{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:49:57Z","timestamp":1792651797959,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"13","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["01EO1503"],"award-info":[{"award-number":["01EO1503"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["315880\/2021-0"],"award-info":[{"award-number":["315880\/2021-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KA 4035\/1-1"],"award-info":[{"award-number":["KA 4035\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC\/TR 156"],"award-info":[{"award-number":["CRC\/TR 156"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC1292"],"award-info":[{"award-number":["CRC1292"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2013\/08216-2"],"award-info":[{"award-number":["2013\/08216-2"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/10867-0"],"award-info":[{"award-number":["2016\/10867-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.celrep.2022.111897","type":"journal-article","created":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T10:38:43Z","timestamp":1672137523000},"page":"111897","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":38,"title":["Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation"],"prefix":"10.1016","volume":"41","author":[{"given":"Fl\u00e1vio P.","family":"Veras","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel A.","family":"Publio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno M.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas S.","family":"Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thain\u00e1","family":"Norbiato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerry T.","family":"Cecilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Hiroki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Eduardo A.","family":"Damasceno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana E.","family":"Toller-Kawahisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timna V.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella F.","family":"Assun\u00e7\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogenes","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcia G.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel V.","family":"Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas A.","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana L.R.","family":"Alves-Rezende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne H.","family":"Karbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helder I.","family":"Nakaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago M.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cacilda S.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Q.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katiuchia U.","family":"Sales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Waisman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 C.","family":"Alves-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2022.111897_bib1","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri2622","article-title":"Skin immune sentinels in health and disease","volume":"9","author":"Nestle","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.celrep.2022.111897_bib2","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.3389\/fimmu.2018.01549","article-title":"The interplay between keratinocytes and immune cells in the pathogenesis of psoriasis","volume":"9","author":"Albanesi","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111897_bib3","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1038\/s41590-019-0514-y","article-title":"IL-17 receptor\u2013based signaling and implications for disease","volume":"20","author":"Li","year":"2019","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2022.111897_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cyto.2009.07.588","article-title":"Act1, a novel U-box E3 ubiquitin ligase for IL-17R-mediated signalling","volume":"48","author":"Manuscript","year":"2009","journal-title":"Cytokine"},{"key":"10.1016\/j.celrep.2022.111897_bib5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/ni1439","article-title":"The adaptor Act1 is required for interleukin 17 - dependent signaling associated with autoimmune and inflammatory disease","volume":"8","author":"Qian","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2022.111897_bib6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/jid.2012.194","article-title":"The emerging role of IL-17 in the pathogenesis of psoriasis","volume":"133","author":"Martin","year":"2013","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.celrep.2022.111897_bib7","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.jid.2019.01.006","article-title":"Imiquimod-induced psoriasis in mice depends on the IL-17 signaling of keratinocytes","volume":"139","author":"Moos","year":"2019","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2022.111897_bib8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.semcdb.2015.08.004","article-title":"Pyruvate kinase: function, regulation and role in cancer","volume":"43","author":"Israelsen","year":"2015","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2022.111897_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-018-0065-6","article-title":"Non-canonical functions of enzymes facilitate cross-talk between cell metabolic and regulatory pathways","volume":"50","author":"Snaebjornsson","year":"2018","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.celrep.2022.111897_bib10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3389\/fimmu.2016.00145","article-title":"Pyruvate kinase M2: a potential target for regulating inflammation","volume":"7","author":"Alves-Filho","year":"2016","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111897_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.cmet.2014.12.005","article-title":"Pyruvate kinase M2 regulates hif-1\u03b1 activity and il-1\u03b2 induction and is a critical determinant of the warburg effect in LPS-activated macrophages","volume":"21","author":"Palsson-Mcdermott","year":"2015","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2022.111897_bib12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1084\/jem.20150900","article-title":"The glycolytic enzyme PKM2 bridges metabolic and inflammatory dysfunction in coronary artery disease","volume":"213","author":"Shirai","year":"2016","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2022.111897_bib13","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cmet.2019.10.015","article-title":"Pharmacological activation of pyruvate kinase M2 inhibits CD4+ T\u00a0cell pathogenicity and suppresses autoimmunity","volume":"31","author":"Angiari","year":"2020","journal-title":"Cell Metabol."