{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:05:44Z","timestamp":1791860744663,"version":"4.3.4"},"reference-count":67,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"SNSF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004710","name":"Fondazione Umberto Veronesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006390","name":"Universit\u00e9 de Lausanne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006390","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013850","name":"Helmut Horten Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.celrep.2022.110956","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T10:54:24Z","timestamp":1655204064000},"page":"110956","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Gliadin-reactive vitamin D-sensitive proinflammatory ILCPs are enriched in celiac patients"],"prefix":"10.1016","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6026-2588","authenticated-orcid":false,"given":"Giuseppe","family":"Ercolano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3596-825X","authenticated-orcid":false,"given":"Alex","family":"Moretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryline","family":"Falquet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Wyss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngoc Lan","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isis","family":"Senoner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maddalena","family":"Marinoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Agosti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Salvatore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7405-5747","authenticated-orcid":false,"given":"Camilla","family":"Jandus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8648-1324","authenticated-orcid":false,"given":"Sara","family":"Trabanelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2022.110956_bib1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1146\/annurev-immunol-040210-092915","article-title":"Integration of genetic and immunological insights into a model of celiac disease pathogenesis","volume":"29","author":"Abadie","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib2","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1136\/gut.2004.059998","article-title":"T cells in peripheral blood after gluten challenge in coeliac disease","volume":"54","author":"Anderson","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2022.110956_bib3","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1084\/jem.191.4.603","article-title":"The intestinal T\u00a0cell response to alpha-gliadin in adult celiac disease is focused on a single deamidated glutamine targeted by tissue transglutaminase","volume":"191","author":"Arentz-Hansen","year":"2000","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2022.110956_bib4","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nature14189","article-title":"The biology of innate lymphoid cells","volume":"517","author":"Artis","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.110956_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.4049\/jimmunol.1701153","article-title":"CD62L is a functional and phenotypic marker for circulating innate lymphoid cell precursors","volume":"202","author":"Bar-Ephraim","year":"2019","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib6","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.immuni.2015.06.019","article-title":"Interleukin-12 and -23 control plasticity of CD127(+) group 1 and group 3 innate lymphoid cells in the intestinal lamina propria","volume":"43","author":"Bernink","year":"2015","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2022.110956_bib7","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/nature14115","article-title":"Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity","volume":"519","author":"Brestoff","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.110956_bib8","doi-asserted-by":"crossref","first-page":"e3161","DOI":"10.1002\/psc.3161","article-title":"Structural insights on P31-43, a gliadin peptide able to promote an innate but not an adaptive response in celiac disease","volume":"25","author":"Calvanese","year":"2019","journal-title":"J.\u00a0Pept. Sci."},{"key":"10.1016\/j.celrep.2022.110956_bib9","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1017\/S0954422416000214","article-title":"The progression of coeliac disease: its neurological and psychiatric implications","volume":"30","author":"Campagna","year":"2017","journal-title":"Nutr. Res. Rev."},{"key":"10.1016\/j.celrep.2022.110956_bib10","doi-asserted-by":"crossref","first-page":"282","DOI":"10.3389\/fimmu.2014.00282","article-title":"Beyond NK cells: the expanding universe of innate lymphoid cells","volume":"5","author":"Cella","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib11","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1016\/j.jaci.2017.02.015","article-title":"Circulating gluten-specific FOXP3(+)CD39(+) regulatory T\u00a0cells have impaired suppressive function in patients with celiac disease","volume":"140","author":"Cook","year":"2017","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib12","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.it.2006.11.002","article-title":"IL-12p40: an inherently agonistic cytokine","volume":"28","author":"Cooper","year":"2007","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib13","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S1471-4906(01)02060-9","article-title":"The biology of human natural killer-cell subsets","volume":"22","author":"Cooper","year":"2001","journal-title":"Trends Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib14","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.3389\/fimmu.2020.01847","article-title":"Biological therapy in inflammatory bowel disease patients partly restores intestinal innate lymphoid cell subtype equilibrium","volume":"11","author":"Creyns","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib15","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1007\/s10620-010-1363-6","article-title":"Immune phenotype of children with newly diagnosed and gluten-free diet-treated celiac disease","volume":"56","author":"Cseh","year":"2011","journal-title":"Dig. Dis. Sci."