{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T02:23:55Z","timestamp":1791685435100,"version":"4.3.4"},"reference-count":57,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004721","name":"University of Tokyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004721","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017M3A9G7073521"],"award-info":[{"award-number":["NRF-2017M3A9G7073521"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer&apos;s Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018985","name":"KAIST Creative Research Initiatives","doi-asserted-by":"publisher","award":["2019R1A2B5B03070352"],"award-info":[{"award-number":["2019R1A2B5B03070352"]}],"id":[{"id":"10.13039\/501100018985","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.celrep.2021.110102","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T21:00:52Z","timestamp":1638910852000},"page":"110102","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"title":["Aberrant role of pyruvate kinase M2 in the regulation of gamma-secretase and memory deficits in Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"37","author":[{"given":"Jonghee","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junho","family":"Hyun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaesang","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunmin","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9715-2585","authenticated-orcid":false,"given":"Yoonseo","family":"Oh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2872-3924","authenticated-orcid":false,"given":"Youbin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Hyeon","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Il","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2271-1076","authenticated-orcid":false,"given":"Dong-Gyu","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Hye","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9686-3120","authenticated-orcid":false,"given":"Yong-Keun","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2021.110102_bib1","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/nchembio1212-1008b","article-title":"Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis (vol 8, pg 839, 2012)","volume":"8","author":"Anastasiou","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2021.110102_bib2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1042\/AN20120006","article-title":"Hypoxia-inducible factor 1 protects hypoxic astrocytes against glutamate toxicity","volume":"4","author":"Badawi","year":"2012","journal-title":"ASN Neuro"},{"key":"10.1016\/j.celrep.2021.110102_bib3","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s007020050174","article-title":"Activities of key glycolytic enzymes in the brains of patients with Alzheimer\u2019s disease","volume":"106","author":"Bigl","year":"1999","journal-title":"J.\u00a0Neural Transm. (Vienna)"},{"key":"10.1016\/j.celrep.2021.110102_bib4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.18632\/oncotarget.278","article-title":"No evidence for a shift in pyruvate kinase PKM1 to PKM2 expression during tumorigenesis","volume":"2","author":"Bluemlein","year":"2011","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2021.110102_bib5","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.nbd.2005.11.002","article-title":"Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer\u2019s disease","volume":"22","author":"Butterfield","year":"2006","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2021.110102_bib6","doi-asserted-by":"crossref","first-page":"13357","DOI":"10.1523\/JNEUROSCI.2718-07.2007","article-title":"Progesterone and estrogen regulate Alzheimer-like neuropathology in female 3xTg-AD mice","volume":"27","author":"Carroll","year":"2007","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.110102_bib7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pneurobio.2013.06.004","article-title":"Decoding Alzheimer\u2019s disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies","volume":"108","author":"Chen","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.celrep.2021.110102_bib8","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1038\/nature04667","article-title":"TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity","volume":"440","author":"Chen","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.110102_bib9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/nature06667","article-title":"Pyruvate kinase M2 is a phosphotyrosine-binding protein","volume":"452","author":"Christofk","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.110102_bib10","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.nbd.2007.06.013","article-title":"Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice","volume":"28","author":"Clinton","year":"2007","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.celrep.2021.110102_bib11","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.molcel.2012.01.001","article-title":"Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase","volume":"45","author":"Gao","year":"2012","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2021.110102_bib12","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0006-291X(84)80190-4","article-title":"Alzheimer\u2019s disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein","volume":"120","author":"Glenner","year":"1984","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2021.110102_bib13","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1474-9726.2012.00817.x","article-title":"Oxidative lipid modification of nicastrin enhances amyloidogenic \u03b3-secretase activity in Alzheimer\u2019s disease","volume":"11","author":"Gwon","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.celrep.2021.110102_bib14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","article-title":"Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer\u2019s amyloid beta-peptide","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2021.110102_bib15","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1007\/s00018-013-1515-x","article-title":"OCIAD2 activates \u03b3-secretase to enhance amyloid \u03b2 production by interacting with