{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:57:39Z","timestamp":1790189859572,"version":"4.1.0"},"reference-count":81,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001031","name":"ARC","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001031","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000923","name":"Australian Research Council","doi-asserted-by":"publisher","award":["160100627"],"award-info":[{"award-number":["160100627"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.celrep.2022.111191","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T10:42:03Z","timestamp":1660646523000},"page":"111191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Dysbiosis in imiquimod-induced psoriasis alters gut immunity and exacerbates colitis development"],"prefix":"10.1016","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6857-2924","authenticated-orcid":false,"given":"Gabriela Veronica","family":"Pinget","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian Kai","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duan","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jemma","family":"Taitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire Immediato","family":"Daien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Mielle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert John","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragana","family":"Stanley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas Jonathan Cole","family":"King","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Macia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2022.111191_bib1","doi-asserted-by":"crossref","first-page":"620189","DOI":"10.3389\/fped.2020.620189","article-title":"Not all fibers are born equal; variable response to dietary fiber subtypes in IBD","volume":"8","author":"Armstrong","year":"2021","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.celrep.2022.111191_bib2","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.3389\/fimmu.2018.02733","article-title":"Origin, differentiation, and function of intestinal macrophages","volume":"9","author":"Bain","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111191_bib3","first-page":"218","article-title":"Resident and pro-inflammatory macrophages in the colon represent alternative context dependent fates of the same Ly6Chi monocyte precursors","volume":"137","author":"Bain","year":"2012","journal-title":"Immunology"},{"key":"10.1016\/j.celrep.2022.111191_bib4","doi-asserted-by":"crossref","first-page":"6892","DOI":"10.3748\/wjg.v21.i22.6892","article-title":"Nonalcoholic fatty liver disease, spleen and psoriasis: new aspects of low-grade chronic inflammation","volume":"21","author":"Balato","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.celrep.2022.111191_bib5","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.3389\/fmicb.2018.01995","article-title":"Role of short chain fatty acids in controlling tregs and immunopathology during mucosal infection","volume":"9","author":"Bhaskaran","year":"2018","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.celrep.2022.111191_bib6","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.3389\/fimmu.2018.01682","article-title":"The IL-17 family of cytokines in psoriasis: IL-17A and beyond","volume":"9","author":"Brembilla","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111191_bib7","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.immuni.2011.08.001","article-title":"Pivotal role of dermal IL-17-producing gamma delta T\u00a0cells in skin inflammation","volume":"35","author":"Cai","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2022.111191_bib8","article-title":"RDP taxonomic training data formatted for DADA2 (RDP trainset 16\/release 11.5)","author":"Callahan","year":"2017","journal-title":"Zenodo"},{"key":"10.1016\/j.celrep.2022.111191_bib9","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2022.111191_bib13","doi-asserted-by":"crossref","unstructured":"Chang, H.-W. Yan D., Singh R., Bui A., Lee K.M., Truong A., Milush J.M., Somsouk M., Liao W. (2021) Metagenomic analysis of the gut microbiome in psoriasis reveals three subgroups with distinct host-microbe interactions. Available at Research Square. https:\/\/doi.org\/10.21203\/rs.3.rs-58641\/v1.","DOI":"10.21203\/rs.3.rs-58641\/v1"},{"key":"10.1016\/j.celrep.2022.111191_bib10","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12964-016-0126-1","article-title":"GPR91: expanding the frontiers of Krebs cycle intermediates","volume":"14","author":"de Castro Fonseca","year":"2016","journal-title":"Cell Commun. Signal."