{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:44:15Z","timestamp":1790307855410,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T00:00:00Z","timestamp":1658707200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"NIAID","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Gates Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000854","name":"HFSP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000854","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.celrep.2022.111216","type":"journal-article","created":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T10:49:32Z","timestamp":1660646972000},"page":"111216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":40,"title":["Systems approach to define humoral correlates of immunity to Shigella"],"prefix":"10.1016","volume":"40","author":[{"given":"Biana","family":"Bernshtein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Ndungo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deniz","family":"Cizmeci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavol","family":"Kov\u00e1\u010d","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meagan","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilara","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward T.","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Kotloff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcela F.","family":"Pasetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galit","family":"Alter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2022.111216_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jbi.2017.08.005","article-title":"Identification of immune correlates of protection in Shigella infection by application of machine learning","volume":"74","author":"Arevalillo","year":"2017","journal-title":"J.\u00a0Biomed. Inform."},{"key":"10.1016\/j.celrep.2022.111216_bib2","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1097\/INF.0b013e3181a76eab","article-title":"Transmission risk factors and treatment of pediatric shigellosis during a large daycare center-associated outbreak of multidrug resistant shigella sonnei: implications for the management of shigellosis outbreaks among children","volume":"28","author":"Arvelo","year":"2009","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.celrep.2022.111216_bib3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/nrgastro.2013.12","article-title":"Progress and pitfalls in Shigella vaccine research","volume":"10","author":"Barry","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.celrep.2022.111216_bib4","doi-asserted-by":"crossref","first-page":"2222","DOI":"10.1016\/j.vaccine.2005.01.051","article-title":"Meningococcal surrogates of protection--serum bactericidal antibody activity","volume":"23","author":"Borrow","year":"2005","journal-title":"Vaccine"},{"key":"10.1016\/j.celrep.2022.111216_bib5","doi-asserted-by":"crossref","first-page":"2152","DOI":"10.1128\/jcm.31.8.2152-2156.1993","article-title":"Evaluation of the molecular epidemiology of an outbreak of multiply resistant Shigella sonnei in a day-care center by using pulsed-field gel electrophoresis and plasmid DNA analysis","volume":"31","author":"Brian","year":"1993","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.celrep.2022.111216_bib6","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jim.2018.01.013","article-title":"Optimization and qualification of an Fc Array assay for assessments of antibodies against HIV-1\/SIV","volume":"455","author":"Brown","year":"2018","journal-title":"J.\u00a0Immunol. Methods."},{"key":"10.1016\/j.celrep.2022.111216_bib7","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.3389\/fimmu.2019.01851","article-title":"A sample-sparing multiplexed ADCP assay","volume":"10","author":"Butler","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111216_bib8","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1128\/JB.181.3.869-878.1999","article-title":"Functional analysis of a rickettsial OmpA homology domain of Shigella flexneri IcsA","volume":"181","author":"Charles","year":"1999","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.celrep.2022.111216_bib9","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/cid\/ciw145","article-title":"Single-dose live oral cholera vaccine CVD 103-HgR protects against human experimental infection with Vibrio cholerae O1 El tor","volume":"62","author":"Chen","year":"2016","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.celrep.2022.111216_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0252222","article-title":"Shigella-specific antibodies in the first year of life among Zambian infants: a longitudinal cohort study","volume":"16","author":"Chisenga","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2022.111216_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00988-19","article-title":"Immune response characterization after controlled infection with lyophilized Shigella sonnei 53G","volume":"5","author":"Clarkson","year":"2020","journal-title":"mSphere"},{"key":"10.1016\/j.celrep.2022.111216_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2021.103308","article-title":"Immune response characterization in a human challenge study with a Shigella flexneri 2a bioconjugate vaccine","volume":"66","author":"Clarkson","year":"2021","journal-title":"EBioMedicine"},{"key":"10.1016\/j.celrep.2022.111216_bib13","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1093\/infdis\/157.5.1068","article-title":"Serum antibodies to lipopolysaccharide and natural immunity to shigellosis in an Israeli military population","volume":"157","author":"Cohen","year":"1988","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2022.111216_bib14","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1080\/21645515.2019.1606971","article-title":"Serum IgG antibodies to Shigella lipopolysaccharide antigens - a correlate of protection against shigellosis","volume":"15","author":"Cohen","year":"2019","journal-title":"Hum. Vaccines Immunother."},{"key":"10.1016\/j.celrep.2022.111216_bib15","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1128\/jcm.29.2.386-389.1991","article-title":"Prospective study of the association between serum antibodies to lipopolysaccharide O antigen and the attack rate of shigellosis","volume":"29","author":"Cohen","year":"1991","journal-title":"J.\u00a0Clin. Microbiol."