{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:24:59Z","timestamp":1793316299417,"version":"4.5.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T00:00:00Z","timestamp":1660262400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["031L0289B"],"award-info":[{"award-number":["031L0289B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004937","name":"BMBF Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.celrep.2022.111305","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T11:22:53Z","timestamp":1662463373000},"page":"111305","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Landscape and age dynamics of immune cells in the Egyptian rousette bat"],"prefix":"10.1016","volume":"40","author":[{"given":"Virginia","family":"Friedrichs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Toussaint","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Rissmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C.","family":"Mettenleiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Pei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Balkema-Buschmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine-Emmanuel","family":"Saliba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1739-749X","authenticated-orcid":false,"given":"Anca","family":"Dorhoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2022.111305_bib1","doi-asserted-by":"crossref","first-page":"14811","DOI":"10.1038\/ncomms14811","article-title":"The comparative immunology of wild and laboratory mice, Mus musculus domesticus","volume":"8","author":"Abolins","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2022.111305_bib2","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41564-019-0371-3","article-title":"Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host","volume":"4","author":"Ahn","year":"2019","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.celrep.2022.111305_bib3","doi-asserted-by":"crossref","first-page":"21722","DOI":"10.1038\/srep21722","article-title":"Unique loss of the PYHIN gene family in bats amongst mammals: implications for inflammasome sensing","volume":"6","author":"Ahn","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2022.111305_bib4","doi-asserted-by":"crossref","first-page":"e1002877","DOI":"10.1371\/journal.ppat.1002877","article-title":"Seasonal pulses of Marburg virus circulation in juvenile Rousettus aegyptiacus bats coincide with periods of increased risk of human infection","volume":"8","author":"Amman","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2022.111305_bib5","doi-asserted-by":"crossref","first-page":"659","DOI":"10.2174\/1570161111666131219101226","article-title":"Ageing, longevity, exceptional longevity and related genetic and non genetics markers: panel statement","volume":"12","author":"Avery","year":"2014","journal-title":"Curr. Vasc. Pharmacol."},{"key":"10.1016\/j.celrep.2022.111305_bib6","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1863-2378.2012.01528.x","article-title":"Antiviral immune responses of bats: a review","volume":"60","author":"Baker","year":"2013","journal-title":"Zoonoses Public Health"},{"key":"10.1016\/j.celrep.2022.111305_bib7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fimmu.2020.00026","article-title":"Novel insights into immune systems of bats","volume":"11","author":"Banerjee","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111305_bib8","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1056\/NEJMoa051465","article-title":"Marburg hemorrhagic fever associated with multiple genetic lineages of virus","volume":"355","author":"Bausch","year":"2006","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2022.111305_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/nbt.4314","article-title":"Dimensionality reduction for visualizing single-cell data using UMAP","volume":"37","author":"Becht","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2022.111305_bib10","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1093\/icb\/icz007","article-title":"Leukocyte profiles reflect geographic range limits in a widespread neotropical bat","volume":"59","author":"Becker","year":"2019","journal-title":"Integr. Comp. Biol."},{"key":"10.1016\/j.celrep.2022.111305_bib11","doi-asserted-by":"crossref","first-page":"735866","DOI":"10.3389\/fimmu.2021.735866","article-title":"Constitutive IFN\u03b1 protein production in bats","volume":"12","author":"Bondet","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111305_bib12","doi-asserted-by":"crossref","first-page":"943","DOI":"10.3389\/fimmu.2017.00943","article-title":"Different adjuvants induce common innate pathways that are associated with enhanced adaptive responses against a model antigen in humans","volume":"8","author":"Burny","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111305_bib13","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1189\/jlb.70.6.881","article-title":"Senescence in innate immune responses: reduced neutrophil phagocytic capacity and CD16 expression in elderly humans","volume":"70","author":"Butcher","year":"2001","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.celrep.2022.111305_bib14","doi-asserted-by":"crossref","first-page":"6876","DOI":"10.1038\/s41467-021-27150-6","article-title":"scCODA is a Bayesian model for compositional single-cell data analysis","volume":"12","author":"B\u00fcttner","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2022.111305_bib15","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0145-305X(87)90053-X","article-title":"Analysis