},{"key":"10.1016\/j.celrep.2022.110956_bib16","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.3389\/fimmu.2019.02739","article-title":"Immunomodulatory effects of vitamin D in pregnancy and beyond","volume":"10","author":"Cyprian","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib17","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/MPG.0000000000001475","article-title":"Serum vitamins and minerals at diagnosis and follow-up in children with celiac disease","volume":"65","author":"Deora","year":"2017","journal-title":"J.\u00a0Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.celrep.2022.110956_bib18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1136\/gut.2005.068684","article-title":"Epithelium derived interleukin 15 regulates intraepithelial lymphocyte Th1 cytokine production, cytotoxicity, and survival in coeliac disease","volume":"55","author":"Di Sabatino","year":"2006","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2022.110956_bib19","doi-asserted-by":"crossref","first-page":"81729","DOI":"10.18632\/oncotarget.21046","article-title":"'ILC-poiesis': generating tissue ILCs from naive precursors","volume":"8","author":"Di Santo","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.celrep.2022.110956_bib20","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/ajg.2011.24","article-title":"CD62L(neg)CD38(+) expression on circulating CD4(+) T\u00a0cells identifies mucosally differentiated cells in protein fed mice and in human celiac disease patients and controls","volume":"106","author":"du Pr\u00e9","year":"2011","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.celrep.2022.110956_bib21","doi-asserted-by":"crossref","first-page":"e76008","DOI":"10.1371\/journal.pone.0076008","article-title":"Persistent changes in circulating and intestinal \u03b3\u03b4 T\u00a0cell subsets, invariant natural killer T\u00a0cells and mucosal-associated invariant T\u00a0cells in children and adults with coeliac disease","volume":"8","author":"Dunne","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2022.110956_bib22","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/JLB.5MA0120-209R","article-title":"Distinct and shared gene expression for human innate versus adaptive helper lymphoid cells","volume":"108","author":"Ercolano","year":"2020","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.celrep.2022.110956_bib23","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/bies.201500143","article-title":"Extraintestinal manifestations of celiac disease: 33-mer gliadin binding to glutamate receptor GRINA as a new explanation","volume":"38","author":"Garcia-Quintanilla","year":"2016","journal-title":"Bioessays"},{"key":"10.1016\/j.celrep.2022.110956_bib24","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.immuni.2014.01.011","article-title":"Group 2 innate lymphoid cells are critical for the initiation of adaptive T helper 2 cell-mediated allergic lung inflammation","volume":"40","author":"Halim","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2022.110956_bib25","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1038\/cti.2016.58","article-title":"Coeliac disease: a unique model for investigating broken tolerance in autoimmunity","volume":"5","author":"Hardy","year":"2016","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/nature12240","article-title":"Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria","volume":"498","author":"Hepworth","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.110956_bib27","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1111\/j.1365-2036.2008.03609.x","article-title":"Coeliac disease: a biopsy is not always necessary for diagnosis","volume":"27","author":"Hill","year":"2008","journal-title":"Aliment. Pharmacol. Ther."},{"key":"10.1016\/j.celrep.2022.110956_bib28","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","article-title":"European society for pediatric Gastroenterology, Hepatology, and nutrition guidelines for the diagnosis of coeliac disease.","volume":"54","author":"Husby","year":"2012","journal-title":"J.\u00a0Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.celrep.2022.110956_bib29","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nature11813","article-title":"A T-bet gradient controls the fate and function of CCR6\u2212ROR\u03b3t+ innate lymphoid cells","volume":"494","author":"Klose","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.110956_bib30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jaci.2017.01.045","article-title":"Vitamin D downregulates the IL-23 receptor pathway in human mucosal group 3 innate lymphoid cells","volume":"141","author":"Konya","year":"2018","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.cyto.2009.09.015","article-title":"TNF\u03b1 and TGF-\u03b21 influence IL-18-induced IFN\u03b3 production through regulation of IL-18 receptor and T-bet