{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:42:44Z","timestamp":1790714564055,"version":"4.1.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T00:00:00Z","timestamp":1644278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK119955"],"award-info":[{"award-number":["DK119955"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK101530"],"award-info":[{"award-number":["DK101530"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004890","name":"Illinois Humanities Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004890","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008630","name":"Children&apos;s Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008630","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014549","name":"Stanford Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014549","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.celrep.2022.110453","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T12:03:56Z","timestamp":1646136236000},"page":"110453","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":44,"title":["SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB\/NF1 loss yields SDHx-like pheochromocytomas"],"prefix":"10.1016","volume":"38","author":[{"given":"Neali","family":"Armstrong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0792-1569","authenticated-orcid":false,"given":"Claire M.","family":"Storey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E.","family":"Noll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Margulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1380-0165","authenticated-orcid":false,"given":"Myat Han","family":"Soe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9397-6392","authenticated-orcid":false,"given":"Benjamin","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8151-5107","authenticated-orcid":false,"given":"Lauren","family":"Fishbein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Electron","family":"Kebebew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0309-6680","authenticated-orcid":false,"given":"Brooke E.","family":"Howitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard N.","family":"Zare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Sage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8431-3589","authenticated-orcid":false,"given":"Justin P.","family":"Annes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2022.110453_bib1","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ccr.2011.09.006","article-title":"Renal cyst formation in Fh1-deficient mice is independent of the Hif\/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling","volume":"20","author":"Adam","year":"2011","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2022.110453_bib2","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/nature23876","article-title":"Ascorbate regulates haematopoietic stem cell function and leukaemogenesis","volume":"549","author":"Agathocleous","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.110453_bib3","doi-asserted-by":"crossref","first-page":"e21227","DOI":"10.1096\/fj.202002100R","article-title":"Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency","volume":"35","author":"Al Khazal","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.celrep.2022.110453_bib4","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.ccell.2016.08.017","article-title":"Expression of Idh1(R132H) in the murine subventricular zone stem cell niche recapitulates features of early gliomagenesis","volume":"30","author":"Bardella","year":"2016","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2022.110453_bib5","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1126\/science.287.5454.848","article-title":"Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma","volume":"287","author":"Baysal","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.celrep.2022.110453_bib6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1002\/hed.25386","article-title":"Clinical significance and peculiarities of succinate dehydrogenase B and hypoxia inducible factor 1alpha expression in parasympathetic versus sympathetic paragangliomas","volume":"41","author":"Bernardo-Castineira","year":"2019","journal-title":"Head Neck"},{"key":"10.1016\/j.celrep.2022.110453_bib7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s13361-017-1809-6","article-title":"MSiReader v1.0: evolving open-source mass spectrometry imaging software for targeted and untargeted analyses","volume":"29","author":"Bokhart","year":"2018","journal-title":"J.\u00a0Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.celrep.2022.110453_bib8","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1038\/nbt.2377","article-title":"A cross-platform toolkit for mass spectrometry and proteomics","volume":"30","author":"Chambers","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2022.110453_bib9","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/cr.2015.150","article-title":"Loss of 5-hydroxymethylcytosine is linked to gene body hypermethylation in kidney cancer","volume":"26","author":"Chen","year":"2016","journal-title":"Cell Res"},{"key":"10.1016\/j.celrep.2022.110453_bib10","first-page":"115","article-title":"Succinate dehydrogenase subunit B inhibits the AMPK-HIF-1alpha pathway in human ovarian cancer in\u00a0vitro","volume":"7","author":"Chen","year":"2014","journal-title":"J.