of suppressor factor in delayed immune responses of a bat, Pteropus giganteus","volume":"11","author":"Chakravarty","year":"1987","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.celrep.2022.111305_bib16","first-page":"97","article-title":"Immunofluorescence analysis of immunoglobulin bearing lymphocytes in the Indian fruit bat: Pteropus giganteus","volume":"27","author":"Chakravarty","year":"1994","journal-title":"Lymphology"},{"key":"10.1016\/j.celrep.2022.111305_bib17","doi-asserted-by":"crossref","first-page":"e0240769","DOI":"10.1371\/journal.pone.0240769","article-title":"Glyoxal fixation facilitates transcriptome analysis after antigen staining and cell sorting by flow cytometry","volume":"16","author":"Channathodiyil","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2022.111305_bib18","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/intimm\/13.4.593","article-title":"CD11b expression as a marker to distinguish between recently activated effector CD8(+) T\u00a0cells and memory cells","volume":"13","author":"Christensen","year":"2001","journal-title":"Int. Immunol."},{"key":"10.1016\/j.celrep.2022.111305_bib19","doi-asserted-by":"crossref","first-page":"10543","DOI":"10.1093\/nar\/gkz833","article-title":"Improved annotation of protein-coding genes boundaries in metazoan mitochondrial genomes","volume":"47","author":"Donath","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2022.111305_bib20","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.immuni.2019.08.008","article-title":"Single-cell analysis of human mononuclear phagocytes reveals subset-defining markers and identifies circulating inflammatory dendritic cells","volume":"51","author":"Dutertre","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2022.111305_bib21","doi-asserted-by":"crossref","first-page":"e240","DOI":"10.1017\/S0950268819001237","article-title":"Time of year, age class and body condition predict Hendra virus infection in Australian black flying foxes (Pteropus alecto)","volume":"147","author":"Edson","year":"2019","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.celrep.2022.111305_bib22","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41598-019-57212-1","article-title":"Immunophenotyping monocytes, macrophages and granulocytes in the Pteropodid bat Eonycteris spelaea","volume":"10","author":"Gamage","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2022.111305_bib23","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/j.cell.2019.11.010","article-title":"Cross-species single-cell analysis reveals divergence of the primate microglia program","volume":"179","author":"Geirsdottir","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.111305_bib24","doi-asserted-by":"crossref","first-page":"28939","DOI":"10.1073\/pnas.2003352117","article-title":"Complementary regulation of caspase-1 and IL-1\u03b2 reveals additional mechanisms of dampened inflammation in bats","volume":"117","author":"Goh","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2022.111305_bib25","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cub.2020.10.015","article-title":"Asymptomatic infection of Marburg virus reservoir bats is explained by a strategy of immunoprotective disease tolerance","volume":"31","author":"Guito","year":"2021","journal-title":"Curr. Biol."},{"key":"10.1016\/j.celrep.2022.111305_bib26","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.3389\/fimmu.2017.01222","article-title":"Functional analysis of phagocyte activity in whole blood from HIV\/Tuberculosis-Infected individuals using a novel flow cytometry-based assay","volume":"8","author":"Gupta-Wright","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111305_bib27","doi-asserted-by":"crossref","first-page":"946","DOI":"10.4269\/ajtmh.2011.10-0567","article-title":"Pteropid bats are confirmed as the reservoir hosts of henipaviruses: a comprehensive experimental study of virus transmission","volume":"85","author":"Halpin","year":"2011","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.celrep.2022.111305_bib28","doi-asserted-by":"crossref","first-page":"6712","DOI":"10.4049\/jimmunol.151.12.6712","article-title":"CD44 expression on activated B cells. Differential capacity for CD44-dependent binding to hyaluronic acid","volume":"151","author":"Hathcock","year":"1993","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2022.111305_bib29","doi-asserted-by":"crossref","first-page":"883","DOI":"10.3389\/fimmu.2019.00883","article-title":"Human double-negative regulatory T-cells induce a metabolic and functional switch in effector T-cells by suppressing mTOR activity","volume":"10","author":"Haug","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111305_bib30","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1128\/JVI.03403-13","article-title":"Anti-lyssaviral activity of interferons kappa and omega from the serotine bat, Eptesicus serotinus","volume":"88","author":"He","year":"2014","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2022.111305_bib31","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1474-9726.2012.00851.x","article-title":"Aging is associated with chronic innate immune activation and dysregulation of monocyte phenotype and function","volume":"11","author":"Hearps","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.celrep.2022.111305_bib32","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/s41592-020-0820-1","article-title":"Souporcell: robust clustering of single-cell RNA-seq data by genotype without reference