},{"key":"10.1016\/j.celrep.2022.111216_bib16","first-page":"1","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J.\u00a0Stat. Softw."},{"key":"10.1016\/j.celrep.2022.111216_bib17","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.intimp.2013.06.034","article-title":"Neutrophil cell surface receptors and their intracellular signal transduction pathways","volume":"17","author":"Futosi","year":"2013","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.celrep.2022.111216_bib18","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1016\/j.vaccine.2013.04.045","article-title":"Evaluation of immunogenicity and protective efficacy of orally delivered Shigella type III secretion system proteins IpaB and IpaD","volume":"31","author":"Heine","year":"2013","journal-title":"Vaccine"},{"key":"10.1016\/j.celrep.2022.111216_bib19","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1128\/MMBR.62.2.379-433.1998","article-title":"Type III protein secretion systems in bacterial pathogens of animals and plants","volume":"62","author":"Hueck","year":"1998","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"10.1016\/j.celrep.2022.111216_bib20","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1128\/jb.177.14.3965-3971.1995","article-title":"Homologs of the Shigella IpaB and IpaC invasins are required for Salmonella typhimurium entry into cultured epithelial cells","volume":"177","author":"Kaniga","year":"1995","journal-title":"J.\u00a0Bacteriol."},{"key":"10.1016\/j.celrep.2022.111216_bib21","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0264-410X(94)00011-B","article-title":"Evaluation of the safety, immunogenicity, and efficacy in healthy adults of four doses of live oral hybrid Escherichia coli-Shigella flexneri 2a vaccine strain EcSf2a-2","volume":"13","author":"Kotloff","year":"1995","journal-title":"Vaccine"},{"key":"10.1016\/j.celrep.2022.111216_bib23","first-page":"651","article-title":"Global burden of Shigella infections: implications for vaccine development and implementation of control strategies","volume":"77","author":"Kotloff","year":"1999","journal-title":"Bull World Health Organ"},{"key":"10.1016\/j.celrep.2022.111216_bib22","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/0264-410X(95)00102-7","article-title":"A modified Shigella volunteer challenge model in which the inoculum is administered with bicarbonate buffer: clinical experience and implications for Shigella infectivity","volume":"13","author":"Kotloff","year":"1995","journal-title":"Vaccine"},{"key":"10.1016\/j.celrep.2022.111216_bib24","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0140-6736(13)60844-2","article-title":"Burden and aetiology of diarrhoeal disease in infants and young children in developing countries (the Global Enteric Multicenter Study, GEMS): a prospective, case-control study","volume":"382","author":"Kotloff","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2022.111216_bib25","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1016\/S0140-6736(18)32335-3","article-title":"Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017","volume":"392","author":"Kyu","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2022.111216_bib26","doi-asserted-by":"crossref","first-page":"4449","DOI":"10.1093\/emboj\/cdf457","article-title":"Initial steps of Shigella infection depend on the cholesterol\/sphingolipid raft-mediated CD44-IpaB interaction","volume":"21","author":"Lafont","year":"2002","journal-title":"EMBO. J."},{"key":"10.1016\/j.celrep.2022.111216_bib27","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrmicro1662","article-title":"Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road","volume":"5","author":"Levine","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2022.111216_bib28","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1128\/CVI.00148-16","article-title":"Monoclonal antibodies to Shigella lipopolysaccharide are useful for vaccine production","volume":"23","author":"Lin","year":"2016","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.celrep.2022.111216_bib29","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S0140-6736(16)31529-X","article-title":"Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study","volume":"388","author":"Liu","year":"2016","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.celrep.2022.111216_bib30","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nri.2017.106","article-title":"Beyond binding: antibody effector functions in infectious diseases","volume":"18","author":"Lu","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2022.111216_bib31","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1016\/j.vaccine.2016.02.075","article-title":"Status of vaccine research and development for Shigella","volume":"34","author":"Mani","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.celrep.2022.111216_bib32","doi-asserted-by":"crossref","first-page":"4470","DOI":"10.1128\/IAI.00859-13","article-title":"Characterization of a novel fusion protein from IpaB and IpaD of Shigella spp. and its potential as a pan-Shigella vaccine","volume":"81","author":"Martinez-Becerra","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2022.111216_bib33","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1128\/IAI.06174-11","article-title":"Broadly protective Shigella vaccine based on type III secretion apparatus proteins","volume":"80","author":"Martinez-Becerra","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2022.111216_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.671325","article-title":"Antibodies Elicited by the Shigella sonnei GMMA vaccine in adults trigger complement-mediated serum bactericidal activity: results from a Phase 1 dose Escalation trial followed by a booster Extension","volume":"12","author":"Micoli","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111216_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003588","article-title":"The zebrafish as a new model for the in\u00a0vivo study of Shigella flexneri interaction with phagocytes and bacterial autophagy","volume":"9","author":"Mostowy","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2022.111216_bib36","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.00146-18","article-title":"Development, interlaboratory Evaluations, and application of a simple, high-throughput Shigella serum bactericidal