nicastrin","volume":"71","author":"Han","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.celrep.2021.110102_bib16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0005-2744(78)90169-9","article-title":"Purification of four pyruvate kinase isozymes of rats by affinity elution chromatography","volume":"524","author":"Harada","year":"1978","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2021.110102_bib17","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1756-6606-2-6","article-title":"Transgenic up-regulation of alpha-CaMKII in forebrain leads to increased anxiety-like behaviors and aggression","volume":"2","author":"Hasegawa","year":"2009","journal-title":"Mol. Brain"},{"key":"10.1016\/j.celrep.2021.110102_bib18","doi-asserted-by":"crossref","first-page":"17706","DOI":"10.1074\/jbc.M700094200","article-title":"Regulation of cell proliferation by interleukin-3-induced nuclear translocation of pyruvate kinase","volume":"282","author":"Hoshino","year":"2007","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.110102_bib19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.274.5284.99","article-title":"Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice","volume":"274","author":"Hsiao","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.110102_bib20","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1172\/JCI66827","article-title":"Fc\u03b3RIIb mediates amyloid-\u03b2 neurotoxicity and memory impairment in Alzheimer\u2019s disease","volume":"123","author":"Kam","year":"2013","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2021.110102_bib21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s004320050175","article-title":"Expression of hypoxia-inducible genes in tumor cells","volume":"124","author":"Kress","year":"1998","journal-title":"J.\u00a0Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.celrep.2021.110102_bib22","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1038\/nprot.2013.155","article-title":"Object recognition test in mice","volume":"8","author":"Leger","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2021.110102_bib23","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.neurobiolaging.2007.10.011","article-title":"Hypoxia increases Abeta generation by altering beta- and gamma-cleavage of APP","volume":"30","author":"Li","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.celrep.2021.110102_bib24","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.tem.2012.06.010","article-title":"Emerging roles of PKM2 in cell metabolism and cancer progression","volume":"23","author":"Luo","year":"2012","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2021.110102_bib25","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.cell.2011.03.054","article-title":"Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1","volume":"145","author":"Luo","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.110102_bib26","doi-asserted-by":"crossref","first-page":"4245","DOI":"10.1073\/pnas.82.12.4245","article-title":"Amyloid plaque core protein in Alzheimer disease and Down syndrome","volume":"82","author":"Masters","year":"1985","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.110102_bib27","doi-asserted-by":"crossref","first-page":"13139","DOI":"10.1073\/pnas.0806133105","article-title":"NGF and BDNF signaling control amyloidogenic route and Abeta production in hippocampal neurons","volume":"105","author":"Matrone","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.110102_bib28","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.biocel.2010.02.005","article-title":"Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells","volume":"43","author":"Mazurek","year":"2011","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.celrep.2021.110102_bib29","doi-asserted-by":"crossref","first-page":"6891","DOI":"10.1038\/sj.onc.1204792","article-title":"Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7","volume":"20","author":"Mazurek","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2021.110102_bib30","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.semcancer.2005.04.009","article-title":"Pyruvate kinase type M2 and its role in tumor growth and spreading","volume":"15","author":"Mazurek","year":"2005","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.celrep.2021.110102_bib31","doi-asserted-by":"crossref","first-page":"13807","DOI":"10.1016\/S0021-9258(18)67091-7","article-title":"The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing","volume":"261","author":"Noguchi","year":"1986","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.110102_bib32","doi-asserted-by":"crossref","first-page":"14366","DOI":"10.1016\/S0021-9258(18)47947-1","article-title":"The L- and R-type isozymes of rat pyruvate kinase are produced from a single gene by use of different promoters","volume":"262","author":"Noguchi","year":"1987","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.110102_bib33","doi-asserted-by":"crossref","first-page":"43430","DOI":"10.1074\/jbc.M306957200","article-title":"Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin","volume":"278","author":"Nyabi","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.110102_bib34","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.110102_bib35","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer\u2019s disease with plaques and tangles: intracellular Abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.110102_bib36","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.bbrc.2011.11.042","article-title":"Endoplasmic reticulum stress enhances \u03b3-secretase activity","volume":"416","author":"Ohta","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2021.110102_bib37","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/jnr.20203","article-title":"Functional reconstitution of gamma-secretase through coordinated expression of presenilin, nicastrin, Aph-1, and Pen-2","volume":"77","author":"Periz","year":"2004","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.celrep.2021.110102_bib38","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer\u2019s Disease