},{"key":"10.1016\/j.celrep.2022.111191_bib11","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1038\/jid.2009.59","article-title":"The IL-23\/Th17 Axis in the\u00a0immunopathogenesis of psoriasis","volume":"129","author":"Di Cesare","year":"2009","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2022.111191_bib12","doi-asserted-by":"crossref","first-page":"J314","DOI":"10.1016\/j.jaut.2009.12.001","article-title":"Geoepidemiology and environmental factors of psoriasis and psoriatic arthritis","volume":"34","author":"Chandran","year":"2010","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.celrep.2022.111191_bib14","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1021\/acs.jafc.6b05207","article-title":"Isogarcinol extracted from Garcinia mangostana L. Ameliorates imiquimod-induced psoriasis -like skin lesions in mice","volume":"65","author":"Chen","year":"2017","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.celrep.2022.111191_bib15","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.jfda.2016.06.003","article-title":"Lactobacillus pentosus GMNL-77 inhibits skin lesions in imiquimod-induced psoriasis-like mice","volume":"25","author":"Chen","year":"2017","journal-title":"J.\u00a0Food Drug Anal."},{"key":"10.1016\/j.celrep.2022.111191_bib16","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1046\/j.1365-2230.2001.00832.x","article-title":"Psoriasis--epidemiology and clinical spectrum","volume":"26","author":"Christophers","year":"2001","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.celrep.2022.111191_bib17","doi-asserted-by":"crossref","first-page":"3812","DOI":"10.1038\/s41598-018-22125-y","article-title":"Gut microbial composition in patients with psoriasis","volume":"8","author":"Codoner","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2022.111191_bib18","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/nu11010025","article-title":"The role of succinate in the regulation of intestinal inflammation","volume":"11","author":"Connors","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.celrep.2022.111191_bib19","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1002\/eji.201970107","article-title":"Guidelines for\u00a0the use of flow cytometry and cell sorting in immunological studies (second\u00a0edition)","volume":"49","author":"Cossarizza","year":"2019","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2022.111191_bib20","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1159\/000500116","article-title":"Psoriasis and inflammatory bowel disease","volume":"37","author":"Cottone","year":"2019","journal-title":"Dig. Dis."},{"key":"10.1016\/j.celrep.2022.111191_bib21","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.3390\/jcm10051122","article-title":"The role of extracellular matrix components in inflammatory bowel diseases","volume":"10","author":"Derkacz","year":"2021","journal-title":"J.\u00a0Clin. Med."},{"key":"10.1016\/j.celrep.2022.111191_bib22","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1038\/s41467-019-11148-2","article-title":"Inflammation triggers immediate rather than progressive changes in monocyte differentiation in the small intestine","volume":"10","author":"Desalegn","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2022.111191_bib23","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4103\/2229-5178.193906","article-title":"Psoriasis: epidemiology, clinical features, co-morbidities, and clinical scoring","volume":"7","author":"Dogra","year":"2016","journal-title":"Indian Dermatol. Online J."},{"key":"10.1016\/j.celrep.2022.111191_bib24","doi-asserted-by":"crossref","first-page":"e9125","DOI":"10.1371\/journal.pone.0009125","article-title":"The induction of colitis and ileitis in mice is associated with marked increases in intestinal concentrations of stimulants of TLRs 2, 4, and 5","volume":"5","author":"Erridge","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2022.111191_bib25","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s11154-019-09513-z","article-title":"Gut microbiota-derived succinate: friend or foe in human metabolic diseases?","volume":"20","author":"Fernandez-Veledo","year":"2019","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.celrep.2022.111191_bib26","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 Axis","volume":"182","author":"van der Fits","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2022.111191_bib27","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1111\/ced.13561","article-title":"Association between serum interleukin-17A and clinical response to tofacitinib and etanercept in moderate to severe psoriasis","volume":"43","author":"Fitz","year":"2018","journal-title":"Clin. Exp. Dermatol."},{"key":"10.1016\/j.celrep.2022.111191_bib28","doi-asserted-by":"crossref","first-page":"109521","DOI":"10.1016\/j.celrep.2021.109521","article-title":"A transepithelial pathway delivers succinate to macrophages, thus perpetuating their pro-inflammatory metabolic state","volume":"36","author":"Fremder","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2022.111191_bib29","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/nature13041","article-title":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T\u00a0cells (vol 504, pg 446, 2013)","author":"Furusawa","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111191_bib30","doi-asserted-by":"crossref","first-page":"219ra7","DOI":"10.1126\/scitranslmed.3007563","article-title":"Therapeutic inflammatory monocyte modulation using immune-modifying microparticles","volume":"6","author":"Getts","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2022.111191_bib31","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.3389\/fmicb.2017.02224","article-title":"Microbiome datasets are compositional: and this is not optional","volume":"8","author":"Gloor","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.celrep.2022.111191_bib32","doi-asserted-by":"crossref","first-page":"20134","DOI":"10.1038\/srep20134","article-title":"Topical imiquimod yields systemic effects due to unintended oral uptake","volume":"6","author":"Grine","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2022.111191_bib33","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4161\/gmic.25487","article-title":"Bifidobacterium infantis 35624 modulates host inflammatory processes beyond the gut","volume":"4","author":"Groeger","year":"2013","journal-title":"Gut Microb."