},{"key":"10.1016\/j.celrep.2022.111897_bib14","doi-asserted-by":"crossref","first-page":"e20190613","DOI":"10.1084\/jem.20190613","article-title":"PKM2 promotes Th17 cell differentiation and autoimmune inflammation by fine-tuning STAT3 activation","volume":"217","author":"Damasceno","year":"2020","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2022.111897_bib15","doi-asserted-by":"crossref","first-page":"e127395","DOI":"10.1172\/jci.insight.127395","article-title":"Pyruvate kinase M2 is requisite for Th1 and Th17 differentiation","volume":"4","author":"Kono","year":"2019","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2022.111897_bib16","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1038\/jid.2014.28","article-title":"Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms","volume":"134","author":"Li","year":"2014","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2022.111897_bib17","doi-asserted-by":"crossref","first-page":"e2737","DOI":"10.1371\/journal.pone.0002737","article-title":"Type I interferon: potential therapeutic target for psoriasis?","volume":"3","author":"Yao","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2022.111897_bib18","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1038\/jid.2012.184","article-title":"Expanding the psoriasis disease profile: interrogation of the skin and serum of patients with moderate-to-severe psoriasis","volume":"132","author":"Su\u00e1rez-Fari\u00f1as","year":"2012","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2022.111897_bib19","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/sj.jid.5700488","article-title":"Increased expression of Wnt5a in psoriatic plaques","volume":"127","author":"Reischl","year":"2007","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2022.111897_bib20","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1046\/j.1523-1747.2001.01327.x","article-title":"Keratins and the keratinocyte activation cycle","volume":"116","author":"Freedberg","year":"2001","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2022.111897_bib21","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/j.1600-0625.2012.01571.x","article-title":"Novel insights into the role of S100A8\/A9 in skin biology","volume":"21","author":"Kerkhoff","year":"2012","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.celrep.2022.111897_bib22","doi-asserted-by":"crossref","first-page":"5836","DOI":"10.4049\/jimmunol.0802999","article-title":"Imiquimod-induced psoriasis-like skin inflammation in mice is mediated via the IL-23\/IL-17 Axis","volume":"182","author":"van der Fits","year":"2009","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2022.111897_bib23","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.immuni.2018.03.019","article-title":"An interleukin-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation","volume":"48","author":"Xu","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2022.111897_bib26","doi-asserted-by":"crossref","first-page":"2466","DOI":"10.1038\/jid.2012.163","article-title":"Anti-IL-17 receptor antibody AMG 827 leads to rapid clinical response in subjects with moderate to severe psoriasis: results from a phase I, randomized, placebo-controlled trial","volume":"132","author":"Papp","year":"2012","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2022.111897_bib24","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/jid.2013.404","article-title":"IL-6 regulates neutrophil microabscess formation in IL-17A-driven psoriasiform lesions","volume":"134","author":"Croxford","year":"2014","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2022.111897_bib25","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.4049\/jimmunol.1301737","article-title":"Gene expression profiles normalized in psoriatic skin by treatment with brodalumab, a human anti\u2013IL-17 receptor monoclonal antibody","volume":"192","author":"Russell","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2022.111897_bib27","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.cell.2013.09.025","article-title":"XPKM2 Isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells","volume":"155","author":"Israelsen","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.celrep.2022.111897_bib28","doi-asserted-by":"crossref","first-page":"4775","DOI":"10.1242\/dev.127.22.4775","article-title":"Sonic hedgehog regulates growth and morphogenesis of the tooth","volume":"127","author":"Dassule","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.celrep.2022.111897_bib29","doi-asserted-by":"crossref","first-page":"8551","DOI":"10.1073\/pnas.96.15.8551","article-title":"The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skin","volume":"96","author":"Vasioukhin","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2022.111897_bib30","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1038\/nchembio.1060","article-title":"Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis","volume":"8","author":"Anastasiou","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.celrep.2022.111897_bib31","doi-asserted-by":"crossref","first-page":"13280","DOI":"10.1038\/ncomms13280","article-title":"PKM2-Dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation","volume":"7","author":"Xie","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2022.111897_bib32","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.jaci.2017.07.004","article-title":"Psoriasis pathogenesis and the development of novel targeted immune therapies","volume":"140","author":"Hawkes","year":"2017","journal-title":"J.\u00a0Allergy Clin. Immunol."