{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:46:50Z","timestamp":1792622810427,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013669","name":"Ionis Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000747","name":"Wolfson College, University of Oxford","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000747","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.celrep.2021.110108","type":"journal-article","created":{"date-parts":[[2021,12,14]],"date-time":"2021-12-14T11:20:18Z","timestamp":1639480818000},"page":"110108","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration"],"prefix":"10.1016","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-0300","authenticated-orcid":false,"given":"Stacey Anne","family":"Gould","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Gilley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5895-6684","authenticated-orcid":false,"given":"Karen","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5176-739X","authenticated-orcid":false,"given":"Paymaan","family":"Jafar-Nejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Rigo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Coleman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.celrep.2021.110108_bib56","doi-asserted-by":"crossref","first-page":"e1002472.","DOI":"10.1371\/journal.pbio.1002472","article-title":"NMNAT2:HSP90 complex mediates proteostasis in proteinopathies","volume":"14","author":"Ali","year":"2016","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2021.110108_bib2","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/hmg\/ddr449","article-title":"NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy","volume":"21","author":"Ali","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2021.110108_bib3","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jneumeth.2003.10.016","article-title":"Quantitative and qualitative analysis of Wallerian degeneration using restricted axonal labelling in YFP-H mice","volume":"134","author":"Beirowski","year":"2004","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.celrep.2021.110108_bib4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1471-2202-6-6","article-title":"The progressive nature of Wallerian degeneration in wild-type and slow Wallerian degeneration (WldS) nerves","volume":"6","author":"Beirowski","year":"2005","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.celrep.2021.110108_bib5","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1111\/j.1460-9568.1995.tb01155.x","article-title":"The rate of Wallerian degeneration in cultured neurons from wild type and C57BL\/WldS mice depends on time in culture and may be extended in the presence of elevated K+ levels","volume":"7","author":"Buckmaster","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.celrep.2021.110108_bib6","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1083\/jcb.201008050","article-title":"Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology","volume":"193","author":"Chen","year":"2011","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2021.110108_bib7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/s41583-020-0269-3","article-title":"Programmed axon degeneration: from mouse to mechanism to medicine","volume":"21","author":"Coleman","year":"2020","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2021.110108_bib8","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nrn3680","article-title":"Wallerian degeneration: an emerging axon death pathway linking injury and disease","volume":"15","author":"Conforti","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2021.110108_bib9","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.cub.2017.01.070","article-title":"NMN Deamidase Delays Wallerian Degeneration and Rescues Axonal Defects Caused by NMNAT2 Deficiency In\u00a0Vivo","volume":"27","author":"Di Stefano","year":"2017","journal-title":"Curr. Biol."},{"issue":"Suppl 1","key":"10.1016\/j.celrep.2021.110108_bib10","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1097\/j.pain.0000000000001528","article-title":"Axon degeneration: mechanistic insights lead to therapeutic opportunities for the prevention and treatment of peripheral neuropathy","volume":"160","author":"DiAntonio","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.celrep.2021.110108_bib11","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.neuron.2017.02.022","article-title":"The SARM1 Toll\/Interleukin-1 Receptor Domain Possesses Intrinsic NAD+ Cleavage Activity that Promotes Pathological Axonal Degeneration","volume":"93","author":"Essuman","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.110108_bib12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cub.2017.12.024","article-title":"TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes","volume":"28","author":"Essuman","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2021.110108_bib13","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1093\/hmg\/ddt587","article-title":"A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis","volume":"23","author":"Fogh","year":"2014","journal-title":"Hum. Mol. Genet."