{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T21:48:22Z","timestamp":1785448102986,"version":"3.56.0"},"reference-count":89,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006668","name":"Fondo para la Investigaci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT-2018-01107 \/ PICT-2019-00642"],"award-info":[{"award-number":["PICT-2018-01107 \/ PICT-2019-00642"]}],"id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009945","name":"Merck KGaA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR130"],"award-info":[{"award-number":["TRR130"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["310030_156961"],"award-info":[{"award-number":["310030_156961"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["31003A_176256"],"award-info":[{"award-number":["31003A_176256"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.celrep.2022.110583","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T11:30:07Z","timestamp":1648553407000},"page":"110583","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells"],"prefix":"10.1016","volume":"38","author":[{"given":"Cristian R.","family":"Smulski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Burek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariadna","family":"Teixid\u00f3 Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana-Susann","family":"Briem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio P.","family":"Sica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirini","family":"Sevdali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Vigolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laure","family":"Willen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Odermatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Istanbullu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Herr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Cavallari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Hess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Rizzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Eibel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2022.110583_bib1","doi-asserted-by":"crossref","first-page":"154790","DOI":"10.1016\/j.cyto.2019.154790","article-title":"Silencing of the cytokine receptor TNFRSF13B: a new therapeutic target for triple-negative breast cancer","volume":"125","author":"Abo-Elfadl","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.celrep.2022.110583_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1-2","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"key":"10.1016\/j.celrep.2022.110583_bib3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1145\/304181.304187","article-title":"OPTICS: ordering points to identify the clustering structure","volume":"28","author":"Ankerst","year":"1999","journal-title":"ACM SIGMOD Rec."},{"key":"10.1016\/j.celrep.2022.110583_bib4","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/ene.14105","article-title":"Failed B cell survival factor trials support the importance of memory B cells in multiple sclerosis","volume":"27","author":"Baker","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.celrep.2022.110583_bib5","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1084\/jem.192.10.1453","article-title":"BAFF mediates survival of peripheral immature B lymphocytes","volume":"192","author":"Batten","year":"2000","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2022.110583_bib6","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.4049\/jimmunol.180.6.3655","article-title":"Cutting edge: the dependence of plasma cells and independence of memory B cells on BAFF and APRIL","volume":"180","author":"Benson","year":"2008","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib85","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0968-0004(01)01995-8","article-title":"The molecular architecture of the TNF superfamily","volume":"27","author":"Bodmer","year":"2002","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.celrep.2022.110583_bib7","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1126\/science.278.5335.138","article-title":"NF-AT activation induced by a CAML-interacting member of the tumor necrosis factor receptor superfamily","volume":"278","author":"B\u00fclow, von","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.celrep.2022.110583_bib8","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1074-7613(01)00130-3","article-title":"Regulation of the T-independent humoral response by TACI","volume":"14","author":"B\u00fclow, von","year":"2001","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2022.110583_bib9","doi-asserted-by":"crossref","first-page":"014101","DOI":"10.1063\/1.2408420","article-title":"Canonical sampling through velocity rescaling","volume":"126","author":"Bussi","year":"2007","journal-title":"J.\u00a0Chem. Phys."},{"key":"10.1016\/j.celrep.2022.110583_bib10","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/ng1601","article-title":"TACI is mutant in common variable immunodeficiency and IgA deficiency","volume":"37","author":"Castigli","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2022.110583_bib11","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1126\/science.288.5475.2351","article-title":"A domain in TNF receptors that mediates ligand-independent receptor assembly and signaling","volume":"288","author":"Chan","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.celrep.2022.110583_bib12","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.jaci.2011.02.046","article-title":"Transmembrane activator and CAML interactor (TACI) haploinsufficiency results in B-cell dysfunction in patients with Smith-Magenis