},{"key":"10.1016\/j.celrep.2022.111191_bib34","doi-asserted-by":"crossref","first-page":"625423","DOI":"10.3389\/fcell.2021.625423","article-title":"Roles of macrophages in the development and treatment of gut inflammation","volume":"9","author":"Han","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2022.111191_bib35","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/S0140-6736(02)08512-4","article-title":"Maintenance infliximab for Crohn\u2019s disease: the ACCENT I randomised trial","volume":"359","author":"Hanauer","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2022.111191_bib36","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jss.2010.03.002","article-title":"The role of matrix metalloproteinases in intestinal epithelial wound healing during normal and inflammatory states","volume":"168","author":"Hayden","year":"2011","journal-title":"J.\u00a0Surg. Res."},{"key":"10.1016\/j.celrep.2022.111191_bib37","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1172\/JCI123374","article-title":"Fbxw7 increases CCL2\/7 in CX3CR1hi macrophages to promote intestinal inflammation","volume":"129","author":"He","year":"2019","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2022.111191_bib38","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.jaad.2008.01.006","article-title":"National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening","volume":"58","author":"Kimball","year":"2008","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.celrep.2022.111191_bib39","doi-asserted-by":"crossref","first-page":"eaax0062","DOI":"10.1126\/sciimmunol.aax0062","article-title":"Gut-resident CX3CR1hi macrophages induce tertiary lymphoid structures and IgA response in\u00a0situ","volume":"5","author":"Koscs\u00f3","year":"2020","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.celrep.2022.111191_bib40","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1189\/jlb.1109768","article-title":"Crucial involvement of the CX3CR1-CX3CL1 axis in dextran sulfate sodium-mediated acute colitis in mice","volume":"88","author":"Kostadinova","year":"2010","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.celrep.2022.111191_bib41","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.3389\/fimmu.2018.01830","article-title":"Aspects of gut microbiota and immune system interactions in infectious diseases, immunopathology, and cancer","volume":"9","author":"Lazar","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111191_bib42","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1136\/annrheumdis-2012-202143","article-title":"Psoriasis, psoriatic arthritis and increased risk of incident Crohn\u2019s disease in US women","volume":"72","author":"Li","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.celrep.2022.111191_bib43","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1084\/jem.20160061","article-title":"GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis","volume":"213","author":"Littlewood-Evans","year":"2016","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2022.111191_bib44","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1038\/ncomms7734","article-title":"Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome","volume":"6","author":"Macia","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2022.111191_bib45","doi-asserted-by":"crossref","first-page":"2016809","DOI":"10.1155\/2020\/2016809","article-title":"Succinate supplement elicited \u201cPseudohypoxia\u201d condition to promote proliferation, migration, and osteogenesis of periodontal ligament cells","volume":"2020","author":"Mao","year":"2020","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.celrep.2022.111191_bib46","doi-asserted-by":"crossref","first-page":"4787","DOI":"10.1172\/JCI59150","article-title":"CX3CR1 regulates intestinal macrophage homeostasis, bacterial translocation, and colitogenic Th17 responses in mice","volume":"121","author":"Medina-Contreras","year":"2011","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2022.111191_bib47","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.celrep.2018.06.110","article-title":"Ki67 is a graded rather than a binary marker of proliferation versus quiescence","volume":"24","author":"Miller","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2022.111191_bib48","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/s41586-019-0884-1","article-title":"GPR31-dependent dendrite protrusion of intestinal CX3CR1(+) cells by bacterial