{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:10:38Z","timestamp":1792059038427,"version":"4.4.0"},"reference-count":106,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:00:00Z","timestamp":1632960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI124346"],"award-info":[{"award-number":["AI124346"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI160179"],"award-info":[{"award-number":["AI160179"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA253095"],"award-info":[{"award-number":["CA253095"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI101935"],"award-info":[{"award-number":["AI101935"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AR056296"],"award-info":[{"award-number":["AR056296"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","award":["63\/196,986"],"award-info":[{"award-number":["63\/196,986"]}],"id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.celrep.2021.109858","type":"journal-article","created":{"date-parts":[[2021,10,22]],"date-time":"2021-10-22T02:56:24Z","timestamp":1634871384000},"page":"109858","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":441,"title":["ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4436-9128","authenticated-orcid":false,"given":"Rajendra","family":"Karki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balamurugan","family":"Sundaram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3609-833X","authenticated-orcid":false,"given":"Bhesh Raj","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SangJoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.K. Subbarao","family":"Malireddi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8419-8354","authenticated-orcid":false,"given":"Lam Nhat","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelbi","family":"Christgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7655-5713","authenticated-orcid":false,"given":"Parimal","family":"Samir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3776-0858","authenticated-orcid":false,"given":"Geoffrey","family":"Neale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7535-0545","authenticated-orcid":false,"given":"Peter","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6395-6443","authenticated-orcid":false,"given":"Thirumala-Devi","family":"Kanneganti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2021.109858_bib1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cell.2017.12.016","article-title":"Breaching self-tolerance to Alu duplex RNA underlies MDA5-mediated inflammation","volume":"172","author":"Ahmad","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109858_bib2","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","article-title":"Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3","volume":"413","author":"Alexopoulou","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib3","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.3390\/cancers11121943","article-title":"Type I interferons and cancer: An evolving story demanding novel clinical applications","volume":"11","author":"Aric\u00f2","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.celrep.2021.109858_bib4","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13045-020-00903-4","article-title":"XPO1-dependent nuclear export as a target for cancer therapy","volume":"13","author":"Azizian","year":"2020","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.celrep.2021.109858_bib5","doi-asserted-by":"crossref","first-page":"D991","DOI":"10.1093\/nar\/gks1193","article-title":"NCBI GEO: archive for functional genomics data sets--update","volume":"41","author":"Barrett","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2021.109858_bib6","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1056\/NEJMoa1903455","article-title":"Oral selinexor-dexamethasone for triple-class refractory multiple myeloma","volume":"381","author":"Chari","year":"2019","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2021.109858_bib7","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1016\/j.celrep.2019.02.032","article-title":"A pan-ALDH1A inhibitor induces necroptosis in ovarian cancer stem-like cells","volume":"26","author":"Chefetz","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.109858_bib8","doi-asserted-by":"crossref","first-page":"e101638","DOI":"10.15252\/embj.2019101638","article-title":"Extrinsic and intrinsic apoptosis activate pannexin-1 to drive NLRP3 inflammasome assembly","volume":"38","author":"Chen","year":"2019","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2021.109858_bib9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.3389\/fcimb.2020.00237","article-title":"Identification of the PANoptosome: A molecular platform triggering pyroptosis, apoptosis, and necroptosis (PANoptosis)","volume":"10","author":"Christgen","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.celrep.2021.109858_bib10","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/j.cell.2017.12.038","article-title":"Human ADAR1 prevents endogenous RNA from triggering translational shutdown","volume":"172","author":"Chung","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109858_bib11","doi-asserted-by":"crossref","first-page":"10119","DOI":"10.1128\/JVI.02457-08","article-title":"ADAR1 interacts with PKR during human immunodeficiency virus infection of lymphocytes and contributes to viral replication","volume":"83","author":"Clerzius","year":"2009","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2021.109858_bib12","doi-asserted-by":"crossref","first-page":"109500","DOI":"10.1016\/j.celrep.2021.109500","article-title":"ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation","volume":"36","author":"de Reuver","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.109858_bib13","doi-asserted-by":"crossref","first-page":"a008789","DOI":"10.1101\/cshperspect.a008789","article-title":"The role of the apoptotic machinery in tumor suppression","volume":"4","author":"Delbridge","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.celrep.2021.109858_bib14","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1038\/s41467-020-15435-1","article-title":"Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila","volume":"11","author":"Deng","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2021.109858_bib15","doi-asserted-by":"crossref","first-page":"e20191913","DOI":"10.1084\/jem.20191913","article-title":"Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation","volume":"217","author":"Devos","year":"2020","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2021.109858_bib16","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1091\/mbc.12.7.1911","article-title":"The