genotypes","volume":"17","author":"Heaton","year":"2020","journal-title":"Nat. Methods"},{"key":"10.1016\/j.celrep.2022.111305_bib33","doi-asserted-by":"crossref","first-page":"689406","DOI":"10.3389\/fgene.2021.689406","article-title":"Reference transcriptomes of porcine peripheral immune cells created through bulk and single-cell RNA sequencing","volume":"12","author":"Herrera-Uribe","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.celrep.2022.111305_bib34","doi-asserted-by":"crossref","first-page":"e3000528","DOI":"10.1371\/journal.pbio.3000528","article-title":"Single-cell transcriptomics of the naked mole-rat reveals unexpected features of mammalian immunity","volume":"17","author":"Hilton","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.celrep.2022.111305_bib35","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.3389\/fimmu.2018.03143","article-title":"Control of leukocyte trafficking by stress-associated hormones","volume":"9","author":"Ince","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111305_bib36","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41586-020-03128-0","article-title":"Lessons from the host defences of bats, a unique viral reservoir","volume":"589","author":"Irving","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111305_bib37","series-title":"NBISweden\/AGAT: AGAT-v0.6.2 (v0.6.2)","author":"Jacques Dainat","year":"2021"},{"key":"10.1016\/j.celrep.2022.111305_bib38","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1038\/s41586-020-2486-3","article-title":"Six reference-quality genomes reveal evolution of bat adaptations","volume":"583","author":"Jebb","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111305_bib39","doi-asserted-by":"crossref","first-page":"e01059-18","DOI":"10.1128\/JVI.01059-18","article-title":"Isolation and characterization of a distinct influenza A virus from Egyptian bats","volume":"93","author":"Kandeil","year":"2019","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2022.111305_bib40","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1080\/10253890701248079","article-title":"Granulocyte activation in humans is modulated by psychological stress and relaxation","volume":"10","author":"Keresztes","year":"2007","journal-title":"Stress"},{"key":"10.1016\/j.celrep.2022.111305_bib41","series-title":"Bats in the Anthropocene: Conservation of Bats in a Changing World","first-page":"539","article-title":"Networking networks for global bat conservation","author":"Kingston","year":"2016"},{"key":"10.1016\/j.celrep.2022.111305_bib42","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.immuni.2017.03.009","article-title":"Protecting the newborn and young infant from infectious diseases: lessons from immune ontogeny","volume":"46","author":"Kollmann","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2022.111305_bib43","series-title":"Ecology of Bats","author":"Kunz","year":"1982"},{"key":"10.1016\/j.celrep.2022.111305_bib44","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.cell.2016.09.027","article-title":"Molecular diversity of midbrain development in mouse, human, and stem cells","volume":"167","author":"La Manno","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.111305_bib45","doi-asserted-by":"crossref","first-page":"109140","DOI":"10.1016\/j.celrep.2021.109140","article-title":"Genomic features of humoral immunity support tolerance model in Egyptian rousette bats","volume":"35","author":"Larson","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.celrep.2022.111305_bib46","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1186\/s12864-015-2124-x","article-title":"De novo transcriptome reconstruction and annotation of the Egyptian rousette bat","volume":"16","author":"Lee","year":"2015","journal-title":"BMC Genom."},{"key":"10.1016\/j.celrep.2022.111305_bib47","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1097\/00000542-199304000-00013","article-title":"Inhibition of interferon stimulation of natural killer cell activity in mice anesthetized with halothane or isoflurane","volume":"78","author":"Markovic","year":"1993","journal-title":"Anesthesiology"},{"key":"10.1016\/j.celrep.2022.111305_bib48","doi-asserted-by":"crossref","first-page":"37796","DOI":"10.1038\/srep37796","article-title":"Phenotypic and functional characterization of the major lymphocyte populations in the fruit-eating bat Pteropus alecto","volume":"6","author":"Mart\u00ednez G\u00f3mez","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2022.111305_bib49","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.4049\/jimmunol.149.4.1326","article-title":"CD11b (Mac-1): a marker for CD8+ cytotoxic T\u00a0cell activation and memory in virus infection","volume":"149","author":"McFarland","year":"1992","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2022.111305_bib50","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.jcpa.2007.03.002","article-title":"Experimental Nipah virus infection in pteropid bats (Pteropus poliocephalus)","volume":"136","author":"Middleton","year":"2007","journal-title":"J.\u00a0Comp. Pathol."