syndrome","volume":"127","author":"Chinen","year":"2011","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib13","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1182\/blood-2006-04-015958","article-title":"Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL","volume":"109","author":"Chiu","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2022.110583_bib14","series-title":"The Diversity and Similarity of Transmembrane Trimerization of TNF Receptors","author":"Chou","year":"2020"},{"key":"10.1016\/j.celrep.2022.110583_bib15","doi-asserted-by":"crossref","first-page":"18099","DOI":"10.1073\/pnas.0507329102","article-title":"Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis","volume":"102","author":"Clancy","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.celrep.2022.110583_bib16","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jaci.2011.01.048","article-title":"Functional analysis of transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) mutations associated with common variable immunodeficiency","volume":"128","author":"Fried","year":"2011","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib17","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.molcel.2016.01.009","article-title":"Structural basis and functional role of intramembrane trimerization of the Fas\/CD95 death receptor","volume":"61","author":"Fu","year":"2016","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2022.110583_bib18","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1002\/art.30613","article-title":"A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus","volume":"63","author":"Furie","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.celrep.2022.110583_bib19","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1182\/blood-2014-05-575845","article-title":"Differential induction of plasma cells by isoforms of human TACI","volume":"125","author":"Garcia-Carmona","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2022.110583_bib20","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.3389\/fimmu.2018.02125","article-title":"TACI isoforms regulate ligand binding and receptor function","volume":"9","author":"Garcia-Carmona","year":"2018","journal-title":"Front Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib21","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1172\/JCI31023","article-title":"Dominant-negative effect of the heterozygous C104R TACI mutation in common variable immunodeficiency (CVID)","volume":"117","author":"Garibyan","year":"2007","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2022.110583_bib22","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1038\/sj.onc.1207410","article-title":"The c-Rel transcription factor and B-cell proliferation: a deal with the devil","volume":"23","author":"Gilmore","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2022.110583_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat7117","article-title":"Gut T\u00a0cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells","volume":"5","author":"Grasset","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib24","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1084\/jem.20062567","article-title":"BAFF and MyD88 signals promote a lupuslike disease independent of T\u00a0cells","volume":"204","author":"Groom","year":"2007","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2022.110583_bib25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-4614-0899-4_2","article-title":"The role of Adams in Notch signaling","volume":"727","author":"Groot","year":"2012","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.celrep.2022.110583_bib26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1046\/j.1365-2249.2000.01131.x","article-title":"Selective IgA deficiency (SIgAD) and common variable immunodeficiency (CVID)","volume":"120","author":"Hammarstr\u00f6m","year":"2000","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib27","doi-asserted-by":"crossref","first-page":"542","DOI":"10.4049\/jimmunol.1402070","article-title":"The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity","volume":"194","author":"Hoffmann","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib28","doi-asserted-by":"crossref","first-page":"7218","DOI":"10.1074\/jbc.M411714200","article-title":"Structures of APRIL-receptor complexes: like BCMA, TACI employs only a single cysteine-rich domain for high affinity ligand binding","volume":"280","author":"Hymowitz","year":"2005","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2022.110583_bib29","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/j.jaci.2016.07.028","article-title":"Heterozygosity for transmembrane activator and calcium modulator ligand interactor A144E causes haploinsufficiency and pneumococcal susceptibility in mice","volume":"139","author":"Jabara","year":"2017","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib30","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1021\/ct300646g","article-title":"Improved parameters for the Martini coarse-grained protein force field","volume":"9","author":"de Jong","year":"2013","journal-title":"J.\u00a0Chem. Theor. Comput"},{"key":"10.1016\/j.celrep.2022.110583_bib31","doi-asserted-by":"crossref","DOI":"10.1021\/ja9621760","article-title":"Development and testing of the OPLS all-atom force field on conformational energetics and properties of organic liquids","author":"Jorgensen","year":"1996","journal-title":"J.\u00a0Am. Chem. Soc."},{"key":"10.1016\/j.celrep.2022.110583_bib32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0097-8485(89)85005-3","article-title":"Defining the axis of a helix","volume":"13","author":"Kahn","year":"2001","journal-title":"Comput. Chem."