human but not the Xenopus RNA-editing enzyme ADAR1 has an atypical nuclear localization signal and displays the characteristics of a shuttling protein","volume":"12","author":"Eckmann","year":"2001","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.celrep.2021.109858_bib17","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1186\/1471-2407-13-580","article-title":"The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis","volume":"13","author":"Fu","year":"2013","journal-title":"BMC Cancer"},{"key":"10.1016\/j.celrep.2021.109858_bib18","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.celrep.2015.09.032","article-title":"Principles governing A-to-I RNA editing in the breast cancer transcriptome","volume":"13","author":"Fumagalli","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.109858_bib19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0378-1119(99)00017-7","article-title":"Characterization of the 5\u2032-flanking region of the human RNA-specific adenosine deaminase ADAR1 gene and identification of an interferon-inducible ADAR1 promoter","volume":"229","author":"George","year":"1999","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2021.109858_bib20","doi-asserted-by":"crossref","first-page":"4621","DOI":"10.1073\/pnas.96.8.4621","article-title":"Human RNA-specific adenosine deaminase ADAR1 transcripts possess alternative exon 1 structures that initiate from different promoters, one constitutively active and the other interferon inducible","volume":"96","author":"George","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109858_bib21","doi-asserted-by":"crossref","first-page":"8459","DOI":"10.1073\/pnas.0603082103","article-title":"Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus","volume":"103","author":"Gitlin","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109858_bib22","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13045-014-0085-1","article-title":"Nucleo-cytoplasmic transport as a therapeutic target of cancer","volume":"7","author":"Gravina","year":"2014","journal-title":"J.\u00a0Hematol. Oncol."},{"key":"10.1016\/j.celrep.2021.109858_bib23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S1535-6108(02)00024-7","article-title":"A matter of life and death","volume":"1","author":"Green","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2021.109858_bib24","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.4049\/jimmunol.1302839","article-title":"FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes","volume":"192","author":"Gurung","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109858_bib25","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ccell.2015.08.013","article-title":"The genomic landscape and clinical relevance of A-to-I RNA editing in human cancers","volume":"28","author":"Han","year":"2015","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2021.109858_bib26","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","article-title":"The hallmarks of cancer","volume":"100","author":"Hanahan","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109858_bib27","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109858_bib28","doi-asserted-by":"crossref","first-page":"4894","DOI":"10.1074\/jbc.M311347200","article-title":"Liver disintegration in the mouse embryo caused by deficiency in the RNA-editing enzyme ADAR1","volume":"279","author":"Hartner","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.109858_bib29","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/ni.1680","article-title":"ADAR1 is essential for the maintenance of hematopoiesis and suppression of interferon signaling","volume":"10","author":"Hartner","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2021.109858_bib30","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/cr.2015.139","article-title":"Gasdermin D is an executor of pyroptosis and required for interleukin-1\u03b2 secretion","volume":"25","author":"He","year":"2015","journal-title":"Cell Res."},{"key":"10.1016\/j.celrep.2021.109858_bib31","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nature06537","article-title":"TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines","volume":"451","author":"Ishii","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib32","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/s41586-018-0768-9","article-title":"Loss of ADAR1 in tumours overcomes resistance to immune checkpoint blockade","volume":"565","author":"Ishizuka","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib33","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/s41586-020-2129-8","article-title":"Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation","volume":"580","author":"Jiao","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib34","doi-asserted-by":"crossref","first-page":"9771","DOI":"10.1073\/pnas.1003738107","article-title":"Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis","volume":"107","author":"Jones","year":"2010","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109858_bib35","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nature04517","article-title":"Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin\/Nalp3","volume":"440","author":"Kanneganti","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/s41568-019-0123-y","article-title":"Diverging inflammasome signals in tumorigenesis and potential targeting","volume":"19","author":"Karki","year":"2019","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2021.109858_bib40","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cell.2018.02.055","article-title":"IRF8 regulates transcription of Naips for NLRC4 inflammasome activation","volume":"173","author":"Karki","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109858_bib39","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1158\/2326-6066.CIR-16-0269","article-title":"Inflammasomes and