{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:46:01Z","timestamp":1790700361604,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004271","name":"Sapienza Universit\u00e0 di Roma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004271","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009592","name":"Beijing Municipal Science and Technology Commission","doi-asserted-by":"publisher","award":["Z181100001518001"],"award-info":[{"award-number":["Z181100001518001"]}],"id":[{"id":"10.13039\/501100009592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2016YFA0500401"],"award-info":[{"award-number":["2016YFA0500401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010346","name":"University of Colorado Denver","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010346","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019404","name":"Shenzhen-Hong Kong Institute of Brain Science","doi-asserted-by":"publisher","award":["2019SHIBS0004"],"award-info":[{"award-number":["2019SHIBS0004"]}],"id":[{"id":"10.13039\/501100019404","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21790394"],"award-info":[{"award-number":["21790394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31761133016"],"award-info":[{"award-number":["31761133016"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31821091"],"award-info":[{"award-number":["31821091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31930061"],"award-info":[{"award-number":["31930061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070958"],"award-info":[{"award-number":["32070958"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82022018"],"award-info":[{"award-number":["82022018"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82101568"],"award-info":[{"award-number":["82101568"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82161138025"],"award-info":[{"award-number":["82161138025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021524","name":"School of Life Sciences and Biotechnology Division of Life Sciences, Korea University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021524","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.celrep.2022.111199","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T10:45:12Z","timestamp":1660646712000},"page":"111199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Cocaine increases quantal norepinephrine secretion through NET-dependent PKC activation in locus coeruleus neurons"],"prefix":"10.1016","volume":"40","author":[{"given":"Feipeng","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinglong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiying","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Younus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Hokfelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Qing David","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9048-6638","authenticated-orcid":false,"given":"Zhuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2022.111199_bib1","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.neuron.2017.10.032","article-title":"Alcohol and the brain: neuronal molecular targets, synapses, and circuits","volume":"96","author":"Abrahao","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2022.111199_bib2","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3389\/fnsyn.2014.00019","article-title":"Cocaine inhibition of nicotinic acetylcholine receptors influences dopamine release","volume":"6","author":"Acevedo-Rodriguez","year":"2014","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib3","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1523\/JNEUROSCI.01-08-00887.1981","article-title":"Norepinephrine-containing locus coeruleus neurons in behaving rats exhibit pronounced responses to non-noxious environmental stimuli","volume":"1","author":"Aston-Jones","year":"1981","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib4","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0079-6123(08)61877-4","article-title":"Role of the locus coeruleus in emotional activation","volume":"107","author":"Aston-Jones","year":"1996","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.celrep.2022.111199_bib5","first-page":"597","article-title":"The metabolism, storage, and release of catecholamines","volume":"21","author":"Axelrod","year":"1965","journal-title":"Recent Prog. Horm. Res."},{"key":"10.1016\/j.celrep.2022.111199_bib6","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1126\/science.173.3997.598","article-title":"Noradrenaline: fate and control of its biosynthesis","volume":"173","author":"Axelrod","year":"1971","journal-title":"Science"},{"key":"10.1016\/j.celrep.2022.111199_bib7","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1038\/nn.2930","article-title":"In utero exposure to cocaine delays postnatal synaptic maturation of glutamatergic transmission in the VTA","volume":"14","author":"Bellone","year":"2011","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0165-0173(03)00143-7","article-title":"The locus coeruleus-noradrenergic system: modulation of behavioral state and state-dependent cognitive processes","volume":"42","author":"Berridge","year":"2003","journal-title":"Brain Res. Brain Res. Rev."},{"key":"10.1016\/j.celrep.2022.111199_bib9","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1523\/JNEUROSCI.4858-08.2009","article-title":"Genetically determined interaction between the dopamine transporter and the D-2 receptor on prefronto-striatal activity and volume in humans","volume":"29","author":"Bertolino","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib10","doi-asserted-by":"crossref","first-page":"19700","DOI":"10.3390\/ijms151119700","article-title":"Cell-surface receptors transactivation mediated by g protein-coupled receptors","volume":"15","author":"Cattaneo","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2022.111199_bib11","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1083\/jcb.42.3.804","article-title":"The effects of reserpine and hypoxia on the amine-storing granules of the hamster carotid body","volume":"42","author":"Chen","year":"1969","journal-title":"J.\u00a0Cell Biol."