{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:08:03Z","timestamp":1792440483526,"version":"4.5.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T00:00:00Z","timestamp":1674000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/P011284\/1"],"award-info":[{"award-number":["MR\/P011284\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Reports"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.celrep.2023.112054","type":"journal-article","created":{"date-parts":[[2023,1,30]],"date-time":"2023-01-30T18:28:44Z","timestamp":1675103324000},"page":"112054","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["TNFR2+ regulatory T\u00a0cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing \u03b3\u03b4 T\u00a0cells in the lung"],"prefix":"10.1016","volume":"42","author":[{"given":"Rong","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Jacques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shadia","family":"Khandaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daan","family":"Beentjes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Leon-Rios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel R.","family":"Neill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aras","family":"Kadioglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.celrep.2023.112054_bib1","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nature01320","article-title":"Points of control in inflammation","volume":"420","author":"Nathan","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112054_bib2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.micinf.2015.01.004","article-title":"How bacterial pathogens colonize their hosts and invade deeper tissues","volume":"17","author":"Ribet","year":"2015","journal-title":"Microbes Infect."},{"key":"10.1016\/j.celrep.2023.112054_bib3","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/nrmicro1871","article-title":"The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease","volume":"6","author":"Kadioglu","year":"2008","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.celrep.2023.112054_bib4","doi-asserted-by":"crossref","first-page":"e60273","DOI":"10.1371\/journal.pone.0060273","article-title":"Estimating the burden of pneumococcal pneumonia among adults: a systematic review and meta-analysis of diagnostic techniques","volume":"8","author":"Said","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.celrep.2023.112054_bib5","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s15010-015-0837-z","article-title":"Bacteremic pneumococcal pneumonia: clinical outcomes and preliminary results of inflammatory response","volume":"43","author":"Bordon","year":"2015","journal-title":"Infection"},{"key":"10.1016\/j.celrep.2023.112054_bib6","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1017\/S0950268810002402","article-title":"Outcomes of hospitalized patients with bacteraemic and non-bacteraemic community-acquired pneumonia caused by Streptococcus pneumoniae","volume":"139","author":"Lin","year":"2011","journal-title":"Epidemiol. Infect."},{"key":"10.1016\/j.celrep.2023.112054_bib7","doi-asserted-by":"crossref","first-page":"2620","DOI":"10.1128\/IAI.01169-09","article-title":"Importance of CXC chemokine receptor 2 in alveolar neutrophil and exudate macrophage recruitment in response to pneumococcal lung infection","volume":"78","author":"Herbold","year":"2010","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2023.112054_bib8","first-page":"1","article-title":"Neutrophil activation and acute lung injury","volume":"7","author":"Lee","year":"2001","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.celrep.2023.112054_bib9","doi-asserted-by":"crossref","first-page":"6024","DOI":"10.4049\/jimmunol.1500124","article-title":"Regulation of neutrophilic inflammation by proteinase-activated receptor 1 during bacterial pulmonary infection","volume":"194","author":"Jos\u00e9","year":"2015","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.112054_bib10","doi-asserted-by":"crossref","first-page":"666732","DOI":"10.3389\/fphar.2021.666732","article-title":"Phagocytosis, degranulation and extracellular traps release by neutrophils\u2014the current knowledge, pharmacological modulation and future prospects","volume":"12","author":"Gierlikowska","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.celrep.2023.112054_bib11","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1186\/s12985-020-01449-0","article-title":"Role of \u03b3\u03b4 T\u00a0cells in controlling viral infections with a focus on influenza virus: implications for designing novel therapeutic approaches","volume":"17","author":"Sabbaghi","year":"2020","journal-title":"Virol. J."