{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T06:47:07Z","timestamp":1790750827486,"version":"4.1.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T00:00:00Z","timestamp":1640304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21904107"],"award-info":[{"award-number":["21904107"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672086"],"award-info":[{"award-number":["81672086"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972492"],"award-info":[{"award-number":["81972492"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020T130106ZX"],"award-info":[{"award-number":["2020T130106ZX"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFE0202200"],"award-info":[{"award-number":["2020YFE0202200"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.celrep.2021.110271","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:34:22Z","timestamp":1640651662000},"page":"110271","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":135,"title":["Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19"],"prefix":"10.1016","volume":"38","author":[{"given":"Xiaojie","family":"Bi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4905-3061","authenticated-orcid":false,"given":"Xuan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9520-0619","authenticated-orcid":false,"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6288-5233","authenticated-orcid":false,"given":"Xiao","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juping","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Die","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1803-4327","authenticated-orcid":false,"given":"Weigang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinke","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangjun","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donglian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongguo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haihong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiannan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2021.110271_bib1","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2006-7-9-r80","article-title":"The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins","volume":"7","author":"Adachi","year":"2006","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2021.110271_bib2","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1016\/j.febslet.2011.09.001","article-title":"Assembly and disassembly of the ESCRT-III membrane scission complex","volume":"585","author":"Adell","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.celrep.2021.110271_bib3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1503\/cmaj.061590","article-title":"Urine proteomics: the present and future of measuring urinary protein components in disease","volume":"177","author":"Barratt","year":"2007","journal-title":"CMAJ"},{"key":"10.1016\/j.celrep.2021.110271_bib4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00005-008-0009-2","article-title":"1-Methylnicotinamide and nicotinamide: two related anti-inflammatory agents that differentially affect the functions of activated macrophages","volume":"56","author":"Biedro\u0144","year":"2008","journal-title":"Arch. Immunol. Ther. Exp. (Warsz)"},{"key":"10.1016\/j.celrep.2021.110271_bib5","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1097\/00001756-199411000-00008","article-title":"Expression of GFAP in the striatum and its projection areas in response to striatal quinolinic acid lesion in rats","volume":"5","author":"Block","year":"1994","journal-title":"Neuroreport"},{"key":"10.1016\/j.celrep.2021.110271_bib6","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.freeradbiomed.2011.01.002","article-title":"Interactions of plasmalogens and their diacyl analogs with singlet oxygen in selected model systems","volume":"50","author":"Broniec","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.celrep.2021.110271_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/cells8070733","article-title":"RhoA as a key regulator of innate and adaptive immunity","volume":"8","author":"Bros","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.celrep.2021.110271_bib8","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41577-020-0308-3","article-title":"COVID-19: immunopathology and its implications for therapy","volume":"20","author":"Cao","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2021.110271_bib9","doi-asserted-by":"crossref","first-page":"110102","DOI":"10.1016\/j.mehy.2020.110102","article-title":"SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression","volume":"143","author":"Cecchini","year":"2020","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.celrep.2021.110271_bib10","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.4049\/jimmunol.0900525","article-title":"Overexpression of CXC chemokine ligand 