\u00a0Ovarian Res."},{"key":"10.1016\/j.celrep.2022.110453_bib11","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.cell.2017.07.032","article-title":"Restoration of TET2 function blocks aberrant self-Renewal and leukemia progression","volume":"170","author":"Cimmino","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.110453_bib12","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1371\/journal.pgen.0010008","article-title":"A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas","volume":"1","author":"Dahia","year":"2005","journal-title":"PLoS Genet."},{"key":"10.1016\/j.celrep.2022.110453_bib13","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/nature08617","article-title":"Cancer-associated IDH1 mutations produce 2-hydroxyglutarate","volume":"462","author":"Dang","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.110453_bib14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0002-9440(10)64547-6","article-title":"Losses of chromosomes 1p and 3q are early genetic events in the development of sporadic pheochromocytomas","volume":"157","author":"Dannenberg","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2022.110453_bib15","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1128\/MCB.00128-12","article-title":"Differential impairment of catecholaminergic cell maturation and survival by genetic mitochondrial complex II dysfunction","volume":"32","author":"Diaz-Castro","year":"2012","journal-title":"Mol. Cell Biol"},{"key":"10.1016\/j.celrep.2022.110453_bib16","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/path.1461","article-title":"SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology","volume":"201","author":"Douwes Dekker","year":"2003","journal-title":"J.\u00a0Pathol."},{"key":"10.1016\/j.celrep.2022.110453_bib17","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1002\/cbic.201100411","article-title":"Nondestructive, histologically compatible tissue imaging by desorption electrospray ionization mass spectrometry","volume":"12","author":"Eberlin","year":"2011","journal-title":"Chembiochem"},{"key":"10.1016\/j.celrep.2022.110453_bib18","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0002-9440(10)64769-4","article-title":"Comparative genomic hybridization reveals frequent losses of chromosomes 1p and 3q in pheochromocytomas and abdominal paragangliomas, suggesting a common genetic etiology","volume":"156","author":"Edstrom","year":"2000","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2022.110453_bib19","doi-asserted-by":"crossref","first-page":"W606","DOI":"10.1093\/nar\/gkm324","article-title":"LIPID MAPS online tools for lipid research","volume":"35","author":"Fahy","year":"2007","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2022.110453_bib20","doi-asserted-by":"crossref","first-page":"e7094","DOI":"10.1371\/journal.pone.0007094","article-title":"The Warburg effect is genetically determined in inherited pheochromocytomas","volume":"4","author":"Favier","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2022.110453_bib21","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.ccell.2017.01.001","article-title":"Comprehensive molecular characterization of pheochromocytoma and paraganglioma","volume":"31","author":"Fishbein","year":"2017","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2022.110453_bib22","doi-asserted-by":"crossref","first-page":"3480","DOI":"10.1158\/0008-5472.CAN-20-2936","article-title":"Loss of SDHB promotes dysregulated iron homeostasis, oxidative stress, and sensitivity to ascorbate","volume":"81","author":"Goncalves","year":"2021","journal-title":"Cancer Res."},{"key":"10.1016\/j.celrep.2022.110453_bib23","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cmet.2019.07.012","article-title":"The MYC oncogene cooperates with sterol-regulated element-binding protein to regulate lipogenesis essential for neoplastic growth","volume":"30","author":"Gouw","year":"2019","journal-title":"Cell Metab"},{"key":"10.1016\/j.celrep.2022.110453_bib24","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1021\/acs.analchem.7b04424","article-title":"METLIN: a technology platform for identifying knowns and unknowns","volume":"90","author":"Guijas","year":"2018","journal-title":"Anal Chem."