assay","volume":"3","author":"Nahm","year":"2018","journal-title":"mSphere"},{"key":"10.1016\/j.celrep.2022.111216_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.725129","article-title":"Repertoire of naturally acquired maternal antibodies transferred to infants for protection against shigellosis","volume":"12","author":"Ndungo","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111216_bib39","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1128\/iai.59.7.2341-2350.1991","article-title":"Prospective study of systemic and mucosal immune responses in dysenteric patients to specific Shigella invasion plasmid antigens and lipopolysaccharides","volume":"59","author":"Oberhelman","year":"1991","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2022.111216_bib40","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1016\/j.vaccine.2009.12.050","article-title":"Age-related efficacy of Shigella O-specific polysaccharide conjugates in 1-4-year-old Israeli children","volume":"28","author":"Passwell","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.celrep.2022.111216_bib41","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.tim.2018.01.010","article-title":"Host cell targeting by enteropathogenic bacteria T3SS effectors","volume":"26","author":"Pinaud","year":"2018","journal-title":"Trends. Microbiol."},{"key":"10.1016\/j.celrep.2022.111216_bib42","doi-asserted-by":"crossref","first-page":"e564","DOI":"10.1016\/S2214-109X(15)00151-5","article-title":"Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED)","volume":"3","author":"Platts-Mills","year":"2015","journal-title":"Lancet. Glob. Health"},{"key":"10.1016\/j.celrep.2022.111216_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0194325","article-title":"Clinical endpoints in the controlled human challenge model for Shigella: a call for standardization and the development of a disease severity score","volume":"13","author":"Porter","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2022.111216_bib44","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1128\/CVI.13.2.165-169.2006","article-title":"Use of opsonophagocytosis for serological evaluation of pneumococcal vaccines","volume":"13","author":"Romero-Steiner","year":"2006","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.celrep.2022.111216_bib45","doi-asserted-by":"crossref","DOI":"10.1093\/infdis\/jiab395","article-title":"224, S829, S839 Functional antibodies and innate immune responses to WRSS1, a live oral Shigella sonnei vaccine candidate in Bangladeshi adults and children","author":"Sarker","year":"2021","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2022.111216_bib46","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jim.2005.11.019","article-title":"A novel chemistry for conjugating pneumococcal polysaccharides to Luminex microspheres","volume":"309","author":"Schlottmann","year":"2006","journal-title":"J.\u00a0Immunol. Methods."},{"key":"10.1016\/j.celrep.2022.111216_bib47","doi-asserted-by":"crossref","first-page":"e00412-16","DOI":"10.1128\/CVI.00412-16","article-title":"Functional and antigen-specific serum antibody levels as correlates of protection against shigellosis in a controlled human challenge study","volume":"24","author":"Shimanovich","year":"2017","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.celrep.2022.111216_bib48","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1046\/j.1462-5822.2000.00028.x","article-title":"CD44 binds to the Shigella IpaB protein and participates in bacterial invasion of epithelial cells","volume":"2","author":"Skoudy","year":"2000","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.celrep.2022.111216_bib49","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1021\/acs.jproteome.5b00354","article-title":"Analysis of the human adult urinary metabolome variations with age, body mass index, and gender by implementing a comprehensive workflow for univariate and OPLS statistical analyses","volume":"14","author":"Th\u00e9venot","year":"2015","journal-title":"J.\u00a0Proteome Res."},{"key":"10.1016\/j.celrep.2022.111216_bib50","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.vaccine.2015.12.047","article-title":"The transfer and decay of maternal antibody against Shigella sonnei in a longitudinal cohort of Vietnamese infants","volume":"34","author":"Thompson","year":"2016","journal-title":"Vaccine"},{"key":"10.1016\/j.celrep.2022.111216_bib51","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1093\/infdis\/166.1.158","article-title":"Age-specific prevalence of serum antibodies to the invasion plasmid and lipopolysaccharide antigens of Shigella species in Chilean and north American populations","volume":"166","author":"Van De Verg","year":"1992","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2022.111216_bib52","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.clim.2013.03.009","article-title":"Shigella antigen-specific B memory cells are associated with decreased disease severity in subjects challenged with wild-type Shigella flexneri 2a","volume":"148","author":"Wahid","year":"2013","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.celrep.2022.111216_bib53","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S0140-6736(16)31012-1","article-title":"Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980\u20132015: a systematic analysis for the global burden of disease study 2015","volume":"388","author":"Wang","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.celrep.2022.111216_bib54","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0169-7439(87)80084-9","article-title":"Principal component analysis","volume":"2","author":"Wold","year":"1987","journal-title":"Chemometr. Intell. Lab. Syst."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722010336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722010336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:51:48Z","timestamp":1761911508000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124722010336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":53,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["S2211124722010336"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2022.111216","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systems approach to define humoral correlates of immunity to Shigella","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2022.111216","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s).","name":"copyright","label":"Copyright"}],"article-number":"111216"}}