REPLY","volume":"362","author":"Querfurth","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2021.110102_bib39","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1126\/science.1132813","article-title":"100 years and counting: prospects for defeating Alzheimer\u2019s disease","volume":"314","author":"Roberson","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.110102_bib40","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1006\/abio.1994.1112","article-title":"Analysis of molecular masses and oligomeric states of protein complexes by blue native electrophoresis and isolation of membrane protein complexes by two-dimensional native electrophoresis","volume":"217","author":"Sch\u00e4gger","year":"1994","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.celrep.2021.110102_bib41","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2007.10.012","article-title":"Presenilin: running with scissors in the membrane","volume":"131","author":"Selkoe","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.110102_bib42","doi-asserted-by":"crossref","first-page":"17721","DOI":"10.1074\/jbc.M800013200","article-title":"Hydrogen peroxide promotes Abeta production through JNK-dependent activation of gamma-secretase","volume":"283","author":"Shen","year":"2008","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.110102_bib43","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0896-6273(03)00367-2","article-title":"The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide","volume":"39","author":"Soucek","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.110102_bib44","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1158\/0008-5472.CAN-06-2870","article-title":"Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death","volume":"67","author":"Stet\u00e1k","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2021.110102_bib45","doi-asserted-by":"crossref","first-page":"18727","DOI":"10.1073\/pnas.0606298103","article-title":"Hypoxia facilitates Alzheimer\u2019s disease pathogenesis by up-regulating BACE1 gene expression","volume":"103","author":"Sun","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.110102_bib46","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1126\/science.1160649","article-title":"The orphan G protein-coupled receptor 3 modulates amyloid-beta peptide generation in neurons","volume":"323","author":"Thathiah","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.110102_bib47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1038\/nm.3023","article-title":"\u03b2-arrestin 2 regulates A\u03b2 generation and \u03b3-secretase activity in Alzheimer\u2019s disease","volume":"19","author":"Thathiah","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2021.110102_bib48","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1016\/j.celrep.2014.07.028","article-title":"Nontranscriptional role of Hif-1\u03b1 in activation of \u03b3-secretase and notch signaling in breast cancer","volume":"8","author":"Villa","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.110102_bib49","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1096\/fj.06-5839fje","article-title":"Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia","volume":"20","author":"Wang","year":"2006","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2021.110102_bib50","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1073\/pnas.1311249111","article-title":"JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1\u03b1-mediated glucose metabolism","volume":"111","author":"Wang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.110102_bib51","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nrc3064","article-title":"Targeting hypoxia in cancer therapy","volume":"11","author":"Wilson","year":"2011","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2021.110102_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj3370001","article-title":"Nutrient and hormonal regulation of pyruvate kinase gene expression","volume":"337","author":"Yamada","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/j.celrep.2021.110102_bib53","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.cell.2012.07.018","article-title":"PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis","volume":"150","author":"Yang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.110102_bib54","doi-asserted-by":"crossref","first-page":"e28263","DOI":"10.1371\/journal.pone.0028263","article-title":"Hypoxia due to cardiac arrest induces a time-dependent increase in serum amyloid \u03b2 levels in humans","volume":"6","author":"Zetterberg","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2021.110102_bib55","doi-asserted-by":"crossref","first-page":"11929","DOI":"10.1523\/JNEUROSCI.1860-14.2014","article-title":"An RNA-sequencing transcriptome and splicing database of glia, neurons, and vascular cells of the cerebral cortex","volume":"34","author":"Zhang","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.110102_bib56","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1080\/15384101.2015.1064203","article-title":"Nuclear translocation of PKM2 modulates astrocyte proliferation via p27 and -catenin pathway after spinal cord injury","volume":"14","author":"Zhang","year":"2015","journal-title":"Cell Cycle"},{"key":"10.1016\/j.celrep.2021.110102_bib57","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1073\/pnas.96.4.1291","article-title":"Modulation of type M2 pyruvate kinase activity by the human papillomavirus type 16 E7 oncoprotein","volume":"96","author":"Zwerschke","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721015965?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721015965?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:46:19Z","timestamp":1778841979000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124721015965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S2211124721015965"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2021.110102","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aberrant role of pyruvate kinase M2 in the regulation of gamma-secretase and memory deficits in Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.110102","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"110102"}}