},{"key":"10.1016\/j.celrep.2022.110583_bib33","doi-asserted-by":"crossref","DOI":"10.1021\/jp003919d","article-title":"Evaluation and reparametrization of the OPLS-AA force field for proteins via comparison with accurate quantum chemical calculations on peptides","author":"Kaminski","year":"2001","journal-title":"The J. Phys. Chem. B"},{"key":"10.1016\/j.celrep.2022.110583_bib34","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3389\/fonc.2020.00827","article-title":"The TNFSF members APRIL and BAFF and their receptors TACI, BCMA, and BAFFR in oncology, with a special Focus in breast cancer","volume":"10","author":"Kampa","year":"2020","journal-title":"Front. Oncol."},{"key":"10.1016\/j.celrep.2022.110583_bib35","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/j.jaci.2013.01.018","article-title":"Inhibition of human B-cell development into plasmablasts by histone deacetylase inhibitor valproic acid","volume":"131","author":"Kienzler","year":"2013","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib36","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1172\/JCI124382","article-title":"c-Rel gain in B cells drives germinal center reactions and autoantibody production","volume":"130","author":"Kober-Hasslacher","year":"2020","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2022.110583_bib37","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1111\/bph.14811","article-title":"No interactions between heparin and atacicept, an antagonist of B cell survival cytokines","volume":"176","author":"Kowalczyk-Quintas","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.celrep.2022.110583_bib89","doi-asserted-by":"crossref","first-page":"497","DOI":"10.4049\/jimmunol.1102321","article-title":"Soluble BAFF Levels Inversely Correlate with Peripheral B Cell Numbers and the Expression of BAFF Receptors","volume":"188","author":"Kreuzaler","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib38","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1182\/blood-2008-11-189720","article-title":"The murine equivalent of the A181E TACI mutation associated with common variable immunodeficiency severely impairs B-cell function","volume":"114","author":"Lee","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2022.110583_bib39","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.jmb.2016.09.005","article-title":"TMDOCK: an energy-based method for modeling \u03b1-helical dimers in membranes","volume":"429","author":"Lomize","year":"2017","journal-title":"J.\u00a0Mol. Biol."},{"key":"10.1016\/j.celrep.2022.110583_bib86","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/nri2572","article-title":"Cracking the BAFF code","volume":"9","author":"Mackay","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.celrep.2022.110583_bib40","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1084\/jem.190.11.1697","article-title":"Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations","volume":"190","author":"Mackay","year":"1999","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2022.110583_bib41","doi-asserted-by":"crossref","first-page":"7812","DOI":"10.1021\/jp071097f","article-title":"The MARTINI force field: coarse grained model for biomolecular simulations","volume":"111","author":"Marrink","year":"2007","journal-title":"J.\u00a0Phys. Chem. B"},{"key":"10.1016\/j.celrep.2022.110583_bib42","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jaci.2012.10.029","article-title":"TACI mutations and impaired B-cell function in subjects with CVID and healthy heterozygotes","volume":"131","author":"Martinez-Gallo","year":"2013","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib43","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.molcel.2020.08.012","article-title":"Structural\u00a0basis of tail-anchored membrane protein biogenesis by the GET insertase\u00a0complex","volume":"80","author":"McDowell","year":"2020","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2022.110583_bib44","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.it.2018.07.002","article-title":"Shedding of BAFF\/APRIL receptors controls B cells","volume":"39","author":"Meinl","year":"2018","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib45","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1007\/s10875-009-9317-5","article-title":"Novel mutations in TACI (TNFRSF13B) causing common variable immunodeficiency","volume":"29","author":"Mohammadi","year":"2009","journal-title":"J.\u00a0Clin. Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib46","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1021\/ct700324x","article-title":"The MARTINI coarse-grained force field: extension to proteins","volume":"4","author":"Monticelli","year":"2008","journal-title":"J.\u00a0Chem. Theor. Comput"},{"key":"10.1016\/j.celrep.2022.110583_bib47","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.jaci.2015.08.040","article-title":"CD19 controls Toll-like receptor 9 responses in human B cells","volume":"137","author":"Morbach","year":"2016","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib48","doi-asserted-by":"crossref","first-page":"E888","DOI":"10.1073\/pnas.1319944111","article-title":"A frequent, GxxxG-mediated, transmembrane association motif is optimized for the formation of interhelical C\u03b1-H hydrogen bonds","volume":"111","author":"Mueller","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.celrep.2022.110583_bib49","doi-asserted-by":"crossref","first-page":"12346","DOI":"10.1074\/jbc.M116.723585","article-title":"Structural basis of p75 transmembrane domain dimerization","volume":"291","author":"Nadezhdin","year":"2016","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2022.110583_bib87","doi-asserted-by":"crossref","first-page":"13303","DOI":"10.1074\/jbc.270.22.13303","article-title":"Crystallographic evidence for dimerization of unliganded tumor necrosis factor receptor","volume":"270","author":"Naismith","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.celrep.2022.110583_bib88","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S0969-2126(96)00134-7","article-title":"Structures of the extracellular domain of the type I tumor necrosis factor