14 exacerbates collagen-induced arthritis","volume":"184","author":"Chen","year":"2010","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2021.110271_bib11","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/s41577-020-0402-6","article-title":"T cell responses in patients with COVID-19","volume":"20","author":"Chen","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2021.110271_bib12","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.ajpath.2012.06.043","article-title":"Eph\/Ephrin signaling in injury and inflammation","volume":"181","author":"Coulthard","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2021.110271_bib13","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-2141.2005.05753.x","article-title":"The interactions between inflammation and coagulation","volume":"131","author":"Esmon","year":"2005","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.celrep.2021.110271_bib14","doi-asserted-by":"crossref","first-page":"11894","DOI":"10.1096\/fj.201901080R","article-title":"Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms","volume":"33","author":"Felizardo","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2021.110271_bib15","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1365-2125.2010.03899.x","article-title":"Inhibitors of propagation of coagulation (factors VIII, IX and XI): a review of current therapeutic practice","volume":"72","author":"Franchini","year":"2011","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.celrep.2021.110271_bib16","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/jmv.25770","article-title":"Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19","volume":"92","author":"Gao","year":"2020","journal-title":"J.\u00a0Med. Virol."},{"key":"10.1016\/j.celrep.2021.110271_bib17","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1152\/physrev.00055.2006","article-title":"Properties of the glomerular barrier and mechanisms of proteinuria","volume":"88","author":"Haraldsson","year":"2008","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.celrep.2021.110271_bib18","article-title":"Coronavirus and PARP expression dysregulate the NAD Metabolome: a potentially actionable component of innate immunity","author":"Heer","year":"2020","journal-title":"bioRxiv"},{"key":"10.1016\/j.celrep.2021.110271_bib19","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1749-6632.1993.tb18300.x","article-title":"Quinolinic acid and inflammation","volume":"679","author":"Heyes","year":"1993","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.celrep.2021.110271_bib20","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1038\/nrm2937","article-title":"Membrane budding and scission by the ESCRT machinery: it's all in the neck","volume":"11","author":"Hurley","year":"2010","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2021.110271_bib21","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.1016\/j.biocel.2013.06.013","article-title":"Podocyte energy metabolism and glomerular diseases","volume":"45","author":"Imasawa","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.celrep.2021.110271_bib22","series-title":"Gene Summary","year":"2020"},{"key":"10.1016\/j.celrep.2021.110271_bib23","doi-asserted-by":"crossref","first-page":"577","DOI":"10.2217\/bmm-2019-0008","article-title":"An update of urine and blood metabolomics in chronic kidney disease","volume":"13","author":"Kalantari","year":"2019","journal-title":"Biomark. Med."},{"key":"10.1016\/j.celrep.2021.110271_bib24","first-page":"e0170","article-title":"Evaluation of coronavirus disease 2019 severity using urine biomarkers","volume":"2","author":"Katagiri","year":"2020","journal-title":"Crit. Care Explor."},{"key":"10.1016\/j.celrep.2021.110271_bib25","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/bioinformatics\/btt703","article-title":"Causal analysis approaches in ingenuity pathway analysis","volume":"30","author":"Kr\u00e4mer","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2021.110271_bib26","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1159\/000045172","article-title":"Plasma and urinary levels of adrenomedullin in chronic glomerulonephritis patients with proteinuria","volume":"80","author":"Kubo","year":"1998","journal-title":"Nephron"},{"key":"10.1016\/j.celrep.2021.110271_bib27","doi-asserted-by":"crossref","first-page":"5","DOI":"10.6026\/97320630002005","article-title":"Mfuzz: a software package for soft clustering of microarray data","volume":"2","author":"Kumar","year":"2007","journal-title":"Bioinformation"},{"key":"10.1016\/j.celrep.2021.110271_bib28","doi-asserted-by":"crossref","first-page":"49459","DOI":"10.1074\/jbc.M108369200","article-title":"The seven amino acids of human RAMP2 (86) and RAMP3 (59) are critical for agonist binding to human adrenomedullin