},{"key":"10.1016\/j.celrep.2022.111305_bib51","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1179\/136485910X12851868779948","article-title":"Emerging tropical diseases in Australia. Part 3. Australian bat lyssavirus","volume":"104","author":"Moore","year":"2010","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"10.1016\/j.celrep.2022.111305_bib52","doi-asserted-by":"crossref","first-page":"21878","DOI":"10.1038\/srep21878","article-title":"Replication and shedding of MERS-CoV in Jamaican fruit bats (Artibeus jamaicensis)","volume":"6","author":"Munster","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2022.111305_bib53","series-title":"Walker's Bats of the World","author":"Nowak","year":"1994"},{"key":"10.1016\/j.celrep.2022.111305_bib54","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/1471-2164-13-261","article-title":"The immune gene repertoire of an important viral reservoir, the Australian black flying fox","volume":"13","author":"Papenfuss","year":"2012","journal-title":"BMC Genom."},{"key":"10.1016\/j.celrep.2022.111305_bib55","first-page":"600","article-title":"High CD99 expression in memory T and B cells in reactive lymph nodes","volume":"14","author":"Park","year":"1999","journal-title":"J.\u00a0Kor. Med. Sci."},{"key":"10.1016\/j.celrep.2022.111305_bib56","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12915-020-00947-5","article-title":"Single-cell resolution landscape of equine peripheral blood mononuclear cells reveals diverse cell types including T-bet(+) B cells","volume":"19","author":"Patel","year":"2021","journal-title":"BMC Biol."},{"key":"10.1016\/j.celrep.2022.111305_bib57","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.cell.2018.03.070","article-title":"The Egyptian rousette genome reveals unexpected features of bat antiviral immunity","volume":"173","author":"Pavlovich","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.111305_bib58","doi-asserted-by":"crossref","DOI":"10.3390\/v8020029","article-title":"Experimental inoculation of Egyptian fruit bats (Rousettus aegyptiacus) with Ebola virus","volume":"8","author":"Paweska","year":"2016","journal-title":"Viruses"},{"key":"10.1016\/j.celrep.2022.111305_bib59","doi-asserted-by":"crossref","first-page":"489","DOI":"10.3389\/fimmu.2019.00489","article-title":"Studies on B Cells in the fruit-eating black flying fox (Pteropus alecto)","volume":"10","author":"Periasamy","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111305_bib60","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/cyto.b.20536","article-title":"B cell subsets in healthy children: reference values for evaluation of B cell maturation process in peripheral blood","volume":"78","author":"Pi\u0105tosa","year":"2010","journal-title":"Cytometry B Clin. Cytom."},{"key":"10.1016\/j.celrep.2022.111305_bib61","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1474-9728.2004.00102.x","article-title":"Innate immunity in aging: impact on macrophage function","volume":"3","author":"Plowden","year":"2004","journal-title":"Aging Cell"},{"key":"10.1016\/j.celrep.2022.111305_bib62","article-title":"Single-cell transcriptional atlas of the Chinese horseshoe bat (Rhinolophus sinicus) provides insight into the cellular mechanisms which enable bats to be viral reservoirs","author":"Ren","year":"2020","journal-title":"biorxiv"},{"key":"10.1016\/j.celrep.2022.111305_bib63","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0145-305X(91)90034-V","article-title":"Analysis of immunocompetent cells in the bat, Pteropus giganteus: isolation and scanning electron microscopic characterization","volume":"15","author":"Sarkar","year":"1991","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.celrep.2022.111305_bib64","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nbt.3192","article-title":"Spatial reconstruction of single-cell gene expression data","volume":"33","author":"Satija","year":"2015","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2022.111305_bib65","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/j.vaccine.2010.12.121","article-title":"Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis","volume":"29","author":"Simell","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.celrep.2022.111305_bib66","first-page":"20143085","article-title":"Evolution of the immune system in humans from infancy to old age","volume":"282","author":"Simon","year":"2015","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.celrep.2022.111305_bib67","doi-asserted-by":"crossref","first-page":"602539","DOI":"10.3389\/fimmu.2021.602539","article-title":"Single-cell transcriptomic analyses define distinct peripheral B cell subsets and discrete development pathways","volume":"12","author":"Stewart","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111305_bib68","doi-asserted-by":"crossref","first-page":"E73","DOI":"10.3390\/v10020073","article-title":"Antibody responses to Marburg virus in Egyptian rousette bats and their role in protection against infection","volume":"10","author":"Storm","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.celrep.2022.111305_bib69","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1016\/j.cell.2019.05.031","article-title":"Comprehensive integration of single-cell data","volume":"177","author":"Stuart","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.111305_bib70","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.3201\/eid1312.071115","article-title":"Studies of reservoir hosts for Marburg virus","volume":"13","author":"Swanepoel","year":"2007","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.celrep.2022.111305_bib71","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.3201\/eid1508.090015","article-title":"Response to imported case of Marburg hemorrhagic fever, The Netherlands","volume":"15","author":"Timen","year":"2009","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.celrep.2022.111305_bib72","doi-asserted-by":"crossref","first-page":"e1000536","DOI":"10.1371\/journal.ppat.1000536","article-title":"Isolation