cancer","volume":"5","author":"Karki","year":"2017","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.celrep.2021.109858_bib37","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.chom.2015.01.006","article-title":"Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection","volume":"17","author":"Karki","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2021.109858_bib38","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nature20597","article-title":"NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer","volume":"540","author":"Karki","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib41","doi-asserted-by":"crossref","first-page":"e136720","DOI":"10.1172\/jci.insight.136720","article-title":"Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer","volume":"5","author":"Karki","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2021.109858_bib43","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nature10558","article-title":"Non-canonical inflammasome activation targets caspase-11","volume":"479","author":"Kayagaki","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib42","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.cell.2020.11.025","article-title":"Synergism of TNF-\u03b1 and IFN-\u03b3 triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes","volume":"184","author":"Karki","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109858_bib44","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib45","doi-asserted-by":"crossref","first-page":"8325","DOI":"10.1074\/jbc.RA120.013752","article-title":"The Z\u03b12 domain of ZBP1 is a molecular switch regulating influenza-induced PANoptosis and perinatal lethality during development","volume":"295","author":"Kesavardhana","year":"2020","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.109858_bib46","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1101\/gr.2855504","article-title":"Widespread RNA editing of embedded alu elements in the human transcriptome","volume":"14","author":"Kim","year":"2004","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2021.109858_bib47","doi-asserted-by":"crossref","first-page":"11506","DOI":"10.1073\/pnas.1700999114","article-title":"Inhibition of DAI-dependent necroptosis by the Z-DNA binding domain of the vaccinia virus innate immune evasion protein, E3","volume":"114","author":"Koehler","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109858_bib48","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1084\/jem.20060792","article-title":"Essential role of IPS-1 in innate immune responses against RNA viruses","volume":"203","author":"Kumar","year":"2006","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2021.109858_bib49","doi-asserted-by":"crossref","first-page":"aag2045","DOI":"10.1126\/sciimmunol.aag2045","article-title":"ZBP1\/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways","volume":"1","author":"Kuriakose","year":"2016","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2021.109858_bib50","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.4049\/jimmunol.1701538","article-title":"IRF1 Is a Transcriptional Regulator of ZBP1 Promoting NLRP3 Inflammasome Activation and Cell Death during Influenza Virus Infection","volume":"200","author":"Kuriakose","year":"2018","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109858_bib51","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0014-5793(01)02304-3","article-title":"DFNA5 (ICERE-1) contributes to acquired etoposide resistance in melanoma cells","volume":"494","author":"Lage","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.celrep.2021.109858_bib52","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1126\/science.1115035","article-title":"Caspases 3 and 7: key mediators of mitochondrial events of apoptosis","volume":"311","author":"Lakhani","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.109858_bib53","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.3389\/fimmu.2019.01763","article-title":"ADAR1: \u201cEditor-in-chief\u201d of cytoplasmic innate immunity","volume":"10","author":"Lamers","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2021.109858_bib54","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1006\/viro.1994.1151","article-title":"The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis","volume":"199","author":"Lee","year":"1994","journal-title":"Virology"},{"issue":"7876","key":"10.1016\/j.celrep.2021.109858_bib106","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-021-03875-8","article-title":"AIM2 forms a complex with pyrin and ZBP1 to drive PANoptosis and host defence","volume":"597","author":"Lee","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib55","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.virol.2009.10.026","article-title":"RNA adenosine deaminase ADAR1 deficiency leads to increased activation of protein kinase PKR and reduced vesicular stomatitis virus growth following interferon treatment","volume":"396","author":"Li","year":"2010","journal-title":"Virology"},{"key":"10.1016\/j.celrep.2021.109858_bib56","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.aac7049","article-title":"RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself","volume":"349","author":"Liddicoat","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.109858_bib57","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/nature20558","article-title":"RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation","volume":"540","author":"Lin","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib58","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/s41591-018-0302-5","article-title":"Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss","volume":"25","author":"Liu","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2021.109858_bib60","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.cell.2016.09.012","article-title":"IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes","volume":"167","author":"Man","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109858_bib59","doi-asserted-by":"crossref","first-page":"568","DOI":"10.4049\/immunohorizons.2100059","article-title":"Inflammatory cell death, PANoptosis, mediated by cytokines in diverse cancer lineages inhibits tumor