{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:47:45Z","timestamp":1792097265237,"version":"4.4.0"},"reference-count":59,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010663","name":"ERC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001698","name":"Israel Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001927","name":"Advanced Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001927","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005984","name":"Dr. Miriam and Sheldon G. Adelson Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005984","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.celrep.2022.110418","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T16:16:46Z","timestamp":1645546606000},"page":"110418","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors"],"prefix":"10.1016","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2970-6739","authenticated-orcid":false,"given":"Nishanth Belugali","family":"Nataraj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Noronha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joo Sang","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soma","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsha Raj","family":"Mohan Raju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunachalam","family":"Sekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6216-011X","authenticated-orcid":false,"given":"Binyamin","family":"Zuckerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshit","family":"Lindzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Tarcitano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Selitrennik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ido","family":"Livneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Drago-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0008-4884","authenticated-orcid":false,"given":"Oscar","family":"Rueda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Caldas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2108-3330","authenticated-orcid":false,"given":"Sima","family":"Lev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9526-197X","authenticated-orcid":false,"given":"Tamar","family":"Geiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Ciechanover","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Ulitsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rony","family":"Seger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eytan","family":"Ruppin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosef","family":"Yarden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2022.110418_bib1","doi-asserted-by":"crossref","first-page":"eaan3000","DOI":"10.1126\/scisignal.aan3000","article-title":"The transcription factor Lef1 switches partners from beta-catenin to Smad3 during muscle stem cell quiescence","volume":"11","author":"Aloysius","year":"2018","journal-title":"Sci. Signal"},{"key":"10.1016\/j.celrep.2022.110418_bib2","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq--a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2022.110418_bib3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.canlet.2006.02.019","article-title":"The human Cyr61 gene is a transcriptional target of transforming growth factor beta in cancer cells","volume":"246","author":"Bartholin","year":"2007","journal-title":"Cancer Lett."},{"key":"10.1016\/j.celrep.2022.110418_bib4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3816\/CBC.2010.n.065","article-title":"CLEOPATRA: a phase III evaluation of pertuzumab and trastuzumab for HER2-positive metastatic breast cancer","volume":"10","author":"Baselga","year":"2010","journal-title":"Clin. Breast Cancer"},{"key":"10.1016\/j.celrep.2022.110418_bib5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J.\u00a0R. Stat. Soc. Ser. B (Methodological)"},{"key":"10.1016\/j.celrep.2022.110418_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.26508\/lsa.201900623","article-title":"Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling","volume":"3","author":"Bersini","year":"2020","journal-title":"Life Sci. Alliance"},{"key":"10.1016\/j.celrep.2022.110418_bib7","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ng.3512","article-title":"Mutations in nuclear pore genes NUP93, NUP205 and XPO5 cause steroid-resistant nephrotic syndrome","volume":"48","author":"Braun","year":"2016","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2022.110418_bib8","doi-asserted-by":"crossref","first-page":"21183","DOI":"10.1074\/jbc.M603270200","article-title":"The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression","volume":"281","author":"Chen","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2022.110418_bib9","doi-asserted-by":"crossref","first-page":"4022","DOI":"10.1128\/MCB.00124-10","article-title":"Specific nucleoporin requirement for Smad nuclear translocation","volume":"30","author":"Chen","year":"2010","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2022.110418_bib10","doi-asserted-by":"crossref","first-page":"12372","DOI":"10.1073\/pnas.1109363108","article-title":"Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer","volume":"108","author":"Cheung","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.celrep.2022.110418_bib11","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.molcel.2008.08.007","article-title":"Identification and characterization of a general nuclear translocation signal in signaling proteins","volume":"31","author":"Chuderland","year":"2008","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2022.110418_bib12","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1021\/pr101065j","article-title":"Andromeda: a peptide search engine integrated into the MaxQuant environment","volume":"10","author":"Cox","year":"2011","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.celrep.2022.110418_bib13","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature10983","article-title":"The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups","volume":"486","author":"Curtis","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.110418_bib14","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/emboj.2013.19","article-title":"A new genome-driven integrated classification of breast cancer and its