receptors","volume":"276","author":"Kuwasako","year":"2001","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2021.110271_bib29","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nbt.4152","article-title":"Immune-centric network of cytokines and cells in disease context identified by computational mining of PubMed","volume":"36","author":"Kveler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2021.110271_bib30","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1002\/jlb.48.2.174","article-title":"Taurine and hypotaurine content of human leukocytes","volume":"48","author":"Learn","year":"1990","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.celrep.2021.110271_bib31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/j.1440-1797.2010.01386.x","article-title":"Sphingosine-1-phosphate reduces hepatic ischaemia\/reperfusion-induced acute kidney injury through attenuation of endothelial injury in mice","volume":"16","author":"Lee","year":"2011","journal-title":"Nephrology (Carlton)"},{"key":"10.1016\/j.celrep.2021.110271_bib32","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1097\/CCM.0b013e3181c98d21","article-title":"Inflammation and coagulation","volume":"38","author":"Levi","year":"2010","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.celrep.2021.110271_bib33","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1007\/s00467-018-3988-1","article-title":"Urinary epidermal growth factor as a prognostic marker for the progression of Alport syndrome in children","volume":"33","author":"Li","year":"2018","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.celrep.2021.110271_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.urine.2021.02.001","article-title":"Urine proteome of COVID-19 patients","volume":"2","author":"Li","year":"2020","journal-title":"Urine"},{"key":"10.1016\/j.celrep.2021.110271_bib35","doi-asserted-by":"crossref","first-page":"104024","DOI":"10.1155\/2013\/104024","article-title":"Quinolinic acid: an endogenous neurotoxin with multiple targets","volume":"2013","author":"Lugo-Huitr\u00f3n","year":"2013","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.celrep.2021.110271_bib36","first-page":"16","article-title":"The beneficial role of retinoids in glomerular disease","volume":"2","author":"Mallipattu","year":"2015","journal-title":"Front. Med. (Lausanne)"},{"key":"10.1016\/j.celrep.2021.110271_bib37","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00726-012-1361-4","article-title":"Taurine and inflammatory diseases","volume":"46","author":"Marcinkiewicz","year":"2014","journal-title":"Amino Acids"},{"key":"10.1016\/j.celrep.2021.110271_bib38","article-title":"UMAP: uniform manifold approximation and projection for dimension reduction","author":"McInnes","year":"2018","journal-title":"arXiv"},{"key":"10.1016\/j.celrep.2021.110271_bib39","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cels.2020.05.012","article-title":"Ultra-high-throughput clinical proteomics reveals classifiers of COVID-19 infection","volume":"11","author":"Messner","year":"2020","journal-title":"Cell Syst."},{"key":"10.1016\/j.celrep.2021.110271_bib40","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF02550580","article-title":"Urinary cAMP activity in chronic renal failure","volume":"30","author":"Mocan","year":"1998","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.celrep.2021.110271_bib41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1177\/0300985812469883","article-title":"Getting leukocytes to the site of inflammation","volume":"50","author":"Muller","year":"2013","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.celrep.2021.110271_bib42","doi-asserted-by":"crossref","first-page":"4752","DOI":"10.1021\/acs.jproteome.5b00826","article-title":"Advancing urinary protein biomarker discovery by data-independent acquisition on a quadrupole-orbitrap mass spectrometer","volume":"14","author":"Muntel","year":"2015","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.celrep.2021.110271_bib43","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1681\/ASN.V131125","article-title":"Urinary megalin deficiency implicates abnormal tubular endocytic function in Fanconi syndrome","volume":"13","author":"Norden","year":"2002","journal-title":"J.\u00a0Am. Soc. Nephrol."},{"key":"10.1016\/j.celrep.2021.110271_bib44","doi-asserted-by":"crossref","first-page":"12","DOI":"10.11604\/pamj.supp.2020.35.2.22877","article-title":"COVID-19 infection and oxidative stress: an under-explored approach for prevention and treatment?","volume":"35","author":"Ntyonga-Pono","year":"2020","journal-title":"Pan Afr. Med. J."},{"key":"10.1016\/j.celrep.2021.110271_bib45","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1242\/jcs.02777","article-title":"EphB2 and ephrin-B1 expressed in the adult kidney regulate the cytoarchitecture of medullary tubule cells through Rho family GTPases","volume":"119","author":"Ogawa","year":"2006","journal-title":"J.