon responses in COVID-19","volume":"20","author":"Acharya","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2021.109798_bib2","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.4049\/jimmunol.173.5.3305","article-title":"TGF-\u03b2 receptor signaling is critical for mucosal IgA responses","volume":"173","author":"Borsutzky","year":"2004","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109798_bib3","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/s41577-020-00410-0","article-title":"The role of IgG Fc receptors in antibody-dependent enhancement","volume":"20","author":"Bournazos","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2021.109798_bib4","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/s41586-020-2600-6","article-title":"Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis","volume":"588","author":"Carvelli","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109798_bib5","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/s41587-020-0602-4","article-title":"COVID-19 severity correlates with airway epithelium-immune cell interactions identified by single-cell analysis","volume":"38","author":"Chua","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2021.109798_bib6","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/15513815.2020.1761491","article-title":"Fatal eosinophilic myocarditis in a healthy 17-year-old male with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2c)","volume":"39","author":"Craver","year":"2020","journal-title":"Fetal Pediatr. Pathol."},{"key":"10.1016\/j.celrep.2021.109798_bib7","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jaci.2020.05.006","article-title":"Complement activation in patients with COVID-19: A novel therapeutic target","volume":"146","author":"Cugno","year":"2020","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2021.109798_bib8","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1164\/rccm.201710-1967CI","article-title":"Acute eosinophilic pneumonia. Causes, diagnosis, and management","volume":"197","author":"De Giacomi","year":"2018","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.celrep.2021.109798_bib9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.cytogfr.2020.05.009","article-title":"IL-6: Relevance for immunopathology of SARS-CoV-2","volume":"53","author":"Gubernatorova","year":"2020","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.celrep.2021.109798_bib10","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China","volume":"395","author":"Huang","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2021.109798_bib11","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1164\/rccm.201203-0506OC","article-title":"Patients with idiopathic pulmonary fibrosis with antibodies to heat shock protein 70 have poor prognoses","volume":"187","author":"Kahloon","year":"2013","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.celrep.2021.109798_bib12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cell.2020.08.025","article-title":"Loss of Bcl-6-expressing T follicular helper cells and germinal centers in COVID-19","volume":"183","author":"Kaneko","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109798_bib13","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/s41577-020-00429-3","article-title":"The type I interferon response in COVID-19: Implications for treatment","volume":"20","author":"Lee","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2021.109798_bib14","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1016\/j.ad.2020.05.003","article-title":"Eosinophilic panniculitis associated with COVID-19","volume":"111","author":"Leis-Dosil","year":"2020","journal-title":"Actas Dermosifiliogr (Eng. Ed.)"},{"key":"10.1016\/j.celrep.2021.109798_bib15","doi-asserted-by":"crossref","first-page":"P646","DOI":"10.1016\/j.jinf.2020.03.035","article-title":"SAA is a biomarker to distinguish the severity and prognosis of coronavirus disease 2019 (COVID-19)","volume":"80","author":"Li","year":"2020","journal-title":"J.\u00a0Infect."},{"key":"10.1016\/j.celrep.2021.109798_bib16","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1038\/s41591-020-0901-9","article-title":"Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19","volume":"26","author":"Liao","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2021.109798_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaci.2020.04.021","article-title":"Eosinophil responses during COVID-19 infections and coronavirus vaccination","volume":"146","author":"Lindsley","year":"2020","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2021.109798_bib18","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/s41591-020-0897-1","article-title":"Antibody responses to SARS-CoV-2 in patients with COVID-19","volume":"26","author":"Long","year":"2020","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2021.109798_bib19","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/s41586-020-2588-y","article-title":"Longitudinal analyses reveal immunological misfiring in severe COVID-19","volume":"584","author":"Lucas","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109798_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.trsl.2020.04.007","article-title":"Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases","volume":"220","author":"Magro","year":"2020","journal-title":"Transl. Res."