growth","volume":"5","author":"Malireddi","year":"2021","journal-title":"Immunohorizons"},{"key":"10.1016\/j.celrep.2021.109858_bib61","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/imr.12534","article-title":"Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases","volume":"277","author":"Man","year":"2017","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.celrep.2021.109858_bib62","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature02664","article-title":"Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf","volume":"430","author":"Mariathasan","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib63","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.immuni.2013.06.018","article-title":"The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism","volume":"39","author":"Murphy","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.109858_bib64","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1158\/0008-5472.CAN-08-0858","article-title":"Identification of nuclear export inhibitors with potent anticancer activity in\u00a0vivo","volume":"69","author":"Mutka","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2021.109858_bib65","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.tranon.2019.04.010","article-title":"Activation of pyroptotic cell death pathways in cancer: An alternative therapeutic approach","volume":"12","author":"Nagarajan","year":"2019","journal-title":"Transl. Oncol."},{"key":"10.1016\/j.celrep.2021.109858_bib66","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1261\/rna.165106","article-title":"RNA editing level in the mouse is determined by the genomic repeat repertoire","volume":"12","author":"Neeman","year":"2006","journal-title":"RNA"},{"key":"10.1016\/j.celrep.2021.109858_bib67","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1128\/MCB.24.4.1464-1469.2004","article-title":"Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4","volume":"24","author":"Newton","year":"2004","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2021.109858_bib68","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/nature20559","article-title":"RIPK1 inhibits ZBP1-driven necroptosis during development","volume":"540","author":"Newton","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib69","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1146\/annurev-biochem-060208-105251","article-title":"Functions and regulation of RNA editing by ADAR deaminases","volume":"79","author":"Nishikura","year":"2010","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.celrep.2021.109858_bib70","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/nature09852","article-title":"Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis","volume":"471","author":"Oberst","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib71","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.4049\/jimmunol.176.7.4337","article-title":"Distinct roles of TLR2 and the adaptor ASC in IL-1beta\/IL-18 secretion in response to Listeria monocytogenes","volume":"176","author":"Oz\u00f6ren","year":"2006","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.109858_bib72","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/nrc.2016.14","article-title":"Antitumour actions of interferons: implications for cancer therapy","volume":"16","author":"Parker","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2021.109858_bib73","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1128\/MCB.15.10.5376","article-title":"Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: evidence for two forms of the deaminase","volume":"15","author":"Patterson","year":"1995","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2021.109858_bib74","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.celrep.2015.08.080","article-title":"Elevated RNA editing activity Is a major contributor to transcriptomic diversity in tumors","volume":"13","author":"Paz-Yaacov","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.109858_bib75","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.immuni.2015.11.001","article-title":"Isoforms of RNA-editing enzyme ADAR1 independently control nucleic acid sensor MDA5-driven autoimmunity and multi-organ development","volume":"43","author":"Pestal","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.109858_bib76","doi-asserted-by":"crossref","first-page":"e2006577","DOI":"10.1371\/journal.pbio.2006577","article-title":"Extensive editing of cellular and viral double-stranded RNA structures accounts for innate immunity suppression and the proviral activity of ADAR1p150","volume":"16","author":"Pfaller","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2021.109858_bib77","doi-asserted-by":"crossref","first-page":"7862","DOI":"10.1128\/MCB.21.22.7862-7871.2001","article-title":"CRM1 mediates the export of ADAR1 through a nuclear export signal within the Z-DNA binding domain","volume":"21","author":"Poulsen","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2021.109858_bib78","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1038\/embor.2009.109","article-title":"DAI\/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB","volume":"10","author":"Rebsamen","year":"2009","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2021.109858_bib79","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/ng.2414","article-title":"Mutations in ADAR1 cause Aicardi-Gouti\u00e8res syndrome associated with a type I interferon signature","volume":"44","author":"Rice","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2021.109858_bib80","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41418-018-0122-7","article-title":"Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis","volume":"26","author":"Sarhan","year":"2019","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.celrep.2021.109858_bib81","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1126\/science.284.5421.1841","article-title":"Crystal structure of the Zalpha domain of the human editing enzyme ADAR1 bound to left-handed Z-DNA","volume":"284","author":"Schwartz","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.109858_bib82","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/nsb0901-761","article-title":"Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins","volume":"8","author":"Schwartz","year":"2001","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.celrep.2021.109858_bib83","doi-asserted-by":"crossref","first-page":"41067","DOI":"10.1038\/srep41067","article-title":"IL-1\u03b2 induces apoptosis and autophagy via mitochondria pathway in human degenerative nucleus pulposus cells","volume":"7","author":"Shen","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2021.109858_bib84","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.cell.2018.05.052","article-title":"LSD1 