implications","volume":"32","author":"Dawson","year":"2013","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2022.110418_bib15","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2022.110418_bib16","doi-asserted-by":"crossref","first-page":"15942","DOI":"10.1074\/jbc.M500814200","article-title":"NF-{kappa}B is transported into the nucleus by importin {alpha}3 and importin {alpha}4","volume":"280","author":"Fagerlund","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2022.110418_bib17","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1056\/NEJMra1001389","article-title":"Triple-negative breast cancer","volume":"363","author":"Foulkes","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2022.110418_bib18","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1091\/mbc.e03-11-0839","article-title":"Importin 7 and importin alpha\/importin beta are nuclear import receptors for the glucocorticoid receptor","volume":"15","author":"Freedman","year":"2004","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.celrep.2022.110418_bib19","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1471-2164-15-74","article-title":"Comprehensive analysis of beta-catenin target genes in colorectal carcinoma cell lines with deregulated Wnt\/beta-catenin signaling","volume":"15","author":"Herbst","year":"2014","journal-title":"BMC Genomics"},{"key":"10.1016\/j.celrep.2022.110418_bib20","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s41596-018-0082-x","article-title":"Single-pot, solid-phase-enhanced sample preparation for proteomics experiments","volume":"14","author":"Hughes","year":"2019","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2022.110418_bib21","doi-asserted-by":"crossref","first-page":"a004903","DOI":"10.1101\/cshperspect.a004903","article-title":"Overview of the matrisome--an inventory of extracellular matrix constituents and functions","volume":"4","author":"Hynes","year":"2012","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.celrep.2022.110418_bib22","doi-asserted-by":"crossref","first-page":"3238","DOI":"10.1101\/gad.1616307","article-title":"A role for microRNAs in maintenance of mouse mammary epithelial progenitor cells","volume":"21","author":"Ibarra","year":"2007","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2022.110418_bib23","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1128\/MCB.01830-05","article-title":"Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2","volume":"26","author":"Itahana","year":"2006","journal-title":"Mol. Cell Biol"},{"key":"10.1016\/j.celrep.2022.110418_bib24","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nature10822","article-title":"Ubiquitin-dependent regulation of COPII coat size and function","volume":"482","author":"Jin","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.110418_bib25","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1158\/1535-7163.MCT-14-0950","article-title":"betaIII-tubulin regulates breast cancer metastases to the brain","volume":"14","author":"Kanojia","year":"2015","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.celrep.2022.110418_bib26","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1016\/j.cell.2016.01.034","article-title":"The nuclear pore complex as a flexible and dynamic gate","volume":"164","author":"Knockenhauer","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.110418_bib27","doi-asserted-by":"crossref","first-page":"7329","DOI":"10.1038\/s41598-018-25672-6","article-title":"Dramatic dysbalancing of the Wnt pathway in breast cancers","volume":"8","author":"Koval","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2022.110418_bib28","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.cell.2018.03.007","article-title":"Evolutionary convergence of pathway-specific enzyme expression stoichiometry","volume":"173","author":"Lalanne","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.110418_bib29","doi-asserted-by":"crossref","first-page":"16025","DOI":"10.1038\/celldisc.2016.25","article-title":"Integrative analysis of mutational and transcriptional profiles reveals driver mutations of metastatic breast cancers","volume":"2","author":"Lee","year":"2016","journal-title":"Cell Discov"},{"key":"10.1016\/j.celrep.2022.110418_bib30","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.celrep.2022.110418_bib31","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0378-1119(95)00508-4","article-title":"Positive regulation of human alpha 1 (I) collagen promoter activity by transcription factor Sp1","volume":"164","author":"Li","year":"1995","journal-title":"Gene"},{"key":"10.1016\/j.celrep.2022.110418_bib32","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2022.110418_bib33","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.3390\/ijms20051194","article-title":"Nuclear ERK: mechanism of translocation, substrates, and role in cancer","volume":"20","author":"Maik-Rachline","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2022.110418_bib34","doi-asserted-by":"crossref","first-page":"e2005970","DOI":"10.1371\/journal.pbio.2005970","article-title":"CellProfiler 3.0: next-generation image processing for biology","volume":"16","author":"McQuin","year":"2018","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2022.110418_bib35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1083\/jcb.201903017","article-title":"IPO11 mediates betacatenin nuclear import in a subset of colorectal cancers","volume":"219","author":"Mis","year":"2020","journal-title":"J.\u00a0Cell Biol"},{"key":"10.1016\/j.celrep.2022.110418_bib36","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nmeth.2406","article-title":"FISH-quant: automatic counting of transcripts in 3D FISH images","volume":"10","author":"Mueller","year":"2013","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2022.110418_bib37","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/nature25459","article-title":"Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes","volume":"554","author":"Mueller","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.110418_bib38","doi-asserted-by":"crossref","first-page":"10989","DOI":"10.1038\/s41598-019-47440-w","article-title":"Migration rather than proliferation transcriptomic signatures are strongly associated with breast cancer patient survival","volume":"9","author":"Nair","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2022.110418_bib39","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.cell.2017.05.016","article-title":"Wnt\/beta-Catenin signaling, disease, and emerging therapeutic modalities","volume":"169","author":"Nusse","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.110418_bib40","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/febs.14123","article-title":"Invadosomes are coming: new insights into function and disease relevance","volume":"285","author":"Paterson","year":"2018","journal-title":"FEBS J."