},{"key":"10.1016\/j.celrep.2021.109798_bib21","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1172\/JCI138554","article-title":"Impaired immune cell cytotoxicity in severe COVID-19 is IL-6 dependent","volume":"130","author":"Mazzoni","year":"2020","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2021.109798_bib22","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41577-020-0331-4","article-title":"Pathological inflammation in patients with COVID-19: a key role for monocytes and macrophages","volume":"20","author":"Merad","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2021.109798_bib23","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3389\/fcimb.2017.00160","article-title":"With friends like these: The complex role of neutrophils in the progression of severe pneumonia","volume":"7","author":"Pechous","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.celrep.2021.109798_bib24","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.jaci.2018.07.037","article-title":"Airways exudation of plasma macromolecules: Innate defense, epithelial regeneration, and asthma","volume":"143","author":"Persson","year":"2019","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2021.109798_bib25","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1164\/rccm.2112056","article-title":"Idiopathic acute eosinophilic pneumonia: A study of 22 patients","volume":"166","author":"Philit","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.celrep.2021.109798_bib26","doi-asserted-by":"crossref","first-page":"e133","DOI":"10.1093\/nar\/gkz601","article-title":"Single-Cell Signature Explorer for comprehensive visualization of single cell signatures across scRNA-seq datasets","volume":"47","author":"Pont","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2021.109798_bib27","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1001\/jama.2020.16747","article-title":"Corticosteroids in COVID-19 ARDS: Evidence and hope during the pandemic","volume":"324","author":"Prescott","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.celrep.2021.109798_bib28","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1093\/cid\/ciaa248","article-title":"Dysregulation of immune response in patients with COVID-19 in Wuhan, China","volume":"71","author":"Qin","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.celrep.2021.109798_bib29","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nrneph.2016.70","article-title":"Complement in disease: A defence system turning offensive","volume":"12","author":"Ricklin","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.celrep.2021.109798_bib30","doi-asserted-by":"crossref","first-page":"108487","DOI":"10.1016\/j.clim.2020.108487","article-title":"Type 3 hypersensitivity in COVID-19 vasculitis","volume":"217","author":"Roncati","year":"2020","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.celrep.2021.109798_bib31","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nri3341","article-title":"Eosinophils: Changing perspectives in health and disease","volume":"13","author":"Rosenberg","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2021.109798_bib32","doi-asserted-by":"crossref","first-page":"102538","DOI":"10.1016\/j.autrev.2020.102538","article-title":"Corona (COVID-19) time musings: Our involvement in COVID-19 pathogenesis, diagnosis, treatment and vaccine planning","volume":"19","author":"Shoenfeld","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.celrep.2021.109798_bib33","article-title":"Diverse functional autoantibodies in patients with COVID-19","author":"Wang","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.celrep.2021.109798_bib34","doi-asserted-by":"crossref","first-page":"5235","DOI":"10.1172\/JCI138759","article-title":"Kinetics of viral load and antibody response in relation to COVID-19 severity","volume":"130","author":"Wang","year":"2020","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2021.109798_bib35","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1038\/s41590-020-00814-z","article-title":"Extrafollicular B cell responses correlate with neutralizing antibodies and morbidity in COVID-19","volume":"21","author":"Woodruff","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2021.109798_bib36","doi-asserted-by":"crossref","first-page":"e00362-20","DOI":"10.1128\/msphere.00362-20","article-title":"Clinical characteristics and immune injury mechanisms in 71 patients with COVID-19","volume":"5","author":"Wu","year":"2020","journal-title":"MSphere"},{"key":"10.1016\/j.celrep.2021.109798_bib37","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S2213-2600(20)30079-5","article-title":"Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: A single-centered, retrospective, observational study","volume":"8","author":"Yang","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"10.1016\/j.celrep.2021.109798_bib38","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/his.14138","article-title":"Pulmonary pathology of early phase COVID-19 pneumonia in a patient with a benign lung lesion","volume":"77","author":"Zeng","year":"2020","journal-title":"Histopathology"},{"key":"10.1016\/j.celrep.2021.109798_bib39","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(20)30566-3","article-title":"Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: A retrospective cohort study","volume":"395","author":"Zhou","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2021.109798_bib40","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1038\/s41577-020-0359-5","article-title":"Dissecting antibody-mediated protection against SARS-CoV-2","volume":"20","author":"Zohar","year":"2020","journal-title":"Nat. Rev. Immunol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721012584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721012584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:25:35Z","timestamp":1761909935000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124721012584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S2211124721012584"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109798","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced eosinophil-mediated inflammation associated with antibody and complement-dependent pneumonic insults in critical COVID-19","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109798","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"109798"}}