\u00a0Cell Sci."},{"key":"10.1016\/j.celrep.2021.110271_bib46","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1161\/ATVBAHA.110.205500","article-title":"Inhibition of liver x receptor\/retinoid X receptor-mediated transcription contributes to the proatherogenic effects of arsenic in macrophages in\u00a0vitro","volume":"30","author":"Padovani","year":"2010","journal-title":"Arteriosc. Thromb. Vasc. Biol."},{"key":"10.1016\/j.celrep.2021.110271_bib47","doi-asserted-by":"crossref","DOI":"10.3390\/metabo10050186","article-title":"MetaboAnalystR 3.0: toward an optimized workflow for global metabolomics","volume":"10","author":"Pang","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.celrep.2021.110271_bib48","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/nrneph.2016.127","article-title":"Podocyte-actin dynamics in health and disease","volume":"12","author":"Perico","year":"2016","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.celrep.2021.110271_bib49","article-title":"Dysregulation of immune response in patients with COVID-19 in Wuhan, China","author":"Qin","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.celrep.2021.110271_bib50","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S1074-7613(00)80545-2","article-title":"Networking Rho family GTPases in lymphocytes","volume":"8","author":"Reif","year":"1998","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2021.110271_bib51","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.1016\/S0140-6736(19)32563-2","article-title":"Acute kidney injury","volume":"394","author":"Ronco","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2021.110271_bib52","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1515\/cclm-2020-0220","article-title":"The value of urine biochemical parameters in the prediction of the severity of coronavirus disease 2019","volume":"58","author":"Rui","year":"2020","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.celrep.2021.110271_bib53","doi-asserted-by":"crossref","DOI":"10.12688\/f1000research.20105.1","article-title":"Podocyte RhoGTPases: new therapeutic targets for nephrotic syndrome?","volume":"8","author":"Saleem","year":"2019","journal-title":"F1000Res"},{"key":"10.1016\/j.celrep.2021.110271_bib54","doi-asserted-by":"crossref","DOI":"10.4161\/sgtp.28208","article-title":"Rho-GTPases as key regulators of T lymphocyte biology","volume":"5","author":"Saoudi","year":"2014","journal-title":"Small GTPases"},{"key":"10.1016\/j.celrep.2021.110271_bib55","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/S0165-5728(98)00133-7","article-title":"Expression of interleukin 6 in the rat striatum following stereotaxic injection of quinolinic acid","volume":"89","author":"Schiefer","year":"1998","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.celrep.2021.110271_bib56","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/j.cell.2020.08.001","article-title":"Severe COVID-19 is marked by a dysregulated myeloid cell compartment","volume":"182","author":"Schulte-Schrepping","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.110271_bib57","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1160\/TH07-02-0150","article-title":"Coagulation factor V and thrombophilia: background and mechanisms","volume":"98","author":"Segers","year":"2007","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.celrep.2021.110271_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.05.032","article-title":"Proteomic and metabolomic characterization of COVID-19 patient sera","author":"Shen","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2021.110271_bib59","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/ki.2013.82","article-title":"Inhibition of TGF-\u03b21-receptor posttranslational core fucosylation attenuates rat renal interstitial fibrosis","volume":"84","author":"Shen","year":"2013","journal-title":"Kidney Int."},{"key":"10.1016\/j.celrep.2021.110271_bib60","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.2147\/TCRM.S273700","article-title":"N-acetylcysteine to combat COVID-19: an evidence review","volume":"16","author":"Shi","year":"2020","journal-title":"Ther. Clin. Risk Manag."},{"key":"10.1016\/j.celrep.2021.110271_bib61","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.3389\/fimmu.2019.02565","article-title":"Tryptophan metabolism in inflammaging: from biomarker to therapeutic target","volume":"10","author":"Sorgdrager","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2021.110271_bib62","doi-asserted-by":"crossref","first-page":"17049","DOI":"10.1073\/pnas.0903316106","article-title":"The Tor and PKA signaling pathways independently target the Atg1\/Atg13 protein kinase complex to control autophagy","volume":"106","author":"Stephan","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.celrep.2021.110271_bib63","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.kint.2020.04.003","article-title":"Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China","volume":"98","author":"Su","year":"2020","journal-title":"Kidney Int."