},{"issue":"Pt B","key":"10.1016\/j.celrep.2021.110108_bib14","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.brainres.2016.03.029","article-title":"The UPR and synaptic dysfunction in neurodegeneration","volume":"1648","author":"Freeman","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2021.110108_bib15","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1093\/brain\/aww251","article-title":"Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice","volume":"139","author":"Geisler","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2021.110108_bib16","doi-asserted-by":"crossref","first-page":"129920","DOI":"10.1172\/jci.insight.129920","article-title":"Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program","volume":"4","author":"Geisler","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2021.110108_bib17","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1084\/jem.20181040","article-title":"Gene therapy targeting SARM1 blocks pathological axon degeneration in mice","volume":"216","author":"Geisler","year":"2019","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2021.110108_bib18","doi-asserted-by":"crossref","first-page":"13569","DOI":"10.1523\/JNEUROSCI.1197-13.2013","article-title":"Sarm1-mediated axon degeneration requires both SAM and TIR interactions","volume":"33","author":"Gerdts","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.110108_bib19","doi-asserted-by":"crossref","first-page":"e1000300","DOI":"10.1371\/journal.pbio.1000300","article-title":"Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons","volume":"8","author":"Gilley","year":"2010","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2021.110108_bib20","doi-asserted-by":"crossref","first-page":"13410","DOI":"10.1523\/JNEUROSCI.1534-13.2013","article-title":"Rescue of peripheral and CNS axon defects in mice lacking NMNAT2","volume":"33","author":"Gilley","year":"2013","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.110108_bib21","doi-asserted-by":"crossref","first-page":"1974","DOI":"10.1016\/j.celrep.2015.02.060","article-title":"Absence of SARM1 rescues development and survival of NMNAT2-deficient axons","volume":"10","author":"Gilley","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.110108_bib22","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.celrep.2017.09.027","article-title":"Sarm1 Deletion, but Not WldS, Confers Lifelong Rescue in a Mouse Model of Severe Axonopathy","volume":"21","author":"Gilley","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.110108_bib23","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1093\/hmg\/ddy356","article-title":"Low levels of NMNAT2 compromise axon development and survival","volume":"28","author":"Gilley","year":"2019","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2021.110108_bib24","article-title":"Enrichment of SARM1 alleles encoding variants with constitutively hyperactive NADase in patients with ALS and other motor nerve disorders","author":"Gilley","year":"2021","journal-title":"medRxiv"},{"key":"10.1016\/j.celrep.2021.110108_bib25","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0479-19.2020","article-title":"Collapsin Response Mediator Protein 4 (CRMP4) Facilitates Wallerian Degeneration and Axon Regeneration following Sciatic Nerve Injury","volume":"7","author":"Girouard","year":"2020","journal-title":"eNeuro"},{"key":"10.1016\/j.celrep.2021.110108_bib26","doi-asserted-by":"crossref","first-page":"113607","DOI":"10.1016\/j.expneurol.2021.113607","article-title":"Protection against oxaliplatin-induced mechanical and thermal hypersensitivity in Sarm1-\/- mice","volume":"338","author":"Gould","year":"2021","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.celrep.2021.110108_bib27","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1093\/brain\/awx074","article-title":"Repurposed drugs targeting eIF2\u03b1-P-mediated translational repression prevent neurodegeneration in mice","volume":"140","author":"Halliday","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2021.110108_bib28","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1093\/brain\/aww001","article-title":"Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lacking Sarm1","volume":"139","author":"Henninger","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.celrep.2021.110108_bib29","doi-asserted-by":"crossref","first-page":"e47869","DOI":"10.1371\/journal.pone.0047869","article-title":"Nicotinamide mononucleotide adenylyltransferase 2 (Nmnat2) regulates axon integrity in the mouse embryo","volume":"7","author":"Hicks","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.celrep.2021.110108_bib30","doi-asserted-by":"crossref","first-page":"108588","DOI":"10.1016\/j.celrep.2020.108588","article-title":"Small Molecule SARM1 Inhibitors Recapitulate the SARM1-\/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate","volume":"34","author":"Hughes","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2021.110108_bib31","doi-asserted-by":"crossref","first-page":"112958","DOI":"10.1016\/j.expneurol.2019.112958","article-title":"Homozygous NMNAT2 mutation in sisters with polyneuropathy and erythromelalgia","volume":"320","author":"Huppke","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.celrep.2021.110108_bib32","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2021.110108_bib33","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1084\/jem.20070868","article-title":"MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival","volume":"204","author":"Kim","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2021.110108_bib34","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/s41593-018-0300-4","article-title":"ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair","volume":"22","author":"Klim","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2021.110108_bib35","doi-asserted-by":"crossref","first-page":"dmm043208","DOI":"10.1242\/dmm.043208","article-title":"Control of translation elongation in health and disease","volume":"13","author":"Knight","year":"2020","journal-title":"Dis. Model. Mech."