},{"key":"10.1016\/j.celrep.2022.111199_bib12","doi-asserted-by":"crossref","first-page":"9333","DOI":"10.1073\/pnas.0600905103","article-title":"Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter","volume":"103","author":"Chen","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2022.111199_bib13","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1038\/nn1529","article-title":"Activation of GPCRs modulates quantal size in chromaffin cells through G(betagamma) and PKC","volume":"8","author":"Chen","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib14","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1523\/JNEUROSCI.4426-07.2008","article-title":"Hypocretin-1 potentiates NMDA receptor-mediated somatodendritic secretion from locus ceruleus neurons","volume":"28","author":"Chen","year":"2008","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib15","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1523\/JNEUROSCI.09-10-03584.1989","article-title":"Electrical coupling synchronizes subthreshold activity in locus coeruleus neurons in\u00a0vitro from neonatal rats","volume":"9","author":"Christie","year":"1989","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib16","doi-asserted-by":"crossref","first-page":"7645","DOI":"10.1523\/JNEUROSCI.0166-14.2014","article-title":"The timing of dopamine- and noradrenaline-mediated transmission reflects underlying differences in the extent of spillover and pooling","volume":"34","author":"Courtney","year":"2014","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib17","doi-asserted-by":"crossref","first-page":"13520","DOI":"10.1523\/JNEUROSCI.2745-12.2012","article-title":"Species differences in somatodendritic dopamine transmission determine D2-autoreceptor-mediated inhibition of ventral tegmental area neuron firing","volume":"32","author":"Courtney","year":"2012","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib18","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.cell.2009.07.027","article-title":"Synaptotagmin-1 docks secretory vesicles to syntaxin-1\/SNAP-25 acceptor complexes","volume":"138","author":"de Wit","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.111199_bib19","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1113\/jphysiol.1983.sp014990","article-title":"Noradrenaline-mediated synaptic inhibition in rat locus coeruleus neurones","volume":"345","author":"Egan","year":"1983","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.celrep.2022.111199_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1755-5949.2010.00146.x","article-title":"Relevance of norepinephrine-dopamine interactions in the treatment of major depressive disorder","volume":"16","author":"El Mansari","year":"2010","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.celrep.2022.111199_bib21","doi-asserted-by":"crossref","first-page":"13344","DOI":"10.1523\/JNEUROSCI.3546-09.2009","article-title":"The time course of dopamine transmission in the ventral tegmental area","volume":"29","author":"Ford","year":"2009","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib22","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/(SICI)1098-2396(199802)28:2<111::AID-SYN1>3.0.CO;2-E","article-title":"Measuring dopamine transporter occupancy by cocaine in\u00a0vivo: radiotracer considerations","volume":"28","author":"Fowler","year":"1998","journal-title":"Synapse"},{"key":"10.1016\/j.celrep.2022.111199_bib23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/syn.890040412","article-title":"Mapping cocaine binding sites in human and baboon brain in\u00a0vivo","volume":"4","author":"Fowler","year":"1989","journal-title":"Synapse"},{"key":"10.1016\/j.celrep.2022.111199_bib24","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1038\/mp.2017.176","article-title":"Gbetagamma subunit activation promotes dopamine efflux through the dopamine transporter","volume":"22","author":"Garcia-Olivares","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.celrep.2022.111199_bib25","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/S0896-6273(00)80147-6","article-title":"Protein kinase C enhances exocytosis from chromaffin cells by increasing the size of the readily releasable pool of secretory granules","volume":"16","author":"Gillis","year":"1996","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2022.111199_bib26","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1002\/cne.901930402","article-title":"Fine structure of rat locus coeruleus","volume":"193","author":"Groves","year":"1980","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.celrep.2022.111199_bib27","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1124\/mol.108.048033","article-title":"Cross-talk between dopaminergic and noradrenergic systems in the rat ventral tegmental area, locus ceruleus, and dorsal Hippocampus","volume":"74","author":"Guiard","year":"2008","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.celrep.2022.111199_bib28","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1126\/science.1188462","article-title":"FCHo proteins are nucleators of clathrin-mediated endocytosis","volume":"328","author":"Henne","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.celrep.2022.111199_bib29","doi-asserted-by":"crossref","first-page":"108951","DOI":"10.1016\/j.celrep.2021.108951","article-title":"Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron","author":"Hikima","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2022.111199_bib30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF00306211","article-title":"Studies on reaction and binding of monoamines after fixation and processing for electron microscopy with special reference to fixation with potassium permanganate","volume":"16","author":"Hokfelt","year":"1968","journal-title":"Histochemie"},{"key":"10.1016\/j.celrep.2022.111199_bib31","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1073\/pnas.0608897104","article-title":"Long latency of evoked quantal transmitter release from somata of locus coeruleus neurons in rat pontine slices","volume":"104","author":"Huang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2022.111199_bib32","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.neuro.29.051605.113009","article-title":"Neural mechanisms of addiction: the role of reward-related learning and memory","volume":"29","author":"Hyman","year":"2006","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib33","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1002\/ar.1091980411","article-title":"A histochemical and ultrastructural study of serotonin-containing nerves in cerebral blood vessels of the lamprey","volume":"198","author":"Iijima","year":"1980","journal-title":"Anat. Rec."