},{"key":"10.1016\/j.celrep.2021.110271_bib64","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/labinvest.2015.164","article-title":"Links between coagulation, inflammation, regeneration, and fibrosis in kidney pathology","volume":"96","author":"Su\u00e1rez-\u00c1lvarez","year":"2016","journal-title":"Lab. Invest."},{"key":"10.1016\/j.celrep.2021.110271_bib65","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41392-020-0148-4","article-title":"Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study","volume":"5","author":"Tan","year":"2020","journal-title":"Signal Transduct. Target Ther."},{"key":"10.1016\/j.celrep.2021.110271_bib66","article-title":"COVID-19 infection results in alterations of the kynurenine pathway and fatty acid metabolism that correlate with IL-6 levels and renal status","author":"Thomas","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.celrep.2021.110271_bib67","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1038\/s41467-020-19706-9","article-title":"Immune suppression in the early stage of COVID-19 disease","volume":"11","author":"Tian","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2021.110271_bib68","doi-asserted-by":"crossref","first-page":"e13257","DOI":"10.15252\/emmm.202013257","article-title":"Urinary proteome profiling for stratifying patients with familial Parkinson's disease","author":"Virreira Winter","year":"2021","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.celrep.2021.110271_bib69","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/0009-8981(77)90359-X","article-title":"Urinary cyclic AMP and post-traumatic acute renal failure","volume":"75","author":"Vitek","year":"1977","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.celrep.2021.110271_bib70","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1074\/mcp.RA119.001873","article-title":"Characterizing patients with recurrent urinary tract infections in vesicoureteral reflux: a pilot study of the urinary proteome","volume":"19","author":"Vitko","year":"2020","journal-title":"Mol. Cell Proteomics"},{"issue":"6","key":"10.1016\/j.celrep.2021.110271_bib80","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.chemphyslip.2011.06.008","article-title":"Plasmalogens the neglected regulatory and scavenging lipid species","volume":"164","author":"Wallner","year":"2011","journal-title":"Chem Phys Lipids"},{"key":"10.1016\/j.celrep.2021.110271_bib71","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1189\/jlb.0207092","article-title":"Chorionic gonadotropin can enhance innate immunity by stimulating macrophage function","volume":"82","author":"Wan","year":"2007","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.celrep.2021.110271_bib72","series-title":"COVID-19 Therapeutic Trial Synopsis","year":"2020"},{"key":"10.1016\/j.celrep.2021.110271_bib75","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s11926-019-0825-x","article-title":"Ephrins and Eph receptor signaling in tissue repair and fibrosis","volume":"21","author":"Wu","year":"2019","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.celrep.2021.110271_bib76","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1093\/nsr\/nwaa086","article-title":"Plasma metabolomic and lipidomic alterations associated with COVID-19","volume":"7","author":"Wu","year":"2020","journal-title":"Natl. Sci. Rev."},{"key":"10.1016\/j.celrep.2021.110271_bib77","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1093\/bioinformatics\/btx763","article-title":"shinyCircos: an R\/Shiny application for interactive creation of Circos plot","volume":"34","author":"Yu","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2021.110271_bib78","doi-asserted-by":"crossref","first-page":"1750202","DOI":"10.1080\/20013078.2020.1750202","article-title":"A circulating extracellular vesicles-based novel screening tool for colorectal cancer revealed by shotgun and data-independent acquisition mass spectrometry","volume":"9","author":"Zheng","year":"2020","journal-title":"J.\u00a0Extracell. Vesicles"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721017836?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124721017836?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:35:27Z","timestamp":1761910527000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124721017836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":77,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["S2211124721017836"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2021.110271","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2021.110271","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"110271"}}