},{"key":"10.1016\/j.celrep.2022.110418_bib41","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1083\/jcb.201510036","article-title":"Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes","volume":"213","author":"Petropoulos","year":"2016","journal-title":"J.\u00a0Cell Biol"},{"key":"10.1016\/j.celrep.2022.110418_bib42","doi-asserted-by":"crossref","first-page":"6685","DOI":"10.1038\/ncomms7685","article-title":"The nuclear translocation of ERK1\/2 as an anticancer target","volume":"6","author":"Plotnikov","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2022.110418_bib43","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2022.110418_bib44","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1158\/2159-8290.CD-20-0581","article-title":"Inhibition of nuclear pore complex formation selectively induces cancer cell death","volume":"11","author":"Sakuma","year":"2020","journal-title":"Cancer Discov."},{"key":"10.1016\/j.celrep.2022.110418_bib59","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1038\/s41588-019-0535-3","article-title":"WNT signaling and AHCTF1 promote oncogenic MYC expression through super-enhancer-mediated gene gating","volume":"51","author":"Scholz","year":"2019","journal-title":"Nat Genet"},{"key":"10.1016\/j.celrep.2022.110418_bib45","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1126\/science.2470152","article-title":"Studies of the HER-2\/neu proto-oncogene in human breast and ovarian cancer","volume":"244","author":"Slamon","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.celrep.2022.110418_bib46","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1016\/j.jmb.2015.09.023","article-title":"Nucleocytoplasmic transport of RNAs and RNA-protein complexes","volume":"428","author":"Sloan","year":"2016","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.celrep.2022.110418_bib47","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.celrep.2019.08.088","article-title":"ETS proteins bind with glucocorticoid receptors: relevance for treatment of ewing sarcoma","volume":"29","author":"Srivastava","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2022.110418_bib48","doi-asserted-by":"crossref","first-page":"5027","DOI":"10.1073\/pnas.95.9.5027","article-title":"A cytoplasmic protein, bystin, interacts with trophinin, tastin, and cytokeratin and may be involved in trophinin-mediated cell adhesion between trophoblast and endometrial epithelial cells","volume":"95","author":"Suzuki","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.celrep.2022.110418_bib49","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/1752-0509-5-121","article-title":"Inferring causal genomic alterations in breast cancer using gene expression data","volume":"5","author":"Tran","year":"2011","journal-title":"BMC Syst. Biol."},{"key":"10.1016\/j.celrep.2022.110418_bib50","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2022.110418_bib51","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.bbrc.2005.03.063","article-title":"Extracellular signal-dependent nuclear import of STAT3 is mediated by various importin alphas","volume":"330","author":"Ushijima","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.celrep.2022.110418_bib52","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1038\/sj.onc.1206212","article-title":"An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity","volume":"22","author":"Xiao","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2022.110418_bib53","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nature10598","article-title":"Nuclear PKM2 regulates \u03b2-catenin transactivation upon EGFR activation","volume":"480","author":"Yang","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.110418_bib54","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.cca.2018.11.025","article-title":"Noncoding RNA activated by DNA damage (NORAD): biologic function and mechanisms in human cancers","volume":"489","author":"Yang","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.celrep.2022.110418_bib55","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nrc3309","article-title":"The ERBB network: at last, cancer therapy meets systems biology","volume":"12","author":"Yarden","year":"2012","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2022.110418_bib56","doi-asserted-by":"crossref","first-page":"R69","DOI":"10.1186\/gb-2003-4-10-r69","article-title":"An integrated database of genes responsive to the Myc oncogenic transcription factor: identification of direct genomic targets","volume":"4","author":"Zeller","year":"2003","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2022.110418_bib57","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.molcel.2020.05.013","article-title":"Gene architecture and sequence composition underpin selective dependency of nuclear export of long RNAs on NXF1 and the TREX complex","volume":"79","author":"Zuckerman","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2022.110418_bib58","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1210\/me.2015-1294","article-title":"Minireview: mouse models of Rho GTPase function in mammary gland development, tumorigenesis, and metastasis","volume":"30","author":"Zuo","year":"2016","journal-title":"Mol. Endocrinol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722001425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722001425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:35:23Z","timestamp":1761910523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124722001425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":59,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S2211124722001425"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2022.110418","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nucleoporin-93 reveals a common feature of aggressive breast cancers: robust nucleocytoplasmic transport of transcription factors","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2022.110418","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022","name":"copyright","label":"Copyright"}],"article-number":"110418"}}