{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:56:24Z","timestamp":1791856584476,"version":"4.3.4"},"reference-count":71,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T00:00:00Z","timestamp":1661299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32070594"],"award-info":[{"award-number":["32070594"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32025009"],"award-info":[{"award-number":["32025009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007835","name":"Wenzhou Medical University","doi-asserted-by":"publisher","award":["KYYW202005"],"award-info":[{"award-number":["KYYW202005"]}],"id":[{"id":"10.13039\/100007835","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDB38020300"],"award-info":[{"award-number":["XDB38020300"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.celrep.2022.111352","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T11:40:01Z","timestamp":1663069201000},"page":"111352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"title":["Microbiota dysbiosis in primary Sj\u00f6gren\u2019s syndrome and the ameliorative effect of hydroxychloroquine"],"prefix":"10.1016","volume":"40","author":[{"given":"Xiaobing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Pang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saisai","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxiao","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaomiao","family":"Niu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxia","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangqing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2022.111352_bib1","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1136\/annrheumdis-2018-214856","article-title":"Lupus nephritis is linked to disease-activity associated expansions and immunity to a gut commensal","volume":"78","author":"Azzouz","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.celrep.2022.111352_bib2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.mimet.2003.08.009","article-title":"Review and re-analysis of domain-specific 16S primers","volume":"55","author":"Baker","year":"2003","journal-title":"J.\u00a0Microbiol. Methods"},{"key":"10.1016\/j.celrep.2022.111352_bib3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.immuni.2020.01.007","article-title":"The role of lung and gut microbiota in the pathology of asthma","volume":"52","author":"Barcik","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2022.111352_bib4","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2022.111352_bib5","doi-asserted-by":"crossref","first-page":"16047","DOI":"10.1038\/nrdp.2016.47","article-title":"Sjogren syndrome","volume":"2","author":"Brito-Zeron","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.celrep.2022.111352_bib6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/nrendo.2013.240","article-title":"Metabolism in 2013: the gut microbiota manages host metabolism","volume":"10","author":"Cani","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.celrep.2022.111352_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228733","article-title":"Connection between the gut microbiome, systemic inflammation, gut permeability and FOXP3 expression in patients with primary Sjogren's syndrome","volume":"21","author":"Cano-Ortiz","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.celrep.2022.111352_bib8","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1093\/rheumatology\/keaa695","article-title":"Increased expression of interleukin-21-inducible genes in minor salivary glands are associated with primary Sjogren's syndrome disease characteristics","volume":"60","author":"Chen","year":"2021","journal-title":"Rheumatology"},{"key":"10.1016\/j.celrep.2022.111352_bib9","doi-asserted-by":"crossref","first-page":"ofab175","DOI":"10.1093\/ofid\/ofab175","article-title":"The characteristics of Capnocytophaga infection: 10 Years of experience","volume":"8","author":"Chesdachai","year":"2021","journal-title":"Open Forum Infect. Dis."},{"key":"10.1016\/j.celrep.2022.111352_bib10","first-page":"e181","article-title":"The mixture of bifidobacterium associated with fructo-oligosaccharides reduces the damage of the ocular surface","volume":"168","author":"Chisari","year":"2017","journal-title":"La Clinica Terapeutica"},{"key":"10.1016\/j.celrep.2022.111352_bib11","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1126\/science.1177486","article-title":"Bacterial community variation in human body habitats across space and time","volume":"326","author":"Costello","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.celrep.2022.111352_bib12","first-page":"1","article-title":"The igraph software package for complex network research","volume":"1695","author":"Csardi","year":"2006","journal-title":"Inter J. Complex Sys."