receptor","volume":"4","author":"Naismith","year":"1996","journal-title":"Structure"},{"key":"10.1016\/j.celrep.2022.110583_bib50","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1002\/eji.200635956","article-title":"BAFF costimulation of Toll-like receptor-activated B-1 cells","volume":"36","author":"Ng","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib51","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1084\/jem.20031330","article-title":"BCMA is essential for the survival of long-lived bone marrow plasma cells","volume":"199","author":"O'Connor","year":"2004","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2022.110583_bib52","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.jaci.2011.04.052","article-title":"Toll-like receptor 9, transmembrane activator and calcium-modulating cyclophilin ligand interactor, and CD40 synergize in causing B-cell activation","volume":"128","author":"Ozcan","year":"2011","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib53","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1016\/j.cell.2019.02.001","article-title":"Higher-order clustering of the transmembrane anchor of DR5 drives signaling","volume":"176","author":"Pan","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.110583_bib54","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/ng0407-429","article-title":"Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency","volume":"39","author":"Pan-Hammarstr\u00f6m","year":"2007","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2022.110583_bib55","doi-asserted-by":"crossref","first-page":"e83250","DOI":"10.1371\/journal.pone.0083250","article-title":"BAFF, APRIL, TWEAK, BCMA, TACI and Fn14 proteins are related to human glioma tumor grade: immunohistochemistry and public microarray data meta-analysis","volume":"8","author":"Pelekanou","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2022.110583_bib56","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.jaci.2013.11.021","article-title":"A common single nucleotide polymorphism impairs B-cell activating factor receptor's multimerization, contributing to common variable immunodeficiency","volume":"133","author":"Pieper","year":"2014","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib57","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/bioinformatics\/btt645","article-title":"PREDDIMER: a web server for prediction of transmembrane helical dimers","volume":"30","author":"Polyansky","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2022.110583_bib58","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2010.01.004","article-title":"Notch signaling in the immune system","volume":"32","author":"Radtke","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2022.110583_bib59","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.jaci.2015.05.012","article-title":"TNF receptor superfamily member 13b (TNFRSF13B) hemizygosity reveals transmembrane activator and CAML interactor haploinsufficiency at later stages of B-cell development","volume":"136","author":"Romberg","year":"2015","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib60","doi-asserted-by":"crossref","first-page":"35111","DOI":"10.1074\/jbc.M114.609446","article-title":"Structure of transmembrane domain of lysosome-associated membrane protein type 2a (LAMP-2A) reveals key features for substrate specificity in chaperone-mediated autophagy","volume":"289","author":"Rout","year":"2014","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2022.110583_bib61","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.immuni.2019.02.004","article-title":"A regulatory circuit controlling the dynamics of NF\u03baB cRel transitions B cells from proliferation to plasma cell differentiation","volume":"50","author":"Roy","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2022.110583_bib62","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/ng1600","article-title":"Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans","volume":"37","author":"Salzer","year":"2005","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2022.110583_bib63","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1182\/blood-2008-02-141937","article-title":"Relevance of biallelic versus monoallelic TNFRSF13B mutations in distinguishing disease-causing from risk-increasing TNFRSF13B variants in antibody deficiency syndromes","volume":"113","author":"Salzer","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.celrep.2022.110583_bib64","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/B978-0-12-801430-1.00005-6","article-title":"Tools and techniques to study ligand-receptor interactions and receptor activation by TNF superfamily members","volume":"545","author":"Schneider","year":"2014","journal-title":"Meth. Enzymol."},{"key":"10.1016\/j.celrep.2022.110583_bib65","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jaci.2014.01.037","article-title":"Sphingosine-1-phosphate receptors control B-cell migration through signaling components associated with primary immunodeficiencies, chronic lymphocytic leukemia, and multiple sclerosis","volume":"134","author":"Sic","year":"2014","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib66","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fcell.2020.577278","article-title":"Coarse grained molecular dynamic simulations for the study of TNF receptor family members' transmembrane organization","volume":"8","author":"Sica","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2022.110583_bib67","doi-asserted-by":"crossref","first-page":"2354","DOI":"10.1126\/science.288.5475.2354","article-title":"Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations","volume":"288","author":"Siegel","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.celrep.2022.110583_bib68","doi-asserted-by":"crossref","first-page":"6184","DOI":"10.1021\/acs.chemrev.8b00460","article-title":"Computational Modeling of Realistic Cell Membranes","volume":"119","author":"Siewert","year":"2019","journal-title":"Chem Rev."