metabolites","volume":"566","author":"Morita","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111191_bib49","doi-asserted-by":"crossref","first-page":"5848","DOI":"10.3748\/wjg.v18.i41.5848","article-title":"Changes of the cytokine profile in inflammatory bowel diseases","volume":"18","author":"Muzes","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.celrep.2022.111191_bib50","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/s41575-019-0172-4","article-title":"Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD","volume":"16","author":"Na","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.celrep.2022.111191_bib51","doi-asserted-by":"crossref","first-page":"16148","DOI":"10.1038\/srep16148","article-title":"The effect of short-chain fatty acids on human monocyte-derived dendritic cells","volume":"5","author":"Nastasi","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2022.111191_bib52","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.jaad.2006.08.040","article-title":"Prevalence of cardiovascular risk factors in patients with psoriasis","volume":"55","author":"Neimann","year":"2006","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.celrep.2022.111191_bib53","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1590\/abd1806-4841.20153038","article-title":"Psoriasis: classical and emerging comorbidities","volume":"90","author":"de Oliveira","year":"2015","journal-title":"An. Bras. Dermatol."},{"key":"10.1016\/j.celrep.2022.111191_bib54","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/jid.2012.339","article-title":"Global epidemiology of psoriasis: a systematic review of incidence and prevalence","volume":"133","author":"Parisi","year":"2013","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2022.111191_bib55","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.1016\/j.jid.2020.03.973","article-title":"Immune modulation of monocytes dampens the IL-17(+) gammadelta T\u00a0cell response and associated psoriasis pathology in mice","volume":"140","author":"Pinget","year":"2020","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2022.111191_bib56","doi-asserted-by":"crossref","first-page":"668654","DOI":"10.3389\/fimmu.2021.668654","article-title":"Obesity in humans is characterized by gut inflammation as shown by pro-inflammatory intestinal macrophage accumulation","volume":"12","author":"Rohm","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111191_bib57","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1038\/s42003-022-03305-z","article-title":"Targeting colonic macrophages improves glycemic control in high-fat diet-induced obesity","volume":"5","author":"Rohm","year":"2022","journal-title":"Commun. Biol."},{"key":"10.1016\/j.celrep.2022.111191_bib58","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/art.38892","article-title":"Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease","volume":"67","author":"Scher","year":"2015","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.celrep.2022.111191_bib59","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1002\/hep.27982","article-title":"CX3CR1 is a gatekeeper for intestinal barrier integrity in mice: limiting steatohepatitis by maintaining intestinal homeostasis","volume":"62","author":"Schneider","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.celrep.2022.111191_bib60","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.immuni.2018.12.018","article-title":"The short chain fatty acid butyrate imprints an antimicrobial Program in macrophages","volume":"50","author":"Schulthess","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2022.111191_bib61","doi-asserted-by":"crossref","first-page":"6383","DOI":"10.4049\/jimmunol.161.11.6383","article-title":"IL-17 stimulates granulopoiesis in mice: use of an alternate, novel gene therapy-derived method for in\u00a0vivo evaluation of cytokines","volume":"161","author":"Schwarzenberger","year":"1998","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2022.111191_bib62","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1084\/jem.20180019","article-title":"Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression","volume":"215","author":"Shaw","year":"2018","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2022.111191_bib63","doi-asserted-by":"crossref","first-page":"11265","DOI":"10.1038\/s41598-021-90480-4","article-title":"Abnormal composition of microbiota in the gut and skin of imiquimod-treated mice","volume":"11","author":"Shinno-Hashimoto","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2022.111191_bib64","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1111\/1346-8138.14647","article-title":"Intestinal barrier integrity in patients with plaque psoriasis","volume":"45","author":"Sikora","year":"2018","journal-title":"J.\u00a0Dermatol."