{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:37:02Z","timestamp":1787236622992,"version":"build-2736575974"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA238270"],"award-info":[{"award-number":["R01CA238270"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK107651"],"award-info":[{"award-number":["R01DK107651"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK127180"],"award-info":[{"award-number":["R01DK127180"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK127207"],"award-info":[{"award-number":["R01DK127207"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005190","name":"Melanoma Research Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.celrep.2022.111125","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T18:29:19Z","timestamp":1658255359000},"page":"111125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposis"],"prefix":"10.1016","volume":"40","author":[{"given":"Jennifer L.","family":"Cotton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyvan","family":"Dang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alka","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihir S.","family":"Rajurkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1980-1177","authenticated-orcid":false,"given":"Junhao","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2022.111125_bib1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.cell.2004.07.023","article-title":"Dynamic changes in the response of cells to positive hedgehog signaling during mouse limb patterning","volume":"118","author":"Ahn","year":"2004","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.111125_bib2","doi-asserted-by":"crossref","first-page":"4753","DOI":"10.1242\/dev.129.20.4753","article-title":"Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway","volume":"129","author":"Bai","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.celrep.2022.111125_bib3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/nature01045","article-title":"Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation","volume":"419","author":"Bardeesy","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111125_bib4","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111125_bib5","doi-asserted-by":"crossref","first-page":"G856","DOI":"10.1152\/ajpgi.00178.2011","article-title":"Intestinal epithelial-specific PTEN inactivation results in tumor formation","volume":"301","author":"Byun","year":"2011","journal-title":"Am. J. Physiol. Gastrointest. Liver Physiol."},{"key":"10.1016\/j.celrep.2022.111125_bib6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.devcel.2017.08.019","article-title":"YAP\/TAZ and hedgehog coordinate growth and patterning in gastrointestinal mesenchyme","volume":"43","author":"Cotton","year":"2017","journal-title":"Dev. Cell"},{"key":"10.1016\/j.celrep.2022.111125_bib7","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41586-018-0190-3","article-title":"GLI1-expressing mesenchymal cells form the essential Wnt-secreting niche for colon stem cells","volume":"558","author":"Degirmenci","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111125_bib8","doi-asserted-by":"crossref","first-page":"153339","DOI":"10.1016\/j.prp.2020.153339","article-title":"Colorectal polyposis as a clue to the diagnosis of Cowden syndrome: report of two cases and literature review","volume":"218","author":"Innella","year":"2021","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.celrep.2022.111125_bib9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1750-1172-9-101","article-title":"Hamartomatous polyposis syndromes: a review","volume":"9","author":"Jelsig","year":"2014","journal-title":"Orphanet J. Rare Dis."},{"key":"10.1016\/j.celrep.2022.111125_bib10","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/ng.98","article-title":"LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis","volume":"40","author":"Katajisto","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2022.111125_bib11","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/gene.10036","article-title":"Cre\/loxP-mediated inactivation of the murine Pten tumor suppressor gene","volume":"32","author":"Lesche","year":"2002","journal-title":"Genesis"},{"key":"10.1016\/j.celrep.2022.111125_bib12","doi-asserted-by":"crossref","first-page":"33275","DOI":"10.1074\/jbc.M204935200","article-title":"Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine","volume":"277","author":"Madison","year":"2002","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2022.111125_bib13","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.cell.2007.06.009","article-title":"AKT\/PKB signaling: navigating downstream","volume":"129","author":"Manning","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.111125_bib14","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ajpath.2013.10.003","article-title":"Epithelial-specific loss of PTEN results in colorectal juvenile polyp formation and invasive cancer","volume":"184","author":"Marsh Durban","year":"2014","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.celrep.2022.111125_bib15","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/ncb2884","article-title":"A genetic screen identifies an LKB1-MARK signalling axis controlling the Hippo-YAP pathway","volume":"16","author":"Mohseni","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2022.111125_bib16","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"key":"10.1016\/j.celrep.2022.111125_bib17","doi-asserted-by":"crossref","first-page":"4100","DOI":"10.1038\/onc.2012.431","article-title":"LKB1 tumor suppressor regulates AMP kinase\/mTOR-independent cell growth and proliferation via the phosphorylation of Yap","volume":"32","author":"Nguyen","year":"2013","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2022.111125_bib18","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1172\/JCI93597","article-title":"Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11-JAK\/STAT3 pathway","volume":"128","author":"Ollila","year":"2018","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2022.111125_bib19","doi-asserted-by":"crossref","first-page":"E153","DOI":"10.3390\/biom9040153","article-title":"The PTEN(-)PI3K Axis in cancer","volume":"9","author":"Papa","year":"2019","journal-title":"Biomolecules"},{"key":"10.1016\/j.celrep.2022.111125_bib20","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1126\/science.aan3975","article-title":"LKB1 deficiency in T\u00a0cells promotes the development of gastrointestinal polyposis","volume":"361","author":"Poffenberger","year":"2018","journal-title":"Science"},{"key":"10.1016\/j.celrep.2022.111125_bib21","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1083\/jcb.200903131","article-title":"Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy","volume":"187","author":"Risson","year":"2009","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2022.111125_bib22","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.cell.2017.02.004","article-title":"mTOR signaling in growth, metabolism, and disease","volume":"168","author":"Saxton","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.111125_bib23","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/nrc2676","article-title":"The LKB1-AMPK pathway: metabolism and growth control in tumour suppression","volume":"9","author":"Shackelford","year":"2009","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.celrep.2022.111125_bib24","doi-asserted-by":"crossref","first-page":"11137","DOI":"10.1073\/pnas.0900465106","article-title":"mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome","volume":"106","author":"Shackelford","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2022.111125_bib25","doi-asserted-by":"crossref","first-page":"e60","DOI":"10.1097\/MCG.0000000000000703","article-title":"Gastrointestinal polyposis in cowden syndrome","volume":"51","author":"Shaco-Levy","year":"2017","journal-title":"J.\u00a0Clin. Gastroenterol."},{"key":"10.1016\/j.celrep.2022.111125_bib26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1748-1716.2009.01972.x","article-title":"LKB1 and AMP-activated protein kinase control of mTOR signalling and growth","volume":"196","author":"Shaw","year":"2009","journal-title":"Acta Physiol."},{"key":"10.1016\/j.celrep.2022.111125_bib27","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1897-4287-11-4","article-title":"Hamartomatous polyposis syndromes","volume":"11","author":"Stojcev","year":"2013","journal-title":"Hered. Cancer Clin. Pract."},{"key":"10.1016\/j.celrep.2022.111125_bib28","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1053\/j.gastro.2009.01.009","article-title":"Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development","volume":"136","author":"Verzi","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.celrep.2022.111125_bib29","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10434-001-0319-7","article-title":"Hamartomatous polyposis syndromes: molecular genetics, neoplastic risk, and surveillance recommendations","volume":"8","author":"Wirtzfeld","year":"2001","journal-title":"Ann. Surg Oncol."},{"key":"10.1016\/j.celrep.2022.111125_bib30","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/ncpgasthep0902","article-title":"Hamartomatous polyposis syndromes","volume":"4","author":"Zbuk","year":"2007","journal-title":"Nat. Clin. Pract. Gastroenterol. Hepatol."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722009317?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722009317?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:48:54Z","timestamp":1761911334000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124722009317"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["S2211124722009317"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2022.111125","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposis","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2022.111125","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"111125"}}