ablation stimulates anti-tumoriImmunity and enables checkpoint blockade","volume":"174","author":"Sheng","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109858_bib85","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib86","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature10163","article-title":"A conditional knockout resource for the genome-wide study of mouse gene function","volume":"474","author":"Skarnes","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib87","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41594-020-0398-4","article-title":"irCLASH reveals RNA substrates recognized by human ADARs","volume":"27","author":"Song","year":"2020","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2021.109858_bib88","doi-asserted-by":"crossref","first-page":"12248","DOI":"10.1038\/s41598-018-30686-1","article-title":"Anti-tumor efficacy of Selinexor (KPT-330) in gastric cancer is dependent on nuclear accumulation of p53 tumor suppressor","volume":"8","author":"Subhash","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2021.109858_bib89","doi-asserted-by":"crossref","first-page":"e1000757","DOI":"10.1371\/journal.ppat.1000757","article-title":"IPS-1 is essential for the control of West Nile virus infection and immunity","volume":"6","author":"Suthar","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2021.109858_bib90","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.chembiol.2017.03.009","article-title":"Pyroptosis and apoptosis pathways engage in bidirectional crosstalk in monocytes and macrophages","volume":"24","author":"Taabazuing","year":"2017","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.celrep.2021.109858_bib91","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1089\/gtmb.2017.0207","article-title":"Eight novel mutations of the ADAR1 gene in Chinese patients with dyschromatosis symmetrica hereditaria","volume":"22","author":"Tang","year":"2018","journal-title":"Genet. Test. Mol. Biomarkers"},{"key":"10.1016\/j.celrep.2021.109858_bib92","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13059-021-02271-9","article-title":"ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism","volume":"22","author":"Tassinari","year":"2021","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2021.109858_bib93","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1158\/2159-8290.CD-19-0298","article-title":"Altered nuclear export signal recognition as a driver of oncogenesis","volume":"9","author":"Taylor","year":"2019","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2021.109858_bib94","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s11523-020-00758-2","article-title":"Targeting nuclear export proteins in multiple myeloma therapy","volume":"15","author":"Theodoropoulos","year":"2020","journal-title":"Target. Oncol."},{"key":"10.1016\/j.celrep.2021.109858_bib95","doi-asserted-by":"crossref","first-page":"16054","DOI":"10.1074\/jbc.M611392200","article-title":"RNA binding-independent dimerization of adenosine deaminases acting on RNA and dominant negative effects of nonfunctional subunits on dimer functions","volume":"282","author":"Valente","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.109858_bib96","doi-asserted-by":"crossref","first-page":"14384","DOI":"10.1073\/pnas.1613156113","article-title":"Familial Mediterranean fever mutations lift the obligatory requirement for microtubules in Pyrin inflammasome activation","volume":"113","author":"Van Gorp","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109858_bib97","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.290.5497.1765","article-title":"Requirement of the RNA editing deaminase ADAR1 gene for embryonic erythropoiesis","volume":"290","author":"Wang","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.109858_bib98","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib99","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41586-020-2127-x","article-title":"Gut stem cell necroptosis by genome instability triggers bowel inflammation","volume":"580","author":"Wang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.109858_bib100","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41423-019-0237-x","article-title":"ZBP1 mediates interferon-induced necroptosis","volume":"17","author":"Yang","year":"2020","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.celrep.2021.109858_bib101","doi-asserted-by":"crossref","first-page":"12451","DOI":"10.1073\/pnas.93.22.12451","article-title":"An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells","volume":"93","author":"Yeung","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.109858_bib102","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/ni1087","article-title":"The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses","volume":"5","author":"Yoneyama","year":"2004","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2021.109858_bib103","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.cell.2020.02.050","article-title":"Influenza virus Z-RNAs induce ZBP1-mediated necroptosis","volume":"180","author":"Zhang","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.109858_bib104","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1038\/81343","article-title":"Deficiency in caspase-9 or caspase-3 induces compensatory caspase activation","volume":"6","author":"Zheng","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2021.109858_bib105","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1016\/j.cell.2020.03.040","article-title":"Caspase-6 Is a key regulator of innate immunity, inflammasome activation, and host defense","volume":"181","author":"Zheng","year":"2020","journal-title":"Cell"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721013255?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721013255?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:32:31Z","timestamp":1788985951000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124721013255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":106,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["S2211124721013255"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109858","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.741034475.793595710","asserted-by":"object"}]},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.109858","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"109858"}}