},{"key":"10.1016\/j.celrep.2022.111352_bib13","doi-asserted-by":"crossref","first-page":"23561","DOI":"10.1038\/srep23561","article-title":"Altered mucosal microbiome diversity and disease severity in sjogren syndrome","volume":"6","author":"de Paiva","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2022.111352_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2019.02451","article-title":"The vaginal community state types microbiome-immune network as key factor for bacterial vaginosis and aerobic vaginitis","volume":"10","author":"De Seta","year":"2019","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.celrep.2022.111352_bib15","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/s41587-020-0548-6","article-title":"PICRUSt2 for prediction of metagenome functions","volume":"38","author":"Douglas","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.celrep.2022.111352_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femsre\/fuy035","article-title":"Talk to your gut: the oral-gut microbiome axis and its immunomodulatory role in the etiology of rheumatoid arthritis","volume":"43","author":"du Teil Espina","year":"2019","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.celrep.2022.111352_bib17","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan2306","article-title":"Commensal orthologs of the human autoantigen Ro60 as triggers of autoimmunity in lupus","volume":"10","author":"Greiling","year":"2018","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.celrep.2022.111352_bib18","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1080\/19490976.2020.1768644","article-title":"Alteration in gut microbiota is associated with dysregulation of cytokines and glucocorticoid therapy in systemic lupus erythematosus","volume":"11","author":"Guo","year":"2020","journal-title":"Gut Microb."},{"key":"10.1016\/j.celrep.2022.111352_bib19","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.tim.2010.03.007","article-title":"Haemophilus influenzae and the complement system","volume":"18","author":"Hallstrom","year":"2010","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.celrep.2022.111352_bib20","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.jiph.2017.09.006","article-title":"Health care-associated infections in pre-transplant liver intensive care unit: perspectives and challenges","volume":"11","author":"Hassan","year":"2018","journal-title":"J Infect Public Health"},{"key":"10.1016\/j.celrep.2022.111352_bib21","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1016\/j.cell.2021.04.026","article-title":"SnapShot: microbiota effects on host physiology","volume":"184","author":"Hill","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.111352_bib22","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s40168-019-0679-5","article-title":"Chemotherapy-induced oral mucositis is associated with detrimental bacterial dysbiosis","volume":"7","author":"Hong","year":"2019","journal-title":"Microbiome"},{"key":"10.1016\/j.celrep.2022.111352_bib23","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1086\/514595","article-title":"Nosocomial infections caused by Sphingomonas paucimobilis: clinical features and microbiological characteristics","volume":"26","author":"Hsueh","year":"1998","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.celrep.2022.111352_bib24","doi-asserted-by":"crossref","first-page":"394","DOI":"10.7883\/yoken.JJID.2007.394","article-title":"Nosocomial outbreak of Sphingomonas paucimobilis bacteremia in a hemato\/oncology unit","volume":"60","author":"Kilic","year":"2007","journal-title":"Jpn. J. Infect. Dis."},{"key":"10.1016\/j.celrep.2022.111352_bib25","series-title":"Predictive Modeling with R and the Caret Package","author":"Kuhn","year":"2013"},{"key":"10.1016\/j.celrep.2022.111352_bib26","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.cell.2017.11.024","article-title":"Our gut microbiome: the evolving inner self","volume":"171","author":"Kundu","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.111352_bib27","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/imm.12760","article-title":"The immune response to Prevotella bacteria in chronic inflammatory disease","volume":"151","author":"Larsen","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.celrep.2022.111352_bib28","doi-asserted-by":"crossref","first-page":"795","DOI":"10.3389\/fimmu.2019.00795","article-title":"Elevated CCL19\/CCR7 expression during the disease process of primary Sjogren's syndrome","volume":"10","author":"Liu","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111352_bib29","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.celrep.2022.111352_bib30","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1101\/gr.151803.112","article-title":"Meta-analyses of studies of the human microbiota","volume":"23","author":"Lozupone","year":"2013","journal-title":"Genome Res."},{"key":"10.1016\/j.celrep.2022.111352_bib31","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.chom.2021.03.020","article-title":"Individuals at risk for rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential","volume":"29","author":"Mangalea","year":"2021","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2022.111352_bib32","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1056\/NEJMcp1702514","article-title":"Primary Sjogren's syndrome","volume":"378","author":"Mariette","year":"2018","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.celrep.2022.111352_bib33","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.cell.2020.08.007","article-title":"Longitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome","volume":"182","author":"Mars","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.111352_bib34","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1186\/s12934-020-01348-7","article-title":"Gut microbial dysbiosis in individuals with Sj\u00f6gren's syndrome","volume":"19","author":"Mendez","year":"2020","journal-title":"Microb. Cell Fact."