{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:50:05Z","timestamp":1790171405994,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003852","name":"Regione Campania","doi-asserted-by":"publisher","award":["POR Campania FESR 2014\\u20132020"],"award-info":[{"award-number":["POR Campania FESR 2014\\u20132020"]}],"id":[{"id":"10.13039\/501100003852","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007076","name":"Airc Italian Foundation for Cancer Research","doi-asserted-by":"publisher","award":["IG 20793"],"award-info":[{"award-number":["IG 20793"]}],"id":[{"id":"10.13039\/501100007076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.celrep.2022.111207","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T10:47:08Z","timestamp":1660646828000},"page":"111207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["NCOA4 links iron bioavailability to DNA metabolism"],"prefix":"10.1016","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9420-6699","authenticated-orcid":false,"given":"Giorgia","family":"Federico","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Carrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Dapporto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Chiariello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Bellelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Carlomagno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2022.111207_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/nrm3721","article-title":"Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration","volume":"15","author":"Barker","year":"2014","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2022.111207_bib2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1038\/nature06196","article-title":"Identification of stem cells in small intestine and colon by marker gene Lgr5","volume":"449","author":"Barker","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111207_bib3","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/ncb2008","article-title":"HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes","volume":"12","author":"Bekker-Jensen","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2022.111207_bib4","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1534\/genetics.115.186452","article-title":"Chromosome duplication in Saccharomyces cerevisiae","volume":"203","author":"Bell","year":"2016","journal-title":"Genetics"},{"key":"10.1016\/j.celrep.2022.111207_bib5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.celrep.2015.12.065","article-title":"NCOA4 deficiency impairs systemic iron homeostasis","volume":"14","author":"Bellelli","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2022.111207_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.molcel.2014.04.031","article-title":"NCOA4 transcriptional coactivator inhibits activation of DNA replication origins","volume":"55","author":"Bellelli","year":"2014","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2022.111207_bib7","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/s41594-018-0075-z","article-title":"RPA and RAD51: fork reversal, fork protection, and genome stability","volume":"25","author":"Bhat","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2022.111207_bib8","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev-biochem-061516-044709","article-title":"Eukaryotic DNA replication fork","volume":"86","author":"Burgers","year":"2017","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.celrep.2022.111207_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/0471142735.im1525s104","article-title":"Dextran sulfate sodium (DSS)-induced colitis in mice","volume":"104","author":"Chassaing","year":"2014","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.celrep.2022.111207_bib10","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/j.cell.2012.03.043","article-title":"Cyclin F-mediated degradation of ribonucleotide reductase M2 controls genome integrity and DNA repair","volume":"149","author":"D'Angiolella","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.111207_bib11","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1038\/ncb3053","article-title":"Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in\u00a0vivo","volume":"16","author":"Dowdle","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2022.111207_bib12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/978-1-4939-1680-1_10","article-title":"Purification of proteins on newly synthesized DNA using iPOND","volume":"1228","author":"Dungrawala","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.celrep.2022.111207_bib13","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0968-0004(92)90249-9","article-title":"Ribonucleotide reductase: regulation, regulation, regulation","volume":"17","author":"Elledge","year":"1992","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.celrep.2022.111207_bib14","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/0024-3205(92)90572-7","article-title":"Iron deprivation decreases ribonucleotide reductase activity and DNA synthesis","volume":"50","author":"Furukawa","year":"1992","journal-title":"Life Sci."},{"key":"10.1016\/j.celrep.2022.111207_bib15","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.bbamcr.2015.01.018","article-title":"Emerging critical roles of Fe-S clusters in DNA replication and repair","volume":"1853","author":"Fuss","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.celrep.2022.111207_bib16","doi-asserted-by":"crossref","first-page":"118535","DOI":"10.1016\/j.bbamcr.2019.118535","article-title":"Iron homeostasis and oxidative stress: an intimate relationship","volume":"1866","author":"Galaris","year":"2019","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.celrep.2022.111207_bib17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1126\/science.1219664","article-title":"MMS19 links cytoplasmic iron-sulfur cluster assembly to DNA metabolism","volume":"337","author":"Gari","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.celrep.2022.111207_bib18","doi-asserted-by":"crossref","first-page":"8956","DOI":"10.1073\/pnas.0803978105","article-title":"Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication","volume":"105","author":"Ibarra","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2022.111207_bib19","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111207_bib20","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nsmb1288","article-title":"An Fe-S domain of the eukaryotic primase is essential for RNA primer synthesis","volume":"14","author":"Klinge","year":"2007","journal-title":"Nat. Struct. Mol. Biol."