},{"key":"10.1016\/j.celrep.2022.111199_bib34","doi-asserted-by":"crossref","first-page":"5196","DOI":"10.1523\/JNEUROSCI.16-16-05196.1996","article-title":"Synchronous activity in locus coeruleus results from dendritic interactions in pericoerulear regions","volume":"16","author":"Ishimatsu","year":"1996","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib35","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/nn.4245","article-title":"Resilience to chronic stress is mediated by noradrenergic regulation of dopamine neurons","volume":"19","author":"Isingrini","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib36","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1523\/JNEUROSCI.18-10-03548.1998","article-title":"Extrasynaptic vesicular transmitter release from the somata of substantia nigra neurons in rat midbrain slices. The Journal of neuroscience :","volume":"18","author":"Jaffe","year":"1998","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib37","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1146\/annurev-physiol-030212-183750","article-title":"Mammalian phospholipase C","volume":"75","author":"Kadamur","year":"2013","journal-title":"Annu. Rev.\u00a0Physiol."},{"key":"10.1016\/j.celrep.2022.111199_bib38","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0022-3565(25)30726-3","article-title":"Molecular geometry of inhibitors of the uptake of catecholamines and serotonin in synaptosomal preparations of rat brain","volume":"199","author":"Koe","year":"1976","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.celrep.2022.111199_bib39","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1038\/sj.emboj.7601656","article-title":"Dopamine transporter cell surface localization facilitated by a direct interaction with the dopamine D2 receptor","volume":"26","author":"Lee","year":"2007","journal-title":"EMBO J."},{"key":"10.1016\/j.celrep.2022.111199_bib40","doi-asserted-by":"crossref","first-page":"17555","DOI":"10.1073\/pnas.0809621105","article-title":"Selective saturation of slow endocytosis at a giant glutamatergic central synapse lacking dynamin 1","volume":"105","author":"Lou","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2022.111199_bib41","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/BF00307083","article-title":"[The different picture of organ-specific structures in the carotid body and adrenal medulla]","volume":"138","author":"Matthiessen","year":"1973","journal-title":"Z.\u00a0Zellforsch. Mikrosk. Anat."},{"key":"10.1016\/j.celrep.2022.111199_bib42","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.neuron.2015.08.038","article-title":"Merits and limitations of vesicle pool models in view of heterogeneous populations of synaptic vesicles","volume":"87","author":"Neher","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2022.111199_bib43","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.neuron.2008.08.019","article-title":"Multiple roles of calcium ions in the regulation of neurotransmitter release","volume":"59","author":"Neher","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2022.111199_bib44","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/350350a0","article-title":"Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter","volume":"350","author":"Pacholczyk","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111199_bib70","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2001"},{"key":"10.1016\/j.celrep.2022.111199_bib45","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1124\/mol.56.5.1047","article-title":"Ion dependence of carrier-mediated release in dopamine or norepinephrine transporter-transfected cells questions the hypothesis of facilitated exchange diffusion","volume":"56","author":"Pifl","year":"1999","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.celrep.2022.111199_bib46","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1126\/science.2820058","article-title":"Cocaine receptors on dopamine transporters are related to self-administration of cocaine","volume":"237","author":"Ritz","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.celrep.2022.111199_bib47","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1016\/j.biopsych.2010.12.028","article-title":"Synaptic adaptations in the nucleus accumbens caused by experiences linked to relapse","volume":"69","author":"Rothwell","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.celrep.2022.111199_bib48","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1523\/JNEUROSCI.0297-16.2017","article-title":"Sleep to remember","volume":"37","author":"Sara","year":"2017","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib49","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature14600","article-title":"Viral-genetic tracing of the input-output organization of a central noradrenaline circuit","volume":"524","author":"Schwarz","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111199_bib50","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/BF01474260","article-title":"The fine structural organization of the locus coeruleus in the rat with reference to noradrenaline contents","volume":"37","author":"Shimizu","year":"1979","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.celrep.2022.111199_bib51","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0896-6273(00)80504-8","article-title":"Cytosolic Ca2+ acts by two separate pathways to modulate the supply of release-competent vesicles in chromaffin cells","volume":"20","author":"Smith","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2022.111199_bib52","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.neuron.2014.04.008","article-title":"Chemogenetic