},{"key":"10.1016\/j.celrep.2022.111897_bib33","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.3389\/fimmu.2019.02376","article-title":"Neutrophils in psoriasis","volume":"10","author":"Chiang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2022.111897_bib34","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.4049\/jimmunol.1302959","article-title":"Interplay between CXCR2 and BLT1 facilitates neutrophil infiltration and resultant keratinocyte activation in a murine model of imiquimod-induced psoriasis","volume":"192","author":"Sumida","year":"2014","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2022.111897_bib35","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12943-015-0490-2","article-title":"PKM2 promotes tumor angiogenesis by regulating HIF-1 \u03b1 through NF- \u03ba B activation","volume":"15","author":"Azoitei","year":"2016","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.celrep.2022.111897_bib36","doi-asserted-by":"crossref","first-page":"4543","DOI":"10.1172\/JCI120912","article-title":"Endothelial pyruvate kinase M2 maintains vascular integrity Graphical abstract Find the latest version : endothelial pyruvate kinase M2 maintains vascular integrity","volume":"128","author":"Kim","year":"2018","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2022.111897_bib37","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1172\/JCI11830","article-title":"NF- \u03ba B in defense and disease NF- \u03ba B : a key role in inflammatory diseases","volume":"107","author":"Tak","year":"2001","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2022.111897_bib38","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1084\/jem.191.7.1233","article-title":"Requirement of tumor necrosis factor receptor-associated factor (TRAF)6 in interleukin 17 signal transduction","volume":"191","author":"Schwandner","year":"2000","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.celrep.2022.111897_bib39","doi-asserted-by":"crossref","first-page":"35603","DOI":"10.1074\/jbc.C600256200","article-title":"Act1 adaptor protein is an immediate and essential signaling component of interleukin-17 receptor","volume":"281","author":"Chang","year":"2006","journal-title":"J.\u00a0Biol. Chem."},{"key":"10.1016\/j.celrep.2022.111897_bib40","doi-asserted-by":"crossref","first-page":"765790","DOI":"10.3389\/fphar.2021.765790","article-title":"Pyruvate kinase M2 mediates glycolysis contributes to psoriasis by promoting keratinocyte proliferation","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.celrep.2022.111897_bib41","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.bcp.2019.05.001","article-title":"Shikonin inhibits triple-negative breast cancer-cell metastasis by reversing the epithelial-to-mesenchymal transition via glycogen synthase kinase 3\u03b2-regulated suppression of \u03b2-catenin signaling","volume":"166","author":"Chen","year":"2019","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.celrep.2022.111897_bib42","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1007\/s10753-019-00982-7","article-title":"Shikonin controls the differentiation of CD4+CD25+ regulatory T\u00a0cells by inhibiting AKT\/mTOR pathway","volume":"42","author":"Zhang","year":"2019","journal-title":"Inflammation"},{"key":"10.1016\/j.celrep.2022.111897_bib43","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-18551-z","article-title":"Combined shRNA over CRISPR\/cas9 as a methodology to detect off-target effects and a potential compensatory mechanism","volume":"8","author":"Peretz","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2022.111897_bib44","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1101\/gad.278549.116","article-title":"Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma","volume":"30","author":"Dayton","year":"2016","journal-title":"Genes Dev."},{"key":"10.1016\/j.celrep.2022.111897_bib45","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1038\/ncomms2186","article-title":"Supporting conditional mouse mutagenesis with a comprehensive cre characterization resource","volume":"3","author":"Heffner","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.celrep.2022.111897_bib46","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1023\/A:1008942828960","article-title":"Conditional gene targeting in macrophages and granulocytes using LysMcre mice","volume":"8","author":"Clausen","year":"1999","journal-title":"Transgenic Res."},{"key":"10.1016\/j.celrep.2022.111897_bib47","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.immuni.2016.02.007","article-title":"Intestinal interleukin-17 receptor signaling mediates reciprocal control of the gut microbiota and autoimmune inflammation","volume":"44","author":"Kumar","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2022.111897_bib48","first-page":"61","article-title":"IL-17A and IL-17F do not contribute vitally to autoimmune neuro-inflammation in mice","volume":"119","author":"Haak","year":"2009","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2022.111897_bib49","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00401-020-02187-x","article-title":"Interleukin-1 promotes autoimmune neuroinflammation by suppressing endothelial heme oxygenase-1 at the blood\u2013brain barrier","volume":"140","author":"Hauptmann","year":"2020","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.celrep.2022.111897_bib50","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1038\/nprot.2013.143","article-title":"Genome engineering using the CRISPR-Cas9 system","volume":"8","author":"Ran","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.celrep.2022.111897_bib51","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature06734","article-title":"The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth","volume":"452","author":"Christofk","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2022.111897_bib52","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1261\/rna.2192803","article-title":"Lentivirus-delivered stable gene silencing by RNAi in primary cells","volume":"9","author":"Stewart","year":"2003","journal-title":"RNA"},{"key":"10.1016\/j.celrep.2022.111897_bib53","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/mt.2013.19","article-title":"Lentiviral delivery of RNAi for in\u00a0vivo lineage-specific modulation of gene expression in mouse lung macrophages","volume":"21","author":"Wilson","year":"2013","journal-title":"Mol. Ther."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472201796X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221112472201796X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:53:09Z","timestamp":1778842389000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221112472201796X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":53,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S221112472201796X"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2022.111897","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pyruvate kinase M2 mediates IL-17 signaling in keratinocytes driving psoriatic skin inflammation","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2022.111897","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"111897"}}