expression","volume":"49","author":"Koutoulaki","year":"2010","journal-title":"Cytokine"},{"key":"10.1016\/j.celrep.2022.110956_bib32","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1365-2249.2005.02661.x","article-title":"Enhanced interleukin-18 levels in the peripheral blood of children with coeliac disease","volume":"139","author":"Lettesjo","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/eji.201747294","article-title":"ILC-poiesis: ensuring tissue ILC differentiation at the right place and time","volume":"49","author":"Lim","year":"2019","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib34","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1016\/j.cell.2017.02.021","article-title":"Systemic human ILC precursors provide a substrate for tissue ILC differentiation","volume":"168","author":"Lim","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.110956_bib35","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/gutjnl-2013-306578","article-title":"Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology","volume":"63","author":"Ludvigsson","year":"2014","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2022.110956_bib36","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/S0140-6736(03)13803-2","article-title":"Association between innate response to gliadin and activation of pathogenic T\u00a0cells in coeliac disease","volume":"362","author":"Maiuri","year":"2003","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2022.110956_bib37","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1053\/j.gastro.2005.07.054","article-title":"Unexpected role of surface transglutaminase type II in celiac disease","volume":"129","author":"Maiuri","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2022.110956_bib38","doi-asserted-by":"crossref","first-page":"e0126291","DOI":"10.1371\/journal.pone.0126291","article-title":"TNF-alpha producing innate lymphoid cells (ILCs) are increased in active celiac disease and contribute to promote intestinal atrophy in mice","volume":"10","author":"Marafini","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2022.110956_bib39","doi-asserted-by":"crossref","first-page":"e0155103","DOI":"10.1371\/journal.pone.0155103","article-title":"Celiac disease-related inflammation is marked by reduction of nkp44\/nkp46-double positive natural killer cells","volume":"11","author":"Marafini","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2022.110956_bib40","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1186\/s40425-019-0719-5","article-title":"Adenosine mediates functional and metabolic suppression of peripheral and tumor-infiltrating CD8(+) T\u00a0cells","volume":"7","author":"Mastelic-Gavillet","year":"2019","journal-title":"J.\u00a0Immunother. Cancer"},{"key":"10.1016\/j.celrep.2022.110956_bib41","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1093\/ibd\/izaa316","article-title":"Crohn's disease is associated with activation of circulating innate lymphoid cells","volume":"27","author":"Mazzurana","year":"2021","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.celrep.2022.110956_bib42","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.immuni.2014.09.006","article-title":"Innate lymphoid cells in inflammation and immunity","volume":"41","author":"McKenzie","year":"2014","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2022.110956_bib43","doi-asserted-by":"crossref","first-page":"1762","DOI":"10.1084\/jem.20190490","article-title":"KLRG1 and NKp46 discriminate subpopulations of human CD117(+)CRTH2(-) ILCs biased toward ILC2 or ILC3","volume":"216","author":"Nagasawa","year":"2019","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2022.110956_bib44","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1084\/jem.182.5.1281","article-title":"Antibodies to interleukin 12 abrogate established experimental colitis in mice","volume":"182","author":"Neurath","year":"1995","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2022.110956_bib45","doi-asserted-by":"crossref","first-page":"254","DOI":"10.4049\/jimmunol.175.1.254","article-title":"Refining the rules of gliadin T\u00a0cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation","volume":"175","author":"Qiao","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib46","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.immuni.2011.11.011","article-title":"The aryl hydrocarbon receptor regulates gut immunity through modulation of innate lymphoid cells","volume":"36","author":"Qiu","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2022.110956_bib47","doi-asserted-by":"crossref","first-page":"2831","DOI":"10.1073\/pnas.0608610104","article-title":"Tetramer visualization of gut-homing gluten-specific T\u00a0cells in the peripheral blood of celiac disease patients","volume":"104","author":"Raki","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.celrep.2022.110956_bib48","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nrgastro.2017.121","article-title":"Coeliac disease: to biopsy or not?","volume":"15","author":"Reilly","year":"2018","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.celrep.2022.110956_bib49","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"Limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2022.110956_bib50","doi-asserted-by":"crossref","first-page":"e94821","DOI":"10.1172\/jci.insight.94821","article-title":"Essential role for CCR6 in certain inflammatory diseases demonstrated using specific antagonist and knockin mice","volume":"2","author":"Robert","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2022.110956_bib51","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.celrep.2022.110956_bib52","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13052-018-0488-7","article-title":"Vitamin D in pediatric age: consensus of the Italian pediatric society and the Italian society of preventive and social pediatrics, jointly with the Italian federation of pediatricians","volume":"44","author":"Saggese","year":"2018","journal-title":"Ital. J. Pediatr."