},{"key":"10.1016\/j.celrep.2022.110453_bib25","doi-asserted-by":"crossref","first-page":"30772","DOI":"10.1074\/jbc.M304982200","article-title":"Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor","volume":"278","author":"Hirsila","year":"2003","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2022.110453_bib26","doi-asserted-by":"crossref","first-page":"38777","DOI":"10.18632\/oncotarget.6091","article-title":"Inactivation of SDH and FH cause loss of 5hmC and increased H3K9me3 in paraganglioma\/pheochromocytoma and smooth muscle tumors","volume":"6","author":"Hoekstra","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2022.110453_bib27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.semcdb.2015.05.011","article-title":"Models of parent-of-origin tumorigenesis in hereditary paraganglioma","volume":"43","author":"Hoekstra","year":"2015","journal-title":"Semin. Cell Dev Biol"},{"key":"10.1016\/j.celrep.2022.110453_bib28","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.jmb.2009.02.028","article-title":"Mutations in the C. elegans succinate dehydrogenase iron-sulfur subunit promote superoxide generation and premature aging","volume":"387","author":"Huang","year":"2009","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.celrep.2022.110453_bib29","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ng0794-353","article-title":"Tumour predisposition in mice heterozygous for a targeted mutation in Nf1","volume":"7","author":"Jacks","year":"1994","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2022.110453_bib30","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1093\/bioinformatics\/btn323","article-title":"ProteoWizard: open source software for rapid proteomics tools development","volume":"24","author":"Kessner","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2022.110453_bib31","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4110\/in.2012.12.1.18","article-title":"The analysis of vitamin C concentration in organs of gulo(-\/-) mice upon vitamin C withdrawal","volume":"12","author":"Kim","year":"2012","journal-title":"Immune Netw."},{"key":"10.1016\/j.celrep.2022.110453_bib32","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/labinvest.2016.142","article-title":"The NF1 gene in tumor syndromes and melanoma","volume":"97","author":"Kiuru","year":"2017","journal-title":"Lab Invest"},{"key":"10.1016\/j.celrep.2022.110453_bib33","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3389\/fonc.2014.00359","article-title":"Ascorbate as a co-factor for fe- and 2-oxoglutarate dependent dioxygenases: physiological activity in tumor growth and progression","volume":"4","author":"Kuiper","year":"2014","journal-title":"Front Oncol."},{"key":"10.1016\/j.celrep.2022.110453_bib34","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1016\/j.jmb.2018.06.048","article-title":"Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylases","volume":"430","author":"Laukka","year":"2018","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.celrep.2022.110453_bib35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ccr.2005.06.015","article-title":"Neuronal apoptosis linked to EglN3 prolyl hydroxylase and familial pheochromocytoma genes: developmental culling and cancer","volume":"8","author":"Lee","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2022.110453_bib36","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1210\/en.2013-1549","article-title":"Succinate-to-fumarate ratio as a new metabolic marker to detect the presence of SDHB\/D-related paraganglioma: initial experimental and ex\u00a0vivo findings","volume":"155","author":"Lendvai","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.celrep.2022.110453_bib37","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.mce.2015.06.027","article-title":"From Nf1 to Sdhb knockout: successes and failures in the quest for animal models of pheochromocytoma","volume":"421","author":"Lepoutre-Lussey","year":"2016","journal-title":"Mol. Cell Endocrinol"},{"key":"10.1016\/j.celrep.2022.110453_bib38","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.ccr.2013.04.018","article-title":"SDH mutations establish a hypermethylator phenotype in paraganglioma","volume":"23","author":"Letouze","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.celrep.2022.110453_bib39","doi-asserted-by":"crossref","first-page":"26591","DOI":"10.1038\/srep26591","article-title":"Epigenetic inactivation of the CpG demethylase TET1 as a DNA methylation feedback loop in human cancers","volume":"6","author":"Li","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2022.110453_bib40","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1158\/1078-0432.CCR-19-2335","article-title":"Therapeutic targeting of SDHB-mutated pheochromocytoma\/paraganglioma with pharmacologic ascorbic acid","volume":"26","author":"Liu","year":"2020","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2022.110453_bib41","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1210\/me.2010-0256","article-title":"Research resource: transcriptional profiling reveals different pseudohypoxic signatures in SDHB and VHL-related pheochromocytomas","volume":"24","author":"Lopez-Jimenez","year":"2010","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.celrep.2022.110453_bib42","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/s41568-020-00303-3","article-title":"2-Oxoglutarate-dependent dioxygenases in cancer","volume":"20","author":"Losman","year":"2020","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2022.110453_bib43","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/nature10860","article-title":"IDH mutation impairs histone