},{"key":"10.1016\/j.celrep.2021.110108_bib36","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/hmg\/ddr492","article-title":"CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy","volume":"21","author":"Ljungberg","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.celrep.2021.110108_bib37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-0716-0585-1_2","article-title":"Axon Degeneration Assays in Superior Cervical Ganglion Explant Cultures","volume":"2143","author":"Loreto","year":"2020","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2021.110108_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chembiol.2019.11.002","article-title":"Emergence of SARM1 as a Potential Therapeutic Target for Wallerian-type Diseases","volume":"27","author":"Loring","year":"2020","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.celrep.2021.110108_bib39","doi-asserted-by":"crossref","first-page":"115644","DOI":"10.1016\/j.bmc.2020.115644","article-title":"Identification of the first noncompetitive SARM1 inhibitors","volume":"28","author":"Loring","year":"2020","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.celrep.2021.110108_bib40","doi-asserted-by":"crossref","first-page":"112961","DOI":"10.1016\/j.expneurol.2019.112961","article-title":"Severe biallelic loss-of-function mutations in nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) in two fetuses with fetal akinesia deformation sequence","volume":"320","author":"Lukacs","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.celrep.2021.110108_bib41","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/s41593-018-0293-z","article-title":"Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration","volume":"22","author":"Melamed","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2021.110108_bib42","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/nn.2290","article-title":"A DLK and JNK Dependent Axon Self-destruction Program Promotes Wallerian Degeneration","volume":"12","author":"Miller","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2021.110108_bib43","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1126\/science.1223899","article-title":"dSarm\/Sarm1 is required for activation of an injury-induced axon death pathway","volume":"337","author":"Osterloh","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.celrep.2021.110108_bib44","doi-asserted-by":"crossref","first-page":"5525","DOI":"10.1523\/JNEUROSCI.5469-08.2009","article-title":"Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide","volume":"29","author":"Sasaki","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.110108_bib45","doi-asserted-by":"crossref","first-page":"E3696","DOI":"10.1073\/pnas.1216204109","article-title":"SCG10 is a JNK target in the axonal degeneration pathway","volume":"109","author":"Shin","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2021.110108_bib46","doi-asserted-by":"crossref","first-page":"9338","DOI":"10.1523\/JNEUROSCI.0877-14.2014","article-title":"Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons","volume":"34","author":"Summers","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2021.110108_bib47","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1093\/nar\/gkl1071","article-title":"Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals","volume":"35","author":"Swayze","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2021.110108_bib48","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/jns.12219","article-title":"Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy","volume":"22","author":"Turkiew","year":"2017","journal-title":"J.\u00a0Peripher. Nerv. Syst."},{"issue":"9","key":"10.1016\/j.celrep.2021.110108_bib49","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1038\/ng.3622","article-title":"Genome-wide association analyses identify new risk variants and the genetic architecture of amyotrophic lateral sclerosis","volume":"48","author":"van Rheenen","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2021.110108_bib50","doi-asserted-by":"crossref","first-page":"e22540","DOI":"10.7554\/eLife.22540","article-title":"MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2","volume":"6","author":"Walker","year":"2017","journal-title":"eLife"},{"key":"10.1016\/j.celrep.2021.110108_bib51","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/jnen\/59.7.599","article-title":"Pathogenesis of axonal degeneration: parallels between Wallerian degeneration and vincristine neuropathy","volume":"59","author":"Wang","year":"2000","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.celrep.2021.110108_bib52","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/s40478-019-0800-9","article-title":"Sarm1 deletion suppresses TDP-43-linked motor neuron degeneration and cortical spine loss","volume":"7","author":"White","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.celrep.2021.110108_bib53","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1016\/j.neuron.2013.08.034","article-title":"Regulation of axon degeneration after injury and in development by the endogenous calpain inhibitor calpastatin","volume":"80","author":"Yang","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2021.110108_bib54","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.isci.2019.05.001","article-title":"A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death","volume":"15","author":"Zhao","year":"2019","journal-title":"iScience"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721016028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721016028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:30:51Z","timestamp":1761910251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124721016028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":54,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["S2211124721016028"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2021.110108","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sarm1 haploinsufficiency or low expression levels after antisense oligonucleotides delay programmed axon degeneration","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.110108","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"110108"}}