of genetically diverse Marburg viruses from Egyptian fruit bats","volume":"5","author":"Towner","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2022.111305_bib73","doi-asserted-by":"crossref","first-page":"e764","DOI":"10.1371\/journal.pone.0000764","article-title":"Marburg virus infection detected in a common African bat","volume":"2","author":"Towner","year":"2007","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2022.111305_bib74","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1038\/s41598-019-41695-z","article-title":"From Louvain to Leiden: guaranteeing well-connected communities","volume":"9","author":"Traag","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2022.111305_bib75","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/sji.12413","article-title":"Effects of ageing on the immune system: infants to elderly","volume":"83","author":"Valiathan","year":"2016","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.celrep.2022.111305_bib76","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0300-9629(88)91015-8","article-title":"Haematology and iron status of the egyptian fruit bat, rousettus aegyptiacus","volume":"90","author":"Van Der Westhuyzen","year":"1988","journal-title":"Comp. Biochem. Physiol. A Comp. Physiol."},{"key":"10.1016\/j.celrep.2022.111305_bib77","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1099\/vir.0.000099","article-title":"Novel paramyxoviruses in Australian flying-fox populations support host-virus\u00a0co-evolution","volume":"96","author":"Vidgen","year":"2015","journal-title":"J.\u00a0Gen. Virol."},{"key":"10.1016\/j.celrep.2022.111305_bib78","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41577-021-00523-0","article-title":"Decoding bat immunity: the need for a coordinated research approach","volume":"21","author":"Wang","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2022.111305_bib79","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.3201\/eid1608.100208","article-title":"Bat coronaviruses and experimental infection of bats, the Philippines","volume":"16","author":"Watanabe","year":"2010","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.celrep.2022.111305_bib80","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1177\/28.9.7410816","article-title":"Isolation of mouse bone marrow neutrophils by light scatter and autofluorescence","volume":"28","author":"Watt","year":"1980","journal-title":"J.\u00a0Histochem. Cytochem."},{"key":"10.1016\/j.celrep.2022.111305_bib81","doi-asserted-by":"crossref","first-page":"2748","DOI":"10.1084\/jem.20181308","article-title":"CXCR6 regulates localization of tissue-resident memory CD8 T\u00a0cells to the airways","volume":"216","author":"Wein","year":"2019","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2022.111305_bib82","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/jlb.67.1.40","article-title":"Effect of age on human neutrophil function","volume":"67","author":"Wenisch","year":"2000","journal-title":"J.\u00a0Leukoc. Biol."},{"key":"10.1016\/j.celrep.2022.111305_bib83","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/j.1751-0813.1998.tb12335.x","article-title":"Transmission studies of Hendra virus (equine morbillivirus) in fruit bats, horses and cats","volume":"76","author":"Williamson","year":"1998","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.celrep.2022.111305_bib84","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1053\/jcpa.1999.0364","article-title":"Experimental hendra virus infectionin pregnant Guinea-pigs and fruit Bats (Pteropus poliocephalus)","volume":"122","author":"Williamson","year":"2000","journal-title":"J.\u00a0Comp. Pathol."},{"key":"10.1016\/j.celrep.2022.111305_bib85","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.chom.2018.01.006","article-title":"Dampened STING-dependent interferon activation in bats","volume":"23","author":"Xie","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2022.111305_bib86","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1126\/science.1230835","article-title":"Comparative analysis of bat genomes provides insight into the evolution of flight and immunity","volume":"339","author":"Zhang","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.celrep.2022.111305_bib87","doi-asserted-by":"crossref","first-page":"38597","DOI":"10.1038\/srep38597","article-title":"Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages","volume":"6","author":"Zhou","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2022.111305_bib88","doi-asserted-by":"crossref","first-page":"2696","DOI":"10.1073\/pnas.1518240113","article-title":"Contraction of the type I IFN locus and unusual constitutive expression of IFN-\u03b1 in bats","volume":"113","author":"Zhou","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722011299?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722011299?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T12:02:44Z","timestamp":1775476964000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124722011299"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":88,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S2211124722011299"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2022.111305","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Landscape and age dynamics of immune cells in the Egyptian rousette bat","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2022.111305","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"111305"}}