},{"key":"10.1016\/j.celrep.2022.111191_bib65","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/MIB.0b013e3182a69dca","article-title":"The role of macrophages and dendritic cells in the initiation of inflammation in IBD","volume":"20","author":"Steinbach","year":"2014","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.celrep.2022.111191_bib66","doi-asserted-by":"crossref","first-page":"e78461","DOI":"10.1371\/journal.pone.0078461","article-title":"Local IL-17A potentiates early neutrophil recruitment to the respiratory tract during severe RSV infection","volume":"8","author":"Stoppelenburg","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2022.111191_bib67","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2022.111191_bib68","doi-asserted-by":"crossref","first-page":"7931031","DOI":"10.1155\/2018\/7931031","article-title":"Antipsoriatic effects of wannachawee recipe on imiquimod-induced psoriasis-like dermatitis in BALB\/c mice","author":"Takuathung","year":"2018","journal-title":"Evid. Base Compl. Alternative Med."},{"key":"10.1016\/j.celrep.2022.111191_bib81","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/B978-0-12-800100-4.00003-9","article-title":"The role of short-chain fatty acids in health and disease","volume":"121","author":"Tan","year":"2014","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.celrep.2022.111191_bib69","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1016\/j.celrep.2016.05.047","article-title":"Dietary fiber and bacterial SCFA enhance oral tolerance and protect against food allergy through diverse cellular pathways","volume":"15","author":"Tan","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2022.111191_bib71","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1038\/s41467-022-31761-y","article-title":"Dietary protein increases T cell independent sIgA production through changes in gut microbiota-derived extracellular vesicles","volume":"13","author":"Tan","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2022.111191_bib70","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/exd.13463","article-title":"The Akkermansia muciniphila is a gut microbiota signature in psoriasis","volume":"27","author":"Tan","year":"2018","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.celrep.2022.111191_bib72","doi-asserted-by":"crossref","first-page":"823","DOI":"10.3390\/nu13030823","article-title":"How changes in the nutritional landscape shape gut immunometabolism","volume":"13","author":"Tan","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.celrep.2022.111191_bib73","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1 beta through HIF-1 alpha","volume":"496","author":"Tannahill","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111191_bib74","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3389\/fcimb.2019.00007","article-title":"Bacterial dysbiosis and translocation in psoriasis vulgaris","volume":"9","author":"Visser","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.celrep.2022.111191_bib75","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.jaad.2013.10.044","article-title":"Psoriasis is independently associated with nonalcoholic fatty liver disease in patients 55 years old or older: results from a population-based study","volume":"70","author":"van der Voort","year":"2014","journal-title":"J.\u00a0Am. Acad. Dermatol."},{"key":"10.1016\/j.celrep.2022.111191_bib76","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jdermsci.2017.10.016","article-title":"Resolvin D1 attenuates imiquimod-induced mice psoriasiform dermatitis through MAPKs and NF-kappa B pathways","volume":"89","author":"Xu","year":"2018","journal-title":"J.\u00a0Dermatol. Sci."},{"key":"10.1016\/j.celrep.2022.111191_bib77","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1111\/1346-8138.12119","article-title":"Mustard seed (Sinapis Alba Linn) attenuates imiquimod-induced psoriasiform inflammation of BALB\/c mice","volume":"40","author":"Yang","year":"2013","journal-title":"J.\u00a0Dermatol."},{"key":"10.1016\/j.celrep.2022.111191_bib78","doi-asserted-by":"crossref","first-page":"e0159539","DOI":"10.1371\/journal.pone.0159539","article-title":"Intestinal microbiota promotes psoriasis-like skin inflammation by enhancing Th17 response","volume":"11","author":"Zakostelska","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2022.111191_bib79","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s40348-016-0041-y","article-title":"The impact of hypoxia on intestinal epithelial cell functions: consequences for invasion by bacterial pathogens","volume":"3","author":"Zeitouni","year":"2016","journal-title":"Mol. Cell. Pediatr."},{"key":"10.1016\/j.celrep.2022.111191_bib80","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.immuni.2014.03.012","article-title":"Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis","volume":"40","author":"Zigmond","year":"2014","journal-title":"Immunity"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722010087?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722010087?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:49:35Z","timestamp":1761911375000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124722010087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":81,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S2211124722010087"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2022.111191","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysbiosis in imiquimod-induced psoriasis alters gut immunity and exacerbates colitis development","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2022.111191","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"111191"}}