},{"key":"10.1016\/j.celrep.2023.112054_bib12","doi-asserted-by":"crossref","first-page":"e1004300","DOI":"10.1371\/journal.ppat.1004300","article-title":"Role of non-conventional T lymphocytes in respiratory infections: the case of the pneumococcus","volume":"10","author":"Ivanov","year":"2014","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2023.112054_bib13","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1002\/eji.200737216","article-title":"Evidence for the involvement of lung-specific gammadelta T\u00a0cell subsets in local responses to Streptococcus pneumoniae infection","volume":"37","author":"Kirby","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2023.112054_bib14","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.immuni.2011.08.001","article-title":"Pivotal role of dermal IL-17-producing \u03b3\u03b4 T\u00a0cells in skin inflammation","volume":"35","author":"Cai","year":"2011","journal-title":"Immunity"},{"key":"10.1016\/j.celrep.2023.112054_bib15","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nature14282","article-title":"IL-17-producing \u03b3\u03b4 T\u00a0cells and neutrophils conspire to promote breast cancer metastasis","volume":"522","author":"Coffelt","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.celrep.2023.112054_bib16","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/mi.2017.93","article-title":"Protective role of \u03b3\u03b4 T\u00a0cells in cigarette smoke and influenza infection","volume":"11","author":"Hong","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.celrep.2023.112054_bib17","doi-asserted-by":"crossref","first-page":"e1002660","DOI":"10.1371\/journal.ppat.1002660","article-title":"T regulatory cells control susceptibility to invasive pneumococcal pneumonia in mice","volume":"8","author":"Neill","year":"2012","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.celrep.2023.112054_bib18","doi-asserted-by":"crossref","first-page":"e133251","DOI":"10.1172\/jci.insight.133251","article-title":"Estradiol resolves pneumonia via ER\u03b2 in regulatory T\u00a0cells","volume":"6","author":"Xiong","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.celrep.2023.112054_bib19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1128\/iai.65.1.257-260.1997","article-title":"Role of tumor necrosis factor alpha in pathogenesis of pneumococcal pneumonia in mice","volume":"65","author":"Takashima","year":"1997","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2023.112054_bib20","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1086\/429296","article-title":"The role played by tumor necrosis factor during localized and systemic infection withStreptococcus pneumoniae","volume":"191","author":"Kirby","year":"2005","journal-title":"J.\u00a0Infect. Dis."},{"key":"10.1016\/j.celrep.2023.112054_bib21","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1128\/IAI.70.3.1547-1557.2002","article-title":"Role of inflammatory mediators in resistance and susceptibility to pneumococcal infection","volume":"70","author":"Kerr","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2023.112054_bib22","doi-asserted-by":"crossref","first-page":"154","DOI":"10.4049\/jimmunol.179.1.154","article-title":"Interaction of TNF with TNF receptor type 2 promotes expansion and function of mouse CD4+CD25+ T regulatory cells","volume":"179","author":"Chen","year":"2007","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.112054_bib23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1159\/000289201","article-title":"TNF-\u03b1: an activator of CD4+FoxP3+TNFR2+ regulatory T\u00a0cells","author":"Chen","year":"2010","journal-title":"Curr. Dir. Autoimmun."},{"key":"10.1016\/j.celrep.2023.112054_bib24","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3389\/fcell.2020.00401","article-title":"Selective targeting of TNF receptors as a novel therapeutic approach","volume":"8","author":"Fischer","year":"2020","journal-title":"Front. Cell Dev. Biol."},{"key":"10.1016\/j.celrep.2023.112054_bib25","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.4049\/jimmunol.1202659","article-title":"TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment","volume":"190","author":"Chen","year":"2013","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.112054_bib26","doi-asserted-by":"crossref","first-page":"13051","DOI":"10.1073\/pnas.1807499115","article-title":"Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity","volume":"115","author":"Atretkhany","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.112054_bib27","doi-asserted-by":"crossref","first-page":"784","DOI":"10.3389\/fimmu.2018.00784","article-title":"Role of TNF\u2013TNF receptor 2 signal in regulatory T\u00a0cells and its therapeutic implications","volume":"9","author":"Yang","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.celrep.2023.112054_bib28","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0025-6196(11)62418-X","article-title":"Fatal sepsis in a patient with rheumatoid arthritis treated with