demethylation and results in a block to cell differentiation","volume":"483","author":"Lu","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.110453_bib44","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1158\/1078-0432.CCR-15-1576","article-title":"In\u00a0vivo detection of succinate by magnetic Resonance spectroscopy as a hallmark of SDHx mutations in paraganglioma","volume":"22","author":"Lussey-Lepoutre","year":"2016","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.celrep.2022.110453_bib45","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00441-018-2797-y","article-title":"Rodent models of pheochromocytoma, parallels in rodent and human tumorigenesis","volume":"372","author":"Lussey-Lepoutre","year":"2018","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.celrep.2022.110453_bib46","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1073\/pnas.97.2.841","article-title":"Aortic wall damage in mice unable to synthesize ascorbic acid","volume":"97","author":"Maeda","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U S A."},{"key":"10.1016\/j.celrep.2022.110453_bib47","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.celrep.2016.12.056","article-title":"Absence of neurofibromin induces an oncogenic metabolic switch via mitochondrial ERK-mediated phosphorylation of the chaperone TRAP1","volume":"18","author":"Masgras","year":"2017","journal-title":"Cell Rep"},{"key":"10.1016\/j.celrep.2022.110453_bib48","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/leu.2017.171","article-title":"Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia","volume":"32","author":"Mingay","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.celrep.2022.110453_bib49","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ajpath.2012.04.017","article-title":"Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas","volume":"181","author":"Muller","year":"2012","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2022.110453_bib50","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.celrep.2022.110453_bib51","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1159\/000455864","article-title":"The mTORC1 complex is significantly overactivated in SDHX-mutated paragangliomas","volume":"105","author":"Oudijk","year":"2017","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.celrep.2022.110453_bib52","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00441-014-1896-7","article-title":"The role of 5-hydroxymethylcytosine in human cancer","volume":"356","author":"Pfeifer","year":"2014","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.celrep.2022.110453_bib53","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1016\/j.celrep.2018.03.133","article-title":"Mutant IDH1 promotes glioma formation in\u00a0vivo","volume":"23","author":"Philip","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.celrep.2022.110453_bib54","doi-asserted-by":"crossref","first-page":"10933","DOI":"10.1128\/MCB.24.24.10933-10940.2004","article-title":"The mitochondrial SDHD gene is required for early embryogenesis, and its partial deficiency results in persistent carotid body glomus cell activation with full responsiveness to hypoxia","volume":"24","author":"Piruat","year":"2004","journal-title":"Mol. Cell Biol"},{"key":"10.1016\/j.celrep.2022.110453_bib55","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1210\/jc.2006-0920","article-title":"Expression of HIF-1alpha, HIF-2alpha (EPAS1), and their target genes in paraganglioma and pheochromocytoma with VHL and SDH mutations","volume":"91","author":"Pollard","year":"2006","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2022.110453_bib56","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1016\/j.jprot.2012.05.035","article-title":"Inclusive sharing of mass spectrometry imaging data requires a converter for all","volume":"75","author":"Race","year":"2012","journal-title":"J.\u00a0Proteomics"},{"key":"10.1016\/j.celrep.2022.110453_bib57","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1530\/ERC-11-0263","article-title":"Mitochondrial function and content in pheochromocytoma\/paraganglioma of succinate dehydrogenase mutation carriers","volume":"19","author":"Rapizzi","year":"2012","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.celrep.2022.110453_bib58","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1038\/s41436-018-0003-y","article-title":"Gain-of-function mutations in DNMT3A in patients with paraganglioma","volume":"20","author":"Remacha","year":"2018","journal-title":"Genet. Med."},{"key":"10.1016\/j.celrep.2022.110453_bib59","doi-asserted-by":"crossref","first-page":"3903","DOI":"10.1210\/jc.2014-2151","article-title":"Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas\/paragangliomas due to succinate dehydrogenase deficiency","volume":"99","author":"Richter","year":"2014","journal-title":"J.\u00a0Clin. Endocrinol. Metab."},{"key":"10.1016\/j.celrep.2022.110453_bib60","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/s13361-013-0607-z","article-title":"MSiReader: an open-source interface to view and analyze high resolving power MS imaging files on Matlab platform","volume":"24","author":"Robichaud","year":"2013","journal-title":"J.