},{"key":"10.1016\/j.celrep.2022.111352_bib35","doi-asserted-by":"crossref","first-page":"e0229029","DOI":"10.1371\/journal.pone.0229029","article-title":"Gut dysbiosis is prevailing in Sj\u00f6gren's syndrome and is related to dry eye severity","volume":"15","author":"Moon","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2022.111352_bib36","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrrheum.2018.1","article-title":"B cells in the pathogenesis of primary Sjogren syndrome","volume":"14","author":"Nocturne","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.celrep.2022.111352_bib37","series-title":"Community Ecology Package. R package version 2","author":"Oksanen","year":"2013"},{"key":"10.1016\/j.celrep.2022.111352_bib38","doi-asserted-by":"crossref","first-page":"2420","DOI":"10.1038\/ajg.2010.281","article-title":"Mucolytic bacteria with increased prevalence in IBD mucosa augment in\u00a0vitro utilization of mucin by other bacteria","volume":"105","author":"Png","year":"2010","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.celrep.2022.111352_bib39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/BOR.0000000000000473","article-title":"Current views on the pathogenesis of Sjogren's syndrome","volume":"30","author":"Pontarini","year":"2018","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.celrep.2022.111352_bib40","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.celrep.2022.111352_bib41","doi-asserted-by":"crossref","DOI":"10.1111\/1574-6976.12075","article-title":"The first 1000 cultured species of the human gastrointestinal microbiota","volume":"38","author":"Rajili\u0107-Stojanovi\u0107","year":"2014","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.celrep.2022.111352_bib42","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1136\/annrheumdis-2018-213645","article-title":"Characterisation of the nasal microbiota in granulomatosis with polyangiitis","volume":"77","author":"Rhee","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.celrep.2022.111352_bib43","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.chom.2019.05.003","article-title":"Pathogenic autoreactive T and B cells cross-react with mimotopes expressed by a common human gut commensal to trigger autoimmunity","volume":"26","author":"Ruff","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.celrep.2022.111352_bib44","doi-asserted-by":"crossref","first-page":"e000022","DOI":"10.1136\/rmdopen-2014-000022","article-title":"EULAR Sjogren's syndrome disease activity index (ESSDAI): a user guide","volume":"1","author":"Seror","year":"2015","journal-title":"RMD Open"},{"key":"10.1016\/j.celrep.2022.111352_bib45","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.cell.2019.05.004","article-title":"Human gut microbiota from autism spectrum disorder promote behavioral symptoms in mice","volume":"177","author":"Sharon","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.111352_bib46","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1136\/annrheumdis-2016-210571","article-title":"2016 American College of Rheumatology\/European League against Rheumatism classification criteria for primary Sjogren's syndrome: a consensus and data-driven methodology involving three international patient cohorts","volume":"76","author":"Shiboski","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.celrep.2022.111352_bib47","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/acr.21591","article-title":"American College of Rheumatology classification criteria for Sjogren's syndrome: a data-driven, expert consensus approach in the Sjogren's International Collaborative Clinical Alliance cohort","volume":"64","author":"Shiboski","year":"2012","journal-title":"Arthritis Care Res."},{"key":"10.1016\/j.celrep.2022.111352_bib48","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1038\/s41467-021-23472-7","article-title":"A new molecular classification to drive precision treatment strategies in primary Sjogren's syndrome","volume":"12","author":"Soret","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2022.111352_bib49","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1038\/d41586-021-01837-8","article-title":"Gut feeling yields evidence of microbial involvement in autoimmunity","volume":"595","author":"Svoboda","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111352_bib50","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2217\/fmb-2016-0130","article-title":"Roseburia spp.: a marker of health?","volume":"12","author":"Tamanai-Shacoori","year":"2017","journal-title":"Future Microbiol."},{"key":"10.1016\/j.celrep.2022.111352_bib51","doi-asserted-by":"crossref","DOI":"10.1136\/annrheumdis-2021-220687","article-title":"Metagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese","author":"Tomofuji","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.celrep.2022.111352_bib52","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41522-021-00192-w","article-title":"Salivary dysbiosis in Sjogren's syndrome and a commensal-mediated immunomodulatory effect of salivary gland epithelial cells","volume":"7","author":"Tseng","year":"2021","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.celrep.2022.111352_bib53","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1093\/rheumatology\/key215","article-title":"Dysbiosis of the buccal mucosa microbiome in primary Sjogren's syndrome patients","volume":"57","author":"van der Meulen","year":"2018","journal-title":"Rheumatology"},{"key":"10.1016\/j.celrep.2022.111352_bib54","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1136\/annrheumdis-2018-213026","article-title":"Reduced salivary secretion contributes more to changes in the oral microbiome of patients with primary Sj\u00f6gren\u2019s syndrome than underlying disease","volume":"77","author":"van der Meulen","year":"2018","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.celrep.2022.111352_bib55","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jaut.2018.10.009","article-title":"Shared gut, but distinct oral microbiota composition in primary Sj\u00f6gren's syndrome and systemic lupus erythematosus","volume":"97","author":"van der Meulen","year":"2019","journal-title":"J.