},{"key":"10.1016\/j.celrep.2022.111207_bib21","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/nature08301","article-title":"Function and biogenesis of iron-sulphur proteins","volume":"460","author":"Lill","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111207_bib22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/nature13148","article-title":"Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy","volume":"509","author":"Mancias","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111207_bib23","doi-asserted-by":"crossref","first-page":"e10308","DOI":"10.7554\/eLife.10308","article-title":"Ferritinophagy via NCOA4 is required for erythropoiesis and is regulated by iron dependent HERC2-mediated proteolysis","volume":"4","author":"Mancias","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.celrep.2022.111207_bib24","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1038\/nprot.2013.153","article-title":"In\u00a0vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture","volume":"8","author":"Miyoshi","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2022.111207_bib25","first-page":"795","article-title":"NCOA4-mediated ferritinophagy in macrophages is crucial to sustain erythropoiesis in mice","volume":"106","author":"Nai","year":"2021","journal-title":"Haematologica"},{"key":"10.1016\/j.celrep.2022.111207_bib26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/nchembio.721","article-title":"Eukaryotic DNA polymerases require an iron\u2013sulfur cluster for the formation of active complexes","volume":"8","author":"Netz","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2022.111207_bib27","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1128\/MCB.26.6.2373-2386.2006","article-title":"Activation of transferrin receptor 1 by c-Myc enhances cellular proliferation and tumorigenesis","volume":"26","author":"O'Donnell","year":"2006","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.celrep.2022.111207_bib28","doi-asserted-by":"crossref","first-page":"7821","DOI":"10.1093\/nar\/gks534","article-title":"Cross talk between the nuclease and helicase activities of Dna2: role of an essential Fe-S cluster domain","volume":"40","author":"Pokharel","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2022.111207_bib29","first-page":"92","article-title":"Iron and genome stability: an update","volume":"733","author":"Pr\u00e1","year":"2012","journal-title":"Mutat. Res."},{"key":"10.1016\/j.celrep.2022.111207_bib30","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrm3909","article-title":"Mammalian iron-sulphur proteins: novel insights into biogenesis and function","volume":"16","author":"Rouault","year":"2015","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.celrep.2022.111207_bib31","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.molcel.2006.07.019","article-title":"The DNA repair helicases XPD and FancJ have essential Fe-S domains","volume":"23","author":"Rudolf","year":"2006","journal-title":"Mol. Cell"},{"key":"10.1016\/j.celrep.2022.111207_bib32","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/ng.165","article-title":"Bmi1 is expressed in\u00a0vivo in intestinal stem cells","volume":"40","author":"Sangiorgi","year":"2008","journal-title":"Nat. Genet."},{"key":"10.1016\/j.celrep.2022.111207_bib33","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.3324\/haematol.2018.204123","article-title":"NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms","volume":"104","author":"Santana-Codina","year":"2019","journal-title":"Haematologica"},{"key":"10.1016\/j.celrep.2022.111207_bib34","first-page":"509","article-title":"Molecular characterization of RET\/PTC3; a novel rearranged version of the RET proto-oncogene in a human thyroid papillary carcinoma","volume":"9","author":"Santoro","year":"1994","journal-title":"Oncogene"},{"key":"10.1016\/j.celrep.2022.111207_bib35","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nature07935","article-title":"Single Lgr5 stem cells build crypt-villus structures in\u00a0vitro without a mesenchymal niche","volume":"459","author":"Sato","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111207_bib36","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1126\/science.aao3172","article-title":"Redox-sensitive alteration of replisome architecture safeguards genome integrity","volume":"358","author":"Somyajit","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.celrep.2022.111207_bib37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1126\/science.1219723","article-title":"MMS19 assembles Fe-S proteins required for DNA metabolism and genomic integrity","volume":"337","author":"Stehling","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.celrep.2022.111207_bib38","doi-asserted-by":"crossref","first-page":"a011312","DOI":"10.1101\/cshperspect.a011312","article-title":"The role of mitochondria in cellular iron-sulfur protein biogenesis: mechanisms, connected processes, and diseases","volume":"5","author":"Stehling","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.celrep.2022.111207_bib39","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrg.2017.46","article-title":"The impact of replication stress on replication dynamics and DNA damage in vertebrate cells","volume":"18","author":"T\u00e9cher","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.celrep.2022.111207_bib40","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev-nutr-082117-051732","article-title":"Iron and cancer","volume":"38","author":"Torti","year":"2018","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.celrep.2022.111207_bib41","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/nar\/gkq1045","article-title":"RTEL1: an essential helicase for telomere maintenance and the regulation of homologous recombination","volume":"39","author":"Uringa","year":"2011","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2022.111207_bib42","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.cell.2009.01.031","article-title":"Transcription factor achaete scute-like 2 controls intestinal stem cell fate","volume":"136","author":"van der Flier","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.111207_bib43","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.cmet.2016.07.015","article-title":"Iron uptake via DMT1 integrates cell cycle with JAK-STAT3 signaling to promote colorectal tumorigenesis","volume":"24","author":"Xue","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.celrep.2022.111207_bib44","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.4161\/cc.6.16.4603","article-title":"Tuning cell cycle regulation with an iron key","volume":"6","author":"Yu","year":"2007","journal-title":"Cell Cycle"},{"key":"10.1016\/j.celrep.2022.111207_bib45","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ncb2897","article-title":"Causes and consequences of replication stress","volume":"16","author":"Zeman","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.celrep.2022.111207_bib46","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s13238-014-0083-7","article-title":"Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control","volume":"5","author":"Zhang","year":"2014","journal-title":"Protein Cell"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722010245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722010245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:50:34Z","timestamp":1778842234000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124722010245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":46,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S2211124722010245"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2022.111207","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NCOA4 links iron bioavailability to DNA metabolism","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2022.111207","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"111207"}}