},{"key":"10.1016\/j.celrep.2022.110956_bib53","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1182\/bloodadvances.2018030478","article-title":"CD56 as a marker of an ILC1-like population with NK cell properties that is functionally impaired in AML","volume":"3","author":"Salome","year":"2019","journal-title":"Blood Adv."},{"key":"10.1016\/j.celrep.2022.110956_bib54","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/ni.1684","article-title":"ROR\u03b3t and commensal microflora are required for the differentiation of mucosal interleukin 22\u2013producing NKp46+ cells","volume":"10","author":"Sanos","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib55","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1177\/1087057110366035","article-title":"A profiling platform for the characterization of transglutaminase 2 (TG2) inhibitors","volume":"15","author":"Schaertl","year":"2010","journal-title":"J.\u00a0Biomol. Screen"},{"key":"10.1016\/j.celrep.2022.110956_bib56","doi-asserted-by":"crossref","first-page":"R1264","DOI":"10.1152\/ajpregu.2001.281.4.R1264","article-title":"Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production","volume":"281","author":"Siegmund","year":"2001","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.celrep.2022.110956_bib57","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1146\/annurev.immunol.18.1.53","article-title":"Molecular basis of celiac disease","volume":"18","author":"Sollid","year":"2000","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib58","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nm.3892","article-title":"Innate lymphoid cells in the initiation, regulation and resolution of inflammation","volume":"21","author":"Sonnenberg","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.celrep.2022.110956_bib59","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nri3365","article-title":"Innate lymphoid cells--a proposal for uniform nomenclature","volume":"13","author":"Spits","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib60","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.20072713","article-title":"Lymphoid tissue inducer-like cells are an innate source of IL-17 and IL-22","volume":"206","author":"Takatori","year":"2009","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2022.110956_bib61","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/MCG.0000000000001267","article-title":"Celiac disease: extraintestinal manifestations and associated conditions","volume":"54","author":"Therrien","year":"2020","journal-title":"J.\u00a0Clin. Gastroenterol."},{"key":"10.1016\/j.celrep.2022.110956_bib62","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/s41467-017-00678-2","article-title":"Tumour-derived PGD2 and NKp30-B7H6 engagement drives an immunosuppressive ILC2-MDSC axis","volume":"8","author":"Trabanelli","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2022.110956_bib63","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/cei.13414","article-title":"Phenotypic shift of small intestinal intraepithelial type 1 innate lymphoid cells in celiac disease is associated with enhanced cytotoxic potential","volume":"200","author":"Uhde","year":"2020","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.celrep.2022.110956_bib64","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1084\/jem.20012028","article-title":"Specificity of tissue transglutaminase explains cereal toxicity in celiac disease","volume":"195","author":"Vader","year":"2002","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2022.110956_bib65","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.cell.2018.07.017","article-title":"Innate lymphoid cells: 10 Years on","volume":"174","author":"Vivier","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.110956_bib66","doi-asserted-by":"crossref","first-page":"12835","DOI":"10.1073\/pnas.1406908111","article-title":"Activated group 3 innate lymphoid cells promote T-cell-mediated immune responses","volume":"111","author":"von Burg","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U\u00a0S\u00a0A"},{"key":"10.1016\/j.celrep.2022.110956_bib67","doi-asserted-by":"crossref","first-page":"e613","DOI":"10.1097\/MD.0000000000000613","article-title":"IL12p40 regulates functional development of human CD4+ T\u00a0cells: enlightenment by the elevated expressions of IL12p40 in patients with inflammatory bowel diseases","volume":"94","author":"Wang","year":"2015","journal-title":"Medicine (Baltim.)"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722007380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722007380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:45:24Z","timestamp":1761911124000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124722007380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":67,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S2211124722007380"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2022.110956","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gliadin-reactive vitamin D-sensitive proinflammatory ILCPs are enriched in celiac patients","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2022.110956","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"110956"}}