},{"key":"10.1016\/j.celrep.2022.110583_bib69","doi-asserted-by":"crossref","first-page":"10914","DOI":"10.1074\/jbc.M112.427583","article-title":"Cysteine-rich domain 1 of CD40 mediates receptor self-assembly","volume":"288","author":"Smulski","year":"2013","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2022.110583_bib70","doi-asserted-by":"crossref","first-page":"e2601","DOI":"10.1038\/cddis.2017.22","article-title":"Hetero-oligomerization between the TNF receptor superfamily members CD40, Fas and TRAILR2 modulate CD40 signalling","volume":"8","author":"Smulski","year":"2017","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.celrep.2022.110583_bib71","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1016\/j.celrep.2017.02.005","article-title":"BAFF- and TACI-dependent processing of BAFFR by ADAM proteases regulates the survival of B cells","volume":"18","author":"Smulski","year":"2017","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2022.110583_bib72","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1056\/NEJMoa1610528","article-title":"Overexpression of the cytokine BAFF and autoimmunity risk","volume":"376","author":"Steri","year":"2017","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2022.110583_bib73","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1002\/art.34400","article-title":"Belimumab reduces autoantibodies, normalizes low complement levels, and reduces select B cell populations in patients with systemic lupus erythematosus","volume":"64","author":"Stohl","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.celrep.2022.110583_bib74","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1093\/neuonc\/nox097","article-title":"Soluble TACI and soluble BCMA as biomarkers in primary central nervous system lymphoma","volume":"19","author":"Thaler","year":"2017","journal-title":"Neuro Oncol."},{"key":"10.1016\/j.celrep.2022.110583_bib75","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/prot.21519","article-title":"Monte Carlo folding of trans-membrane helical peptides in an implicit generalized Born membrane","volume":"69","author":"Ulmschneider","year":"2007","journal-title":"Proteins: Struct. Funct. Bioinformatics"},{"key":"10.1016\/j.celrep.2022.110583_bib76","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1529\/biophysj.106.081810","article-title":"A generalized born implicit-membrane representation compared to experimental insertion free energies","volume":"92","author":"Ulmschneider","year":"2007","journal-title":"Biophysical J."},{"key":"10.1016\/j.celrep.2022.110583_bib77","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/s41467-018-03323-8","article-title":"A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors","volume":"9","author":"Vigolo","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2022.110583_bib78","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1002\/art.30372","article-title":"Atacicept in patients with rheumatoid arthritis and an inadequate response to methotrexate: results of a phase II, randomized, placebo-controlled trial","volume":"63","author":"van Vollenhoven","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.celrep.2022.110583_bib79","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1002\/art.24699","article-title":"A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus","volume":"61","author":"Wallace","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.celrep.2022.110583_bib80","doi-asserted-by":"crossref","first-page":"13945","DOI":"10.1073\/pnas.0903543106","article-title":"B-cell activating factor receptor deficiency is associated with an adult-onset antibody deficiency syndrome in humans","volume":"106","author":"Warnatz","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.celrep.2022.110583_bib81","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1084\/jem.192.1.137","article-title":"TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B\u00a0cell regulation","volume":"192","author":"Xia","year":"2000","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2022.110583_bib82","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.tibs.2003.12.003","article-title":"IkappaB kinases: key regulators of the NF-kappaB pathway","volume":"29","author":"Yamamoto","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.celrep.2022.110583_bib83","doi-asserted-by":"crossref","first-page":"14","DOI":"10.18176\/jiaci.0388","article-title":"Common variable immunodeficiency: epidemiology, pathogenesis, clinical manifestations, diagnosis, classification, and management","volume":"30","author":"Yazdani","year":"2020","journal-title":"J.\u00a0Investig. Allergol. Clin. Immunol."},{"key":"10.1016\/j.celrep.2022.110583_bib84","first-page":"214","article-title":"Hodgkin's lymphoma: the role of cell surface receptors in regulation of tumor cell fate","volume":"32","author":"Yurchenko","year":"2010","journal-title":"Exp. Oncol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722003278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722003278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:46:51Z","timestamp":1778842011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124722003278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":89,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["S2211124722003278"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2022.110583","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ligand-independent oligomerization of TACI is controlled by the transmembrane domain and regulates proliferation of activated B cells","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2022.110583","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"110583"}}