etanercept","volume":"76","author":"Baghai","year":"2001","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.celrep.2023.112054_bib29","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1093\/rheumatology\/keh167","article-title":"Pneumococcal vaccination for RA patients on TNF- antagonists","volume":"43","author":"Wright","year":"2004","journal-title":"Rheumatology"},{"key":"10.1016\/j.celrep.2023.112054_bib30","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1093\/rheumatology\/keh680","article-title":"Fatal streptococcal toxic shock syndrome in a patient with rheumatoid arthritis treated with etanercept","volume":"44","author":"Uthman","year":"2005","journal-title":"Rheumatology"},{"key":"10.1016\/j.celrep.2023.112054_bib31","doi-asserted-by":"crossref","first-page":"193","DOI":"10.5414\/CPP46193","article-title":"Septic shock and community-acquired pneumonia associated with etanercept therapy","volume":"46","author":"Nu\u00f1ez-Cornejo","year":"2008","journal-title":"Int. J. Clin. Pharmacol. Ther."},{"key":"10.1016\/j.celrep.2023.112054_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.1997.8218","article-title":"Selective modulation of T\u00a0cell memory markers CD62L and CD44 on murine draining lymph node cells following allergen and irritant treatment","volume":"146","author":"Gerberick","year":"1997","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.celrep.2023.112054_bib33","series-title":"In\u00a0Vivo Depletion of FoxP3+ Tregs Using the DEREG Mouse Model","first-page":"157","author":"Lahl","year":"2011"},{"key":"10.1016\/j.celrep.2023.112054_bib34","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.4049\/jimmunol.164.9.4783","article-title":"Requirement of endogenous stem cell factor and granulocyte-colony-stimulating factor for IL-17-mediated granulopoiesis","volume":"164","author":"Schwarzenberger","year":"2000","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.112054_bib35","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/s41385-019-0212-y","article-title":"Interleukin-7 protects against bacterial respiratory infection by promoting IL-17A-producing innate T-cell response","volume":"13","author":"Hassane","year":"2020","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.celrep.2023.112054_bib36","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1038\/mi.2016.113","article-title":"Neutrophilic NLRP3 inflammasome-dependent IL-1beta secretion regulates the gammadeltaT17 cell response in respiratory bacterial infections","volume":"10","author":"Hassane","year":"2017","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.celrep.2023.112054_bib37","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1093\/rheumatology\/keg263","article-title":"Serious bacterial infections in patients with rheumatoid arthritis under anti-TNF-alpha therapy","volume":"42","author":"Kroesen","year":"2003","journal-title":"Rheumatology"},{"key":"10.1016\/j.celrep.2023.112054_bib38","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1164\/ajrccm.155.2.9032201","article-title":"Passive immunization against tumor necrosis factor-alpha impairs host defense during pneumococcal pneumonia in mice","volume":"155","author":"van der Poll","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.celrep.2023.112054_bib39","doi-asserted-by":"crossref","first-page":"5240","DOI":"10.4049\/jimmunol.167.9.5240","article-title":"TNF-\u03b1 compensates for the impaired host defense of IL-1 type I receptor-deficient mice during pneumococcal pneumonia","volume":"167","author":"Rijneveld","year":"2001","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.112054_bib40","doi-asserted-by":"crossref","first-page":"7530","DOI":"10.4049\/jimmunol.175.11.7530","article-title":"Lung NF-\u03baB activation and neutrophil recruitment require IL-1 and TNF receptor signaling during pneumococcal pneumonia","volume":"175","author":"Jones","year":"2005","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.112054_bib41","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1038\/s41590-020-0785-3","article-title":"Interleukin-33 activates regulatory T\u00a0cells to suppress innate \u03b3\u03b4 T\u00a0cell responses in the lung","volume":"21","author":"Faustino","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2023.112054_bib42","doi-asserted-by":"crossref","first-page":"943","DOI":"10.4049\/jimmunol.160.2.943","article-title":"TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation","volume":"160","author":"Peschon","year":"1998","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.celrep.2023.112054_bib43","doi-asserted-by":"crossref","first-page":"e144016","DOI":"10.1172\/JCI144016","article-title":"TNFR2\/14-3-3epsilon signaling complex instructs macrophage plasticity in inflammation and autoimmunity","volume":"131","author":"Fu","year":"2021","journal-title":"J.