\u00a0Am. Soc. Mass Spectrom."},{"key":"10.1016\/j.celrep.2022.110453_bib61","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1101\/gad.198200.112","article-title":"D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function","volume":"26","author":"Sasaki","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2022.110453_bib62","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1523\/JNEUROSCI.0760-05.2005","article-title":"Bcl-x is required for proper development of the mouse substantia nigra","volume":"25","author":"Savitt","year":"2005","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2022.110453_bib63","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1097\/01.ftd.0000179845.53213.39","article-title":"METLIN: a metabolite mass spectral database","volume":"27","author":"Smith","year":"2005","journal-title":"Ther. Drug Monit."},{"key":"10.1016\/j.celrep.2022.110453_bib64","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/s41586-020-2363-0","article-title":"Oncometabolites suppress DNA repair by disrupting local chromatin signalling","volume":"582","author":"Sulkowski","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.110453_bib65","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/s41588-018-0170-4","article-title":"Krebs-cycle-deficient hereditary cancer syndromes are defined by defects in homologous-recombination DNA repair","volume":"50","author":"Sulkowski","year":"2018","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2022.110453_bib66","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1210\/en.2018-00064","article-title":"High resolution tissue mass spectrometry imaging reveals a refined functional anatomy of the human adult adrenal gland","volume":"159","author":"Sun","year":"2018","journal-title":"Endocrinology"},{"key":"10.1016\/j.celrep.2022.110453_bib67","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1530\/ERC-15-0069","article-title":"Carney triad, SDH-deficient tumors, and Sdhb+\/- mice share abnormal mitochondria","volume":"22","author":"Szarek","year":"2015","journal-title":"Endocr. Relat. Cancer"},{"key":"10.1016\/j.celrep.2022.110453_bib68","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1593\/neo.91646","article-title":"Dual loss of rb1 and Trp53 in the adrenal medulla leads to spontaneous pheochromocytoma","volume":"12","author":"Tonks","year":"2010","journal-title":"Neoplasia"},{"key":"10.1016\/j.celrep.2022.110453_bib69","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/ijc.32843","article-title":"Identification of diagnostic metabolic signatures in clear cell renal cell carcinoma using mass spectrometry imaging","volume":"147","author":"Vijayalakshmi","year":"2020","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.celrep.2022.110453_bib70","doi-asserted-by":"crossref","first-page":"7188","DOI":"10.1002\/anie.200602449","article-title":"Tissue imaging at atmospheric pressure using desorption electrospray ionization (DESI) mass spectrometry","volume":"45","author":"Wiseman","year":"2006","journal-title":"Angew. Chem. Int. Ed. Engl."},{"key":"10.1016\/j.celrep.2022.110453_bib71","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1039\/B919816D","article-title":"Molecular imaging of adrenal gland by desorption electrospray ionization mass spectrometry","volume":"135","author":"Wu","year":"2010","journal-title":"Analyst"},{"key":"10.1016\/j.celrep.2022.110453_bib72","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1101\/gad.191056.112","article-title":"Inhibition of alpha-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors","volume":"26","author":"Xiao","year":"2012","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2022.110453_bib73","doi-asserted-by":"crossref","first-page":"3652","DOI":"10.1172\/JCI67228","article-title":"Oncometabolites: linking altered metabolism with cancer","volume":"123","author":"Yang","year":"2013","journal-title":"J.\u00a0Clin. Invest"},{"key":"10.1016\/j.celrep.2022.110453_bib74","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1101\/gad.862101","article-title":"Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain","volume":"15","author":"Zhu","year":"2001","journal-title":"Genes Dev."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722001802?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722001802?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:47:23Z","timestamp":1778842043000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124722001802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":74,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S2211124722001802"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2022.110453","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SDHB knockout and succinate accumulation are insufficient for tumorigenesis but dual SDHB\/NF1 loss yields SDHx-like pheochromocytomas","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2022.110453","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"110453"}}