\u00a0Autoimmun."},{"key":"10.1016\/j.celrep.2022.111352_bib56","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1136\/annrheumdis-2018-214404","article-title":"Normal vaginal microbiome in women with primary Sjogren's syndrome-associated vaginal dryness","volume":"78","author":"van der Meulen","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.celrep.2022.111352_bib57","article-title":"Microbiome in Sjogren's syndrome: here we are","author":"van der Meulen","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.celrep.2022.111352_bib58","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41584-021-00605-2","article-title":"Epithelial-immune cell interplay in primary Sjogren syndrome salivary gland pathogenesis","volume":"17","author":"Verstappen","year":"2021","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.celrep.2022.111352_bib59","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group","volume":"61","author":"Vitali","year":"2002","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.celrep.2022.111352_bib60","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/nrmicro.2016.83","article-title":"Metagenome-wide association studies: fine-mining the microbiome","volume":"14","author":"Wang","year":"2016","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2022.111352_bib61","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1136\/gutjnl-2019-318977","article-title":"Tracing the accumulation of in\u00a0vivo human oral microbiota elucidates microbial community dynamics at the gateway to the GI tract","volume":"69","author":"Wang","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2022.111352_bib62","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1136\/gutjnl-2018-315988","article-title":"Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus","volume":"67","author":"Wang","year":"2018","journal-title":"Gut"},{"key":"10.1016\/j.celrep.2022.111352_bib63","doi-asserted-by":"crossref","DOI":"10.1038\/s41575-021-00512-7","article-title":"Leveraging diet to engineer the gut microbiome","author":"Wolter","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"10.1016\/j.celrep.2022.111352_bib64","first-page":"100141","article-title":"clusterProfiler 4.0: a universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation"},{"key":"10.1016\/j.celrep.2022.111352_bib65","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/s43588-022-00247-8","article-title":"Large-scale microbiome data integration enables robust biomarker identification","volume":"2","author":"Xiao","year":"2022","journal-title":"Nat. Comput. Sci."},{"key":"10.1016\/j.celrep.2022.111352_bib66","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1136\/annrheumdis-2019-215763","article-title":"Shotgun metagenomics reveals an enrichment of potentially cross-reactive bacterial epitopes in ankylosing spondylitis patients, as well as the effects of TNFi therapy upon microbiome composition","volume":"79","author":"Yin","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.celrep.2022.111352_bib67","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/s41467-022-28746-2","article-title":"Changes to gut amino acid transporters and microbiome associated with increased E\/I ratio in Chd8(+\/-) mouse model of ASD-like behavior","volume":"13","author":"Yu","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2022.111352_bib68","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1039\/D0FO02984J","article-title":"Lactobacillus plantarum and Bifidobacterium bifidum alleviate dry eye in mice with exorbital lacrimal gland excision by modulating gut inflammation and microbiota","volume":"12","author":"Yun","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.celrep.2022.111352_bib69","article-title":"Gut microbiome and metabolites in systemic lupus erythematosus: link, mechanisms and intervention","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111352_bib70","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.molmed.2020.04.001","article-title":"The gut microbiota: emerging evidence in autoimmune diseases","volume":"26","author":"Zhang","year":"2020","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.celrep.2022.111352_bib71","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/nm.3914","article-title":"The oral and gut microbiomes are perturbed in rheumatoid arthritis and partly normalized after treatment","volume":"21","author":"Zhang","year":"2015","journal-title":"Nat. Med."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722011809?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124722011809?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:51:36Z","timestamp":1778842296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124722011809"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":71,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S2211124722011809"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2022.111352","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microbiota dysbiosis in primary Sj\u00f6gren\u2019s syndrome and the ameliorative effect of hydroxychloroquine","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2022.111352","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"111352"}}