synaptic silencing of neural circuits localizes a hypothalamus-->midbrain pathway for feeding behavior","volume":"82","author":"Stachniak","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2022.111199_bib53","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S0896-6273(00)80603-0","article-title":"Regulation of the readily releasable vesicle pool by protein kinase C","volume":"21","author":"Stevens","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2022.111199_bib54","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.neuron.2011.02.010","article-title":"How addictive drugs disrupt presynaptic dopamine neurotransmission","volume":"69","author":"Sulzer","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.celrep.2022.111199_bib55","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.neuint.2006.07.002","article-title":"Involvement of G-protein betagamma subunits on the influence of inhibitory alpha2-autoreceptors on the angiotensin AT1-receptor modulation of noradrenaline release in the rat vas deferens","volume":"49","author":"Talaia","year":"2006","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.celrep.2022.111199_bib56","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1002\/jnr.23956","article-title":"The noradrenergic locus coeruleus as a chronic pain generator","volume":"95","author":"Taylor","year":"2017","journal-title":"J.\u00a0Neurosci. Res."},{"key":"10.1016\/j.celrep.2022.111199_bib57","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.neuroscience.2018.04.043","article-title":"Ultrastructural characterization of corticotropin-releasing factor and neuropeptide Y in the rat locus coeruleus: anatomical evidence for putative interactions","volume":"384","author":"Theisen","year":"2018","journal-title":"Neuroscience"},{"key":"10.1016\/j.celrep.2022.111199_bib58","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0006-8993(94)91646-2","article-title":"Focal and systemic cocaine differentially affect extracellular norepinephrine in the locus coeruleus, frontal cortex and hippocampus of the anaesthetized rat","volume":"645","author":"Thomas","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.celrep.2022.111199_bib59","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1038\/nrn1008","article-title":"Plasma membrane monoamine transporters: structure, regulation and function. Nature reviews","volume":"4","author":"Torres","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib60","doi-asserted-by":"crossref","first-page":"11328","DOI":"10.1523\/JNEUROSCI.1559-04.2004","article-title":"Nicotine enhancement of dopamine release by a calcium-dependent increase in the size of the readily releasable pool of synaptic vesicles","volume":"24","author":"Turner","year":"2004","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib61","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1523\/JNEUROSCI.23-05-01879.2003","article-title":"Norepinephrine in the prefrontal cortex is critical for amphetamine-induced reward and mesoaccumbens dopamine release","volume":"23","author":"Ventura","year":"2003","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.celrep.2022.111199_bib62","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/cne.22105","article-title":"Dendritic synthesis and release of the neuropeptide galanin: morphological evidence from studies on rat locus coeruleus neurons","volume":"516","author":"Vila-Porcile","year":"2009","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.celrep.2022.111199_bib63","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1126\/science.173.3993.202","article-title":"Adrenergic neurotransmitter functions","volume":"173","author":"von Euler","year":"1971","journal-title":"Science"},{"key":"10.1016\/j.celrep.2022.111199_bib64","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41467-017-02593-y","article-title":"Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology","volume":"9","author":"Wang","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2022.111199_bib65","doi-asserted-by":"crossref","first-page":"47","DOI":"10.15252\/embr.201540689","article-title":"Synaptotagmin-11 inhibits clathrin-mediated and bulk\u00a0endocytosis","volume":"17","author":"Wang","year":"2016","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2022.111199_bib66","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s002130050358","article-title":"Binge cocaine self-administration in humans: intravenous cocaine","volume":"132","author":"Ward","year":"1997","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.celrep.2022.111199_bib67","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.neuropharm.2008.09.008","article-title":"Functional mutations in mouse norepinephrine transporter reduce sensitivity to cocaine inhibition","volume":"56","author":"Wei","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.celrep.2022.111199_bib68","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1038\/sj.npp.1301263","article-title":"There and back again: a tale of norepinephrine and drug addiction","volume":"32","author":"Weinshenker","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.celrep.2022.111199_bib69","doi-asserted-by":"crossref","first-page":"6938","DOI":"10.1073\/pnas.92.15.6938","article-title":"Amperometric detection of stimulus-induced quantal release of catecholamines from cultured superior cervical ganglion neurons","volume":"92","author":"Zhou","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722010166?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722010166?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:50:18Z","timestamp":1761911418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124722010166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":70,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S2211124722010166"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2022.111199","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cocaine increases quantal norepinephrine secretion through NET-dependent PKC activation in locus coeruleus neurons","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2022.111199","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"111199"}}