\u00a0Clin. Invest."},{"key":"10.1016\/j.celrep.2023.112054_bib44","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.micinf.2006.11.015","article-title":"Accumulation of gamma\/delta T\u00a0cells in the lungs and their roles in neutrophil-mediated host defense against pneumococcal infection","volume":"9","author":"Nakasone","year":"2007","journal-title":"Microbes Infect."},{"key":"10.1016\/j.celrep.2023.112054_bib45","doi-asserted-by":"crossref","first-page":"12304","DOI":"10.1128\/JVI.01269-12","article-title":"Type I interferon induction during influenza virus infection increases susceptibility to secondary Streptococcus pneumoniae infection by negative regulation of T\u00a0cells","volume":"86","author":"Li","year":"2012","journal-title":"J.\u00a0Virol."},{"key":"10.1016\/j.celrep.2023.112054_bib46","doi-asserted-by":"crossref","first-page":"17034","DOI":"10.1073\/pnas.0708426104","article-title":"Optimal induction of T helper 17 cells in humans requires T\u00a0cell receptor ligation in the context of Toll-like receptor-activated monocytes","volume":"104","author":"Evans","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.celrep.2023.112054_bib47","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17\u2013producing CD4+ effector T\u00a0cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.celrep.2023.112054_bib48","doi-asserted-by":"crossref","first-page":"e48647","DOI":"10.15252\/embr.201948647","article-title":"STAT 3 but not STAT 4 is critical for \u03b3\u03b4T17 cell responses and skin inflammation","volume":"20","author":"Agerholm","year":"2019","journal-title":"EMBO Rep."},{"key":"10.1016\/j.celrep.2023.112054_bib49","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.jid.2017.09.035","article-title":"STAT1 gain-of-function and dominant negative STAT3 mutations impair IL-17 and IL-22 immunity associated with CMC","volume":"138","author":"Hiller","year":"2018","journal-title":"J.\u00a0Invest. Dermatol."},{"key":"10.1016\/j.celrep.2023.112054_bib50","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s41385-019-0246-1","article-title":"IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue","volume":"13","author":"Xu","year":"2020","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.celrep.2023.112054_bib51","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1002\/eji.200737810","article-title":"IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T\u00a0cells and suppression of Th17 cells","volume":"37","author":"Niedbala","year":"2007","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.celrep.2023.112054_bib52","first-page":"e0310322","article-title":"Influence of Streptococcus pneumoniae within-strain population diversity on virulence and pathogenesis","author":"Jacques","year":"2022","journal-title":"Microbiol. Spectr."},{"key":"10.1016\/j.celrep.2023.112054_bib53","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.celrep.2023.112054_bib54","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1128\/IAI.68.2.492-501.2000","article-title":"Host cellular immune response to pneumococcal lung infection in mice","volume":"68","author":"Kadioglu","year":"2000","journal-title":"Infect. Immun."},{"key":"10.1016\/j.celrep.2023.112054_bib55","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1136\/vr.116.16.431","article-title":"Guidelines on the recognition of pain, distress and discomfort in experimental animals and an hypothesis for assessment","volume":"116","author":"Morton","year":"1985","journal-title":"Vet. Rec."},{"key":"10.1016\/j.celrep.2023.112054_bib56","first-page":"55398","article-title":"Bronchoalveolar lavage of murine lungs to analyze inflammatory cell infiltration","author":"Van Hoecke","year":"2017","journal-title":"J.\u00a0Vis. Exp."},{"key":"10.1016\/j.celrep.2023.112054_bib57","first-page":"54596","article-title":"Isolation and activation of murine lymphocytes","author":"Lim","year":"2016","journal-title":"J.\u00a0Vis. Exp."}],"container-title":["Cell Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723000657?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211124723000657?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T11:59:56Z","timestamp":1761911996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211124723000657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S2211124723000657"],"URL":"https:\/\/doi.org\/10.1016\/j.celrep.2023.112054","relation":{},"ISSN":["2211-1247"],"issn-type":[{"value":"2211-1247","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TNFR2+ regulatory T\u00a0cells protect against bacteremic pneumococcal pneumonia by suppressing IL-17A-producing \u03b3\u03b4 T\u00a0cells in the lung","name":"articletitle","label":"Article Title"},{"value":"Cell Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.celrep.2023.112054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"112054"}}